Structure of human RNase L reveals the basis for regulated RNA decay in the IFN response

Science

Volumn 343, Issue 6176, 2014, Pages 1244-1248

  Han, Yuchen ^a   Donovan, Jesse ^a   Rath, Sneha ^a   Whitney, Gena ^a   Chitrakar, Alisha ^a   Korennykh, Alexei ^a  

^a PRINCETON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HOMODIMER; INTERFERON; LIGAND; NUCLEASE; NUCLEOTIDE; PHOSPHOTRANSFERASE; RIBONUCLEASE L; 2-5A-DEPENDENT RIBONUCLEASE; RIBONUCLEASE; VIRUS RNA;

CRYSTAL STRUCTURE; ENZYME ACTIVITY; HOMOLOGY; LIGAND; RNA; SUBSTRATE;

ARTICLE; CRYSTAL STRUCTURE; CYTOKINE RESPONSE; ENZYME PHOSPHORYLATION; ENZYME STABILITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; HUMAN; INTERACTIONS WITH RNA; MOLECULAR RECOGNITION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN QUATERNARY STRUCTURE; RNA CLEAVAGE; RNA DECAY; RNA SEQUENCE; STRUCTURAL HOMOLOGY; WESTERN BLOTTING; CHEMISTRY; GENETICS; HELA CELL LINE; HEPATITIS B VIRUS; METABOLISM; PHYSIOLOGY; PROTEIN MULTIMERIZATION; PROTEIN TERTIARY STRUCTURE; RNA STABILITY; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; ENDORIBONUCLEASES; HELA CELLS; HEPATITIS B VIRUS; HUMANS; INTERFERON TYPE I; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, TERTIARY; RNA CLEAVAGE; RNA STABILITY; RNA, VIRAL;

EID: 84896045262     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1249845     Document Type: Article

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