RNA:DNA hybrids are a novel molecular pattern sensed by TLR9

EMBO Journal

Volumn 33, Issue 6, 2014, Pages 542-558

  Rigby, Rachel E ^a,f   Webb, Lauren M ^b,g   Mackenzie, Karen J ^a   Li, Yue ^c   Leitch, Andrea ^a   Reijns, Martin A M ^a   Lundie, Rachel J ^b   Revuelta, Ailsa ^a   Davidson, Donald J ^d   Diebold, Sandra ^e   Modis, Yorgo ^c   MacDonald, Andrew S ^b,g   Jackson, Andrew P ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c YALE UNIVERSITY   (United States)

^d UNIVERSITY OF EDINBURGH   (United Kingdom)

^e KING'S COLLEGE LONDON   (United Kingdom)

^f UNIVERSITY OF OXFORD   (United Kingdom)

^g UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

innate immune signalling; pathogen associated molecular pattern; RNA:DNA hybrid; TLR9

Indexed keywords

CD135 ANTIGEN; CYTOKINE; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 9;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOSOL; DENDRITIC CELL; DNA PURIFICATION; DNA RNA HYBRIDIZATION; DNA SYNTHESIS; ENDOSOME; FEMALE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; IMMUNE RESPONSE; INNATE IMMUNITY; INTERFERON PRODUCTION; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; RETROVIRUS INFECTION; RNA PURIFICATION; RNA SYNTHESIS; SIGNAL TRANSDUCTION;

ANIMALS; BLOTTING, WESTERN; DENDRITIC CELLS; ENDOSOMES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FLUORESCENCE POLARIZATION; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IMMUNITY, INNATE; IMMUNOBLOTTING; MICE; MICE, INBRED C57BL; MODELS, IMMUNOLOGICAL; MYELOID DIFFERENTIATION FACTOR 88; NUCLEIC ACID HETERODUPLEXES; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 9;

EID: 84898636091     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1002/embj.201386117     Document Type: Article

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