Nuclease activity of the human SAMHD1 protein implicated in the aicardi-goutières syndrome and HIV-1 restriction

Journal of Biological Chemistry

Volumn 288, Issue 12, 2013, Pages 8101-8110

  Beloglazova, Natalia ^a   Flick, Robert ^a   Tchigvintsev, Anatoli ^a   Brown, Greg ^a   Popovic, Ana ^a   Nocek, Boguslaw ^b   Yakunin, Alexander F ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b ARGONNE NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EXONUCLEASE ACTIVITY; IN-VITRO; MYELOID CELLS; NUCLEASE ACTIVITY; RNA BINDING; SECONDARY STRUCTURES; SINGLE-STRANDED DNA;

PROTEINS; RNA;

DISEASES;

DOUBLE STRANDED DNA; DOUBLE STRANDED RNA; NUCLEASE; NUCLEOSIDE TRIPHOSPHATASE; PROTEIN SAMHD1; SINGLE STRANDED DNA; SINGLE STRANDED RNA; UNCLASSIFIED DRUG;

AICARDI GOUTIERES SYNDROME; ARTICLE; CONTROLLED STUDY; DNA CLEAVAGE; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN RNA BINDING; PROTEIN SECONDARY STRUCTURE; RNA CLEAVAGE; STRUCTURE ACTIVITY RELATION; VIRUS REPLICATION;

AMINO ACID SUBSTITUTION; AUTOIMMUNE DISEASES OF THE NERVOUS SYSTEM; CATALYTIC DOMAIN; DNA CLEAVAGE; DNA, SINGLE-STRANDED; EXONUCLEASES; GAG GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; HIV-1; HUMANS; HYDROLYSIS; MAGNESIUM; MOLECULAR SEQUENCE ANNOTATION; MONOMERIC GTP-BINDING PROTEINS; MUTAGENESIS, SITE-DIRECTED; NERVOUS SYSTEM MALFORMATIONS; PROTEIN BINDING; RNA; RNA CLEAVAGE; RNA, VIRAL; TAT GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS 1; PROKARYOTA;

EID: 84874959500     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.431148     Document Type: Article

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