Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 42, 2015, Pages E5699-E5705

  Gao, Daxing ^a   Li, Tuo ^a   Li, Xiao Dong ^a   Chen, Xiang ^a   Li, Quan Zhen ^a   Wight Carter, Mary ^a   Chen, Zhijian J ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Autoimmune disease; CGAMP; CGAS; DNaseII; Trex1

Indexed keywords

ADAPTOR PROTEIN; CYCLIC GMP; CYCLIC GMP AMP SYNTHASE; DEOXYRIBONUCLEASE II; EXONUCLEASE; GAMMA INTERFERON; INTERLEUKIN 12; PROTEIN STING; PROTEIN TREX1; UNCLASSIFIED DRUG; AUTACOID; AUTOANTIBODY; CYCLIC AMP; CYTOKINE; DNA; EXODEOXYRIBONUCLEASE; MB21D1 PROTEIN, MOUSE; NUCLEOTIDYLTRANSFERASE; PHOSPHOPROTEIN; THREE PRIME REPAIR EXONUCLEASE 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONFERENCE PAPER; EMBRYO; ENZYME ACTIVATION; GENE EXPRESSION; MASS SPECTROMETRY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; SECOND MESSENGER; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; ANIMAL; BIOSYNTHESIS; ENZYMOLOGY; GENETICS; IMMUNOLOGY; KNOCKOUT MOUSE; LYMPHOCYTE ACTIVATION; METABOLISM; T LYMPHOCYTE;

ANIMALS; AUTOANTIBODIES; AUTOIMMUNE DISEASES; CYCLIC AMP; CYTOKINES; DNA; ENZYME ACTIVATION; EXODEOXYRIBONUCLEASES; INFLAMMATION MEDIATORS; LYMPHOCYTE ACTIVATION; MICE; MICE, KNOCKOUT; NUCLEOTIDYLTRANSFERASES; PHOSPHOPROTEINS; T-LYMPHOCYTES;

EID: 84947245185     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1516465112     Document Type: Article

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