메뉴 건너뛰기




Volumn 18, Issue 11, 2012, Pages 1682-1687

SAMHD1 restricts HIV-1 infection in resting CD4 + T cells

(20)  Baldauf, Hanna Mari a,b   Pan, Xiaoyu a   Erikson, Elina a,b   Schmidt, Sarah a   Daddacha, Waaqo c   Burggraf, Manja d   Schenkova, Kristina a   Ambiel, Ina a,b   Wabnitz, Guido a   Gramberg, Thomas e   Panitz, Sylvia d   Flory, Egbert d   Landau, Nathaniel R f   Sertel, Serkan a   Rutsch, Frank g   Lasitschka, Felix a   Kim, Baek c,h   König, Renate d,i   Fackler, Oliver T a   Keppler, Oliver T a,b  


Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; PROTEASOME; PROTEIN X; SAMHD1 PROTEIN; UNCLASSIFIED DRUG; VIRUS RNA;

EID: 84869170593     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm.2964     Document Type: Article
Times cited : (495)

References (47)
  • 1
    • 79251480064 scopus 로고    scopus 로고
    • Abortive HIV infection mediates CD4 T cell depletion and inflammation in human lymphoid tissue
    • Doitsh, G. et al. Abortive HIV infection mediates CD4 T cell depletion and inflammation in human lymphoid tissue. Cell 143, 789-801 (2010
    • (2010) Cell , vol.143 , pp. 789-801
    • Doitsh, G.1
  • 3
    • 0031594498 scopus 로고    scopus 로고
    • 1b phase of the cell cycle is required for completion of human immunodeficiency virus type 1 reverse transcription in T cells
    • Korin, Y.D. & Zack, J.A. Progression to the G1b phase of the cell cycle is required for completion of human immunodeficiency virus type 1 reverse transcription in T cells. J. Virol. 72, 3161-3168 (1998 (Pubitemid 28175559)
    • (1998) Journal of Virology , vol.72 , Issue.4 , pp. 3161-3168
    • Korin, Y.D.1    Zack, J.A.2
  • 4
    • 0036340605 scopus 로고    scopus 로고
    • Molecular characterization of preintegration latency in human immunodeficiency virus type 1 infection
    • DOI 10.1128/JVI.76.17.8518-8513.2002
    • Pierson, T.C. et al. Molecular characterization of preintegration latency in human immunodeficiency virus type 1 infection. J. Virol. 76, 8518-8531 (2002 (Pubitemid 34864046)
    • (2002) Journal of Virology , vol.76 , Issue.17 , pp. 8518-8531
    • Pierson, T.C.1    Zhou, Y.2    Kieffer, T.L.3    Ruff, C.T.4    Buck, C.5    Siliciano, R.F.6
  • 5
    • 0025238945 scopus 로고
    • HIV-1 replication is controlled at the level of T cell activation and proviral integration
    • Stevenson, M., Stanwick, T.L., Dempsey, M.P. & Lamonica, C.A. HIV-1 replication is controlled at the level of T cell activation and proviral integration. EMBO J. 9, 1551-1560 (1990
    • (1990) EMBO J. , vol.9 , pp. 1551-1560
    • Stevenson, M.1    Stanwick, T.L.2    Dempsey, M.P.3    Lamonica, C.A.4
  • 6
    • 0025342694 scopus 로고
    • HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure
    • Zack, J.A. et al. HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure. Cell 61, 213-222 (1990
    • (1990) Cell , vol.61 , pp. 213-222
    • Zack, J.A.1
  • 7
    • 66149118152 scopus 로고    scopus 로고
    • Human immunodeficiency virus integrates directly into naive resting CD4+ T cells but enters naive cells less efficiently than memory cells
    • Dai, J. et al. Human immunodeficiency virus integrates directly into naive resting CD4+ T cells but enters naive cells less efficiently than memory cells. J. Virol. 83, 4528-4537 (2009
    • (2009) J. Virol , vol.83 , pp. 4528-4537
    • Dai, J.1
  • 9
    • 50249107532 scopus 로고    scopus 로고
    • HIV envelope-CXCR4 signaling activates cofilin to overcome cortical actin restriction in resting CD4 T cells
    • Yoder, A. et al. HIV envelope-CXCR4 signaling activates cofilin to overcome cortical actin restriction in resting CD4 T cells. Cell 134, 782-792 (2008
    • (2008) Cell , vol.134 , pp. 782-792
    • Yoder, A.1
  • 10
    • 0038342442 scopus 로고    scopus 로고
    • HIV-1 Nef intersects the macrophage CD40L signalling pathway to promote resting-cell infection
    • DOI 10.1038/nature01749
    • Swingler, S. et al. HIV-1 Nef intersects the macrophage CD40L signalling pathway to promote resting-cell infection. Nature 424, 213-219 (2003 (Pubitemid 36858691)
    • (2003) Nature , vol.424 , Issue.6945 , pp. 213-219
    • Swingler, S.1    Brichacek, B.2    Jacque, J.-M.3    Ulich, C.4    Zhou, J.5    Stevenson, M.6
  • 11
    • 65349104493 scopus 로고    scopus 로고
    • The human immunodeficiency virus type 2 Vpx protein usurps the CUL4A-DDB1 DCAF1 ubiquitin ligase to overcome a postentry block in macrophage infection
    • Bergamaschi, A. et al. The human immunodeficiency virus type 2 Vpx protein usurps the CUL4A-DDB1 DCAF1 ubiquitin ligase to overcome a postentry block in macrophage infection. J. Virol. 83, 4854-4860 (2009
    • (2009) J. Virol , vol.83 , pp. 4854-4860
    • Bergamaschi, A.1
  • 12
    • 58149459998 scopus 로고    scopus 로고
    • SIVMAC Vpx improves the transduction of dendritic cells with nonintegrative HIV-1-derived vectors
    • Berger, G., Goujon, C., Darlix, J.L. & Cimarelli, A. SIVMAC Vpx improves the transduction of dendritic cells with nonintegrative HIV-1-derived vectors. Gene Ther. 16, 159-163 (2009
    • (2009) Gene Ther , vol.16 , pp. 159-163
    • Berger, G.1    Goujon, C.2    Darlix, J.L.3    Cimarelli, A.4
  • 13
    • 57349088182 scopus 로고    scopus 로고
    • Characterization of simian immunodeficiency virus SIVSM/human immunodeficiency virus type 2 Vpx function in human myeloid cells
    • Goujon, C. et al. Characterization of simian immunodeficiency virus SIVSM/human immunodeficiency virus type 2 Vpx function in human myeloid cells. J. Virol. 82, 12335-12345 (2008
    • (2008) J. Virol , vol.82 , pp. 12335-12345
    • Goujon, C.1
  • 14
    • 79959353247 scopus 로고    scopus 로고
    • Vpx rescues HIV-1 transduction of dendritic cells from the antiviral state established by type 1 interferon
    • Pertel, T., Reinhard, C. & Luban, J. Vpx rescues HIV-1 transduction of dendritic cells from the antiviral state established by type 1 interferon. Retrovirology 8, 49 (2011
    • (2011) Retrovirology , vol.8 , Issue.49
    • Pertel, T.1    Reinhard, C.2    Luban, J.3
  • 15
    • 44449129551 scopus 로고    scopus 로고
    • Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction
    • Sharova, N. et al. Primate lentiviral Vpx commandeers DDB1 to counteract a macrophage restriction. PLoS Pathog. 4, e1000057 (2008
    • (2008) PLoS Pathog , vol.4
    • Sharova, N.1
  • 16
    • 44449107162 scopus 로고    scopus 로고
    • Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection
    • Srivastava, S. et al. Lentiviral Vpx accessory factor targets VprBP/DCAF1 substrate adaptor for cullin 4 E3 ubiquitin ligase to enable macrophage infection. PLoS Pathog. 4, e1000059 (2008
    • (2008) PLoS Pathog , vol.4
    • Srivastava, S.1
  • 17
    • 84855272511 scopus 로고    scopus 로고
    • SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutieres syndrome are highly susceptible to HIV-1 infection
    • Berger, A. et al. SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutieres syndrome are highly susceptible to HIV-1 infection. PLoS Pathog. 7, e1002425 (2011
    • (2011) PLoS Pathog , vol.7
    • Berger, A.1
  • 19
    • 79959858243 scopus 로고    scopus 로고
    • Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein
    • Hrecka, K. et al. Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein. Nature 474, 658-661 (2011
    • (2011) Nature , vol.474 , pp. 658-661
    • Hrecka, K.1
  • 20
    • 79959843617 scopus 로고    scopus 로고
    • SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx
    • Laguette, N. et al. SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx. Nature 474, 654-657 (2011
    • (2011) Nature , vol.474 , pp. 654-657
    • Laguette, N.1
  • 21
    • 83555164881 scopus 로고    scopus 로고
    • HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase
    • Goldstone, D.C. et al. HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase. Nature 480, 379-382 (2011
    • (2011) Nature , vol.480 , pp. 379-382
    • Goldstone, D.C.1
  • 22
    • 84862777555 scopus 로고    scopus 로고
    • SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates
    • Lahouassa, H. et al. SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates. Nat. Immunol. 13, 223-228 (2012
    • (2012) Nat. Immunol , vol.13 , pp. 223-228
    • Lahouassa, H.1
  • 23
    • 83755162644 scopus 로고    scopus 로고
    • Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase
    • Powell, R.D., Holland, P.J., Hollis, T. & Perrino, F.W. Aicardi-Goutieres syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase. J. Biol. Chem. 286, 43596-43600 (2011
    • (2011) J. Biol. Chem , vol.286 , pp. 43596-43600
    • Powell, R.D.1    Holland, P.J.2    Hollis, T.3    Perrino, F.W.4
  • 25
    • 77956486432 scopus 로고    scopus 로고
    • Sustained LFA-1 cluster formation in the immune synapse requires the combined activities of L-plastin and calmodulin
    • Wabnitz, G.H. et al. Sustained LFA-1 cluster formation in the immune synapse requires the combined activities of L-plastin and calmodulin. Eur. J. Immunol. 40, 2437-2449 (2010
    • (2010) Eur. J. Immunol , vol.40 , pp. 2437-2449
    • Wabnitz, G.H.1
  • 26
    • 68749115269 scopus 로고    scopus 로고
    • APOBEC3G-depleted resting CD4+ T cells remain refractory to HIV1 infection
    • Santoni de Sio, F.R. & Trono, D. APOBEC3G-depleted resting CD4+ T cells remain refractory to HIV1 infection. Plos One 4, e6571 (2009
    • (2009) Plos One , vol.4
    • Santoni De Sio, F.R.1    Trono, D.2
  • 27
    • 78049446781 scopus 로고    scopus 로고
    • Cerebral arterial stenoses and stroke: Novel features of Aicardi-Goutieres syndrome caused by the Arg164X mutation in SAMHD1 are associated with altered cytokine expression
    • Thiele, H. et al. Cerebral arterial stenoses and stroke: Novel features of Aicardi-Goutieres syndrome caused by the Arg164X mutation in SAMHD1 are associated with altered cytokine expression. Hum. Mutat. 31, E1836-E1850 (2010
    • (2010) Hum. Mutat , vol.31
    • Thiele, H.1
  • 28
    • 84857347109 scopus 로고    scopus 로고
    • The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein Vpx
    • Lim, E.S. et al. The ability of primate lentiviruses to degrade the monocyte restriction factor SAMHD1 preceded the birth of the viral accessory protein Vpx. Cell Host Microbe 11, 194-204 (2012
    • (2012) Cell Host Microbe , vol.11 , pp. 194-204
    • Lim, E.S.1
  • 29
    • 84857333841 scopus 로고    scopus 로고
    • Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein
    • Laguette, N. et al. Evolutionary and functional analyses of the interaction between the myeloid restriction factor SAMHD1 and the lentiviral Vpx protein. Cell Host Microbe 11, 205-217 (2012
    • (2012) Cell Host Microbe , vol.11 , pp. 205-217
    • Laguette, N.1
  • 30
    • 77956497003 scopus 로고    scopus 로고
    • A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells
    • Manel, N. et al. A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells. Nature 467, 214-217 (2010
    • (2010) Nature , vol.467 , pp. 214-217
    • Manel, N.1
  • 31
    • 80054697388 scopus 로고    scopus 로고
    • Hiding in plain sight: How HIV evades innate immune responses
    • Manel, N. & Littman, D.R. Hiding in plain sight: How HIV evades innate immune responses. Cell 147, 271-274 (2011
    • (2011) Cell , vol.147 , pp. 271-274
    • Manel, N.1    Littman, D.R.2
  • 34
    • 61849183569 scopus 로고    scopus 로고
    • HIV-1 antagonism of CD317 is species specific and involves Vpumediated proteasomal degradation of the restriction factor
    • Goffinet, C. et al. HIV-1 antagonism of CD317 is species specific and involves Vpumediated proteasomal degradation of the restriction factor. Cell Host Microbe 5, 285-297 (2009
    • (2009) Cell Host Microbe , vol.5 , pp. 285-297
    • Goffinet, C.1
  • 36
    • 80051792497 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 modified to package simian immunodeficiency virus Vpx efficiently infects macrophages and dendritic cells
    • Sunseri, N., O'Brien, M., Bhardwaj, N. & Landau, N.R. Human immunodeficiency virus type 1 modified to package simian immunodeficiency virus Vpx efficiently infects macrophages and dendritic cells. J. Virol. 85, 6263-6274 (2011
    • (2011) J. Virol , vol.85 , pp. 6263-6274
    • Sunseri, N.1    O'Brien, M.2    Bhardwaj, N.3    Landau, N.R.4
  • 37
    • 73949153266 scopus 로고    scopus 로고
    • Evidence for an activation domain at the amino terminus of simian immunodeficiency virus Vpx
    • Gramberg, T., Sunseri, N. & Landau, N.R. Evidence for an activation domain at the amino terminus of simian immunodeficiency virus Vpx. J. Virol. 84, 1387-1396 (2010
    • (2010) J. Virol , vol.84 , pp. 1387-1396
    • Gramberg, T.1    Sunseri, N.2    Landau, N.R.3
  • 38
    • 77951216193 scopus 로고    scopus 로고
    • Interaction of Vpx and apolipoprotein B mRNA-editing catalytic polypeptide 3 family member A (APOBEC3A) correlates with efficient lentivirus infection of monocytes
    • Berger, A. et al. Interaction of Vpx and apolipoprotein B mRNA-editing catalytic polypeptide 3 family member A (APOBEC3A) correlates with efficient lentivirus infection of monocytes. J. Biol. Chem. 285, 12248-12254 (2010
    • (2010) J. Biol. Chem , vol.285 , pp. 12248-12254
    • Berger, A.1
  • 39
    • 33646082756 scopus 로고    scopus 로고
    • + T lymphocytes by the Nef protein of HIV-1
    • DOI 10.1189/jlb.0805461
    • Keppler, O.T., Tibroni, N., Venzke, S., Rauch, S. & Fackler, O.T. Modulation of specific surface receptors and activation sensitization in primary resting CD4+ T lymphocytes by the Nef protein of HIV-1. J. Leukoc. Biol. 79, 616-627 (2006 (Pubitemid 44831238)
    • (2006) Journal of Leukocyte Biology , vol.79 , Issue.3 , pp. 616-627
    • Keppler, O.T.1    Tibroni, N.2    Venzke, S.3    Rauch, S.4    Fackler, O.T.5
  • 40
    • 41949140190 scopus 로고    scopus 로고
    • Aqueous extracts from peppermint sage and lemon balm leaves display potent anti-HIV-1 activity by increasing the virion density
    • Geuenich, S. et al. Aqueous extracts from peppermint, sage and lemon balm leaves display potent anti-HIV-1 activity by increasing the virion density. Retrovirology 5, 27 (2008
    • (2008) Retrovirology , vol.5 , pp. 27
    • Geuenich, S.1
  • 41
    • 53349091520 scopus 로고    scopus 로고
    • Mouse T-cells restrict replication of human immunodeficiency virus at the level of integration
    • Tervo, H.M., Goffinet, C. & Keppler, O.T. Mouse T-cells restrict replication of human immunodeficiency virus at the level of integration. Retrovirology 5, 58 (2008
    • (2008) Retrovirology , vol.5 , pp. 58
    • Tervo, H.M.1    Goffinet, C.2    Keppler, O.T.3
  • 42
    • 13744259226 scopus 로고    scopus 로고
    • Rodent cells support key functions of the human immunodeficiency virus type 1 pathogenicity factor Nef
    • DOI 10.1128/JVI.79.3.1655-1665.2005
    • Keppler, O.T. et al. Rodent cells support key functions of the human immunodeficiency virus type 1 pathogenicity factor Nef. J. Virol. 79, 1655-1665 (2005 (Pubitemid 40459112)
    • (2005) Journal of Virology , vol.79 , Issue.3 , pp. 1655-1665
    • Keppler, O.T.1    Allespach, I.2    Schuller, L.3    Fenard, D.4    Greene, W.C.5    Fackler, O.T.6
  • 43
    • 61849121936 scopus 로고    scopus 로고
    • Human endogenous retrovirus HERV-K(HML-2) encodes a stable signal peptide with biological properties distinct from Rec
    • Ruggieri, A. et al. Human endogenous retrovirus HERV-K(HML-2) encodes a stable signal peptide with biological properties distinct from Rec. Retrovirology 6, 17 (2009
    • (2009) Retrovirology , vol.6 , pp. 17
    • Ruggieri, A.1
  • 44
    • 80052012662 scopus 로고    scopus 로고
    • In vivo expression profile of the antiviral restriction factor and tumortargeting antigen CD317/BST-2/HM1.24/tetherin in humans
    • Erikson, E. et al. In vivo expression profile of the antiviral restriction factor and tumortargeting antigen CD317/BST-2/HM1.24/tetherin in humans. Proc. Natl. Acad. Sci. USA 108, 13688-13693 (2011
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 13688-13693
    • Erikson, E.1
  • 46
    • 77957962634 scopus 로고    scopus 로고
    • Endogenous CD317/ Tetherin limits replication of HIV-1 and murine leukemia virus in rodent cells and is resistant to antagonists from primate viruses
    • Goffinet, C., Schmidt, S., Kern, C., Oberbremer, L. & Keppler, O.T. Endogenous CD317/ Tetherin limits replication of HIV-1 and murine leukemia virus in rodent cells and is resistant to antagonists from primate viruses. J. Virol. 84, 11374-11384 (2010
    • (2010) J. Virol , vol.84 , pp. 11374-11384
    • Goffinet, C.1    Schmidt, S.2    Kern, C.3    Oberbremer, L.4    Keppler, O.T.5
  • 47
    • 0037443424 scopus 로고    scopus 로고
    • IL-7 surface-engineered lentiviral vectors promote survival and efficient gene transfer in resting primary T lymphocytes
    • DOI 10.1182/blood-2002-07-2224
    • Verhoeyen, E. et al. IL-7 surface-engineered lentiviral vectors promote survival and efficient gene transfer in resting primary T lymphocytes. Blood 101, 2167-2174 (2003 (Pubitemid 36302054)
    • (2003) Blood , vol.101 , Issue.6 , pp. 2167-2174
    • Verhoeyen, E.1    Dardalhon, V.2    Ducrey-Rundquist, O.3    Trono, D.4    Taylor, N.5    Cosset, F.-L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.