Differential cytokine production and bystander activation of autoreactive B cells in response to CpG-A and CpG-B oligonucleotides

Journal of Immunology

Volumn 183, Issue 10, 2009, Pages 6262-6268

  Avalos, Ana M ^a   Latz, Eicke ^b   Mousseau, Betty ^c   Christensen, Sean R ^d   Shlomchik, Mark J ^d   Lund, Frances ^c   Marshak Rothstein, Ann ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^d YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B LYMPHOCYTE RECEPTOR; CPG OLIGODEOXYNUCLEOTIDE; DOUBLE STRANDED DNA; GAMMA INTERFERON; IMMUNOGLOBULIN G2A; INTERLEUKIN 6; RANTES; TOLL LIKE RECEPTOR 9;

ANIMAL CELL; ANTIGEN ANTIBODY COMPLEX; ARTICLE; B LYMPHOCYTE ACTIVATION; BYSTANDER EFFECT; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIGEN-ANTIBODY COMPLEX; B-LYMPHOCYTES; CELL PROLIFERATION; CHEMOKINE CCL5; CYTOKINES; LYMPHOCYTE ACTIVATION; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; OLIGODEOXYRIBONUCLEOTIDES; RECEPTORS, ANTIGEN, B-CELL; TOLL-LIKE RECEPTOR 9;

EID: 77953275701     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0901941     Document Type: Article

References (26)

1. Kerkmann, M., L. T. Costa, C. Richter, S. Rothenfusser, J. Battiany, V. Hornung, J. Johnson, S. Englert, T. Ketterer, W. Heckl, et al. 2005. Spontaneous formation of nucleic acid-based nanoparticles is responsible for high interferon-α induction by CpG-A in plasmacytoid dendritic cells. J. Biol. Chem. 280: 8086-8093.
2. Guiducci, C., G. Ott, J. H. Chan, E. Damon, C. Calacsan, T. Matray, K. D. Lee, R. L. Coffman, and F. J. Barrat. 2006. Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation. J. Exp. Med. 203: 1999-2008.
3. Honda, K., Y. Ohba, H. Yanai, H. Negishi, T. Mizutani, A. Takaoka, C. Taya, and T. Taniguchi. 2005. Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature 434: 1035-1040.
4. Gursel, M., I. Gursel, H. S. Mostowski, and D. M. Klinman. 2006. CXCL16 influences the nature and specificity of CpG-induced immune activation. J. Immunol. 177: 1575-1580. (Pubitemid 44092492)
5. Krug, A., S. Rothenfusser, V. Hornung, B. Jahrsdorfer, S. Blackwell, Z. K. Ballas, S. Endres, A. M. Krieg, and G. Hartmann. 2001. Identification of CpG oligonucleotide sequences with high induction of IFN-α/β in plasmacytoid dendritic cells. Eur. J. Immunol. 31: 2154-2163.
6. Verthelyi, D., K. J. Ishii, M. Gursel, F. Takeshita, and D. M. Klinman. 2001. Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs. J. Immunol. 166: 2372-2377. (Pubitemid 32173471)
7. Gursel, M., D. Verthelyi, I. Gursel, K. J. Ishii, and D. M. Klinman. 2002. Differential and competitive activation of human immune cells by distinct classes of CpG oligodeoxynucleotide. J. Leukocyte Biol. 71: 813-820.
8. Latz, E., A. Schoenemeyer, A. Visintin, K. A. Fitzgerald, B. G. Monks, C. F. Knetter, E. Lien, N. J. Nilsen, T. Espevik, and D. T. Golenbock. 2004. TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat. Immunol. 5: 190-198.
9. Pearson, A. M., A. Rich, and M. Krieger. 1993. Polynucleotide binding to macrophage scavenger receptors depends on the formation of base-quartet- stabilized four-stranded helices. J. Biol. Chem. 268: 3546-3554.
10. Suzuki, K., T. Doi, T. Imanishi, T. Kodama, and T. Tanaka. 1999. Oligonucleotide aggregates bind to the macrophage scavenger receptor. Eur. J. Biochem. 260: 855-860.
11. Jozefowski, S., T. H. Sulahian, M. Arredouani, and L. Kobzik. 2006. Role of scavenger receptor MARCO in macrophage responses to CpG oligodeoxynucleotides. J. Leukocyte Biol. 80: 870-879.
12. Ballas, Z. K., A. M. Krieg, T. Warren, W. Rasmussen, H. L. Davis, M. Waldschmidt, and G. J. Weiner. 2001. Divergent therapeutic and immunologic effects of oligodeoxynucleotides with distinct CpG motifs. J. Immunol. 167: 4878-4886.
13. Chaturvedi, A., D. Dorward, and S. K. Pierce. 2008. The B cell receptor governs the subcellular location of Toll-like receptor 9 leading to hyperresponses to DNA-containing antigens. Immunity 28: 799-809.
14. Leadbetter, E. A., I. R. Rifkin, A. M. Hohlbaum, B. C. Beaudette, M. J. Shlomchik, and A. Marshak-Rothstein. 2002. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 416: 603-607.
15. Viglianti, G. A., C. M. Lau, T. M. Hanley, B. A. Miko, M. J. Shlomchik, and A. Marshak-Rothstein. 2003. Activation of autoreactive B cells by CpG dsDNA. Immunity 19: 837-847.
16. Hannum, L. G., D. Ni, A. M. Haberman, M. G. Weigert, and M. J. Shlomchik. 1996. A disease-related rheumatoid factor autoantibody is not tolerized in a normal mouse: implications for the origins of autoantibodies in autoimmune disease. J. Exp. Med. 184: 1269-1278.
17. Uccellini, M. B., L. Busconi, N. M. Green, P. Busto, S. R. Christensen, M. J. Shlomchik, A. Marshak-Rothstein, and G. A. Viglianti. 2008. Autoreactive B cells discriminate CpG-rich and CpG-poor DNA and this response is modulated by IFN-α. J. Immunol. 181: 5875-5884.
18. Song, W., H. Cho, P. Cheng, and S. K. Pierce. 1995. Entry of B cell antigen receptor and antigen into class II peptide-loading compartment is independent of receptor cross-linking. J. Immunol. 155: 4255-4263.
19. Brummel, R., and P. Lenert. 2005. Activation of marginal zone B cells from lupus mice with type A(D) CpG-oligodeoxynucleotides. J. Immunol. 174: 2429-2434. (Pubitemid 40223993)
20. Brummel, R., T. L. Roberts, K. J. Stacey, and P. Lenert. 2006. Higher-order CpG-DNA stimulation reveals distinct activation requirements for marginal zone and follicular B cells in lupus mice. Eur. J. Immunol. 36: 1951-1962.
21. Lit, L. C., C. K. Wong, L. S. Tam, E. K. Li, and C. W. Lam. 2006. Raised plasma concentration and ex vivo production of inflammatory chemokines in patients with systemic lupus erythematosus. Ann. Rheum Dis. 65: 209-215.
22. Vila, L. M., M. J. Molina, A. M. Mayor, J. J. Cruz, E. Rios-Olivares, and Z. Rios. 2007. Association of serum MIP-1α, MIP-1β, and RANTES with clinical manifestations, disease activity, and damage accrual in systemic lupus erythematosus. Clin. Rheumatol. 26: 718-722.
23. Moore, K. J., T. Wada, S. D. Barbee, and V. R. Kelley. 1998. Gene transfer of RANTES elicits autoimmune renal injury in MRL-Fas(1pr) mice. Kidney Int. 53: 1631-1641.
24. Tsukahara, T., Y. Makino, T. Fujii, M. Ogawa, H. Saisho, Y. Hamano, S. Ueda, B. Akikusa, and T. M. Danoff. 2002. Role of RANTES in the development of autoimmune tissue injuries in MRL-Fas lpr mice. Clin. Immunol. 103: 89-97.
25. Busconi, L., J. W. Bauer, J. R. Tumang, A. Laws, K. Perkins-Mesires, A. S. Tabor, C. Lau, R. B. Corley, T. L. Rothstein, F. E. Lund, et al. 2007. Functional outcome of B cell activation by chromatin immune complex engagement of the B cell receptor and TLR9. J. Immunol. 179: 7397-7405.
26. Sfikakis, P. P., J. N. Boletis, and G. C. Tsokos. 2005. Rituximab anti-B-cell therapy in systemic lupus erythematosus: pointing to the future. Curr. Opin. Rheumatol. 17: 550-557.