Structural basis for viral 5′-PPP-RNA recognition by human IFIT proteins

Nature

Volumn 494, Issue 7435, 2013, Pages 60-64

  Abbas, Yazan M ^a   Pichlmair, Andreas ^b,c   Górna, Maria W ^b   Superti Furga, Giulio ^b   Nagar, Bhushan ^a  

^a MCGILL UNIVERSITY   (Canada)

^b ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^c MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

5' TRIPHOSPHATE; IFIT1 PROTEIN; IFIT5 PROTEIN; INTERFERON; RETINOIC ACID INDUCIBLE PROTEIN I; SINGLE STRANDED RNA; UNCLASSIFIED DRUG; VIRUS RNA; CARRIER PROTEIN; IFIT1 PROTEIN, HUMAN; IFIT5 PROTEIN, HUMAN; TUMOR PROTEIN;

ANTIMICROBIAL ACTIVITY; BIOASSAY; CELL ORGANELLE; FRAGMENTATION; GENE EXPRESSION; MOLECULAR ANALYSIS; PHOSPHATE; PROTEIN; RNA;

AMINO TERMINAL SEQUENCE; ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; HUMAN; HUMAN CELL; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; PROTEIN RNA BINDING; PROTEIN STRUCTURE; RNA BINDING; STATIC ELECTRICITY; TETRATRICOPEPTIDE REPEAT; VIRUS REPLICATION; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; GENETICS; IMMUNOLOGY; INNATE IMMUNITY; METABOLISM; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN MOTIF; REPRODUCIBILITY;

AMINO ACID MOTIFS; BINDING SITES; CARRIER PROTEINS; HUMANS; IMMUNITY, INNATE; MODELS, MOLECULAR; NEOPLASM PROTEINS; PHOSPHORYLATION; PROTEIN CONFORMATION; REPRODUCIBILITY OF RESULTS; RNA, VIRAL; SUBSTRATE SPECIFICITY;

MLCS; MLOWN;

EID: 84874671928     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature11783     Document Type: Article

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