RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

Science

Volumn 349, Issue 6252, 2015, Pages 1115-1120

  Liddicoat, Brian J ^a,b   Piskol, Robert ^c   Chalk, Alistair M ^a,b   Ramaswami, Gokul ^c   Higuchi, Miyoko ^d   Hartner, Jochen C ^e   Li, Jin Billy ^c   Seeburg, Peter H ^d   Walkley, Carl R ^a,b  

^a ST VINCENT'S INSTITUTE OF MEDICAL RESEARCH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c STANFORD UNIVERSITY   (United States)

^d MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

^e Taconic Farms Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE; ADENOSINE DEAMINASE; ALANINE; DOUBLE STRANDED RNA; GLUTAMINE; INTERFERON; 3' UNTRANSLATED REGION; ADAR1 PROTEIN, MOUSE; DEAD BOX PROTEIN; IFIH1 PROTEIN, MOUSE; INOSINE;

EMBRYO; EMBRYONIC DEVELOPMENT; GENETIC ANALYSIS; MUTATION; RNA;

3' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOSENSOR; CONTROLLED STUDY; CYTOSOL; EMBRYO; EMBRYO DEATH; GENETIC ANALYSIS; MUTATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; RNA EDITING; ANIMAL; CHEMISTRY; CONFORMATION; GENE DELETION; GENE TARGETING; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MOUSE; MUTANT MOUSE STRAIN;

MUS;

3' UNTRANSLATED REGIONS; ADENOSINE; ADENOSINE DEAMINASE; ANIMALS; DEAD-BOX RNA HELICASES; EMBRYO LOSS; GENE DELETION; GENE KNOCK-IN TECHNIQUES; INOSINE; MICE; MICE, MUTANT STRAINS; MUTATION; NUCLEIC ACID CONFORMATION; RNA EDITING; RNA, DOUBLE-STRANDED; TRANSCRIPTION, GENETIC;

EID: 84941100160     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aac7049     Document Type: Article

References (22)

1. P. Danecek et al., Genome Biol. 13, R26 (2012).
2. J. B. Li et al., Science 324, 1210-1213 (2009).
3. G. Ramaswami et al., Nat. Methods 9, 579-581 (2012).
4. Y. Neeman, E. Y. Levanon, M. F. Jantsch, E. Eisenberg, RNA 12, 1802-1809 (2006).
5. J. B. Patterson, C. E. Samuel, Mol. Cell. Biol. 15, 5376-5388 (1995).
6. J. C. Hartner et al., J. Biol. Chem. 279, 4894-4902 (2004).
7. Q. Wang et al., J. Biol. Chem. 279, 4952-4961 (2004).
8. S. V. Ward et al., Proc. Natl. Acad. Sci. U.S.A. 108, 331-336 (2011).
9. M. Higuchi et al., Cell 75, 1361-1370 (1993).
10. M. Higuchi et al., Nature 406, 78-81 (2000).
11. F. Lai, R. Drakas, K. Nishikura, J. Biol. Chem. 270, 17098-17105 (1995).
12. J. C. Hartner, C. R. Walkley, J. Lu, S. H. Orkin, Nat. Immunol. 10, 109-115 (2009).
13. P. Vitali, A. D. Scadden, Nat. Struct. Mol. Biol. 17, 1043-1050 (2010).
14. G. Ramaswami, J. B. Li, Nucleic Acids Res. 42, D109-D113 (2014).
15. R. Zhang et al., Nat. Methods 11, 51-54 (2014).
16. M. C. Washburn et al., Cell Reports 6, 599-607 (2014).
17. G. I. Rice et al., Nat. Genet. 44, 1243-1248 (2012).
18. G. I. Rice et al., Nat. Genet. 46, 503-509 (2014).
19. E. S. Lander et al., Nature 409, 860-921 (2001).
20. Mouse Genome Sequencing Consortium, Nature 420, 520-562 (2002).
21. B. Wu et al., Cell 152, 276-289 (2013).
22. N. M. Mannion et al., Cell Reports 9, 1482-1494 (2014).