2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members

Nature

Volumn 468, Issue 7322, 2010, Pages 452-456

  Daffis, Stephane ^a   Szretter, Kristy J ^a   Schriewer, Jill ^c   Li, Jianqing ^a   Youn, Soonjeon ^a   Errett, John ^d   Lin, Tsai Yu ^e   Schneller, Stewart ^f   Zust, Roland ^g   Dong, Hongping ⁱ   Thiel, Volker ^g,h   Sen, Ganes C ^j   Fensterl, Volker ^j   Klimstra, William B ^k   Pierson, Theodore C ^e   Buller, R Mark ^b,c   Gale Jr Jr , Michael ^b,d   Shi, Pei Yong ^b,i   Diamond, Michael S ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Midwest Pacific Northwest and Northeast Regional Centers for Biodefense   (United States)

^c SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^e NATIONAL INSTITUTES OF HEALTH   (United States)

^f AUBURN UNIVERSITY   (United States)

^g CANTONAL HOSPITAL ST GALLEN   (Switzerland)

^h UNIVERSITY OF ZURICH   (Switzerland)

ⁱ WADSWORTH CENTER   (United States)

^j LERNER RESEARCH INSTITUTE   (United States)

^k UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

IFIT1 PROTEIN; IFIT2 PROTEIN; INTERFERON; MESSENGER RNA; PROTEIN; UNCLASSIFIED DRUG; VIRUS RNA; ALPHA BETA INTERFERON RECEPTOR; CAPPED RNA; CARRIER PROTEIN; IFIT1 PROTEIN, MOUSE; IFIT2 PROTEIN, MOUSE; IFIT5 PROTEIN, HUMAN; IFNAR1 PROTEIN, MOUSE; METHYLTRANSFERASE; TUMOR PROTEIN;

ENZYME ACTIVITY; EUKARYOTE; METHYLATION; VIRUS;

ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CORONAVIRUS; FIBROBLAST; FLAVIVIRUS INFECTION; INTERFERON INDUCTION; MOUSE; NONHUMAN; POXVIRUS; PRIORITY JOURNAL; PROTEIN FAMILY; RNA METHYLATION; SIGNAL TRANSDUCTION; TETRATRICOPEPTIDE REPEAT; VIRUS MUTANT; WEST NILE FLAVIVIRUS; WILD TYPE; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; CELL CULTURE; CELL STRAIN 3T3; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; HUMAN; IMMUNOLOGY; INNATE IMMUNITY; METABOLISM; METHYLATION; PHYSIOLOGY; PROTEIN SYNTHESIS; SURVIVAL RATE; VIRUS REPLICATION;

CORONAVIRUS; EUKARYOTA; MUS; POXVIRIDAE; WEST NILE VIRUS;

3T3 CELLS; ANIMALS; CARRIER PROTEINS; CELLS, CULTURED; CORONAVIRUS; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY, INNATE; INTERFERONS; METHYLATION; METHYLTRANSFERASES; MICE; MICE, INBRED C57BL; MODELS, GENETIC; MODELS, IMMUNOLOGICAL; NEOPLASM PROTEINS; POXVIRIDAE; PROTEIN BIOSYNTHESIS; PROTEINS; RECEPTOR, INTERFERON ALPHA-BETA; RNA CAPS; RNA, VIRAL; SURVIVAL RATE; VIRUS REPLICATION; WEST NILE VIRUS;

EID: 78549284909     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature09489     Document Type: Article

References (25)

1. Furuichi, Y. & Shatkin, A. J. Viral and cellular mRNA capping: past and prospects. Adv. Virus Res. 55, 135-184 (2000).
2. Wei, C. M. & Moss, B. Methylated nucleotides block 59-terminus of vaccinia virus messenger RNA. Proc. Natl Acad. Sci. USA 72, 318-322 (1975).
3. Wei, C. M., Gershowitz, A. & Moss, B. Methylated nucleotides block 59 terminus of HeLa cell messenger RNA. Cell 4, 379-386 (1975).
4. Muthukrishnan, S., Moss, B., Cooper, J. A. & Maxwell, E. S. Influence of 59-terminal cap structure on the initiation of translation of vaccinia virus mRNA. J. Biol. Chem. 253, 1710-1715 (1978).
5. Langberg, S. R. & Moss, B. Post-transcriptional modifications of mRNA. Purification and characterization of cap I and cap II RNA (nucleoside-29-)-methyltransferases from HeLa cells. J. Biol. Chem. 256, 10054-10060 (1981).
6. Fechter, P. & Brownlee, G. G. Recognition of mRNA cap structures by viral and cellular proteins. J. Gen. Virol. 86, 1239-1249 (2005).
7. Dong, H., Zhang, B. & Shi, P.Y. Flavivirus methyltransferase:anovel antiviral target. Antiviral Res. 80, 1-10 (2008).
8. Zhou, Y. et al. Structure and function of flavivirus NS5 methyltransferase. J. Virol. 81, 3891-3903 (2007).
9. Samuel, M. A. & Diamond, M. S. Alpha/beta IFN protects against lethal West Nile virus infection by restricting cellular tropism and enhancing neuronal survival. J. Virol. 79, 13350-13361 (2005).
10. Daffis, S. et al. Interferon regulatory factor IRF-7 induces the antiviral alpha interferon response and protects against lethal West Nile virus infection. J. Virol. 82, 8465-8475 (2008).
11. Daffis, S., Suthar, M. S., Szretter, K. J., Gale, M.Jr & Diamond, M. S.Inductionof IFN-b and the in nateanti viralresponse in myeloid cell soccur sthroughan IPS-1-dependent signal that does not require IRF-3 and IRF-7. PLoS Pathog. 5, E1000607 (2009).
12. Daffis, S., Samuel, M.A., Suthar, M.S., Gale, M. Jr & Diamond, M.S.Toll-like receptor 3 has a protective role against West Nile virus infection. J. Virol. 82, 10349-10358 (2008).
13. Der, S. D., Zhou, A., Williams, B. R. & Silverman, R. H. Identification of genes differentially regulated by interferon a, B, Or c using oligonucleotide arrays. Proc. Natl Acad. Sci. USA 95, 15623-15628 (1998).
14. Wacher, C. et al. Coordinated regulation and widespread cellular expression of interferon-stimulated genes (ISG) ISG-49, ISG-54, And ISG-56 in the central nervous system after infection with distinct viruses. J. Virol. 81, 860-871 (2007).
15. Daffis, S., Samuel, M.A., Keller, B.C., Gale, M.Jr & Diamond, M.S.Cell-specific IRF-3 responses protect against West Nile virus infection by interferon-dependent and -independent mechanisms. PLoS Pathog. 3, E106 (2007).
16. Fensterl, V., White, C. L., Yamashita, M. & Sen, G. C. Novel characteristics of the function and induction of murine p56 family proteins. J. Virol. 82, 11045-11053 (2008).
17. Sumpter, R. Jr et al. Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase, RIG-I. J. Virol. 79, 2689-2699 (2005).
18. Zhang, Y., Burke, C. W., Ryman, K. D. & Klimstra, W. B. Identification and characterization of interferon-induced proteins that inhibit alphavirus replication. J. Virol. 81, 11246-11255 (2007).
19. Terenzi, F., Hui, D. J., Merrick, W. C. & Sen, G. C. Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56. J. Biol. Chem. 281, 34064-34071 (2006).
20. Hui, D.J., Terenzi, F., Merrick, W.C. & Sen, G.C.Mouse p56 blocksadistinct function of eukaryotic initiation factor 3 in translation initiation. J. Biol. Chem. 280, 3433-3440 (2005).
21. Sarkar, S. N. & Sen, G. C. Novel functions of proteins encoded by viral stress-inducible genes. Pharmacol. Ther. 103, 245-259 (2004).
22. Latner, D. R., Thompson, J. M., Gershon, P. D., Storrs, C. & Condit, R. C. The positive transcription elongation factor activity of the vaccinia virus J3 protein is independent from its (nucleoside-29-O-) methyltransferase and poly(A) polymerase stimulatory functions. Virology 301, 64-80 (2002).
23. Decroly, E. et al. Coronavirus nonstructural protein 16 is a cap-0 binding enzyme possessing (nucleoside-29O)-methyltransferase activity. J. Virol. 82, 8071-8084 (2008).
24. Hui, D. J., Bhasker, C. R., Merrick, W. C. & Sen, G. C. Viral stress-inducible protein p56 inhibits translation by blocking the interaction of eIF3 with the ternary complex eIF2.GTP.Met-tRNAi. J. Biol. Chem. 278, 39477-39482 (2003).
25. Coley, S. E. et al. Recombinant mouse hepatitis virus strain A59 from cloned, Full-length cDNA replicates to high titers in vitro and is fully pathogenic in vivo. J. Virol. 79, 3097-3106 (2005).