Aicardi-Goutières syndrome gene and HIV-1 restriction factor SAMHD1 is a dGTP-regulated deoxynucleotide triphosphohydrolase

Journal of Biological Chemistry

Volumn 286, Issue 51, 2011, Pages 43596-43600

  Powell, Rebecca D ^a   Holland, Paul J ^a,b   Hollis, Thomas ^a   Perrino, Fred W ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GENETIC DISEASE; PHYSIOLOGICAL FUNCTIONS; PURIFIED ENZYME; RECOMBINANT PROTEIN; VIRAL INFECTIONS;

CATALYST ACTIVITY; CLONING; ENZYME ACTIVITY; PROTEINS;

GENES;

DEOXYGUANOSINE TRIPHOSPHATE REGULATED DEOXYNUCLEOTIDE TRIPHOSPHOHYDROLASE; PHOSPHATASE; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN; DEOXYGUANOSINE PHOSPHATE; DEOXYGUANOSINE TRIPHOSPHATE; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; NUCLEOSIDE; SAMHD1 PROTEIN, HUMAN; SAMHD1 PROTEIN, MOUSE; VPX PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 2;

AICARDI GOUTIERES SYNDROME GENE; ANIMAL CELL; ARTICLE; BONE MARROW CELL; CELL LINEAGE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PURIFICATION; GENE; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN TARGETING; SAMHD1 GENE; VIRUS REPLICATION; ANIMAL; AUTOIMMUNE DISEASE; CATALYSIS; CATTLE; CHEMISTRY; CYTOLOGY; DOSE RESPONSE; GENETICS; HUMAN; METABOLISM; NERVOUS SYSTEM MALFORMATION; NEUROLOGIC DISEASE;

ANIMALS; AUTOIMMUNE DISEASES; AUTOIMMUNE DISEASES OF THE NERVOUS SYSTEM; CATALYSIS; CATTLE; DEOXYGUANINE NUCLEOTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; HIV-1; HUMANS; MICE; MONOMERIC GTP-BINDING PROTEINS; MYELOID CELLS; NERVOUS SYSTEM MALFORMATIONS; NUCLEOSIDES; PHOSPHORIC MONOESTER HYDROLASES; VIRAL REGULATORY AND ACCESSORY PROTEINS; VIRUS REPLICATION;

EID: 83755162644     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.C111.317628     Document Type: Article

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