RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates

Science

Volumn 314, Issue 5801, 2006, Pages 997-1001

  Pichlmair, Andreas ^a   Schulz, Oliver ^a   Tan, Choon Ping ^a   Näslund, Tanja I ^b   Liljeström, Peter ^b   Weber, Friedemann ^c   Reis E Sousa, Caetano ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF FREIBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSENSORS; ENZYMES; GENES; IMMUNOLOGY; PHOSPHATES; PROTEINS; RNA;

ANTIVIRAL IMMUNITY; DOUBLE STRANDED RNA (DSRNA); IMMUNE SYSTEMS; MELANOMA;

VIRUSES;

DOUBLE STRANDED RNA; NONSTRUCTURAL PROTEIN 1; PROTEIN; PROTEIN RIG I; RNA HELICASE; SINGLE STRANDED RNA; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS RNA;

IMMUNITY; INFLUENZA; PHOSPHATE (ORGANIC); RNA; VIRUS;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE; INFLUENZA A; INFLUENZA VIRUS A; INNATE IMMUNITY; MDA5 GENE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; VIRUS CELL INTERACTION; VIRUS GENOME; VIRUS IMMUNITY; VIRUS REPLICATION;

ANIMALS; CELL LINE; CELLS, CULTURED; CYTOPLASM; DEAD-BOX RNA HELICASES; DENDRITIC CELLS; ENCEPHALOMYOCARDITIS VIRUS; GENOME, VIRAL; HUMANS; IMMUNITY, NATURAL; INFLUENZA A VIRUS; INTERFERON-ALPHA; INTERFERON-BETA; MICE; MICE, INBRED C57BL; PHOSPHATES; PHOSPHORYLATION; RECOMBINANT FUSION PROTEINS; RNA CAPS; RNA, DOUBLE-STRANDED; RNA, VIRAL; TRANSFECTION; VESICULAR STOMATITIS-INDIANA VIRUS; VIRAL NONSTRUCTURAL PROTEINS; VIRUS REPLICATION;

INFLUENZA A VIRUS;

EID: 33750984771     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1132998     Document Type: Article

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25. This work was funded by Cancer Research UK. We thank I. Kerr for SFV and EMCV, T. Muster for ΔNS1, J. Skehel for purified influenza, S. Diebold for flu vRNA isolation and GFP RNA synthesis, A. Bergthaler for VSV vRNA, J. Yewdell for the antibody to NS1, C. Basler for FLAG-RIG-I, and A. Garcia-Sastre for NS1 constructs. We are grateful to members of the Immunobiology Laboratory for support.