Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 21, 2010, Pages 9813-9818

  Hakkim, Abdul ^a   Fürnrohr, Barbara G ^b   Amann, Kerstin ^b   Laube, Britta ^a   Abed, Ulrike Abu ^a   Brinkmann, Volker ^a   Herrmann, Martin ^b   Voll, Reinhard E ^b   Zychlinsky, Arturo ^a  

^a MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

^b UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

Autoimmunity; DNase1; Innate immunity; Systemic lupus erythematosus

Indexed keywords

DEOXYRIBONUCLEASE I;

ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; LUPUS ERYTHEMATOSUS NEPHRITIS; MAJOR CLINICAL STUDY; MALE; NEUTROPHIL EXTRACELLULAR TRAP; NEUTROPHIL GRANULE; PATHOGENESIS; PRIORITY JOURNAL;

DEOXYRIBONUCLEASE I; EXTRACELLULAR SPACE; FEMALE; HUMANS; LUPUS ERYTHEMATOSUS, SYSTEMIC; LUPUS NEPHRITIS; MALE; NEUTROPHILS;

EID: 77953088427     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0909927107     Document Type: Article

References (45)

1. Rahman A, Isenberg DA (2008) Systemic lupus erythematosus. N Engl J Med 358: 929-939.
2. Kotzin BL (1996) Systemic lupus erythematosus. Cell 85:303-306.
3. Caccavo D, et al. (2005) Anti-lactoferrin antibodies in systemic lupus erythematosus: Isotypes and clinical correlates. Clin Rheumatol 24:381-387.
4. Schnabel A, Csernok E, Isenberg DA, Mrowka C, Gross WL (1995) Antineutrophil cytoplasmic antibodies in systemic lupus erythematosus. Prevalence, specificities, and clinical significance. Arthritis Rheum 38:633-637.
5. Nässberger L, Jonsson H, Sjöholm AG, Sturfelt G, Heubner A (1989) Circulating antielastase in systemic lupus erythematosus. Lancet 1:509. (Pubitemid 19063580)
6. Bosch X, Guilabert A, Font J (2006) Antineutrophil cytoplasmic antibodies. Lancet 368: 404-418.
7. Zandman-Goddard G, Shoenfeld Y (2003) SLE and infections. Clin Rev Allergy Immunol 25:29-40.
8. Ruiz-Irastorza G, Khamashta MA, Castellino G, Hughes GR (2001) Systemic lupus erythematosus. Lancet 357:1027-1032.
9. Brinkmann V, et al. (2004) Neutrophil extracellular traps kill bacteria. Science 303: 1532-1535.
10. Buchanan JT, et al. (2006) DNase expression allows the pathogen group A Streptococcus to escape killing in neutrophil extracellular traps. Curr Biol 16:396-400.
11. Clark SR, et al. (2007) Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood. Nat Med 13:463-469.
12. Bianchi M, et al. (2009) Restoration of NET formation by gene therapy in CGD controls aspergillosis. Blood 114:2619-2622.
13. Fuchs TA, et al. (2007) Novel cell death program leads to neutrophil extracellular traps. J Cell Biol 176:231-241.
14. Brinkmann V, Zychlinsky A (2007) Beneficial suicide: Why neutrophils die to make NETs. Nat Rev Microbiol 5:577-582.
15. Casciola-Rosen LA, Anhalt G, Rosen A (1994) Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med 179:1317-1330. (Pubitemid 24091790)
16. Munoz LE, et al. (2005) SLE - a disease of clearance deficiency? Rheumatology (Oxford) 44:1101-1107.
17. Suck D, Lahm A, Oefner C (1988) Structure refined to 2A of a nicked DNA octanucleotide complex with DNase I. Nature 332:464-468.
18. Liu QY, Ribecco M, Pandey S, Walker PR, Sikorska M (1999) Apoptosis-related functional features of the DNaseI-like family of nucleases. Ann N Y Acad Sci 887:60-76. (Pubitemid 30040219)
19. Kabsch W, Mannherz HG, Suck D, Pai EF, Holmes KC (1990) Atomic structure of the actin:DNase I complex. Nature 347:37-44.
20. Lazarides E, Lindberg U (1974) Actin is the naturally occurring inhibitor of deoxyribonuclease I. Proc Natl Acad Sci USA 71:4742-4746.
21. Yasutomo K, et al. (2001) Mutation of DNASE1 in people with systemic lupus erythematosus. Nat Genet 28:313-314. (Pubitemid 32702418)
22. Bodaño A, Amarelo J, González A, Gómez-Reino JJ, Conde C (2004) Novel DNASE I mutations related to systemic lupus erythematosus. Arthritis Rheum 50:4070-4071.
23. Hahn BH (1998) Antibodies to DNA. N Engl J Med 338:1359-1368.
24. Winkler TH, Jahn S, Kalden JR (1991) IgG human monoclonal anti-DNA autoantibodies from patients with systemic lupus erythematosus. Clin Exp Immunol 85:379-385.
25. Cederholm B, Wieslander J, Bygren P, Heinegård D (1986) Patients with IgA nephropathy have circulating anti-basement membrane antibodies reacting with structures common to collagen I, II, and IV. Proc Natl Acad Sci USA 83:6151-6155.
26. Jeong SJ, et al. (2009) Incidence and risk factors of infection in a single cohort of 110 adults with systemic lupus erythematosus. Scand J Infect Dis 41:268-274.
27. Spronk PE, et al. (1996) Antineutrophil cytoplasmic antibodies in systemic lupus erythematosus. Br J Rheumatol 35:625-631. (Pubitemid 126719515)
28. Puccetti A, Madaio MP, Bellese G, Migliorini P (1995) Anti-DNA antibodies bind to DNase I. J Exp Med 181:1797-1804.
29. Yeh TM, Chang HC, Liang CC, Wu JJ, Liu MF (2003) Deoxyribonuclease- inhibitory antibodies in systemic lupus erythematosus. J Biomed Sci 10:544-551.
30. Emlen W, Ansari R, Burdick G (1984) DNA-anti-DNA immune complexes. Antibody protection of a discrete DNA fragment from DNase digestion in vitro. J Clin Invest 74: 185-190. (Pubitemid 14086059)
31. Bodaño A, et al. (2006) Association of a non-synonymous single-nucleotide polymorphism of DNASEI with SLE susceptibility. Rheumatology (Oxford) 45:819-823.
32. Martínez Valle F, Balada E, Ordi-Ros J, Vilardell-Tarres M (2008) DNase 1 and systemic lupus erythematosus. Autoimmun Rev 7:359-363.
33. Kurien BT, Scofield RH (2008) Autoimmunity and oxidatively modified autoantigens. Autoimmun Rev 7:567-573.
34. Jasin HE (1988) Oxidative cross-linking of immune complexes by human polymorphonuclear leukocytes. J Clin Invest 81:6-15.
35. Griffiths HR (2008) Is the generation of neo-antigenic determinants by free radicals central to the development of autoimmune rheumatoid disease? Autoimmun Rev 7: 544-549.
36. Leadbetter EA, et al. (2002) Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 416:603-607.
37. Fenton K, et al. (2009) Anti-dsDNA antibodies promote initiation, and acquired loss of renal Dnase1 promotes progression of lupus nephritis in autoimmune (NZBxNZW)F1 mice. PLoS One 4:e8474.
38. Gaubitz M, et al. (1998) Prospective randomized trial of two different immunoadsorbers in severe systemic lupus erythematosus. J Autoimmun 11:495-501.
39. Lande R, et al. (2007) Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature 449:564-569.
40. Kessenbrock K, et al. (2009) Netting neutrophils in autoimmune small-vessel vasculitis. Nat Med 15:623-625.
41. Hochberg MC (1997) Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40: 1725.
42. Tan EM, et al. (1982) The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 25:1271-1277.
43. Isenberg DA, et al. (2005) BILAG 2004. Development and initial validation of an updated version of the British Isles Lupus Assessment Group's disease activity index for patients with systemic lupus erythematosus. Rheumatology (Oxford) 44:902-906.
44. Aga E, et al. (2002) Inhibition of the spontaneous apoptosis of neutrophil granulocytes by the intracellular parasite Leishmania major. J Immunol 169:898-905. (Pubitemid 34753446)
45. Losman MJ, Fasy TM, Novick KE, Monestier M (1992) Monoclonal autoantibodies to subnucleosomes from a MRL/Mp(-)+/+ mouse. Oligoclonality of the antibody response and recognition of a determinant composed of histones H2A, H2B, and DNA. J Immunol 148:1561-1569.