-
1
-
-
0008538685
-
A protein factor essential for microtubule assembly
-
1057175 432646
-
Weingarten MD, Lockwood AH, Hwo S-Y, Kirschner MW (1975) A protein factor essential for microtubule assembly. Proc Natl Acad Sci USA 72(5):1858-1862
-
(1975)
Proc Natl Acad Sci USA
, vol.72
, Issue.5
, pp. 1858-1862
-
-
Weingarten, M.D.1
Lockwood, A.H.2
Hwo, S.-Y.3
Kirschner, M.W.4
-
2
-
-
84919466585
-
Lost after translation: Missorting of Tau protein and consequences for Alzheimer disease
-
25223701
-
Zempel H, Mandelkow E (2014) Lost after translation: missorting of Tau protein and consequences for Alzheimer disease. Trends Neurosci 37(12):721-732
-
(2014)
Trends Neurosci
, vol.37
, Issue.12
, pp. 721-732
-
-
Zempel, H.1
Mandelkow, E.2
-
3
-
-
0025786986
-
Hydrated autoclave pretreatment enhances tau immunoreactivity in formalin-fixed normal and Alzheimer's disease brain tissues
-
1903170
-
Shin R, Iwaki T, Kitamoto T, Tateishi J (1991) Hydrated autoclave pretreatment enhances tau immunoreactivity in formalin-fixed normal and Alzheimer's disease brain tissues. Lab Invest 64(5):693-702
-
(1991)
Lab Invest
, vol.64
, Issue.5
, pp. 693-702
-
-
Shin, R.1
Iwaki, T.2
Kitamoto, T.3
Tateishi, J.4
-
4
-
-
0022557147
-
Differential localization of MAP-2 and tau in mammalian neurons in situ
-
3089105
-
Binder LI, Frankfurter A, Rebhun LI (1986) Differential localization of MAP-2 and tau in mammalian neurons in situ. Ann N Y Acad Sci 466(1):145-166
-
(1986)
Ann N y Acad Sci
, vol.466
, Issue.1
, pp. 145-166
-
-
Binder, L.I.1
Frankfurter, A.2
Rebhun, L.I.3
-
5
-
-
0022827447
-
Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2
-
Neve RL, Harris P, Kosik KS, Kurnit DM, Donlon TA (1986) Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2. Mol Brain Res 1(3):271-280
-
(1986)
Mol Brain Res
, vol.1
, Issue.3
, pp. 271-280
-
-
Neve, R.L.1
Harris, P.2
Kosik, K.S.3
Kurnit, D.M.4
Donlon, T.A.5
-
6
-
-
65249116483
-
Tau mutations in neurodegenerative diseases
-
18948254
-
Wolfe MS (2009) Tau mutations in neurodegenerative diseases. J Biol Chem 284(10):6021-6025
-
(2009)
J Biol Chem
, vol.284
, Issue.10
, pp. 6021-6025
-
-
Wolfe, M.S.1
-
7
-
-
0024745894
-
Multiple isoforms of human microtubule-associated protein tau: Sequences and localization in neurofibrillary tangles of Alzheimer's disease
-
2484340
-
Goedert M, Spillantini MG, Jakes R, Rutherford D, Crowther RA (1989) Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease. Neuron 3(4):519-526
-
(1989)
Neuron
, vol.3
, Issue.4
, pp. 519-526
-
-
Goedert, M.1
Spillantini, M.G.2
Jakes, R.3
Rutherford, D.4
Crowther, R.A.5
-
8
-
-
0026488111
-
Structure and novel exons of the human tau gene
-
Andreadis A, Brown WM, Kosik KS (1992) Structure and novel exons of the human tau gene. Biochem 31(43):10626-10633
-
(1992)
Biochem
, vol.31
, Issue.43
, pp. 10626-10633
-
-
Andreadis, A.1
Brown, W.M.2
Kosik, K.S.3
-
9
-
-
0032484089
-
Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17
-
9836646
-
Hong M, Zhukareva V, Vogelsberg-Ragaglia V, Wszolek Z, Reed L, Miller BI et al (1998) Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17. Science 282(5395):1914-1917
-
(1998)
Science
, vol.282
, Issue.5395
, pp. 1914-1917
-
-
Hong, M.1
Zhukareva, V.2
Vogelsberg-Ragaglia, V.3
Wszolek, Z.4
Reed, L.5
Miller, B.I.6
-
10
-
-
0026046950
-
Tau protein binds to microtubules through a flexible array of distributed weak sites
-
1918161
-
Butner K, Kirschner MW (1991) Tau protein binds to microtubules through a flexible array of distributed weak sites. J Cell Biol 115(3):717-730
-
(1991)
J Cell Biol
, vol.115
, Issue.3
, pp. 717-730
-
-
Butner, K.1
Kirschner, M.W.2
-
11
-
-
17144409371
-
Three- and four-repeat tau regulate the dynamic instability of two distinct microtubule subpopulations in qualitatively different manners. Implications for neurodegeneration
-
15671021
-
Levy SF, Leboeuf AC, Massie MR, Jordan MA, Wilson L, Feinstein SC (2005) Three- and four-repeat tau regulate the dynamic instability of two distinct microtubule subpopulations in qualitatively different manners. Implications for neurodegeneration. J Biol Chem 280(14):13520-13528
-
(2005)
J Biol Chem
, vol.280
, Issue.14
, pp. 13520-13528
-
-
Levy, S.F.1
Leboeuf, A.C.2
Massie, M.R.3
Jordan, M.A.4
Wilson, L.5
Feinstein, S.C.6
-
12
-
-
10944227282
-
Tau phosphorylation: Physiological and pathological consequences
-
Stoothoff WH, Johnson GV (2005) Tau phosphorylation: physiological and pathological consequences. BBA Mol Basis Dis 1739(2):280-297
-
(2005)
BBA Mol Basis Dis
, vol.1739
, Issue.2
, pp. 280-297
-
-
Stoothoff, W.H.1
Johnson, G.V.2
-
13
-
-
84872551783
-
Abnormal hyperphosphorylation of tau: Sites, regulation, and molecular mechanism of neurofibrillary degeneration
-
22710920
-
Wang JZ, Xia YY, Grundke-Iqbal I, Iqbal K (2013) Abnormal hyperphosphorylation of tau: sites, regulation, and molecular mechanism of neurofibrillary degeneration. J Alzheimers Dis 33(Suppl 1):S123-S139
-
(2013)
J Alzheimers Dis
, vol.33
, pp. S123-S139
-
-
Wang, J.Z.1
Xia, Y.Y.2
Grundke-Iqbal, I.3
Iqbal, K.4
-
14
-
-
0027370141
-
In vivo phosphorylation sites in fetal and adult rat tau
-
8245007
-
Watanabe A, Hasegawa M, Suzuki M, Takio K, Morishima-Kawashima M, Titani K et al (1993) In vivo phosphorylation sites in fetal and adult rat tau. J Biol Chem 268(34):25712-25717
-
(1993)
J Biol Chem
, vol.268
, Issue.34
, pp. 25712-25717
-
-
Watanabe, A.1
Hasegawa, M.2
Suzuki, M.3
Takio, K.4
Morishima-Kawashima, M.5
Titani, K.6
-
15
-
-
0028172239
-
The phosphorylation state of tau in the developing rat brain is regulated by phosphoprotein phosphatases
-
7983034
-
Mawal-Dewan M, Henley J, Van de Voorde A, Trojanowski JQ, Lee VM (1994) The phosphorylation state of tau in the developing rat brain is regulated by phosphoprotein phosphatases. J Biol Chem 269(49):30981-30987
-
(1994)
J Biol Chem
, vol.269
, Issue.49
, pp. 30981-30987
-
-
Mawal-Dewan, M.1
Henley, J.2
Van De Voorde, A.3
Trojanowski, J.Q.4
Lee, V.M.5
-
16
-
-
0028301455
-
Altered microtubule organization in small-calibre axons of mice lacking tau protein
-
8202139
-
Harada A, Oguchi K, Okabe S, Kuno J, Terada S, Ohshima T et al (1994) Altered microtubule organization in small-calibre axons of mice lacking tau protein. Nature 369(6480):488-491
-
(1994)
Nature
, vol.369
, Issue.6480
, pp. 488-491
-
-
Harada, A.1
Oguchi, K.2
Okabe, S.3
Kuno, J.4
Terada, S.5
Ohshima, T.6
-
17
-
-
0027361281
-
Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease
-
8226987
-
Kopke E, Tung YC, Shaikh S, Alonso AC, Iqbal K, Grundke-Iqbal I (1993) Microtubule-associated protein tau. Abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease. J Biol Chem 268(32):24374-24384
-
(1993)
J Biol Chem
, vol.268
, Issue.32
, pp. 24374-24384
-
-
Kopke, E.1
Tung, Y.C.2
Shaikh, S.3
Alonso, A.C.4
Iqbal, K.5
Grundke-Iqbal, I.6
-
19
-
-
57049095821
-
Function and structure of inherently disordered proteins
-
18952168
-
Dunker AK, Silman I, Uversky VN, Sussman JL (2008) Function and structure of inherently disordered proteins. Curr Opin Struct Biol 18(6):756-764
-
(2008)
Curr Opin Struct Biol
, vol.18
, Issue.6
, pp. 756-764
-
-
Dunker, A.K.1
Silman, I.2
Uversky, V.N.3
Sussman, J.L.4
-
20
-
-
61349120815
-
Structural polymorphism of 441-residue tau at single residue resolution
-
2642882
-
Mukrasch MD, Bibow S, Korukottu J, Jeganathan S, Biernat J, Griesinger C et al (2009) Structural polymorphism of 441-residue tau at single residue resolution. PLoS Biol 7(2):e1000034
-
(2009)
PLoS Biol
, vol.7
, Issue.2
, pp. e1000034
-
-
Mukrasch, M.D.1
Bibow, S.2
Korukottu, J.3
Jeganathan, S.4
Biernat, J.5
Griesinger, C.6
-
21
-
-
34848845327
-
The binding and phosphorylation of Thr231 is critical for Tau's hyperphosphorylation and functional regulation by glycogen synthase kinase 3β
-
17680984
-
Lin YT, Cheng JT, Liang LC, Ko CY, Lo YK, Lu PJ (2007) The binding and phosphorylation of Thr231 is critical for Tau's hyperphosphorylation and functional regulation by glycogen synthase kinase 3β. J Neurochem 103(2):802-813
-
(2007)
J Neurochem
, vol.103
, Issue.2
, pp. 802-813
-
-
Lin, Y.T.1
Cheng, J.T.2
Liang, L.C.3
Ko, C.Y.4
Lo, Y.K.5
Lu, P.J.6
-
22
-
-
19944375450
-
Tau pathology in Alzheimer disease and other tauopathies
-
Iqbal K, del C Alonso A, Chen S, Chohan MO, El-Akkad E, Gong C-X et al (2005) Tau pathology in Alzheimer disease and other tauopathies. BBA Mol Basis Dis 1739(2):198-210
-
(2005)
BBA Mol Basis Dis
, vol.1739
, Issue.2
, pp. 198-210
-
-
Iqbal, K.1
Del Alonso, C.A.2
Chen, S.3
Chohan, M.O.4
El-Akkad, E.5
Gong, C.-X.6
-
23
-
-
0035066332
-
Alzheimer's disease: Genes, proteins, and therapy
-
11274343
-
Selkoe DJ (2001) Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 81(2):741-766
-
(2001)
Physiol Rev
, vol.81
, Issue.2
, pp. 741-766
-
-
Selkoe, D.J.1
-
24
-
-
0037174618
-
Alzheimer's disease is a synaptic failure
-
12399581
-
Selkoe DJ (2002) Alzheimer's disease is a synaptic failure. Science 298(5594):789-791
-
(2002)
Science
, vol.298
, Issue.5594
, pp. 789-791
-
-
Selkoe, D.J.1
-
25
-
-
34548036227
-
Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
-
17684513
-
Ballatore C, Lee VM-Y, Trojanowski JQ (2007) Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nat Rev Neurosci 8(9):663-672
-
(2007)
Nat Rev Neurosci
, vol.8
, Issue.9
, pp. 663-672
-
-
Ballatore, C.1
Lee, V.M.-Y.2
Trojanowski, J.Q.3
-
26
-
-
0030977392
-
Frontotemporal dementia and parkinsonism linked to chromosome 17: A consensus conference
-
9189031
-
Foster NL, Wilhelmsen K, Sima AA, Jones MZ, D'Amato CJ, Gilman S (1997) Frontotemporal dementia and parkinsonism linked to chromosome 17: a consensus conference. Ann Neurol 41(6):706-715
-
(1997)
Ann Neurol
, vol.41
, Issue.6
, pp. 706-715
-
-
Foster, N.L.1
Wilhelmsen, K.2
Sima, A.A.3
Jones, M.Z.4
D'Amato, C.J.5
Gilman, S.6
-
27
-
-
0032897924
-
A clinical pathological comparison of three families with frontotemporal dementia and identical mutations in the tau gene (P301L)
-
10219785
-
Bird TD, Nochlin D, Poorkaj P, Cherrier M, Kaye J, Payami H et al (1999) A clinical pathological comparison of three families with frontotemporal dementia and identical mutations in the tau gene (P301L). Brain 122(4):741-756
-
(1999)
Brain
, vol.122
, Issue.4
, pp. 741-756
-
-
Bird, T.D.1
Nochlin, D.2
Poorkaj, P.3
Cherrier, M.4
Kaye, J.5
Payami, H.6
-
28
-
-
0033059975
-
Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau
-
10374757
-
Bugiani O, Murrell JR, Giaccone G, Hasegawa M, Ghigo G, Tabaton M et al (1999) Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau. J Neuropathol Exp Neurol 58(6):667-677
-
(1999)
J Neuropathol Exp Neurol
, vol.58
, Issue.6
, pp. 667-677
-
-
Bugiani, O.1
Murrell, J.R.2
Giaccone, G.3
Hasegawa, M.4
Ghigo, G.5
Tabaton, M.6
-
29
-
-
0001124925
-
Magnetic resonance imaging studies in rapidly progressive autosomal dominant parkinsonism and dementia with pallido-ponto-nigral degeneration
-
Cordes M, Wszolek Z, Calne D, Rodnitzky R, Pfeiffer R (1992) Magnetic resonance imaging studies in rapidly progressive autosomal dominant parkinsonism and dementia with pallido-ponto-nigral degeneration. Neurodegeneration 1:217-224
-
(1992)
Neurodegeneration
, vol.1
, pp. 217-224
-
-
Cordes, M.1
Wszolek, Z.2
Calne, D.3
Rodnitzky, R.4
Pfeiffer, R.5
-
30
-
-
0026775551
-
Rapidly progressive autosomal dominant parkinsonism and dementia with pallido-ponto-nigral degeneration
-
1416801
-
Wszolek Z, Pfeiffer R, Bhatt M, Schelper R, Cordes M, Snow B et al (1992) Rapidly progressive autosomal dominant parkinsonism and dementia with pallido-ponto-nigral degeneration. Ann Neurol 32(3):312-320
-
(1992)
Ann Neurol
, vol.32
, Issue.3
, pp. 312-320
-
-
Wszolek, Z.1
Pfeiffer, R.2
Bhatt, M.3
Schelper, R.4
Cordes, M.5
Snow, B.6
-
31
-
-
33847103297
-
Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17)
-
16899117 1563447
-
Wszolek ZK, Tsuboi Y, Ghetti B, Pickering-Brown S, Baba Y, Cheshire WP (2006) Frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Orphanet J Rare Dis 1:30
-
(2006)
Orphanet J Rare Dis
, vol.1
, pp. 30
-
-
Wszolek, Z.K.1
Tsuboi, Y.2
Ghetti, B.3
Pickering-Brown, S.4
Baba, Y.5
Cheshire, W.P.6
-
32
-
-
0032543684
-
Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
-
9641683
-
Hutton M, Lendon CL, Rizzu P, Baker M, Froelich S, Houlden H et al (1998) Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17. Nature 393(6686):702-705
-
(1998)
Nature
, vol.393
, Issue.6686
, pp. 702-705
-
-
Hutton, M.1
Lendon, C.L.2
Rizzu, P.3
Baker, M.4
Froelich, S.5
Houlden, H.6
-
33
-
-
0032560487
-
Mutation in the tau gene in familial multiple system tauopathy with presenile dementia
-
9636220 22742
-
Spillantini MG, Murrell JR, Goedert M, Farlow MR, Klug A, Ghetti B (1998) Mutation in the tau gene in familial multiple system tauopathy with presenile dementia. Proc Natl Acad Sci USA 95(13):7737-7741
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, Issue.13
, pp. 7737-7741
-
-
Spillantini, M.G.1
Murrell, J.R.2
Goedert, M.3
Farlow, M.R.4
Klug, A.5
Ghetti, B.6
-
34
-
-
0034718203
-
Tau mutations in frontotemporal dementia FTDP-17 and their relevance for Alzheimer's disease
-
Goedert M, Spillantini MG (2000) Tau mutations in frontotemporal dementia FTDP-17 and their relevance for Alzheimer's disease. BBA Mol Basis Dis 1502(1):110-121
-
(2000)
BBA Mol Basis Dis
, vol.1502
, Issue.1
, pp. 110-121
-
-
Goedert, M.1
Spillantini, M.G.2
-
35
-
-
0036892302
-
Tau gene mutations: Dissecting the pathogenesis of FTDP-17
-
12470988
-
Ingram EM, Spillantini MG (2002) Tau gene mutations: dissecting the pathogenesis of FTDP-17. Trends Mol Med 8(12):555-562
-
(2002)
Trends Mol Med
, vol.8
, Issue.12
, pp. 555-562
-
-
Ingram, E.M.1
Spillantini, M.G.2
-
36
-
-
2442642836
-
Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy
-
15140937
-
Zhang B, Higuchi M, Yoshiyama Y, Ishihara T, Forman MS, Martinez D et al (2004) Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy. J Neurosci 24(19):4657-4667
-
(2004)
J Neurosci
, vol.24
, Issue.19
, pp. 4657-4667
-
-
Zhang, B.1
Higuchi, M.2
Yoshiyama, Y.3
Ishihara, T.4
Forman, M.S.5
Martinez, D.6
-
37
-
-
0035958642
-
Tauopathy in Drosophila: Neurodegeneration without neurofibrillary tangles
-
11408621
-
Wittmann CW, Wszolek MF, Shulman JM, Salvaterra PM, Lewis J, Hutton M et al (2001) Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles. Science 293(5530):711-714
-
(2001)
Science
, vol.293
, Issue.5530
, pp. 711-714
-
-
Wittmann, C.W.1
Wszolek, M.F.2
Shulman, J.M.3
Salvaterra, P.M.4
Lewis, J.5
Hutton, M.6
-
38
-
-
0042889049
-
Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy
-
12872001 187908
-
Kraemer BC, Zhang B, Leverenz JB, Thomas JH, Trojanowski JQ, Schellenberg GD (2003) Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy. Proc Natl Acad Sci USA 100(17):9980-9985
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, Issue.17
, pp. 9980-9985
-
-
Kraemer, B.C.1
Zhang, B.2
Leverenz, J.B.3
Thomas, J.H.4
Trojanowski, J.Q.5
Schellenberg, G.D.6
-
39
-
-
70350370787
-
What have worm models told us about the mechanisms of neuronal dysfunction in human neurodegenerative diseases
-
Teschendorf D, Link CD (2009) What have worm models told us about the mechanisms of neuronal dysfunction in human neurodegenerative diseases. Mol Neurodegener 4(1):1-13
-
(2009)
Mol Neurodegener
, vol.4
, Issue.1
, pp. 1-13
-
-
Teschendorf, D.1
Link, C.D.2
-
40
-
-
56049100463
-
A Caenorhabditis elegans model of tau hyperphosphorylation: Induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau
-
17590239
-
Brandt R, Gergou A, Wacker I, Fath T, Hutter H (2009) A Caenorhabditis elegans model of tau hyperphosphorylation: induction of developmental defects by transgenic overexpression of Alzheimer's disease-like modified tau. Neurobiol Aging 30(1):22-33
-
(2009)
Neurobiol Aging
, vol.30
, Issue.1
, pp. 22-33
-
-
Brandt, R.1
Gergou, A.2
Wacker, I.3
Fath, T.4
Hutter, H.5
-
41
-
-
84855535702
-
Modelling tauopathies in Drosophila: Insights from the fruit fly
-
22254145 3255107
-
Cowan CM, Sealey MA, Quraishe S, Targett M-T, Marcellus K, Allan D et al (2011) Modelling tauopathies in Drosophila: insights from the fruit fly. Int J Alzheimers Dis 2011:598157
-
(2011)
Int J Alzheimers Dis
, vol.2011
, pp. 598157
-
-
Cowan, C.M.1
Sealey, M.A.2
Quraishe, S.3
Targett, M.-T.4
Marcellus, K.5
Allan, D.6
-
42
-
-
2542590202
-
Learning and memory deficits upon TAU accumulation in Drosophila mushroom body neurons
-
15169857 419730
-
Mershin A, Pavlopoulos E, Fitch O, Braden BC, Nanopoulos DV, Skoulakis EM (2004) Learning and memory deficits upon TAU accumulation in Drosophila mushroom body neurons. Learn Mem 11(3):277-287
-
(2004)
Learn Mem
, vol.11
, Issue.3
, pp. 277-287
-
-
Mershin, A.1
Pavlopoulos, E.2
Fitch, O.3
Braden, B.C.4
Nanopoulos, D.V.5
Skoulakis, E.M.6
-
43
-
-
3142592230
-
GSK-3β inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila
-
14993907
-
Mudher A, Shepherd D, Newman T, Mildren P, Jukes J, Squire A et al (2004) GSK-3β inhibition reverses axonal transport defects and behavioural phenotypes in Drosophila. Mol Psychiatry 9(5):522-530
-
(2004)
Mol Psychiatry
, vol.9
, Issue.5
, pp. 522-530
-
-
Mudher, A.1
Shepherd, D.2
Newman, T.3
Mildren, P.4
Jukes, J.5
Squire, A.6
-
44
-
-
1542358895
-
PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila
-
15006350
-
Nishimura I, Yang Y, Lu B (2004) PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila. Cell 116(5):671-682
-
(2004)
Cell
, vol.116
, Issue.5
, pp. 671-682
-
-
Nishimura, I.1
Yang, Y.2
Lu, B.3
-
45
-
-
0346361872
-
Genetic modifiers of tauopathy in Drosophila
-
14668378 1462852
-
Shulman JM, Feany MB (2003) Genetic modifiers of tauopathy in Drosophila. Genetics 165(3):1233-1242
-
(2003)
Genetics
, vol.165
, Issue.3
, pp. 1233-1242
-
-
Shulman, J.M.1
Feany, M.B.2
-
46
-
-
34047106848
-
Cytoskeleton proteins are modulators of mutant tau-induced neurodegeneration in Drosophila
-
17309878
-
Blard O, Feuillette S, Bou J, Chaumette B, Frébourg T, Campion D et al (2007) Cytoskeleton proteins are modulators of mutant tau-induced neurodegeneration in Drosophila. Hum Mol Genet 16(5):555-566
-
(2007)
Hum Mol Genet
, vol.16
, Issue.5
, pp. 555-566
-
-
Blard, O.1
Feuillette, S.2
Bou, J.3
Chaumette, B.4
Frébourg, T.5
Campion, D.6
-
47
-
-
84923060369
-
Zinc binding directly regulates tau toxicity independent of tau hyperphosphorylation
-
25066125 4306234
-
Huang Y, Wu Z, Cao Y, Lang M, Lu B, Zhou B (2014) Zinc binding directly regulates tau toxicity independent of tau hyperphosphorylation. Cell Rep 8(3):831-842
-
(2014)
Cell Rep
, vol.8
, Issue.3
, pp. 831-842
-
-
Huang, Y.1
Wu, Z.2
Cao, Y.3
Lang, M.4
Lu, B.5
Zhou, B.6
-
48
-
-
0036514504
-
Modelling neurodegenerative diseases in Drosophila: A fruitful approach?
-
11994755
-
Muqit MM, Feany MB (2002) Modelling neurodegenerative diseases in Drosophila: a fruitful approach? Nat Rev Neurosci 3(3):237-243
-
(2002)
Nat Rev Neurosci
, vol.3
, Issue.3
, pp. 237-243
-
-
Muqit, M.M.1
Feany, M.B.2
-
49
-
-
77957254409
-
Tau Ser262 phosphorylation is critical for Aβ42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease
-
20466736 2901137
-
Iijima K, Gatt A, Iijima-Ando K (2010) Tau Ser262 phosphorylation is critical for Aβ42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease. Hum Mol Genet 19(15):2947-2957
-
(2010)
Hum Mol Genet
, vol.19
, Issue.15
, pp. 2947-2957
-
-
Iijima, K.1
Gatt, A.2
Iijima-Ando, K.3
-
50
-
-
84863689574
-
Lessons from tau-deficient mice
-
22720190 3375147
-
Ke YD, Suchowerska AK, van der Hoven J, De Silva DM, Wu CW, van Eersel J et al (2012) Lessons from tau-deficient mice. Int J Alzheimers Dis 2012:873270
-
(2012)
Int J Alzheimers Dis
, vol.2012
, pp. 873270
-
-
Ke, Y.D.1
Suchowerska, A.K.2
Van Der Hoven, J.3
De Silva, D.M.4
Wu, C.W.5
Van Eersel, J.6
-
51
-
-
84906922815
-
Motor and cognitive deficits in aged tau knockout mice in two background strains
-
25124182 4141346
-
Lei P, Ayton S, Moon S, Zhang Q, Volitakis I, Finkelstein DI et al (2014) Motor and cognitive deficits in aged tau knockout mice in two background strains. Mol Neurodegener 9(1):29
-
(2014)
Mol Neurodegener
, vol.9
, Issue.1
, pp. 29
-
-
Lei, P.1
Ayton, S.2
Moon, S.3
Zhang, Q.4
Volitakis, I.5
Finkelstein, D.I.6
-
52
-
-
0041803006
-
Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms
-
12859672
-
Andorfer C, Kress Y, Espinoza M, De Silva R, Tucker KL, Barde YA et al (2003) Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms. J Neurochem 86(3):582-590
-
(2003)
J Neurochem
, vol.86
, Issue.3
, pp. 582-590
-
-
Andorfer, C.1
Kress, Y.2
Espinoza, M.3
De Silva, R.4
Tucker, K.L.5
Barde, Y.A.6
-
53
-
-
69449093036
-
Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology
-
19710325 2760256
-
Polydoro M, Acker CM, Duff K, Castillo PE, Davies P (2009) Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology. J Neurosci 29(34):10741-10749
-
(2009)
J Neurosci
, vol.29
, Issue.34
, pp. 10741-10749
-
-
Polydoro, M.1
Acker, C.M.2
Duff, K.3
Castillo, P.E.4
Davies, P.5
-
54
-
-
0035680685
-
FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and tau filaments in forebrain
-
11749044
-
Lim F, Hernandez F, Lucas J, Gomez-Ramos P, Moran M, Avila J (2001) FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and tau filaments in forebrain. Mol Cell Neurosci 18(6):702-714
-
(2001)
Mol Cell Neurosci
, vol.18
, Issue.6
, pp. 702-714
-
-
Lim, F.1
Hernandez, F.2
Lucas, J.3
Gomez-Ramos, P.4
Moran, M.5
Avila, J.6
-
55
-
-
0037108953
-
Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau
-
12368474 129794
-
Tatebayashi Y, Miyasaka T, Chui D-H, Akagi T, K-i Mishima, Iwasaki K et al (2002) Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau. Proc Natl Acad Sci USA 99(21):13896-13901
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, Issue.21
, pp. 13896-13901
-
-
Tatebayashi, Y.1
Miyasaka, T.2
Chui, D.-H.3
Akagi, T.4
Iwasaki, K.5
-
56
-
-
0036850725
-
Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein
-
12417659
-
Allen B, Ingram E, Takao M, Smith MJ, Jakes R, Virdee K et al (2002) Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein. J Neurosci 22(21):9340-9351
-
(2002)
J Neurosci
, vol.22
, Issue.21
, pp. 9340-9351
-
-
Allen, B.1
Ingram, E.2
Takao, M.3
Smith, M.J.4
Jakes, R.5
Virdee, K.6
-
57
-
-
80054896626
-
Truncation of tau at E391 promotes early pathological changes in transgenic mice
-
22002427 3237612
-
McMillan PJ, Kraemer BC, Robinson L, Leverenz JB, Raskind M, Schellenberg G (2011) Truncation of tau at E391 promotes early pathological changes in transgenic mice. J Neuropathol Exp Neurol 70(11):1006
-
(2011)
J Neuropathol Exp Neurol
, vol.70
, Issue.11
, pp. 1006
-
-
McMillan, P.J.1
Kraemer, B.C.2
Robinson, L.3
Leverenz, J.B.4
Raskind, M.5
Schellenberg, G.6
-
58
-
-
79953087890
-
The acetylation of tau inhibits its function and promotes pathological tau aggregation
-
21427723 3120096
-
Cohen TJ, Guo JL, Hurtado DE, Kwong LK, Mills IP, Trojanowski JQ et al (2011) The acetylation of tau inhibits its function and promotes pathological tau aggregation. Nat Commun 2:252
-
(2011)
Nat Commun
, vol.2
, pp. 252
-
-
Cohen, T.J.1
Guo, J.L.2
Hurtado, D.E.3
Kwong, L.K.4
Mills, I.P.5
Trojanowski, J.Q.6
-
59
-
-
66449115032
-
A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation
-
19363289 2673864
-
Paquet D, Bhat R, Sydow A, Mandelkow E-M, Berg S, Hellberg S et al (2009) A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation. J Clin Invest 119(5):1382-1395
-
(2009)
J Clin Invest
, vol.119
, Issue.5
, pp. 1382-1395
-
-
Paquet, D.1
Bhat, R.2
Sydow, A.3
Mandelkow, E.-M.4
Berg, S.5
Hellberg, S.6
-
60
-
-
33745152289
-
Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo
-
16753151
-
Zilka N, Filipcik P, Koson P, Fialova L, Skrabana R, Zilkova M et al (2006) Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo. FEBS Lett 580(15):3582-3588
-
(2006)
FEBS Lett
, vol.580
, Issue.15
, pp. 3582-3588
-
-
Zilka, N.1
Filipcik, P.2
Koson, P.3
Fialova, L.4
Skrabana, R.5
Zilkova, M.6
-
61
-
-
84861189566
-
First transgenic rat model developing progressive cortical neurofibrillary tangles
-
21196063
-
Filipcik P, Zilka N, Bugos O, Kucerak J, Koson P, Novak P et al (2012) First transgenic rat model developing progressive cortical neurofibrillary tangles. Neurobiol Aging 33(7):1448-1456
-
(2012)
Neurobiol Aging
, vol.33
, Issue.7
, pp. 1448-1456
-
-
Filipcik, P.1
Zilka, N.2
Bugos, O.3
Kucerak, J.4
Koson, P.5
Novak, P.6
-
62
-
-
84886179076
-
Modeling Alzheimer's disease in transgenic rats
-
24161192 4231465
-
Do Carmo S, Cuello AC (2013) Modeling Alzheimer's disease in transgenic rats. Mol Neurodegener 8(1):37
-
(2013)
Mol Neurodegener
, vol.8
, Issue.1
, pp. 37
-
-
Do Carmo, S.1
Cuello, A.C.2
-
63
-
-
84878750229
-
Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: Possible link between traumatic brain injury and sporadic tauopathies
-
23632019 3675635
-
Hawkins BE, Krishnamurthy S, Castillo-Carranza DL, Sengupta U, Prough DS, Jackson GR et al (2013) Rapid accumulation of endogenous tau oligomers in a rat model of traumatic brain injury: possible link between traumatic brain injury and sporadic tauopathies. J Biol Chem 288(23):17042-17050
-
(2013)
J Biol Chem
, vol.288
, Issue.23
, pp. 17042-17050
-
-
Hawkins, B.E.1
Krishnamurthy, S.2
Castillo-Carranza, D.L.3
Sengupta, U.4
Prough, D.S.5
Jackson, G.R.6
-
64
-
-
0026176190
-
Homology of the amyloid beta protein precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease
-
1905108 1886384
-
Podlisny M, Tolan D, Selkoe D (1991) Homology of the amyloid beta protein precursor in monkey and human supports a primate model for beta amyloidosis in Alzheimer's disease. Am J Pathol 138(6):1423
-
(1991)
Am J Pathol
, vol.138
, Issue.6
, pp. 1423
-
-
Podlisny, M.1
Tolan, D.2
Selkoe, D.3
-
65
-
-
0031824782
-
Aging renders the brain vulnerable to amyloid β-protein neurotoxicity
-
Guela C, Wu C-K, Saroff D, Lorenzo A, Yuan M, Yankner BA (1998) Aging renders the brain vulnerable to amyloid β-protein neurotoxicity. Nat Med 4(7):827-831
-
(1998)
Nat Med
, vol.4
, Issue.7
, pp. 827-831
-
-
Guela, C.1
Wu, C.-K.2
Saroff, D.3
Lorenzo, A.4
Yuan, M.5
Yankner, B.A.6
-
66
-
-
0342626774
-
Abnormally phosphorylated protein tau in the cortex of aged individuals of various mammalian orders
-
10965801
-
Härtig W, Klein C, Brauer K, Schüppel K-F, Arendt T, Brückner G et al (2000) Abnormally phosphorylated protein tau in the cortex of aged individuals of various mammalian orders. Acta Neuropathol 100(3):305-312
-
(2000)
Acta Neuropathol
, vol.100
, Issue.3
, pp. 305-312
-
-
Härtig, W.1
Klein, C.2
Brauer, K.3
Schüppel, K.-F.4
Arendt, T.5
Brückner, G.6
-
67
-
-
75349095224
-
Alzheimer-type tau pathology in advanced aged nonhuman primate brains harboring substantial amyloid deposition
-
20004650
-
Oikawa N, Kimura N, Yanagisawa K (2010) Alzheimer-type tau pathology in advanced aged nonhuman primate brains harboring substantial amyloid deposition. Brain Res 1315:137-149
-
(2010)
Brain Res
, vol.1315
, pp. 137-149
-
-
Oikawa, N.1
Kimura, N.2
Yanagisawa, K.3
-
68
-
-
0033635056
-
Age-related progression of tau pathology in brains of baboons
-
11124441
-
Schultz C, Hubbard G, Rüb U, Braak E, Braak H (2000) Age-related progression of tau pathology in brains of baboons. Neurobiol Aging 21(6):905-912
-
(2000)
Neurobiol Aging
, vol.21
, Issue.6
, pp. 905-912
-
-
Schultz, C.1
Hubbard, G.2
Rüb, U.3
Braak, E.4
Braak, H.5
-
69
-
-
47049120305
-
Tauopathy with paired helical filaments in an aged chimpanzee
-
18481275 2573460
-
Rosen RF, Farberg AS, Gearing M, Dooyema J, Long PM, Anderson DC et al (2008) Tauopathy with paired helical filaments in an aged chimpanzee. J Comp Neurol 509(3):259-270
-
(2008)
J Comp Neurol
, vol.509
, Issue.3
, pp. 259-270
-
-
Rosen, R.F.1
Farberg, A.S.2
Gearing, M.3
Dooyema, J.4
Long, P.M.5
Anderson, D.C.6
-
70
-
-
84857126830
-
Nonhuman primate models of Alzheimer-like cerebral proteopathy
-
22288403 3381739
-
Heuer E, Rosen RF, Cintron A, Walker LC (2012) Nonhuman primate models of Alzheimer-like cerebral proteopathy. Curr Pharm Des 18(8):1159
-
(2012)
Curr Pharm des
, vol.18
, Issue.8
, pp. 1159
-
-
Heuer, E.1
Rosen, R.F.2
Cintron, A.3
Walker, L.C.4
-
71
-
-
27744491956
-
Pathological tau: A loss of normal function or a gain in toxicity?
-
16127446
-
Trojanowski JQ, Lee VM (2005) Pathological tau: a loss of normal function or a gain in toxicity? Nat Neurosci 8(9):1136-1137
-
(2005)
Nat Neurosci
, vol.8
, Issue.9
, pp. 1136-1137
-
-
Trojanowski, J.Q.1
Lee, V.M.2
-
72
-
-
84864379001
-
Tau oligomers and tau toxicity in neurodegenerative disease
-
22817713 3704193
-
Ward SM, Himmelstein DS, Lancia JK, Binder LI (2012) Tau oligomers and tau toxicity in neurodegenerative disease. Biochem Soc Trans 40(4):667-671
-
(2012)
Biochem Soc Trans
, vol.40
, Issue.4
, pp. 667-671
-
-
Ward, S.M.1
Himmelstein, D.S.2
Lancia, J.K.3
Binder, L.I.4
-
73
-
-
0028937631
-
Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262
-
7706316
-
Drewes G, Trinczek B, Illenberger S, Biernat J, Schmitt-Ulms G, Meyer HE et al (1995) Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262. J Biol Chem 270(13):7679-7688
-
(1995)
J Biol Chem
, vol.270
, Issue.13
, pp. 7679-7688
-
-
Drewes, G.1
Trinczek, B.2
Illenberger, S.3
Biernat, J.4
Schmitt-Ulms, G.5
Meyer, H.E.6
-
74
-
-
0032530145
-
Phosphorylation of tau at both Thr 231 and ser 262 is required for maximal inhibition of its binding to microtubules
-
9735171
-
Sengupta A, Kabat J, Novak M, Wu Q, Grundke-Iqbal I, Iqbal K (1998) Phosphorylation of tau at both Thr 231 and Ser 262 is required for maximal inhibition of its binding to microtubules. Arch Biochem Biophys 357(2):299-309
-
(1998)
Arch Biochem Biophys
, vol.357
, Issue.2
, pp. 299-309
-
-
Sengupta, A.1
Kabat, J.2
Novak, M.3
Wu, Q.4
Grundke-Iqbal, I.5
Iqbal, K.6
-
75
-
-
0027308924
-
Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding
-
8318230
-
Bramblett GT, Goedert M, Jakes R, Merrick SE, Trojanowski JQ, Lee VM (1993) Abnormal tau phosphorylation at Ser396 in Alzheimer's disease recapitulates development and contributes to reduced microtubule binding. Neuron 10(6):1089-1099
-
(1993)
Neuron
, vol.10
, Issue.6
, pp. 1089-1099
-
-
Bramblett, G.T.1
Goedert, M.2
Jakes, R.3
Merrick, S.E.4
Trojanowski, J.Q.5
Lee, V.M.6
-
76
-
-
61649085621
-
Tau pathophysiology in neurodegeneration: A tangled issue
-
19162340
-
Spires-Jones TL, Stoothoff WH, de Calignon A, Jones PB, Hyman BT (2009) Tau pathophysiology in neurodegeneration: a tangled issue. Trends Neurosci 32(3):150-159
-
(2009)
Trends Neurosci
, vol.32
, Issue.3
, pp. 150-159
-
-
Spires-Jones, T.L.1
Stoothoff, W.H.2
De Calignon, A.3
Jones, P.B.4
Hyman, B.T.5
-
77
-
-
41149175575
-
A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease
-
18199809
-
Matsuoka Y, Jouroukhin Y, Gray AJ, Ma L, Hirata-Fukae C, Li H-F et al (2008) A neuronal microtubule-interacting agent, NAPVSIPQ, reduces tau pathology and enhances cognitive function in a mouse model of Alzheimer's disease. J Pharmacol Exp Ther 325(1):146-153
-
(2008)
J Pharmacol Exp Ther
, vol.325
, Issue.1
, pp. 146-153
-
-
Matsuoka, Y.1
Jouroukhin, Y.2
Gray, A.J.3
Ma, L.4
Hirata-Fukae, C.5
Li, H.-F.6
-
78
-
-
34248354279
-
Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage
-
17478890
-
Matsuoka Y, Gray AJ, Hirata-Fukae C, Minami SS, Waterhouse EG, Mattson MP et al (2007) Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage. J Mol Neurosci 31(2):165-170
-
(2007)
J Mol Neurosci
, vol.31
, Issue.2
, pp. 165-170
-
-
Matsuoka, Y.1
Gray, A.J.2
Hirata-Fukae, C.3
Minami, S.S.4
Waterhouse, E.G.5
Mattson, M.P.6
-
79
-
-
14044270858
-
Evidence that phosphorylation of the microtubule-associated protein Tau by SAPK4/p38delta at Thr50 promotes microtubule assembly
-
15632108, PT 2
-
Feijoo C, Campbell DG, Jakes R, Goedert M, Cuenda A (2005) Evidence that phosphorylation of the microtubule-associated protein Tau by SAPK4/p38delta at Thr50 promotes microtubule assembly. J Cell Sci 118(Pt 2):397-408
-
(2005)
J Cell Sci
, vol.118
, pp. 397-408
-
-
Feijoo, C.1
Campbell, D.G.2
Jakes, R.3
Goedert, M.4
Cuenda, A.5
-
80
-
-
0033578356
-
Phosphorylated tau can promote tubulin assembly
-
10449722 22238
-
Tseng HC, Lu Q, Henderson E, Graves DJ (1999) Phosphorylated tau can promote tubulin assembly. Proc Natl Acad Sci USA 96(17):9503-9508
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, Issue.17
, pp. 9503-9508
-
-
Tseng, H.C.1
Lu, Q.2
Henderson, E.3
Graves, D.J.4
-
81
-
-
0032799381
-
Tau regulates the attachment/detachment but not the speed of motors in microtubule-dependent transport of single vesicles and organelles
-
10381391, PT 14
-
Trinczek B, Ebneth A, Mandelkow EM, Mandelkow E (1999) Tau regulates the attachment/detachment but not the speed of motors in microtubule-dependent transport of single vesicles and organelles. J Cell Sci 112(Pt 14):2355-2367
-
(1999)
J Cell Sci
, vol.112
, pp. 2355-2367
-
-
Trinczek, B.1
Ebneth, A.2
Mandelkow, E.M.3
Mandelkow, E.4
-
82
-
-
5444273804
-
MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axons
-
15466480 2172520
-
Mandelkow EM, Thies E, Trinczek B, Biernat J, Mandelkow E (2004) MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axons. J Cell Biol 167(1):99-110
-
(2004)
J Cell Biol
, vol.167
, Issue.1
, pp. 99-110
-
-
Mandelkow, E.M.1
Thies, E.2
Trinczek, B.3
Biernat, J.4
Mandelkow, E.5
-
83
-
-
0030822508
-
Somatodendritic localization of phosphorylated tau in neonatal and adult rat cerebral cortex
-
9295120
-
Tashiro K, Hasegawa M, Ihara Y, Iwatsubo T (1997) Somatodendritic localization of phosphorylated tau in neonatal and adult rat cerebral cortex. NeuroReport 8(12):2797-2801
-
(1997)
NeuroReport
, vol.8
, Issue.12
, pp. 2797-2801
-
-
Tashiro, K.1
Hasegawa, M.2
Ihara, Y.3
Iwatsubo, T.4
-
84
-
-
33749150163
-
Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry
-
16906426 3906709
-
Braak H, Alafuzoff I, Arzberger T, Kretzschmar H, Del Tredici K (2006) Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. Acta Neuropathol 112(4):389-404
-
(2006)
Acta Neuropathol
, vol.112
, Issue.4
, pp. 389-404
-
-
Braak, H.1
Alafuzoff, I.2
Arzberger, T.3
Kretzschmar, H.4
Del Tredici, K.5
-
85
-
-
0025863618
-
Neuropathological stageing of Alzheimer-related changes
-
1759558
-
Braak H, Braak E (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82(4):239-259
-
(1991)
Acta Neuropathol
, vol.82
, Issue.4
, pp. 239-259
-
-
Braak, H.1
Braak, E.2
-
86
-
-
0028838142
-
Sorting mechanisms of tau and MAP2 in neurons: Suppressed axonal transit of MAP2 and locally regulated microtubule binding
-
7857650
-
Kanai Y, Hirokawa N (1995) Sorting mechanisms of tau and MAP2 in neurons: suppressed axonal transit of MAP2 and locally regulated microtubule binding. Neuron 14(2):421-432
-
(1995)
Neuron
, vol.14
, Issue.2
, pp. 421-432
-
-
Kanai, Y.1
Hirokawa, N.2
-
87
-
-
0033596946
-
Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments
-
10090741
-
Schneider A, Biernat J, Von Bergen M, Mandelkow E, Mandelkow E-M (1999) Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments. Biochemistry 38(12):3549-3558
-
(1999)
Biochemistry
, vol.38
, Issue.12
, pp. 3549-3558
-
-
Schneider, A.1
Biernat, J.2
Von Bergen, M.3
Mandelkow, E.4
Mandelkow, E.-M.5
-
88
-
-
82455208974
-
Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration
-
22009197 3243615
-
Li X, Kumar Y, Zempel H, Mandelkow EM, Biernat J, Mandelkow E (2011) Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration. EMBO J 30(23):4825-4837
-
(2011)
EMBO J
, vol.30
, Issue.23
, pp. 4825-4837
-
-
Li, X.1
Kumar, Y.2
Zempel, H.3
Mandelkow, E.M.4
Biernat, J.5
Mandelkow, E.6
-
89
-
-
0030000867
-
Comparison of the neurofibrillary pathology in Alzheimer's disease and familial presenile dementia with tangles
-
8811124
-
Spillantini M, Crowther R, Goedert M (1996) Comparison of the neurofibrillary pathology in Alzheimer's disease and familial presenile dementia with tangles. Acta Neuropathol 92(1):42-48
-
(1996)
Acta Neuropathol
, vol.92
, Issue.1
, pp. 42-48
-
-
Spillantini, M.1
Crowther, R.2
Goedert, M.3
-
90
-
-
0030826625
-
Autosomal dominant dementia with widespread neurofibrillary tangles
-
9382467
-
Reed LA, Schelper RL, Solodkin A, Van Hoesen GW, Morris JC, Trojanowski JQ et al (1997) Autosomal dominant dementia with widespread neurofibrillary tangles. Ann Neurol 42(4):564-572
-
(1997)
Ann Neurol
, vol.42
, Issue.4
, pp. 564-572
-
-
Reed, L.A.1
Schelper, R.L.2
Solodkin, A.3
Van Hoesen, G.W.4
Morris, J.C.5
Trojanowski, J.Q.6
-
91
-
-
0032880430
-
Phenotypic variation in hereditary frontotemporal dementia with tau mutations
-
10514099
-
Van Swieten J, Stevens M, Rosso S, Rizzu P, Joosse M, De Koning I et al (1999) Phenotypic variation in hereditary frontotemporal dementia with tau mutations. Ann Neurol 46(4):617-626
-
(1999)
Ann Neurol
, vol.46
, Issue.4
, pp. 617-626
-
-
Van Swieten, J.1
Stevens, M.2
Rosso, S.3
Rizzu, P.4
Joosse, M.5
De Koning, I.6
-
92
-
-
84874201513
-
Synaptic alterations in the rTg4510 mouse model of tauopathy
-
23047530 3725804
-
Kopeikina KJ, Polydoro M, Tai HC, Yaeger E, Carlson GA, Pitstick R et al (2013) Synaptic alterations in the rTg4510 mouse model of tauopathy. J Comp Neurol 521(6):1334-1353
-
(2013)
J Comp Neurol
, vol.521
, Issue.6
, pp. 1334-1353
-
-
Kopeikina, K.J.1
Polydoro, M.2
Tai, H.C.3
Yaeger, E.4
Carlson, G.A.5
Pitstick, R.6
-
93
-
-
44949185340
-
A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristics
-
18490011
-
Rosenmann H, Grigoriadis N, Eldar-Levy H, Avital A, Rozenstein L, Touloumi O et al (2008) A novel transgenic mouse expressing double mutant tau driven by its natural promoter exhibits tauopathy characteristics. Exp Neurol 212(1):71-84
-
(2008)
Exp Neurol
, vol.212
, Issue.1
, pp. 71-84
-
-
Rosenmann, H.1
Grigoriadis, N.2
Eldar-Levy, H.3
Avital, A.4
Rozenstein, L.5
Touloumi, O.6
-
94
-
-
84879232559
-
Spreading of tau pathology in Alzheimer's disease by cell-to-cell transmission
-
23773063
-
Mohamed NV, Herrou T, Plouffe V, Piperno N, Leclerc N (2013) Spreading of tau pathology in Alzheimer's disease by cell-to-cell transmission. Eur J Neurosci 37(12):1939-1948
-
(2013)
Eur J Neurosci
, vol.37
, Issue.12
, pp. 1939-1948
-
-
Mohamed, N.V.1
Herrou, T.2
Plouffe, V.3
Piperno, N.4
Leclerc, N.5
-
95
-
-
33947307791
-
Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1
-
17360912
-
Thies E, Mandelkow E-M (2007) Missorting of tau in neurons causes degeneration of synapses that can be rescued by the kinase MARK2/Par-1. J Neurosci 27(11):2896-2907
-
(2007)
J Neurosci
, vol.27
, Issue.11
, pp. 2896-2907
-
-
Thies, E.1
Mandelkow, E.-M.2
-
96
-
-
39449138356
-
Tau inhibits anterograde axonal transport and perturbs stability in growing axonal neurites in part by displacing kinesin cargo: Neurofilaments attenuate tau-mediated neurite instability
-
18000878
-
Dubey M, Chaudhury P, Kabiru H, Shea TB (2008) Tau inhibits anterograde axonal transport and perturbs stability in growing axonal neurites in part by displacing kinesin cargo: neurofilaments attenuate tau-mediated neurite instability. Cell Motil Cytoskeleton 65(2):89-99
-
(2008)
Cell Motil Cytoskeleton
, vol.65
, Issue.2
, pp. 89-99
-
-
Dubey, M.1
Chaudhury, P.2
Kabiru, H.3
Shea, T.B.4
-
97
-
-
78650251838
-
Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration
-
21172610 3026458
-
Hoover BR, Reed MN, Su J, Penrod RD, Kotilinek LA, Grant MK et al (2010) Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration. Neuron 68(6):1067-1081
-
(2010)
Neuron
, vol.68
, Issue.6
, pp. 1067-1081
-
-
Hoover, B.R.1
Reed, M.N.2
Su, J.3
Penrod, R.D.4
Kotilinek, L.A.5
Grant, M.K.6
-
98
-
-
84857063878
-
Blocking effects of human tau on squid giant synapse transmission and its prevention by T-817 MA
-
21629767 3099362
-
Moreno H, Choi S, Yu E, Brusco J, Avila J, Moreira JE et al (2011) Blocking effects of human tau on squid giant synapse transmission and its prevention by T-817 MA. Front Synaptic Neurosci 3:3
-
(2011)
Front Synaptic Neurosci
, vol.3
, pp. 3
-
-
Moreno, H.1
Choi, S.2
Yu, E.3
Brusco, J.4
Avila, J.5
Moreira, J.E.6
-
99
-
-
77955322042
-
Dendritic function of tau mediates amyloid-β toxicity in Alzheimer's disease mouse models
-
20655099
-
Ittner LM, Ke YD, Delerue F, Bi M, Gladbach A, van Eersel J et al (2010) Dendritic function of tau mediates amyloid-β toxicity in Alzheimer's disease mouse models. Cell 142(3):387-397
-
(2010)
Cell
, vol.142
, Issue.3
, pp. 387-397
-
-
Ittner, L.M.1
Ke, Y.D.2
Delerue, F.3
Bi, M.4
Gladbach, A.5
Van Eersel, J.6
-
100
-
-
78651506630
-
Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease
-
21228179 3325794
-
Roberson ED, Halabisky B, Yoo JW, Yao J, Chin J, Yan F et al (2011) Amyloid-β/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease. J Neurosci 31(2):700-711
-
(2011)
J Neurosci
, vol.31
, Issue.2
, pp. 700-711
-
-
Roberson, E.D.1
Halabisky, B.2
Yoo, J.W.3
Yao, J.4
Chin, J.5
Yan, F.6
-
101
-
-
79955646293
-
Hyperphosphorylated truncated protein tau induces caspase-3 independent apoptosis-like pathway in the Alzheimer's disease cellular model
-
20966551
-
Zilkova M, Zilka N, Kovac A, Kovacech B, Skrabana R, Skrabanova M et al (2011) Hyperphosphorylated truncated protein tau induces caspase-3 independent apoptosis-like pathway in the Alzheimer's disease cellular model. J Alzheimers Dis 23(1):161-169
-
(2011)
J Alzheimers Dis
, vol.23
, Issue.1
, pp. 161-169
-
-
Zilkova, M.1
Zilka, N.2
Kovac, A.3
Kovacech, B.4
Skrabana, R.5
Skrabanova, M.6
-
102
-
-
84899979081
-
Tau hyperphosphorylation induces apoptotic escape and triggers neurodegeneration in Alzheimer's disease
-
24627329
-
Wang J-Z, Wang Z-H, Tian Q (2014) Tau hyperphosphorylation induces apoptotic escape and triggers neurodegeneration in Alzheimer's disease. Neurosci Bull 30(2):359-366
-
(2014)
Neurosci Bull
, vol.30
, Issue.2
, pp. 359-366
-
-
Wang, J.-Z.1
Wang, Z.-H.2
Tian, Q.3
-
103
-
-
0022744803
-
Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology
-
3088567 323854
-
Grundke-Iqbal I, Iqbal K, Tung Y-C, Quinlan M, Wisniewski HM, Binder LI (1986) Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci USA 83(13):4913-4917
-
(1986)
Proc Natl Acad Sci USA
, vol.83
, Issue.13
, pp. 4913-4917
-
-
Grundke-Iqbal, I.1
Iqbal, K.2
Tung, Y.-C.3
Quinlan, M.4
Wisniewski, H.M.5
Binder, L.I.6
-
104
-
-
0024602479
-
Tau, paired helical filaments and amyloid in the neocortex: A morphometric study of 15 cases with graded intellectual status in aging and senile dementia of Alzheimer type
-
2501966
-
Delaere P, Duyckaerts C, Brion JP, Poulain V, Hauw J-J (1989) Tau, paired helical filaments and amyloid in the neocortex: a morphometric study of 15 cases with graded intellectual status in aging and senile dementia of Alzheimer type. Acta Neuropathol 77(6):645-653
-
(1989)
Acta Neuropathol
, vol.77
, Issue.6
, pp. 645-653
-
-
Delaere, P.1
Duyckaerts, C.2
Brion, J.P.3
Poulain, V.4
Hauw, J.-J.5
-
105
-
-
0030797002
-
Modeling the relation between neurofibrillary tangles and intellectual status
-
9263190
-
Duyckaerts C, Bennecib M, Grignon Y, Uchihara T, He Y, Piette F et al (1997) Modeling the relation between neurofibrillary tangles and intellectual status. Neurobiol Aging 18(3):267-273
-
(1997)
Neurobiol Aging
, vol.18
, Issue.3
, pp. 267-273
-
-
Duyckaerts, C.1
Bennecib, M.2
Grignon, Y.3
Uchihara, T.4
He, Y.5
Piette, F.6
-
106
-
-
0038708285
-
Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease
-
12743238
-
Giannakopoulos P, Herrmann F, Bussiere T, Bouras C, Kövari E, Perl D et al (2003) Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer's disease. Neurology 60(9):1495-1500
-
(2003)
Neurology
, vol.60
, Issue.9
, pp. 1495-1500
-
-
Giannakopoulos, P.1
Herrmann, F.2
Bussiere, T.3
Bouras, C.4
Kövari, E.5
Perl, D.6
-
107
-
-
0028989895
-
Neurons bearing neurofibrillary tangles are responsible for selected synaptic deficits in Alzheimer's disease
-
7566340
-
Callahan LM, Coleman PD (1995) Neurons bearing neurofibrillary tangles are responsible for selected synaptic deficits in Alzheimer's disease. Neurobiol Aging 16(3):311-314
-
(1995)
Neurobiol Aging
, vol.16
, Issue.3
, pp. 311-314
-
-
Callahan, L.M.1
Coleman, P.D.2
-
108
-
-
33750404114
-
Neurofibrillary tangle-related synaptic alterations of spinal motor neurons of P301L tau transgenic mice
-
17010516
-
Katsuse O, Lin W-L, Lewis J, Hutton ML, Dickson DW (2006) Neurofibrillary tangle-related synaptic alterations of spinal motor neurons of P301L tau transgenic mice. Neurosci Lett 409(2):95-99
-
(2006)
Neurosci Lett
, vol.409
, Issue.2
, pp. 95-99
-
-
Katsuse, O.1
Lin, W.-L.2
Lewis, J.3
Hutton, M.L.4
Dickson, D.W.5
-
109
-
-
33646080573
-
Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: In vitro evidence and implications for tangle formation in vivo
-
16606369
-
Guillozet-Bongaarts AL, Cahill ME, Cryns VL, Reynolds MR, Berry RW, Binder LI (2006) Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: in vitro evidence and implications for tangle formation in vivo. J Neurochem 97(4):1005-1014
-
(2006)
J Neurochem
, vol.97
, Issue.4
, pp. 1005-1014
-
-
Guillozet-Bongaarts, A.L.1
Cahill, M.E.2
Cryns, V.L.3
Reynolds, M.R.4
Berry, R.W.5
Binder, L.I.6
-
110
-
-
0033028074
-
Neurons may live for decades with neurofibrillary tangles
-
10029101
-
Morsch R, Simon W, Coleman PD (1999) Neurons may live for decades with neurofibrillary tangles. J Neuropathol Exp Neurol 58(2):188-197
-
(1999)
J Neuropathol Exp Neurol
, vol.58
, Issue.2
, pp. 188-197
-
-
Morsch, R.1
Simon, W.2
Coleman, P.D.3
-
111
-
-
22344438508
-
Tau suppression in a neurodegenerative mouse model improves memory function
-
16020737 1574647
-
Santacruz K, Lewis J, Spires T, Paulson J, Kotilinek L, Ingelsson M et al (2005) Tau suppression in a neurodegenerative mouse model improves memory function. Science 309(5733):476-481
-
(2005)
Science
, vol.309
, Issue.5733
, pp. 476-481
-
-
Santacruz, K.1
Lewis, J.2
Spires, T.3
Paulson, J.4
Kotilinek, L.5
Ingelsson, M.6
-
112
-
-
77958566761
-
Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden
-
21040568 2989315
-
O'Leary JC 3rd, Li Q, Marinec P, Blair LJ, Congdon EE, Johnson AG et al (2010) Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden. Mol Neurodegener 5:45
-
(2010)
Mol Neurodegener
, vol.5
, pp. 45
-
-
O'Leary, J.C.1
Li, Q.2
Marinec, P.3
Blair, L.J.4
Congdon, E.E.5
Johnson, A.G.6
-
113
-
-
79959571777
-
Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease
-
21550980 3123074
-
Patterson KR, Remmers C, Fu Y, Brooker S, Kanaan NM, Vana L et al (2011) Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer disease. J Biol Chem 286(26):23063-23076
-
(2011)
J Biol Chem
, vol.286
, Issue.26
, pp. 23063-23076
-
-
Patterson, K.R.1
Remmers, C.2
Fu, Y.3
Brooker, S.4
Kanaan, N.M.5
Vana, L.6
-
114
-
-
84858965241
-
Identification of oligomers at early stages of tau aggregation in Alzheimer's disease
-
22253473 4046102
-
Lasagna-Reeves CA, Castillo-Carranza DL, Sengupta U, Sarmiento J, Troncoso J, Jackson GR et al (2012) Identification of oligomers at early stages of tau aggregation in Alzheimer's disease. FASEB J 26(5):1946-1959
-
(2012)
FASEB J
, vol.26
, Issue.5
, pp. 1946-1959
-
-
Lasagna-Reeves, C.A.1
Castillo-Carranza, D.L.2
Sengupta, U.3
Sarmiento, J.4
Troncoso, J.5
Jackson, G.R.6
-
115
-
-
84885463056
-
Trimeric tau is toxic to human neuronal cells at low nanomolar concentrations
-
24159335 3789488
-
Tian H, Davidowitz E, Lopez P, Emadi S, Moe J, Sierks M (2013) Trimeric tau is toxic to human neuronal cells at low nanomolar concentrations. Int J Cell Biol 2013:260787
-
(2013)
Int J Cell Biol
, vol.2013
, pp. 260787
-
-
Tian, H.1
Davidowitz, E.2
Lopez, P.3
Emadi, S.4
Moe, J.5
Sierks, M.6
-
116
-
-
79957913270
-
Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice
-
Lasagna-Reeves CA, Castillo-Carranza DL, Sengupta U, Clos AL, Jackson GR, Kayed R (2011) Tau oligomers impair memory and induce synaptic and mitochondrial dysfunction in wild-type mice. Mol Neurodegener 6(39):1-14
-
(2011)
Mol Neurodegener
, vol.6
, Issue.39
, pp. 1-14
-
-
Lasagna-Reeves, C.A.1
Castillo-Carranza, D.L.2
Sengupta, U.3
Clos, A.L.4
Jackson, G.R.5
Kayed, R.6
-
117
-
-
81855190900
-
Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport
-
22039833 3387688
-
Patterson KR, Ward SM, Combs B, Voss K, Kanaan NM, Morfini G et al (2011) Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport. Biochemistry 50(47):10300-10310
-
(2011)
Biochemistry
, vol.50
, Issue.47
, pp. 10300-10310
-
-
Patterson, K.R.1
Ward, S.M.2
Combs, B.3
Voss, K.4
Kanaan, N.M.5
Morfini, G.6
-
118
-
-
84873687399
-
Curcumin suppresses soluble tau dimers and corrects molecular chaperone, synaptic, and behavioral deficits in aged human tau transgenic mice
-
23264626 3567657
-
Ma Q-L, Zuo X, Yang F, Ubeda OJ, Gant DJ, Alaverdyan M et al (2013) Curcumin suppresses soluble tau dimers and corrects molecular chaperone, synaptic, and behavioral deficits in aged human tau transgenic mice. J Biol Chem 288(6):4056-4065
-
(2013)
J Biol Chem
, vol.288
, Issue.6
, pp. 4056-4065
-
-
Ma, Q.-L.1
Zuo, X.2
Yang, F.3
Ubeda, O.J.4
Gant, D.J.5
Alaverdyan, M.6
-
119
-
-
84868269943
-
Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau
-
23050084 3463004
-
Lasagna-Reeves CA, Castillo-Carranza DL, Sengupta U, Guerrero-Munoz MJ, Kiritoshi T, Neugebauer V et al (2012) Alzheimer brain-derived tau oligomers propagate pathology from endogenous tau. Sci Rep 2:700
-
(2012)
Sci Rep
, vol.2
, pp. 700
-
-
Lasagna-Reeves, C.A.1
Castillo-Carranza, D.L.2
Sengupta, U.3
Guerrero-Munoz, M.J.4
Kiritoshi, T.5
Neugebauer, V.6
-
120
-
-
16644369554
-
The potential role of tau protein O-glycosylation in Alzheimer's disease
-
15505370
-
Robertson LA, Moya KL, Breen KC (2004) The potential role of tau protein O-glycosylation in Alzheimer's disease. J Alzheimers Dis 6(5):489-495
-
(2004)
J Alzheimers Dis
, vol.6
, Issue.5
, pp. 489-495
-
-
Robertson, L.A.1
Moya, K.L.2
Breen, K.C.3
-
121
-
-
77957001697
-
Acetylation of tau inhibits its degradation and contributes to tauopathy
-
20869593 3035103
-
Min SW, Cho SH, Zhou Y, Schroeder S, Haroutunian V, Seeley WW et al (2010) Acetylation of tau inhibits its degradation and contributes to tauopathy. Neuron 67(6):953-966
-
(2010)
Neuron
, vol.67
, Issue.6
, pp. 953-966
-
-
Min, S.W.1
Cho, S.H.2
Zhou, Y.3
Schroeder, S.4
Haroutunian, V.5
Seeley, W.W.6
-
122
-
-
14844328111
-
The role of caspase cleavage of tau in Alzheimer disease neuropathology
-
15751224
-
Cotman CW, Poon WW, Rissman RA, Blurton-Jones M (2005) The role of caspase cleavage of tau in Alzheimer disease neuropathology. J Neuropathol Exp Neurol 64(2):104-112
-
(2005)
J Neuropathol Exp Neurol
, vol.64
, Issue.2
, pp. 104-112
-
-
Cotman, C.W.1
Poon, W.W.2
Rissman, R.A.3
Blurton-Jones, M.4
-
123
-
-
3242739968
-
O-GlcNAcylation regulates phosphorylation of tau: A mechanism involved in Alzheimer's disease
-
15249677 490015
-
Liu F, Iqbal K, Grundke-Iqbal I, Hart GW, Gong CX (2004) O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease. Proc Natl Acad Sci USA 101(29):10804-10809
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, Issue.29
, pp. 10804-10809
-
-
Liu, F.1
Iqbal, K.2
Grundke-Iqbal, I.3
Hart, G.W.4
Gong, C.X.5
-
124
-
-
84858664547
-
Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation
-
22366723
-
Yuzwa SA, Shan X, Macauley MS, Clark T, Skorobogatko Y, Vosseller K et al (2012) Increasing O-GlcNAc slows neurodegeneration and stabilizes tau against aggregation. Nat Chem Biol 8(4):393-399
-
(2012)
Nat Chem Biol
, vol.8
, Issue.4
, pp. 393-399
-
-
Yuzwa, S.A.1
Shan, X.2
MacAuley, M.S.3
Clark, T.4
Skorobogatko, Y.5
Vosseller, K.6
-
125
-
-
0036937699
-
Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease
-
11837744
-
Augustinack JC, Schneider A, Mandelkow E-M, Hyman BT (2002) Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer's disease. Acta Neuropathol 103(1):26-35
-
(2002)
Acta Neuropathol
, vol.103
, Issue.1
, pp. 26-35
-
-
Augustinack, J.C.1
Schneider, A.2
Mandelkow, E.-M.3
Hyman, B.T.4
-
126
-
-
80052696800
-
Important neuronal toxicity of microtubule-bound Tau in vivo in Drosophila
-
21705366
-
Talmat-Amar Y, Arribat Y, Redt-Clouet C, Feuillette S, Bougé A-L, Lecourtois M et al (2011) Important neuronal toxicity of microtubule-bound Tau in vivo in Drosophila. Hum Mol Genet 20(19):3738-3745
-
(2011)
Hum Mol Genet
, vol.20
, Issue.19
, pp. 3738-3745
-
-
Talmat-Amar, Y.1
Arribat, Y.2
Redt-Clouet, C.3
Feuillette, S.4
Bougé, A.-L.5
Lecourtois, M.6
-
127
-
-
37149046340
-
Hyperphosphorylated tau in parahippocampal cortex impairs place learning in aged mice expressing wild-type human tau
-
18007595 2140104
-
Kimura T, Yamashita S, Fukuda T, Park JM, Murayama M, Mizoroki T et al (2007) Hyperphosphorylated tau in parahippocampal cortex impairs place learning in aged mice expressing wild-type human tau. EMBO J 26(24):5143-5152
-
(2007)
EMBO J
, vol.26
, Issue.24
, pp. 5143-5152
-
-
Kimura, T.1
Yamashita, S.2
Fukuda, T.3
Park, J.M.4
Murayama, M.5
Mizoroki, T.6
-
128
-
-
33745449875
-
An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice
-
16769887 1480465
-
Le Corre S, Klafki HW, Plesnila N, Hübinger G, Obermeier A, Sahagún H et al (2006) An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice. Proc Natl Acad Sci USA 103(25):9673-9678
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, Issue.25
, pp. 9673-9678
-
-
Le Corre, S.1
Klafki, H.W.2
Plesnila, N.3
Hübinger, G.4
Obermeier, A.5
Sahagún, H.6
-
129
-
-
0037111833
-
Tau-mediated cytotoxicity in a pseudohyperphosphorylation model of Alzheimer's disease
-
12427828
-
Fath T, Eidenmüller J, Brandt R (2002) Tau-mediated cytotoxicity in a pseudohyperphosphorylation model of Alzheimer's disease. J Neurosci 22(22):9733-9741
-
(2002)
J Neurosci
, vol.22
, Issue.22
, pp. 9733-9741
-
-
Fath, T.1
Eidenmüller, J.2
Brandt, R.3
-
130
-
-
0033677809
-
C-terminal inhibition of tau assembly in vitro and in Alzheimer's disease
-
11034902
-
Abraha A, Ghoshal N, Gamblin TC, Cryns V, Berry RW, Kuret J et al (2000) C-terminal inhibition of tau assembly in vitro and in Alzheimer's disease. J Cell Sci 113(21):3737-3745
-
(2000)
J Cell Sci
, vol.113
, Issue.21
, pp. 3737-3745
-
-
Abraha, A.1
Ghoshal, N.2
Gamblin, T.C.3
Cryns, V.4
Berry, R.W.5
Kuret, J.6
-
131
-
-
84892419941
-
Phosphorylation of tau protein at sites Ser396-404 is one of the earliest events in Alzheimer's disease and Down syndrome
-
24033439
-
Mondragón-Rodríguez S, Perry G, Luna-Muñoz J, Acevedo-Aquino M, Williams S (2014) Phosphorylation of tau protein at sites Ser396-404 is one of the earliest events in Alzheimer's disease and Down syndrome. Neuropathol Appl Neurobiol 40(2):121-135
-
(2014)
Neuropathol Appl Neurobiol
, vol.40
, Issue.2
, pp. 121-135
-
-
Mondragón-Rodríguez, S.1
Perry, G.2
Luna-Muñoz, J.3
Acevedo-Aquino, M.4
Williams, S.5
-
132
-
-
80055026234
-
Abnormal tau phosphorylation in the thorny excrescences of CA3 hippocampal neurons in patients with Alzheimer's disease
-
21677375
-
Blazquez-Llorca L, Garcia-Marin V, Merino-Serrais P, Ávila J, DeFelipe J (2011) Abnormal tau phosphorylation in the thorny excrescences of CA3 hippocampal neurons in patients with Alzheimer's disease. J Alzheimers Dis 26(4):683-698
-
(2011)
J Alzheimers Dis
, vol.26
, Issue.4
, pp. 683-698
-
-
Blazquez-Llorca, L.1
Garcia-Marin, V.2
Merino-Serrais, P.3
Ávila, J.4
DeFelipe, J.5
-
133
-
-
0036854327
-
Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity
-
12429843 133611
-
Biernat J, Wu Y-Z, Timm T, Zheng-Fischhöfer Q, Mandelkow E, Meijer L et al (2002) Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity. Mol Biol Cell 13(11):4013-4028
-
(2002)
Mol Biol Cell
, vol.13
, Issue.11
, pp. 4013-4028
-
-
Biernat, J.1
Wu, Y.-Z.2
Timm, T.3
Zheng-Fischhöfer, Q.4
Mandelkow, E.5
Meijer, L.6
-
134
-
-
0030969575
-
MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption
-
9108484
-
Drewes G, Ebneth A, Preuss U, Mandelkow E-M, Mandelkow E (1997) MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. Cell 89(2):297-308
-
(1997)
Cell
, vol.89
, Issue.2
, pp. 297-308
-
-
Drewes, G.1
Ebneth, A.2
Preuss, U.3
Mandelkow, E.-M.4
Mandelkow, E.5
-
135
-
-
0033758105
-
Microtubule-affinity regulating kinase (MARK) is tightly associated with neurofibrillary tangles in Alzheimer brain: A fluorescence resonance energy transfer study
-
11089574
-
Chin JY, Knowles RB, Schneider A, Drewes G, Mandelkow E-M, Hyman BT (2000) Microtubule-affinity regulating kinase (MARK) is tightly associated with neurofibrillary tangles in alzheimer brain: a fluorescence resonance energy transfer study. J Neuropathol Exp Neurol 59(11):966-971
-
(2000)
J Neuropathol Exp Neurol
, vol.59
, Issue.11
, pp. 966-971
-
-
Chin, J.Y.1
Knowles, R.B.2
Schneider, A.3
Drewes, G.4
Mandelkow, E.-M.5
Hyman, B.T.6
-
136
-
-
77952546195
-
GSK3: A possible link between beta amyloid peptide and tau protein
-
19782073
-
Hernández F, Gómez de Barreda E, Fuster-Matanzo A, Lucas JJ, Avila J (2010) GSK3: a possible link between beta amyloid peptide and tau protein. Exp Neurol 223(2):322-325
-
(2010)
Exp Neurol
, vol.223
, Issue.2
, pp. 322-325
-
-
Hernández, F.1
Gómez De Barreda, E.2
Fuster-Matanzo, A.3
Lucas, J.J.4
Avila, J.5
-
137
-
-
0030635495
-
Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brain
-
8990130
-
Pei J-J, Tanaka T, Tung Y-C, Braak E, Iqbal K, Grundke-Iqbal I (1997) Distribution, levels, and activity of glycogen synthase kinase-3 in the Alzheimer disease brain. J Neuropathol Exp Neurol 56(1):70-78
-
(1997)
J Neuropathol Exp Neurol
, vol.56
, Issue.1
, pp. 70-78
-
-
Pei, J.-J.1
Tanaka, T.2
Tung, Y.-C.3
Braak, E.4
Iqbal, K.5
Grundke-Iqbal, I.6
-
138
-
-
0346457015
-
Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3β (GSK3β) plays a critical role in regulating tau's ability to bind and stabilize microtubules
-
14690523
-
Cho JH, Johnson GV (2004) Primed phosphorylation of tau at Thr231 by glycogen synthase kinase 3β (GSK3β) plays a critical role in regulating tau's ability to bind and stabilize microtubules. J Neurochem 88(2):349-358
-
(2004)
J Neurochem
, vol.88
, Issue.2
, pp. 349-358
-
-
Cho, J.H.1
Johnson, G.V.2
-
139
-
-
0028675873
-
Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells
-
7704571
-
Lovestone S, Reynolds CH, Latimer D, Davis DR, Anderton BH, Gallo J-M et al (1994) Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells. Curr Biol 4(12):1077-1086
-
(1994)
Curr Biol
, vol.4
, Issue.12
, pp. 1077-1086
-
-
Lovestone, S.1
Reynolds, C.H.2
Latimer, D.3
Davis, D.R.4
Anderton, B.H.5
Gallo, J.-M.6
-
140
-
-
34250019938
-
Neuronal apoptosis and reversible motor deficit in dominant-negative GSK-3 conditional transgenic mice
-
17510631 1888681
-
Gómez-Sintes R, Hernández F, Bortolozzi A, Artigas F, Avila J, Zaratin P et al (2007) Neuronal apoptosis and reversible motor deficit in dominant-negative GSK-3 conditional transgenic mice. EMBO J 26(11):2743-2754
-
(2007)
EMBO J
, vol.26
, Issue.11
, pp. 2743-2754
-
-
Gómez-Sintes, R.1
Hernández, F.2
Bortolozzi, A.3
Artigas, F.4
Avila, J.5
Zaratin, P.6
-
141
-
-
36048937547
-
Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments
-
17989287
-
Zhu LQ, Wang SH, Liu D, Yin YY, Tian Q, Wang XC et al (2007) Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments. J Neurosci 27(45):12211-12220
-
(2007)
J Neurosci
, vol.27
, Issue.45
, pp. 12211-12220
-
-
Zhu, L.Q.1
Wang, S.H.2
Liu, D.3
Yin, Y.Y.4
Tian, Q.5
Wang, X.C.6
-
142
-
-
0030868557
-
Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3
-
9312151
-
Hong M, Chen DC, Klein PS, Lee VM-Y (1997) Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3. J Biol Chem 272(40):25326-25332
-
(1997)
J Biol Chem
, vol.272
, Issue.40
, pp. 25326-25332
-
-
Hong, M.1
Chen, D.C.2
Klein, P.S.3
Lee, V.M.-Y.4
-
143
-
-
0242720372
-
Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model
-
14624025
-
Pérez M, Hernández F, Lim F, Díaz-Nido J, Avila J (2003) Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model. J Alzheimers Dis 5(4):301-308
-
(2003)
J Alzheimers Dis
, vol.5
, Issue.4
, pp. 301-308
-
-
Pérez, M.1
Hernández, F.2
Lim, F.3
Díaz-Nido, J.4
Avila, J.5
-
144
-
-
0038689162
-
Cdk5 is a key factor in tau aggregation and tangle formation in vivo
-
12765608
-
Noble W, Olm V, Takata K, Casey E, Mary O, Meyerson J et al (2003) Cdk5 is a key factor in tau aggregation and tangle formation in vivo. Neuron 38(4):555-565
-
(2003)
Neuron
, vol.38
, Issue.4
, pp. 555-565
-
-
Noble, W.1
Olm, V.2
Takata, K.3
Casey, E.4
Mary, O.5
Meyerson, J.6
-
145
-
-
12944268979
-
Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5
-
10706614 16029
-
Ahlijanian MK, Barrezueta NX, Williams RD, Jakowski A, Kowsz KP, McCarthy S et al (2000) Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5. Proc Natl Acad Sci USA 97(6):2910-2915
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, Issue.6
, pp. 2910-2915
-
-
Ahlijanian, M.K.1
Barrezueta, N.X.2
Williams, R.D.3
Jakowski, A.4
Kowsz, K.P.5
McCarthy, S.6
-
146
-
-
13244264765
-
A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons
-
15592431 544899
-
Zheng YL, Kesavapany S, Gravell M, Hamilton RS, Schubert M, Amin N et al (2005) A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons. EMBO J 24(1):209-220
-
(2005)
EMBO J
, vol.24
, Issue.1
, pp. 209-220
-
-
Zheng, Y.L.1
Kesavapany, S.2
Gravell, M.3
Hamilton, R.S.4
Schubert, M.5
Amin, N.6
-
147
-
-
3042634127
-
A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons
-
15152189 419914
-
Morfini G, Szebenyi G, Brown H, Pant HC, Pigino G, DeBoer S et al (2004) A novel CDK5-dependent pathway for regulating GSK3 activity and kinesin-driven motility in neurons. EMBO J 23(11):2235-2245
-
(2004)
EMBO J
, vol.23
, Issue.11
, pp. 2235-2245
-
-
Morfini, G.1
Szebenyi, G.2
Brown, H.3
Pant, H.C.4
Pigino, G.5
DeBoer, S.6
-
148
-
-
0036682362
-
P35/Cdk5 pathway mediates soluble amyloid β peptide induced tau phosphorylation in vitro
-
12125077
-
Town T, Zolton J, Shaffner R, Schnell B, Crescentini R, Wu Y et al (2002) p35/Cdk5 pathway mediates soluble amyloid β peptide induced tau phosphorylation in vitro. J Neurosci Res 69(3):362-372
-
(2002)
J Neurosci Res
, vol.69
, Issue.3
, pp. 362-372
-
-
Town, T.1
Zolton, J.2
Shaffner, R.3
Schnell, B.4
Crescentini, R.5
Wu, Y.6
-
149
-
-
0942265972
-
Amyloid-β induced toxicity of primary neurons is dependent upon differentiation-associated increases in tau and cyclin-dependent kinase 5 expression
-
14720205
-
Liu T, Perry G, Chan HW, Verdile G, Martins RN, Smith MA et al (2004) Amyloid-β induced toxicity of primary neurons is dependent upon differentiation-associated increases in tau and cyclin-dependent kinase 5 expression. J Neurochem 88(3):554-563
-
(2004)
J Neurochem
, vol.88
, Issue.3
, pp. 554-563
-
-
Liu, T.1
Perry, G.2
Chan, H.W.3
Verdile, G.4
Martins, R.N.5
Smith, M.A.6
-
150
-
-
0029113874
-
Phosphatase activity toward abnormally phosphorylated τ: Decrease in Alzheimer disease brain
-
7616230
-
Gong CX, Shaikh S, Wang JZ, Zaidi T, Grundke-Iqbal I, Iqbal K (1995) Phosphatase activity toward abnormally phosphorylated τ: decrease in Alzheimer disease brain. J Neurochem 65(2):732-738
-
(1995)
J Neurochem
, vol.65
, Issue.2
, pp. 732-738
-
-
Gong, C.X.1
Shaikh, S.2
Wang, J.Z.3
Zaidi, T.4
Grundke-Iqbal, I.5
Iqbal, K.6
-
151
-
-
27644478606
-
Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation
-
16262633
-
Liu F, Grundke-Iqbal I, Iqbal K, Gong CX (2005) Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation. Eur J Neurosci 22(8):1942-1950
-
(2005)
Eur J Neurosci
, vol.22
, Issue.8
, pp. 1942-1950
-
-
Liu, F.1
Grundke-Iqbal, I.2
Iqbal, K.3
Gong, C.X.4
-
152
-
-
0029669963
-
Site-specific dephosphorylation of tau protein at Ser202/Thr205 in response to microtubule depolymerization in cultured human neurons involves protein phosphatase 2A
-
8621419
-
Merrick SE, Demoise DC, Lee VM (1996) Site-specific dephosphorylation of tau protein at Ser202/Thr205 in response to microtubule depolymerization in cultured human neurons involves protein phosphatase 2A. J Biol Chem 271(10):5589-5594
-
(1996)
J Biol Chem
, vol.271
, Issue.10
, pp. 5589-5594
-
-
Merrick, S.E.1
Demoise, D.C.2
Lee, V.M.3
-
153
-
-
0030461275
-
Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A
-
8982166
-
Sontag E, Nunbhakdi-Craig V, Lee G, Bloom GS, Mumby MC (1996) Regulation of the phosphorylation state and microtubule-binding activity of Tau by protein phosphatase 2A. Neuron 17(6):1201-1207
-
(1996)
Neuron
, vol.17
, Issue.6
, pp. 1201-1207
-
-
Sontag, E.1
Nunbhakdi-Craig, V.2
Lee, G.3
Bloom, G.S.4
Mumby, M.C.5
-
154
-
-
0345700240
-
Inhibition of protein phosphatase 2A induces phosphorylation and accumulation of neurofilaments in metabolically active rat brain slices
-
12668248
-
Gong C-X, Wang J-Z, Iqbal K, Grundke-Iqbal I (2003) Inhibition of protein phosphatase 2A induces phosphorylation and accumulation of neurofilaments in metabolically active rat brain slices. Neurosci Lett 340(2):107-110
-
(2003)
Neurosci Lett
, vol.340
, Issue.2
, pp. 107-110
-
-
Gong, C.-X.1
Wang, J.-Z.2
Iqbal, K.3
Grundke-Iqbal, I.4
-
155
-
-
84870481575
-
Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation
-
22892311
-
Xiong Y, Jing X-P, Zhou X-W, Wang X-L, Yang Y, Sun X-Y et al (2013) Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation. Neurobiol Aging 34(3):745-756
-
(2013)
Neurobiol Aging
, vol.34
, Issue.3
, pp. 745-756
-
-
Xiong, Y.1
Jing, X.-P.2
Zhou, X.-W.3
Wang, X.-L.4
Yang, Y.5
Sun, X.-Y.6
-
156
-
-
51649119364
-
Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus
-
17537547
-
Zhang C-E, Tian Q, Wei W, Peng J-H, Liu G-P, Zhou X-W et al (2008) Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus. Neurobiol Aging 29(11):1654-1665
-
(2008)
Neurobiol Aging
, vol.29
, Issue.11
, pp. 1654-1665
-
-
Zhang, C.-E.1
Tian, Q.2
Wei, W.3
Peng, J.-H.4
Liu, G.-P.5
Zhou, X.-W.6
-
157
-
-
84875854908
-
Ser9 phosphorylation causes cytoplasmic detention of I2PP2A/SET in Alzheimer disease
-
23374587
-
Yu G, Yan T, Feng Y, Liu X, Xia Y, Luo H et al (2013) Ser9 phosphorylation causes cytoplasmic detention of I2PP2A/SET in Alzheimer disease. Neurobiol Aging 34(7):1748-1758
-
(2013)
Neurobiol Aging
, vol.34
, Issue.7
, pp. 1748-1758
-
-
Yu, G.1
Yan, T.2
Feng, Y.3
Liu, X.4
Xia, Y.5
Luo, H.6
-
158
-
-
84872062676
-
Betaine attenuates Alzheimer-like pathological changes and memory deficits induced by homocysteine
-
23157378
-
Chai GS, Jiang X, Ni ZF, Ma ZW, Xie AJ, Cheng XS et al (2013) Betaine attenuates Alzheimer-like pathological changes and memory deficits induced by homocysteine. J Neurochem 124(3):388-396
-
(2013)
J Neurochem
, vol.124
, Issue.3
, pp. 388-396
-
-
Chai, G.S.1
Jiang, X.2
Ni, Z.F.3
Ma, Z.W.4
Xie, A.J.5
Cheng, X.S.6
-
159
-
-
84878870806
-
Nmnat2 attenuates Tau phosphorylation through activation of PP2A
-
23579329
-
Cheng X-S, Zhao K-P, Jiang X, Du L-L, Li X-H, Ma Z-W et al (2013) Nmnat2 attenuates Tau phosphorylation through activation of PP2A. J Alzheimers Dis 36(1):185-195
-
(2013)
J Alzheimers Dis
, vol.36
, Issue.1
, pp. 185-195
-
-
Cheng, X.-S.1
Zhao, K.-P.2
Jiang, X.3
Du, L.-L.4
Li, X.-H.5
Ma, Z.-W.6
-
160
-
-
79959736543
-
Glycogen synthase kinase-3beta regulates Tyr307 phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src
-
Xiu-Qing Y, Xiao-Xue Z, Yang-Yang Y, Bin L, Dan-Ju L, Dan L et al (2011) Glycogen synthase kinase-3beta regulates Tyr307 phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src. Biochem J 437(2):335-344
-
(2011)
Biochem J
, vol.437
, Issue.2
, pp. 335-344
-
-
Xiu-Qing, Y.1
Xiao-Xue, Z.2
Yang-Yang, Y.3
Bin, L.4
Dan-Ju, L.5
Dan, L.6
-
161
-
-
47049089041
-
Activation of glycogen synthase kinase-3 inhibits protein phosphatase-2A and the underlying mechanisms
-
17433504
-
Liu G-P, Zhang Y, Yao X-Q, Zhang C-E, Fang J, Wang Q et al (2008) Activation of glycogen synthase kinase-3 inhibits protein phosphatase-2A and the underlying mechanisms. Neurobiol Aging 29(9):1348-1358
-
(2008)
Neurobiol Aging
, vol.29
, Issue.9
, pp. 1348-1358
-
-
Liu, G.-P.1
Zhang, Y.2
Yao, X.-Q.3
Zhang, C.-E.4
Fang, J.5
Wang, Q.6
-
162
-
-
24044480992
-
Relevance, essentiality and toxicity of trace elements in human health
-
16125765
-
Fraga CG (2005) Relevance, essentiality and toxicity of trace elements in human health. Mol Aspects Med 26(4):235-244
-
(2005)
Mol Aspects Med
, vol.26
, Issue.4
, pp. 235-244
-
-
Fraga, C.G.1
-
163
-
-
80052403741
-
Transition metal homeostasis: From yeast to human disease
-
21479832
-
Bleackley MR, MacGillivray RT (2011) Transition metal homeostasis: from yeast to human disease. Biometals 24(5):785-809
-
(2011)
Biometals
, vol.24
, Issue.5
, pp. 785-809
-
-
Bleackley, M.R.1
MacGillivray, R.T.2
-
164
-
-
0032507975
-
Copper, iron and zinc in Alzheimer's disease senile plaques
-
9667777
-
Lovell M, Robertson J, Teesdale W, Campbell J, Markesbery W (1998) Copper, iron and zinc in Alzheimer's disease senile plaques. J Neurol Sci 158(1):47-52
-
(1998)
J Neurol Sci
, vol.158
, Issue.1
, pp. 47-52
-
-
Lovell, M.1
Robertson, J.2
Teesdale, W.3
Campbell, J.4
Markesbery, W.5
-
165
-
-
27744545492
-
Alterations in zinc transporter protein-1 (ZnT-1) in the brain of subjects with mild cognitive impairment, early, and late-stage Alzheimer's disease
-
16179263
-
Lovell MA, Smith JL, Xiong S, Markesbery WR (2005) Alterations in zinc transporter protein-1 (ZnT-1) in the brain of subjects with mild cognitive impairment, early, and late-stage Alzheimer's disease. Neurotox Res 7(4):265-271
-
(2005)
Neurotox Res
, vol.7
, Issue.4
, pp. 265-271
-
-
Lovell, M.A.1
Smith, J.L.2
Xiong, S.3
Markesbery, W.R.4
-
166
-
-
75949120131
-
Alterations of zinc transporter proteins ZnT-1, ZnT-4 and ZnT-6 in preclinical Alzheimer's disease brain
-
19371353 3175637
-
Lyubartseva G, Smith JL, Markesbery WR, Lovell MA (2010) Alterations of zinc transporter proteins ZnT-1, ZnT-4 and ZnT-6 in preclinical Alzheimer's disease brain. Brain Pathol 20(2):343-350
-
(2010)
Brain Pathol
, vol.20
, Issue.2
, pp. 343-350
-
-
Lyubartseva, G.1
Smith, J.L.2
Markesbery, W.R.3
Lovell, M.A.4
-
167
-
-
0036262473
-
Transferrin C2 allele, haemochromatosis gene mutations, and risk for Alzheimer's disease
-
12023437 1737914
-
Lleo A, Blesa R, Angelopoulos C, Pastor-Rubio P, Villa M, Oliva R et al (2002) Transferrin C2 allele, haemochromatosis gene mutations, and risk for Alzheimer's disease. J Neurol Neurosurg Psychiatry 72(6):820-821
-
(2002)
J Neurol Neurosurg Psychiatry
, vol.72
, Issue.6
, pp. 820-821
-
-
Lleo, A.1
Blesa, R.2
Angelopoulos, C.3
Pastor-Rubio, P.4
Villa, M.5
Oliva, R.6
-
168
-
-
51749106579
-
Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain
-
18639746
-
Zhang L-H, Wang X, Stoltenberg M, Danscher G, Huang L, Wang Z-Y (2008) Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain. Brain Res Bull 77(1):55-60
-
(2008)
Brain Res Bull
, vol.77
, Issue.1
, pp. 55-60
-
-
Zhang, L.-H.1
Wang, X.2
Stoltenberg, M.3
Danscher, G.4
Huang, L.5
Wang, Z.-Y.6
-
169
-
-
0034964390
-
Treatment with a copper-zinc chelator markedly and rapidly inhibits β-amyloid accumulation in Alzheimer's disease transgenic mice
-
11430801
-
Cherny RA, Atwood CS, Xilinas ME, Gray DN, Jones WD, McLean CA et al (2001) Treatment with a copper-zinc chelator markedly and rapidly inhibits β-amyloid accumulation in Alzheimer's disease transgenic mice. Neuron 30(3):665-676
-
(2001)
Neuron
, vol.30
, Issue.3
, pp. 665-676
-
-
Cherny, R.A.1
Atwood, C.S.2
Xilinas, M.E.3
Gray, D.N.4
Jones, W.D.5
McLean, C.A.6
-
170
-
-
1842506368
-
Neuronal zinc exchange with the blood vessel wall promotes cerebral amyloid angiopathy in an animal model of Alzheimer's disease
-
15056725
-
Friedlich AL, Lee J-Y, van Groen T, Cherny RA, Volitakis I, Cole TB et al (2004) Neuronal zinc exchange with the blood vessel wall promotes cerebral amyloid angiopathy in an animal model of Alzheimer's disease. J Neurosci 24(13):3453-3459
-
(2004)
J Neurosci
, vol.24
, Issue.13
, pp. 3453-3459
-
-
Friedlich, A.L.1
Lee, J.-Y.2
Van Groen, T.3
Cherny, R.A.4
Volitakis, I.5
Cole, T.B.6
-
171
-
-
4644238758
-
The lipophilic metal chelator DP-109 reduces amyloid pathology in brains of human beta-amyloid precursor protein transgenic mice
-
15465629
-
Lee J-Y, Friedman JE, Angel I, Kozak A, Koh J-Y (2004) The lipophilic metal chelator DP-109 reduces amyloid pathology in brains of human beta-amyloid precursor protein transgenic mice. Neurobiol Aging 25(10):1315-1321
-
(2004)
Neurobiol Aging
, vol.25
, Issue.10
, pp. 1315-1321
-
-
Lee, J.-Y.1
Friedman, J.E.2
Angel, I.3
Kozak, A.4
Koh, J.-Y.5
-
172
-
-
10744228112
-
In vivo reduction of amyloid-beta by a mutant copper transporter
-
14617772 283568
-
Phinney AL, Drisaldi B, Schmidt SD, Lugowski S, Coronado V, Liang Y et al (2003) In vivo reduction of amyloid-beta by a mutant copper transporter. Proc Natl Acad Sci USA 100(24):14193-14198
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, Issue.24
, pp. 14193-14198
-
-
Phinney, A.L.1
Drisaldi, B.2
Schmidt, S.D.3
Lugowski, S.4
Coronado, V.5
Liang, Y.6
-
173
-
-
0027980901
-
Rapid induction of Alzheimer A beta amyloid formation by zinc
-
8073293
-
Bush AI, Pettingell WH, Multhaup G, d Paradis M, Vonsattel J-P, Gusella JF et al (1994) Rapid induction of Alzheimer A beta amyloid formation by zinc. Science 265(5177):1464-1467
-
(1994)
Science
, vol.265
, Issue.5177
, pp. 1464-1467
-
-
Bush, A.I.1
Pettingell, W.H.2
Multhaup, G.3
Paradis, M.D.4
Vonsattel, J.-P.5
Gusella, J.F.6
-
174
-
-
79952513228
-
Interactions of Zn (II) and Cu (II) ions with Alzheimer's amyloid-beta peptide. Metal ion binding, contribution to fibrillization and toxicity
-
21359283
-
Tõugu V, Tiiman A, Palumaa P (2011) Interactions of Zn (II) and Cu (II) ions with Alzheimer's amyloid-beta peptide. Metal ion binding, contribution to fibrillization and toxicity. Metallomics 3(3):250-261
-
(2011)
Metallomics
, vol.3
, Issue.3
, pp. 250-261
-
-
Tõugu, V.1
Tiiman, A.2
Palumaa, P.3
-
175
-
-
0027327488
-
Aluminum, iron, and zinc ions promote aggregation of physiological concentrations of β-amyloid peptide
-
8360682
-
Mantyh PW, Ghilardi JR, Rogers S, DeMaster E, Allen CJ, Stimson ER et al (1993) Aluminum, iron, and zinc ions promote aggregation of physiological concentrations of β-amyloid peptide. J Neurochem 61(3):1171-1174
-
(1993)
J Neurochem
, vol.61
, Issue.3
, pp. 1171-1174
-
-
Mantyh, P.W.1
Ghilardi, J.R.2
Rogers, S.3
DeMaster, E.4
Allen, C.J.5
Stimson, E.R.6
-
176
-
-
84860549387
-
Genetic inhibition of solute-linked carrier 39 family transporter 1 ameliorates Aβ pathology in a Drosophila model of Alzheimer's disease
-
22570624 3343105
-
Lang M, Wang L, Fan Q, Xiao G, Wang X, Zhong Y et al (2012) Genetic inhibition of solute-linked carrier 39 family transporter 1 ameliorates Aβ pathology in a Drosophila model of Alzheimer's disease. PLoS Genet 8(4):e1002683
-
(2012)
PLoS Genet
, vol.8
, Issue.4
, pp. e1002683
-
-
Lang, M.1
Wang, L.2
Fan, Q.3
Xiao, G.4
Wang, X.5
Zhong, Y.6
-
177
-
-
64049096553
-
Fenton chemistry and oxidative stress mediate the toxicity of the β-amyloid peptide in a Drosophila model of Alzheimer's disease
-
19519625 2777252
-
Rival T, Page RM, Chandraratna DS, Sendall TJ, Ryder E, Liu B et al (2009) Fenton chemistry and oxidative stress mediate the toxicity of the β-amyloid peptide in a Drosophila model of Alzheimer's disease. Eur J Neurosci 29(7):1335-1347
-
(2009)
Eur J Neurosci
, vol.29
, Issue.7
, pp. 1335-1347
-
-
Rival, T.1
Page, R.M.2
Chandraratna, D.S.3
Sendall, T.J.4
Ryder, E.5
Liu, B.6
-
178
-
-
0026573467
-
Selective accumulation of aluminum and iron in the neurofibrillary tangles of Alzheimer's disease: A laser microprobe (LAMMA) study
-
1637136
-
Good PF, Perl DP, Bierer LM, Schmeidler J (1992) Selective accumulation of aluminum and iron in the neurofibrillary tangles of Alzheimer's disease: a laser microprobe (LAMMA) study. Ann Neurol 31(3):286-292
-
(1992)
Ann Neurol
, vol.31
, Issue.3
, pp. 286-292
-
-
Good, P.F.1
Perl, D.P.2
Bierer, L.M.3
Schmeidler, J.4
-
179
-
-
0036724204
-
Iron (III) induces aggregation of hyperphosphorylated τ and its reduction to iron (II) reverses the aggregation: Implications in the formation of neurofibrillary tangles of Alzheimer's disease
-
12358761
-
Yamamoto A, Shin RW, Hasegawa K, Naiki H, Sato H, Yoshimasu F et al (2002) Iron (III) induces aggregation of hyperphosphorylated τ and its reduction to iron (II) reverses the aggregation: implications in the formation of neurofibrillary tangles of Alzheimer's disease. J Neurochem 82(5):1137-1147
-
(2002)
J Neurochem
, vol.82
, Issue.5
, pp. 1137-1147
-
-
Yamamoto, A.1
Shin, R.W.2
Hasegawa, K.3
Naiki, H.4
Sato, H.5
Yoshimasu, F.6
-
180
-
-
35348982797
-
Copper (II) modulates in vitro aggregation of a tau peptide
-
17919778
-
Zhou L-X, Du J-T, Zeng Z-Y, Wu W-H, Zhao Y-F, Kanazawa K et al (2007) Copper (II) modulates in vitro aggregation of a tau peptide. Peptides 28(11):2229-2234
-
(2007)
Peptides
, vol.28
, Issue.11
, pp. 2229-2234
-
-
Zhou, L.-X.1
Du, J.-T.2
Zeng, Z.-Y.3
Wu, W.-H.4
Zhao, Y.-F.5
Kanazawa, K.6
-
181
-
-
71749113077
-
Low micromolar zinc accelerates the fibrillization of human Tau via bridging of Cys-291 and Cys-322
-
19826005 2787327
-
Mo Z-Y, Zhu Y-Z, Zhu H-L, Fan J-B, Chen J, Liang Y (2009) Low micromolar zinc accelerates the fibrillization of human Tau via bridging of Cys-291 and Cys-322. J Biol Chem 284(50):34648-34657
-
(2009)
J Biol Chem
, vol.284
, Issue.50
, pp. 34648-34657
-
-
Mo, Z.-Y.1
Zhu, Y.-Z.2
Zhu, H.-L.3
Fan, J.-B.4
Chen, J.5
Liang, Y.6
-
183
-
-
17844382385
-
Zinc induces neurofilament phosphorylation independent of p70 S6 kinase in N2a cells
-
15812314
-
Björkdahl C, Sjögren MJ, Winblad B, Pei J-J (2005) Zinc induces neurofilament phosphorylation independent of p70 S6 kinase in N2a cells. NeuroReport 16(6):591-595
-
(2005)
NeuroReport
, vol.16
, Issue.6
, pp. 591-595
-
-
Björkdahl, C.1
Sjögren, M.J.2
Winblad, B.3
Pei, J.-J.4
-
184
-
-
80053627394
-
Zinc stimulates tau S214 phosphorylation by the activation of Raf/mitogen-activated protein kinase-kinase/extracellular signal-regulated kinase pathway
-
21934536
-
Kim I, Park EJ, Seo J, Ko SJ, Lee J, Kim CH (2011) Zinc stimulates tau S214 phosphorylation by the activation of Raf/mitogen-activated protein kinase-kinase/extracellular signal-regulated kinase pathway. NeuroReport 22(16):839-844
-
(2011)
NeuroReport
, vol.22
, Issue.16
, pp. 839-844
-
-
Kim, I.1
Park, E.J.2
Seo, J.3
Ko, S.J.4
Lee, J.5
Kim, C.H.6
-
185
-
-
84859506934
-
Synaptic released zinc promotes tau hyperphosphorylation by inhibition of protein phosphatase 2A (PP2A)
-
22334661 3322889
-
Sun X-Y, Wei Y-P, Xiong Y, Wang X-C, Xie A-J, Wang X-L et al (2012) Synaptic released zinc promotes tau hyperphosphorylation by inhibition of protein phosphatase 2A (PP2A). J Biol Chem 287(14):11174-11182
-
(2012)
J Biol Chem
, vol.287
, Issue.14
, pp. 11174-11182
-
-
Sun, X.-Y.1
Wei, Y.-P.2
Xiong, Y.3
Wang, X.-C.4
Xie, A.-J.5
Wang, X.-L.6
-
186
-
-
84883819112
-
Huntington disease arises from a combinatory toxicity of polyglutamine and copper binding
-
23980182 3773747
-
Xiao G, Fan Q, Wang X, Zhou B (2013) Huntington disease arises from a combinatory toxicity of polyglutamine and copper binding. Proc Natl Acad Sci USA 110(37):14995-15000
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, Issue.37
, pp. 14995-15000
-
-
Xiao, G.1
Fan, Q.2
Wang, X.3
Zhou, B.4
-
187
-
-
61349110122
-
Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD
-
19183260 4096128
-
Kitazawa M, Cheng D, LaFerla FM (2009) Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD. J Neurochem 108(6):1550-1560
-
(2009)
J Neurochem
, vol.108
, Issue.6
, pp. 1550-1560
-
-
Kitazawa, M.1
Cheng, D.2
LaFerla, F.M.3
-
188
-
-
7244253060
-
Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: Modulation by zinc
-
15322121
-
Harris FM, Brecht WJ, Xu Q, Mahley RW, Huang Y (2004) Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc. J Biol Chem 279(43):44795-44801
-
(2004)
J Biol Chem
, vol.279
, Issue.43
, pp. 44795-44801
-
-
Harris, F.M.1
Brecht, W.J.2
Xu, Q.3
Mahley, R.W.4
Huang, Y.5
-
189
-
-
0037040541
-
Molecular chaperones in the cytosol: From nascent chain to folded protein
-
11884745
-
Hartl FU, Hayer-Hartl M (2002) Molecular chaperones in the cytosol: from nascent chain to folded protein. Science 295(5561):1852-1858
-
(2002)
Science
, vol.295
, Issue.5561
, pp. 1852-1858
-
-
Hartl, F.U.1
Hayer-Hartl, M.2
-
190
-
-
11144356089
-
CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation
-
14962978
-
Petrucelli L, Dickson D, Kehoe K, Taylor J, Snyder H, Grover A et al (2004) CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation. Hum Mol Genet 13(7):703-714
-
(2004)
Hum Mol Genet
, vol.13
, Issue.7
, pp. 703-714
-
-
Petrucelli, L.1
Dickson, D.2
Kehoe, K.3
Taylor, J.4
Snyder, H.5
Grover, A.6
-
191
-
-
1042266624
-
CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival
-
14612456
-
Shimura H, Schwartz D, Gygi SP, Kosik KS (2004) CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival. J Biol Chem 279(6):4869-4876
-
(2004)
J Biol Chem
, vol.279
, Issue.6
, pp. 4869-4876
-
-
Shimura, H.1
Schwartz, D.2
Gygi, S.P.3
Kosik, K.S.4
-
192
-
-
33745959291
-
Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho-and caspase-3-cleaved tau species
-
16807328
-
Dickey CA, Yue M, Lin W-L, Dickson DW, Dunmore JH, Lee WC et al (2006) Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho-and caspase-3-cleaved tau species. J Neurosci 26(26):6985-6996
-
(2006)
J Neurosci
, vol.26
, Issue.26
, pp. 6985-6996
-
-
Dickey, C.A.1
Yue, M.2
Lin, W.-L.3
Dickson, D.W.4
Dunmore, J.H.5
Lee, W.C.6
-
193
-
-
77956672926
-
Loss of Hsp110 leads to age-dependent tau hyperphosphorylation and early accumulation of insoluble amyloid beta
-
20679486 2950521
-
Eroglu B, Moskophidis D, Mivechi NF (2010) Loss of Hsp110 leads to age-dependent tau hyperphosphorylation and early accumulation of insoluble amyloid beta. Mol Cell Biol 30(19):4626-4643
-
(2010)
Mol Cell Biol
, vol.30
, Issue.19
, pp. 4626-4643
-
-
Eroglu, B.1
Moskophidis, D.2
Mivechi, N.F.3
-
194
-
-
65649110502
-
BAG-1M is up-regulated in hippocampus of Alzheimer's disease patients and associates with tau and APP proteins
-
19317853
-
Elliott E, Laufer O, Ginzburg I (2009) BAG-1M is up-regulated in hippocampus of Alzheimer's disease patients and associates with tau and APP proteins. J Neurochem 109(4):1168-1178
-
(2009)
J Neurochem
, vol.109
, Issue.4
, pp. 1168-1178
-
-
Elliott, E.1
Laufer, O.2
Ginzburg, I.3
-
195
-
-
37549025063
-
BAG-1 associates with Hsc70.Tau complex and regulates the proteasomal degradation of Tau protein
-
17954934
-
Elliott E, Tsvetkov P, Ginzburg I (2007) BAG-1 associates with Hsc70.Tau complex and regulates the proteasomal degradation of Tau protein. J Biol Chem 282(51):37276-37284
-
(2007)
J Biol Chem
, vol.282
, Issue.51
, pp. 37276-37284
-
-
Elliott, E.1
Tsvetkov, P.2
Ginzburg, I.3
-
196
-
-
84872526813
-
Tau triage decisions mediated by the chaperone network
-
22596270
-
Cook C, Petrucelli L (2013) Tau triage decisions mediated by the chaperone network. J Alzheimers Dis 33(Suppl 1):S145-S151
-
(2013)
J Alzheimers Dis
, vol.33
, pp. S145-S151
-
-
Cook, C.1
Petrucelli, L.2
-
197
-
-
33847369469
-
The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins
-
17304350 1794119
-
Dickey CA, Kamal A, Lundgren K, Klosak N, Bailey RM, Dunmore J et al (2007) The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins. J Clin Invest 117(3):648
-
(2007)
J Clin Invest
, vol.117
, Issue.3
, pp. 648
-
-
Dickey, C.A.1
Kamal, A.2
Lundgren, K.3
Klosak, N.4
Bailey, R.M.5
Dunmore, J.6
-
198
-
-
78649767505
-
Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease
-
21056617
-
Salminen A, Ojala J, Kaarniranta K, Hiltunen M, Soininen H (2011) Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease. Prog Neurobiol 93(1):99-110
-
(2011)
Prog Neurobiol
, vol.93
, Issue.1
, pp. 99-110
-
-
Salminen, A.1
Ojala, J.2
Kaarniranta, K.3
Hiltunen, M.4
Soininen, H.5
-
199
-
-
0030936599
-
Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau
-
9130141
-
Jicha GA, Bowser R, Kazam IG, Davies P (1997) Alz-50 and MC-1, a new monoclonal antibody raised to paired helical filaments, recognize conformational epitopes on recombinant tau. J Neurosci Res 48(2):128-132
-
(1997)
J Neurosci Res
, vol.48
, Issue.2
, pp. 128-132
-
-
Jicha, G.A.1
Bowser, R.2
Kazam, I.G.3
Davies, P.4
-
200
-
-
33646246733
-
HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites
-
16464956
-
Dickey CA, Dunmore J, Lu B, Wang JW, Lee WC, Kamal A et al (2006) HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites. FASEB J 20(6):753-755
-
(2006)
FASEB J
, vol.20
, Issue.6
, pp. 753-755
-
-
Dickey, C.A.1
Dunmore, J.2
Lu, B.3
Wang, J.W.4
Lee, W.C.5
Kamal, A.6
-
201
-
-
0032555685
-
Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1
-
9727490
-
Zou J, Guo Y, Guettouche T, Smith DF, Voellmy R (1998) Repression of heat shock transcription factor HSF1 activation by HSP90 (HSP90 complex) that forms a stress-sensitive complex with HSF1. Cell 94(4):471-480
-
(1998)
Cell
, vol.94
, Issue.4
, pp. 471-480
-
-
Zou, J.1
Guo, Y.2
Guettouche, T.3
Smith, D.F.4
Voellmy, R.5
-
202
-
-
77649305375
-
17-AAG induces cytoplasmic alpha-synuclein aggregate clearance by induction of autophagy
-
Riedel M, Goldbaum O, Schwarz L, Schmitt S, Richter-Landsberg C (2010) 17-AAG induces cytoplasmic alpha-synuclein aggregate clearance by induction of autophagy. PLoS One 5(1):0008753
-
(2010)
PLoS One
, vol.5
, Issue.1
, pp. 0008753
-
-
Riedel, M.1
Goldbaum, O.2
Schwarz, L.3
Schmitt, S.4
Richter-Landsberg, C.5
-
203
-
-
70049086585
-
Hsp90 transcriptionally and post-translationally regulates the expression of NDRG1 and maintains the stability of its modifying kinase GSK3beta
-
19682504
-
Banz VM, Medova M, Keogh A, Furer C, Zimmer Y, Candinas D et al (2009) Hsp90 transcriptionally and post-translationally regulates the expression of NDRG1 and maintains the stability of its modifying kinase GSK3beta. Biochim Biophys Acta 1793(10):1597-1603
-
(2009)
Biochim Biophys Acta
, vol.1793
, Issue.10
, pp. 1597-1603
-
-
Banz, V.M.1
Medova, M.2
Keogh, A.3
Furer, C.4
Zimmer, Y.5
Candinas, D.6
-
204
-
-
34547183507
-
Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies
-
17517623 1890525
-
Luo W, Dou F, Rodina A, Chip S, Kim J, Zhao Q et al (2007) Roles of heat-shock protein 90 in maintaining and facilitating the neurodegenerative phenotype in tauopathies. Proc Natl Acad Sci USA 104(22):9511-9516
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, Issue.22
, pp. 9511-9516
-
-
Luo, W.1
Dou, F.2
Rodina, A.3
Chip, S.4
Kim, J.5
Zhao, Q.6
-
205
-
-
84890613378
-
Effects of 17-allylamino-17-demethoxygeldanamycin (17-AAG) in transgenic mouse models of frontotemporal lobar degeneration and Alzheimer's disease
-
24344631 3878847
-
Ho SW, Tsui YT, Wong TT, Cheung SK, Goggins WB, Yi LM et al (2013) Effects of 17-allylamino-17-demethoxygeldanamycin (17-AAG) in transgenic mouse models of frontotemporal lobar degeneration and Alzheimer's disease. Transl Neurodegener 2(1):24
-
(2013)
Transl Neurodegener
, vol.2
, Issue.1
, pp. 24
-
-
Ho, S.W.1
Tsui, Y.T.2
Wong, T.T.3
Cheung, S.K.4
Goggins, W.B.5
Yi, L.M.6
-
206
-
-
77249177547
-
A role for FKBP52 in Tau protein function
-
20133804 2823896
-
Chambraud B, Sardin E, Giustiniani J, Dounane O, Schumacher M, Goedert M et al (2010) A role for FKBP52 in Tau protein function. Proc Natl Acad Sci USA 107(6):2658-2663
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.6
, pp. 2658-2663
-
-
Chambraud, B.1
Sardin, E.2
Giustiniani, J.3
Dounane, O.4
Schumacher, M.5
Goedert, M.6
-
207
-
-
74949110831
-
The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules
-
20071522 2830818
-
Jinwal UK, Koren J 3rd, Borysov SI, Schmid AB, Abisambra JF, Blair LJ et al (2010) The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules. J Neurosci 30(2):591-599
-
(2010)
J Neurosci
, vol.30
, Issue.2
, pp. 591-599
-
-
Jinwal, U.K.1
Koren, J.2
Borysov, S.I.3
Schmid, A.B.4
Abisambra, J.F.5
Blair, L.J.6
-
208
-
-
33646133424
-
Molecular pathways that influence human tau-induced pathology in Caenorhabditis elegans
-
16600994
-
Kraemer BC, Burgess JK, Chen JH, Thomas JH, Schellenberg GD (2006) Molecular pathways that influence human tau-induced pathology in Caenorhabditis elegans. Hum Mol Genet 15(9):1483-1496
-
(2006)
Hum Mol Genet
, vol.15
, Issue.9
, pp. 1483-1496
-
-
Kraemer, B.C.1
Burgess, J.K.2
Chen, J.H.3
Thomas, J.H.4
Schellenberg, G.D.5
-
209
-
-
84885054226
-
Accelerated neurodegeneration through chaperone-mediated oligomerization of tau
-
23999428 3784538
-
Blair LJ, Nordhues BA, Hill SE, Scaglione KM, O'Leary JC 3rd, Fontaine SN et al (2013) Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. J Clin Invest 123(10):4158-4169
-
(2013)
J Clin Invest
, vol.123
, Issue.10
, pp. 4158-4169
-
-
Blair, L.J.1
Nordhues, B.A.2
Hill, S.E.3
Scaglione, K.M.4
O'Leary, J.C.5
Fontaine, S.N.6
-
210
-
-
84878114130
-
Tau degradation: The ubiquitin-proteasome system versus the autophagy-lysosome system
-
23528736
-
Lee MJ, Lee JH, Rubinsztein DC (2013) Tau degradation: the ubiquitin-proteasome system versus the autophagy-lysosome system. Prog Neurobiol 105:49-59
-
(2013)
Prog Neurobiol
, vol.105
, pp. 49-59
-
-
Lee, M.J.1
Lee, J.H.2
Rubinsztein, D.C.3
-
211
-
-
33744950091
-
Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation
-
16443603
-
Cripps D, Thomas SN, Jeng Y, Yang F, Davies P, Yang AJ (2006) Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation. J Biol Chem 281(16):10825-10838
-
(2006)
J Biol Chem
, vol.281
, Issue.16
, pp. 10825-10838
-
-
Cripps, D.1
Thomas, S.N.2
Jeng, Y.3
Yang, F.4
Davies, P.5
Yang, A.J.6
-
212
-
-
0037381710
-
Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease
-
12641733
-
Keck S, Nitsch R, Grune T, Ullrich O (2003) Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease. J Neurochem 85(1):115-122
-
(2003)
J Neurochem
, vol.85
, Issue.1
, pp. 115-122
-
-
Keck, S.1
Nitsch, R.2
Grune, T.3
Ullrich, O.4
-
213
-
-
0034131044
-
Impaired proteasome function in Alzheimer's disease
-
10854289
-
Keller JN, Hanni KB, Markesbery WR (2000) Impaired proteasome function in Alzheimer's disease. J Neurochem 75(1):436-439
-
(2000)
J Neurochem
, vol.75
, Issue.1
, pp. 436-439
-
-
Keller, J.N.1
Hanni, K.B.2
Markesbery, W.R.3
-
214
-
-
0036789647
-
Proteasomal degradation of tau protein
-
12358741
-
David DC, Layfield R, Serpell L, Narain Y, Goedert M, Spillantini MG (2002) Proteasomal degradation of tau protein. J Neurochem 83(1):176-185
-
(2002)
J Neurochem
, vol.83
, Issue.1
, pp. 176-185
-
-
David, D.C.1
Layfield, R.2
Serpell, L.3
Narain, Y.4
Goedert, M.5
Spillantini, M.G.6
-
215
-
-
0034667727
-
Defective ubiquitination of cerebral proteins in Alzheimer's disease
-
11020223
-
Lopez Salon M, Morelli L, Castano EM, Soto EF, Pasquini JM (2000) Defective ubiquitination of cerebral proteins in Alzheimer's disease. J Neurosci Res 62(2):302-310
-
(2000)
J Neurosci Res
, vol.62
, Issue.2
, pp. 302-310
-
-
Lopez Salon, M.1
Morelli, L.2
Castano, E.M.3
Soto, E.F.4
Pasquini, J.M.5
-
216
-
-
0036942289
-
Proteasome-mediated degradation of tau proteins occurs independently of the chymotrypsin-like activity by a nonprocessive pathway
-
12485608
-
Cardozo C, Michaud C (2002) Proteasome-mediated degradation of tau proteins occurs independently of the chymotrypsin-like activity by a nonprocessive pathway. Arch Biochem Biophys 408(1):103-110
-
(2002)
Arch Biochem Biophys
, vol.408
, Issue.1
, pp. 103-110
-
-
Cardozo, C.1
Michaud, C.2
-
217
-
-
84866170154
-
Autophagy impairment: A crossroad between neurodegeneration and tauopathies
-
22999309 3448508
-
Nassif M, Hetz C (2012) Autophagy impairment: a crossroad between neurodegeneration and tauopathies. BMC Biol 10:78
-
(2012)
BMC Biol
, vol.10
, pp. 78
-
-
Nassif, M.1
Hetz, C.2
-
218
-
-
77954955573
-
Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation
-
20546895
-
Rodríguez-Navarro JA, Rodríguez L, Casarejos MJ, Solano RM, Gómez A, Perucho J et al (2010) Trehalose ameliorates dopaminergic and tau pathology in parkin deleted/tau overexpressing mice through autophagy activation. Neurobiol Dis 39(3):423-438
-
(2010)
Neurobiol Dis
, vol.39
, Issue.3
, pp. 423-438
-
-
Rodríguez-Navarro, J.A.1
Rodríguez, L.2
Casarejos, M.J.3
Solano, R.M.4
Gómez, A.5
Perucho, J.6
-
219
-
-
84863210676
-
Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy
-
22689910 3381726, PT 7
-
Schaeffer V, Lavenir I, Ozcelik S, Tolnay M, Winkler DT, Goedert M (2012) Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy. Brain 135(Pt 7):2169-2177
-
(2012)
Brain
, vol.135
, pp. 2169-2177
-
-
Schaeffer, V.1
Lavenir, I.2
Ozcelik, S.3
Tolnay, M.4
Winkler, D.T.5
Goedert, M.6
-
220
-
-
84877109118
-
Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice
-
23667480 3646815
-
Ozcelik S, Fraser G, Castets P, Schaeffer V, Skachokova Z, Breu K et al (2013) Rapamycin attenuates the progression of tau pathology in P301S tau transgenic mice. PLoS One 8(5):e62459
-
(2013)
PLoS One
, vol.8
, Issue.5
, pp. e62459
-
-
Ozcelik, S.1
Fraser, G.2
Castets, P.3
Schaeffer, V.4
Skachokova, Z.5
Breu, K.6
-
221
-
-
84877803859
-
MTOR regulates tau phosphorylation and degradation: Implications for Alzheimer's disease and other tauopathies
-
23425014 3655115
-
Caccamo A, Magri A, Medina DX, Wisely EV, Lopez-Aranda MF, Silva AJ et al (2013) mTOR regulates tau phosphorylation and degradation: implications for Alzheimer's disease and other tauopathies. Aging Cell 12(3):370-380
-
(2013)
Aging Cell
, vol.12
, Issue.3
, pp. 370-380
-
-
Caccamo, A.1
Magri, A.2
Medina, D.X.3
Wisely, E.V.4
Lopez-Aranda, M.F.5
Silva, A.J.6
-
222
-
-
70349987102
-
Tau fragmentation, aggregation and clearance: The dual role of lysosomal processing
-
19654187 2758146
-
Wang Y, Martinez-Vicente M, Kruger U, Kaushik S, Wong E, Mandelkow EM et al (2009) Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing. Hum Mol Genet 18(21):4153-4170
-
(2009)
Hum Mol Genet
, vol.18
, Issue.21
, pp. 4153-4170
-
-
Wang, Y.1
Martinez-Vicente, M.2
Kruger, U.3
Kaushik, S.4
Wong, E.5
Mandelkow, E.M.6
-
223
-
-
84866519178
-
Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway
-
22998728 3544596
-
Inoue K, Rispoli J, Kaphzan H, Klann E, Chen EI, Kim J et al (2012) Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway. Mol Neurodegener 7:48
-
(2012)
Mol Neurodegener
, vol.7
, pp. 48
-
-
Inoue, K.1
Rispoli, J.2
Kaphzan, H.3
Klann, E.4
Chen, E.I.5
Kim, J.6
-
224
-
-
19944429064
-
Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model
-
15615853 544048
-
Zhang B, Maiti A, Shively S, Lakhani F, McDonald-Jones G, Bruce J et al (2005) Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model. Proc Natl Acad Sci USA 102(1):227-231
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, Issue.1
, pp. 227-231
-
-
Zhang, B.1
Maiti, A.2
Shively, S.3
Lakhani, F.4
McDonald-Jones, G.5
Bruce, J.6
-
225
-
-
84863230105
-
The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice
-
22423084 3321513
-
Zhang B, Carroll J, Trojanowski JQ, Yao Y, Iba M, Potuzak JS et al (2012) The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice. J Neurosci 32(11):3601-3611
-
(2012)
J Neurosci
, vol.32
, Issue.11
, pp. 3601-3611
-
-
Zhang, B.1
Carroll, J.2
Trojanowski, J.Q.3
Yao, Y.4
Iba, M.5
Potuzak, J.S.6
-
226
-
-
84861313192
-
Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027
-
22623658
-
Barten DM, Fanara P, Andorfer C, Hoque N, Wong PA, Husted KH et al (2012) Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027. J Neurosci 32(21):7137-7145
-
(2012)
J Neurosci
, vol.32
, Issue.21
, pp. 7137-7145
-
-
Barten, D.M.1
Fanara, P.2
Andorfer, C.3
Hoque, N.4
Wong, P.A.5
Husted, K.H.6
-
227
-
-
84879412186
-
NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy
-
23587881 3690421
-
Quraishe S, Cowan CM, Mudher A (2013) NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy. Mol Psychiatry 18(7):834-842
-
(2013)
Mol Psychiatry
, vol.18
, Issue.7
, pp. 834-842
-
-
Quraishe, S.1
Cowan, C.M.2
Mudher, A.3
-
228
-
-
84877914479
-
NAP (davunetide) modifies disease progression in a mouse model of severe neurodegeneration: Protection against impairments in axonal transport
-
23631872
-
Jouroukhin Y, Ostritsky R, Assaf Y, Pelled G, Giladi E, Gozes I (2013) NAP (davunetide) modifies disease progression in a mouse model of severe neurodegeneration: protection against impairments in axonal transport. Neurobiol Dis 56:79-94
-
(2013)
Neurobiol Dis
, vol.56
, pp. 79-94
-
-
Jouroukhin, Y.1
Ostritsky, R.2
Assaf, Y.3
Pelled, G.4
Giladi, E.5
Gozes, I.6
-
229
-
-
84878127734
-
A double-blind, placebo-controlled, ascending-dose, randomized study to evaluate the safety, tolerability and effects on cognition of AL-108 after 12 weeks of intranasal administration in subjects with mild cognitive impairment
-
23594991
-
Morimoto BH, Schmechel D, Hirman J, Blackwell A, Keith J, Gold M (2013) A double-blind, placebo-controlled, ascending-dose, randomized study to evaluate the safety, tolerability and effects on cognition of AL-108 after 12 weeks of intranasal administration in subjects with mild cognitive impairment. Dement Geriatr Cogn Disord 35(5-6):325-336
-
(2013)
Dement Geriatr Cogn Disord
, vol.35
, Issue.5-6
, pp. 325-336
-
-
Morimoto, B.H.1
Schmechel, D.2
Hirman, J.3
Blackwell, A.4
Keith, J.5
Gold, M.6
-
230
-
-
84897954153
-
New perspectives on the role of tau in Alzheimer's disease. Implications for therapy
-
24462919
-
Medina M, Avila J (2014) New perspectives on the role of tau in Alzheimer's disease. Implications for therapy. Biochem Pharmacol 88(4):540-547
-
(2014)
Biochem Pharmacol
, vol.88
, Issue.4
, pp. 540-547
-
-
Medina, M.1
Avila, J.2
-
231
-
-
84901417472
-
GSK-3beta, a pivotal kinase in Alzheimer disease
-
24904272
-
Llorens-Martin M, Jurado J, Hernandez F, Avila J (2014) GSK-3beta, a pivotal kinase in Alzheimer disease. Front Mol Neurosci 7:46
-
(2014)
Front Mol Neurosci
, vol.7
, pp. 46
-
-
Llorens-Martin, M.1
Jurado, J.2
Hernandez, F.3
Avila, J.4
-
232
-
-
77957954068
-
Glycogen synthase kinase-3 (GSK-3) inhibitors for the treatment of Alzheimer's disease
-
20698823
-
Medina M, Avila J (2010) Glycogen synthase kinase-3 (GSK-3) inhibitors for the treatment of Alzheimer's disease. Curr Pharm Des 16(25):2790-2798
-
(2010)
Curr Pharm des
, vol.16
, Issue.25
, pp. 2790-2798
-
-
Medina, M.1
Avila, J.2
-
233
-
-
84871928885
-
Lithium reverses tau pathology in Drosophila
-
Hayward P (2004) Lithium reverses tau pathology in Drosophila. Lancet Neurol 3(5):265
-
(2004)
Lancet Neurol
, vol.3
, Issue.5
, pp. 265
-
-
Hayward, P.1
-
234
-
-
21044449225
-
Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo
-
15867159 1088065
-
Noble W, Planel E, Zehr C, Olm V, Meyerson J, Suleman F et al (2005) Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo. Proc Natl Acad Sci USA 102(19):6990-6995
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, Issue.19
, pp. 6990-6995
-
-
Noble, W.1
Planel, E.2
Zehr, C.3
Olm, V.4
Meyerson, J.5
Suleman, F.6
-
235
-
-
79955546563
-
Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: Randomised controlled trial
-
21525519
-
Forlenza OV, Diniz BS, Radanovic M, Santos FS, Talib LL, Gattaz WF (2011) Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial. Br J Psychiatry 198(5):351-356
-
(2011)
Br J Psychiatry
, vol.198
, Issue.5
, pp. 351-356
-
-
Forlenza, O.V.1
Diniz, B.S.2
Radanovic, M.3
Santos, F.S.4
Talib, L.L.5
Gattaz, W.F.6
-
236
-
-
84855484573
-
Evidence for irreversible inhibition of glycogen synthase kinase-3beta by tideglusib
-
22102280 3256883
-
Dominguez JM, Fuertes A, Orozco L, del Monte-Millan M, Delgado E, Medina M (2012) Evidence for irreversible inhibition of glycogen synthase kinase-3beta by tideglusib. J Biol Chem 287(2):893-904
-
(2012)
J Biol Chem
, vol.287
, Issue.2
, pp. 893-904
-
-
Dominguez, J.M.1
Fuertes, A.2
Orozco, L.3
Del Monte-Millan, M.4
Delgado, E.5
Medina, M.6
-
237
-
-
16844363453
-
Does lithium therapy protect against the onset of dementia?
-
15764867
-
Dunn N, Holmes C, Mullee M (2005) Does lithium therapy protect against the onset of dementia? Alzheimer Dis Assoc Disord 19(1):20-22
-
(2005)
Alzheimer Dis Assoc Disord
, vol.19
, Issue.1
, pp. 20-22
-
-
Dunn, N.1
Holmes, C.2
Mullee, M.3
-
238
-
-
67649206084
-
Lithium trial in Alzheimer's disease: A randomized, single-blind, placebo-controlled, multicenter 10-week study
-
19573486
-
Hampel H, Ewers M, Burger K, Annas P, Mortberg A, Bogstedt A et al (2009) Lithium trial in Alzheimer's disease: a randomized, single-blind, placebo-controlled, multicenter 10-week study. J Clin Psychiatry 70(6):922-931
-
(2009)
J Clin Psychiatry
, vol.70
, Issue.6
, pp. 922-931
-
-
Hampel, H.1
Ewers, M.2
Burger, K.3
Annas, P.4
Mortberg, A.5
Bogstedt, A.6
-
239
-
-
68149150844
-
A novel GSK-3β inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo
-
19523516
-
Serenó L, Coma M, Rodríguez M, Sánchez-Ferrer P, Sánchez MB, Gich I et al (2009) A novel GSK-3β inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo. Neurobiol Dis 35(3):359-367
-
(2009)
Neurobiol Dis
, vol.35
, Issue.3
, pp. 359-367
-
-
Serenó, L.1
Coma, M.2
Rodríguez, M.3
Sánchez-Ferrer, P.4
Sánchez, M.B.5
Gich, I.6
-
240
-
-
84898056918
-
A phase 2 trial of the GSK-3 inhibitor tideglusib in progressive supranuclear palsy
-
24532007
-
Tolosa E, Litvan I, Höglinger GU, Burn D, Lees A, Andrés MV et al (2014) A phase 2 trial of the GSK-3 inhibitor tideglusib in progressive supranuclear palsy. Mov Disord 29(4):470-478
-
(2014)
Mov Disord
, vol.29
, Issue.4
, pp. 470-478
-
-
Tolosa, E.1
Litvan, I.2
Höglinger, G.U.3
Burn, D.4
Lees, A.5
Andrés, M.V.6
-
241
-
-
84923008414
-
A phase II randomized, double-blind, parallel group, 26-week study of GSK-3 inhibitor tideglusib in Alzheimer's disease (ARGO trial)
-
del Ser T, Lovestone S, Boada-Rovira M, Dubois B, Hüll M, Rinne J et al (2013) A phase II randomized, double-blind, parallel group, 26-week study of GSK-3 inhibitor tideglusib in Alzheimer's disease (ARGO trial). Alzheimers Dement 9(4):P689-P690
-
(2013)
Alzheimers Dement
, vol.9
, Issue.4
, pp. P689-P690
-
-
Del Ser, T.1
Lovestone, S.2
Boada-Rovira, M.3
Dubois, B.4
Hüll, M.5
Rinne, J.6
-
242
-
-
84876666322
-
AZD1080, a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans
-
23410232
-
Georgievska B, Sandin J, Doherty J, Mortberg A, Neelissen J, Andersson A et al (2013) AZD1080, a novel GSK3 inhibitor, rescues synaptic plasticity deficits in rodent brain and exhibits peripheral target engagement in humans. J Neurochem 125(3):446-456
-
(2013)
J Neurochem
, vol.125
, Issue.3
, pp. 446-456
-
-
Georgievska, B.1
Sandin, J.2
Doherty, J.3
Mortberg, A.4
Neelissen, J.5
Andersson, A.6
-
243
-
-
0036926420
-
Cdk5 as a drug target for the treatment of Alzheimer's disease
-
12540052
-
Lau LF, Seymour PA, Sanner MA, Schachter JB (2002) Cdk5 as a drug target for the treatment of Alzheimer's disease. J Mol Neurosci 19(3):267-273
-
(2002)
J Mol Neurosci
, vol.19
, Issue.3
, pp. 267-273
-
-
Lau, L.F.1
Seymour, P.A.2
Sanner, M.A.3
Schachter, J.B.4
-
244
-
-
84893832278
-
Fyn kinase inhibition as a novel therapy for Alzheimer's disease
-
24495408 3978417
-
Nygaard HB, van Dyck CH, Strittmatter SM (2014) Fyn kinase inhibition as a novel therapy for Alzheimer's disease. Alzheimers Res Ther 6(1):8
-
(2014)
Alzheimers Res Ther
, vol.6
, Issue.1
, pp. 8
-
-
Nygaard, H.B.1
Van Dyck, C.H.2
Strittmatter, S.M.3
-
245
-
-
77954085078
-
Sodium selenate specifically activates PP2A phosphatase, dephosphorylates tau and reverses memory deficits in an Alzheimer's disease model
-
20537899
-
Corcoran NM, Martin D, Hutter-Paier B, Windisch M, Nguyen T, Nheu L et al (2010) Sodium selenate specifically activates PP2A phosphatase, dephosphorylates tau and reverses memory deficits in an Alzheimer's disease model. J Clin Neurosci 17(8):1025-1033
-
(2010)
J Clin Neurosci
, vol.17
, Issue.8
, pp. 1025-1033
-
-
Corcoran, N.M.1
Martin, D.2
Hutter-Paier, B.3
Windisch, M.4
Nguyen, T.5
Nheu, L.6
-
246
-
-
78650746798
-
Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling
-
21098287 3003072
-
Kickstein E, Krauss S, Thornhill P, Rutschow D, Zeller R, Sharkey J et al (2010) Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling. Proc Natl Acad Sci USA 107(50):21830-21835
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, Issue.50
, pp. 21830-21835
-
-
Kickstein, E.1
Krauss, S.2
Thornhill, P.3
Rutschow, D.4
Zeller, R.5
Sharkey, J.6
-
247
-
-
79958744416
-
Phosphoprotein phosphatase 2A: A novel druggable target for Alzheimer's disease
-
21644827 3292348
-
Voronkov M, Braithwaite SP, Stock JB (2011) Phosphoprotein phosphatase 2A: a novel druggable target for Alzheimer's disease. Future Med Chem 3(7):821-833
-
(2011)
Future Med Chem
, vol.3
, Issue.7
, pp. 821-833
-
-
Voronkov, M.1
Braithwaite, S.P.2
Stock, J.B.3
-
248
-
-
82755163057
-
Determinants for substrate specificity of protein phosphatase 2A
-
21755039 3132988
-
Slupe AM, Merrill RA, Strack S (2011) Determinants for substrate specificity of protein phosphatase 2A. Enzyme Res 2011:398751
-
(2011)
Enzyme Res
, vol.2011
, pp. 398751
-
-
Slupe, A.M.1
Merrill, R.A.2
Strack, S.3
-
249
-
-
78649859760
-
The carboxy-terminal fragment of inhibitor-2 of protein phosphatase-2A induces Alzheimer disease pathology and cognitive impairment
-
20651003 3229424
-
Wang X, Blanchard J, Kohlbrenner E, Clement N, Linden RM, Radu A et al (2010) The carboxy-terminal fragment of inhibitor-2 of protein phosphatase-2A induces Alzheimer disease pathology and cognitive impairment. FASEB J 24(11):4420-4432
-
(2010)
FASEB J
, vol.24
, Issue.11
, pp. 4420-4432
-
-
Wang, X.1
Blanchard, J.2
Kohlbrenner, E.3
Clement, N.4
Linden, R.M.5
Radu, A.6
-
250
-
-
33745370049
-
Involvement of I2PP2A in the abnormal hyperphosphorylation of tau and its reversal by Memantine
-
16806196
-
Chohan MO, Khatoon S, Iqbal IG, Iqbal K (2006) Involvement of I2PP2A in the abnormal hyperphosphorylation of tau and its reversal by Memantine. FEBS Lett 580(16):3973-3979
-
(2006)
FEBS Lett
, vol.580
, Issue.16
, pp. 3973-3979
-
-
Chohan, M.O.1
Khatoon, S.2
Iqbal, I.G.3
Iqbal, K.4
-
251
-
-
61349145507
-
Development of tau aggregation inhibitors for Alzheimer's disease
-
19189357
-
Bulic B, Pickhardt M, Schmidt B, Mandelkow E-M, Waldmann H, Mandelkow E (2009) Development of tau aggregation inhibitors for Alzheimer's disease. Angew Chem Int Ed Engl 48(10):1740-1752
-
(2009)
Angew Chem Int Ed Engl
, vol.48
, Issue.10
, pp. 1740-1752
-
-
Bulic, B.1
Pickhardt, M.2
Schmidt, B.3
Mandelkow, E.-M.4
Waldmann, H.5
Mandelkow, E.6
-
252
-
-
78650480388
-
The metal chelating and chaperoning effects of clioquinol: Insights from yeast studies
-
21504115
-
Li C, Wang J, Zhou B (2010) The metal chelating and chaperoning effects of clioquinol: insights from yeast studies. J Alzheimers Dis 21(4):1249-1262
-
(2010)
J Alzheimers Dis
, vol.21
, Issue.4
, pp. 1249-1262
-
-
Li, C.1
Wang, J.2
Zhou, B.3
-
253
-
-
33646490404
-
1,1′-Xylyl bis-1,4,8,11-tetraaza cyclotetradecane: A new potential copper chelator agent for neuroprotection in Alzheimer's disease. Its comparative effects with clioquinol on rat brain copper distribution
-
16581247
-
Moret V, Laras Y, Pietrancosta N, Garino C, Quelever G, Rolland A et al (2006) 1,1′-Xylyl bis-1,4,8,11-tetraaza cyclotetradecane: a new potential copper chelator agent for neuroprotection in Alzheimer's disease. Its comparative effects with clioquinol on rat brain copper distribution. Bioorg Med Chem Lett 16(12):3298-3301
-
(2006)
Bioorg Med Chem Lett
, vol.16
, Issue.12
, pp. 3298-3301
-
-
Moret, V.1
Laras, Y.2
Pietrancosta, N.3
Garino, C.4
Quelever, G.5
Rolland, A.6
-
254
-
-
79952610782
-
Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease
-
21412423 3055881
-
Adlard PA, Bica L, White AR, Nurjono M, Filiz G, Crouch PJ et al (2011) Metal ionophore treatment restores dendritic spine density and synaptic protein levels in a mouse model of Alzheimer's disease. PLoS One 6(3):e17669
-
(2011)
PLoS One
, vol.6
, Issue.3
, pp. e17669
-
-
Adlard, P.A.1
Bica, L.2
White, A.R.3
Nurjono, M.4
Filiz, G.5
Crouch, P.J.6
-
255
-
-
46149107512
-
Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta
-
18614028
-
Adlard PA, Cherny RA, Finkelstein DI, Gautier E, Robb E, Cortes M et al (2008) Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta. Neuron 59(1):43-55
-
(2008)
Neuron
, vol.59
, Issue.1
, pp. 43-55
-
-
Adlard, P.A.1
Cherny, R.A.2
Finkelstein, D.I.3
Gautier, E.4
Robb, E.5
Cortes, M.6
-
256
-
-
54249103057
-
Drug development based on the metals hypothesis of Alzheimer's disease
-
18953111
-
Bush AI (2008) Drug development based on the metals hypothesis of Alzheimer's disease. J Alzheimers Dis 15(2):223-240
-
(2008)
J Alzheimers Dis
, vol.15
, Issue.2
, pp. 223-240
-
-
Bush, A.I.1
-
257
-
-
18444399243
-
Treatment of Alzheimer's disease with clioquinol
-
11598313
-
Regland B, Lehmann W, Abedini I, Blennow K, Jonsson M, Karlsson I et al (2001) Treatment of Alzheimer's disease with clioquinol. Dement Geriatr Cogn Disord 12(6):408-414
-
(2001)
Dement Geriatr Cogn Disord
, vol.12
, Issue.6
, pp. 408-414
-
-
Regland, B.1
Lehmann, W.2
Abedini, I.3
Blennow, K.4
Jonsson, M.5
Karlsson, I.6
-
258
-
-
33645502098
-
Clioquinol for the treatment of Alzheimer's disease
-
16437529
-
Jenagaratnam L, McShane R (2006) Clioquinol for the treatment of Alzheimer's disease. Cochrane Database Syst Rev 1:CD005380
-
(2006)
Cochrane Database Syst Rev
, vol.1
, pp. CD005380
-
-
Jenagaratnam, L.1
McShane, R.2
-
259
-
-
48949098573
-
Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: A phase IIa, double-blind, randomised, placebo-controlled trial
-
18672400
-
Lannfelt L, Blennow K, Zetterberg H, Batsman S, Ames D, Harrison J et al (2008) Safety, efficacy, and biomarker findings of PBT2 in targeting Aβ as a modifying therapy for Alzheimer's disease: a phase IIa, double-blind, randomised, placebo-controlled trial. Lancet Neurol 7(9):779-786
-
(2008)
Lancet Neurol
, vol.7
, Issue.9
, pp. 779-786
-
-
Lannfelt, L.1
Blennow, K.2
Zetterberg, H.3
Batsman, S.4
Ames, D.5
Harrison, J.6
-
260
-
-
77954344206
-
PBT2 rapidly improves cognition in Alzheimer's disease: Additional phase II analyses
-
20164561
-
Faux NG, Ritchie CW, Gunn A, Rembach A, Tsatsanis A, Bedo J et al (2010) PBT2 rapidly improves cognition in Alzheimer's disease: additional phase II analyses. J Alzheimers Dis 20(2):509-516
-
(2010)
J Alzheimers Dis
, vol.20
, Issue.2
, pp. 509-516
-
-
Faux, N.G.1
Ritchie, C.W.2
Gunn, A.3
Rembach, A.4
Tsatsanis, A.5
Bedo, J.6
-
261
-
-
14844303721
-
Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins
-
15611092
-
Taniguchi S, Suzuki N, Masuda M, S-i Hisanaga, Iwatsubo T, Goedert M et al (2005) Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins. J Biol Chem 280(9):7614-7623
-
(2005)
J Biol Chem
, vol.280
, Issue.9
, pp. 7614-7623
-
-
Taniguchi, S.1
Suzuki, N.2
Masuda, M.3
Iwatsubo, T.4
Goedert, M.5
-
262
-
-
67349200953
-
O3-04-07: Tau aggregation inhibitor (TAI) therapy with rember™ arrests disease progression in mild and moderate Alzheimer's disease over 50 weeks
-
Wischik CM, Bentham P, Wischik DJ, Seng KM (2008) O3-04-07: tau aggregation inhibitor (TAI) therapy with rember™ arrests disease progression in mild and moderate Alzheimer's disease over 50 weeks. Alzheimers Dement 4(4):T167
-
(2008)
Alzheimers Dement
, vol.4
, Issue.4
, pp. T167
-
-
Wischik, C.M.1
Bentham, P.2
Wischik, D.J.3
Seng, K.M.4
-
263
-
-
84923037846
-
Drug development for tauopathies
-
10.1111/nan.12192
-
Grüninger F (2014) Drug development for tauopathies. Neuropathol Appl Neurobiol 41(1):81-96. doi: 10.1111/nan.12192
-
(2014)
Neuropathol Appl Neurobiol
, vol.41
, Issue.1
, pp. 81-96
-
-
Grüninger, F.1
-
264
-
-
84871003215
-
The MAPT H1 haplotype is associated with tangle-predominant dementia
-
22802095 3608475
-
Santa-Maria I, Haggiagi A, Liu X, Wasserscheid J, Nelson PT, Dewar K et al (2012) The MAPT H1 haplotype is associated with tangle-predominant dementia. Acta Neuropathol 124(5):693-704
-
(2012)
Acta Neuropathol
, vol.124
, Issue.5
, pp. 693-704
-
-
Santa-Maria, I.1
Haggiagi, A.2
Liu, X.3
Wasserscheid, J.4
Nelson, P.T.5
Dewar, K.6
-
265
-
-
0033041179
-
Association of an extended haplotype in the tau gene with progressive supranuclear palsy
-
10072441
-
Baker M, Litvan I, Houlden H, Adamson J, Dickson D, Perez-Tur J et al (1999) Association of an extended haplotype in the tau gene with progressive supranuclear palsy. Hum Mol Genet 8(4):711-715
-
(1999)
Hum Mol Genet
, vol.8
, Issue.4
, pp. 711-715
-
-
Baker, M.1
Litvan, I.2
Houlden, H.3
Adamson, J.4
Dickson, D.5
Perez-Tur, J.6
-
266
-
-
0034011659
-
Corticobasal degeneration shares a common genetic background with progressive supranuclear palsy
-
10716259
-
Di Maria E, Tabaton M, Vigo T, Abbruzzese G, Bellone E, Donati C et al (2000) Corticobasal degeneration shares a common genetic background with progressive supranuclear palsy. Ann Neurol 47(3):374-377
-
(2000)
Ann Neurol
, vol.47
, Issue.3
, pp. 374-377
-
-
Di Maria, E.1
Tabaton, M.2
Vigo, T.3
Abbruzzese, G.4
Bellone, E.5
Donati, C.6
-
267
-
-
33847178181
-
The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts
-
17174556
-
Myers AJ, Pittman AM, Zhao AS, Rohrer K, Kaleem M, Marlowe L et al (2007) The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts. Neurobiol Dis 25(3):561-570
-
(2007)
Neurobiol Dis
, vol.25
, Issue.3
, pp. 561-570
-
-
Myers, A.J.1
Pittman, A.M.2
Zhao, A.S.3
Rohrer, K.4
Kaleem, M.5
Marlowe, L.6
-
268
-
-
34248181511
-
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model
-
17478722
-
Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T et al (2007) Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model. Science 316(5825):750-754
-
(2007)
Science
, vol.316
, Issue.5825
, pp. 750-754
-
-
Roberson, E.D.1
Scearce-Levie, K.2
Palop, J.J.3
Yan, F.4
Cheng, I.H.5
Wu, T.6
-
269
-
-
77953808475
-
Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease
-
20434528 2900546
-
Dawson HN, Cantillana V, Jansen M, Wang H, Vitek MP, Wilcock DM et al (2010) Loss of tau elicits axonal degeneration in a mouse model of Alzheimer's disease. Neuroscience 169(1):516-531
-
(2010)
Neuroscience
, vol.169
, Issue.1
, pp. 516-531
-
-
Dawson, H.N.1
Cantillana, V.2
Jansen, M.3
Wang, H.4
Vitek, M.P.5
Wilcock, D.M.6
-
270
-
-
84864382491
-
Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau
-
22532069
-
Van der Jeugd A, Hochgrafe K, Ahmed T, Decker JM, Sydow A, Hofmann A et al (2012) Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau. Acta Neuropathol 123(6):787-805
-
(2012)
Acta Neuropathol
, vol.123
, Issue.6
, pp. 787-805
-
-
Van Der Jeugd, A.1
Hochgrafe, K.2
Ahmed, T.3
Decker, J.M.4
Sydow, A.5
Hofmann, A.6
-
271
-
-
34248222543
-
Pharmacologic reductions of total tau levels; Implications for the role of microtubule dynamics in regulating tau expression
-
16930453 1570347
-
Dickey CA, Ash P, Klosak N, Lee WC, Petrucelli L, Hutton M et al (2006) Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression. Mol Neurodegener 1:6
-
(2006)
Mol Neurodegener
, vol.1
, pp. 6
-
-
Dickey, C.A.1
Ash, P.2
Klosak, N.3
Lee, W.C.4
Petrucelli, L.5
Hutton, M.6
-
272
-
-
77956527159
-
Enhancement of proteasome activity by a small-molecule inhibitor of USP14
-
20829789 2939003
-
Lee BH, Lee MJ, Park S, Oh DC, Elsasser S, Chen PC et al (2010) Enhancement of proteasome activity by a small-molecule inhibitor of USP14. Nature 467(7312):179-184
-
(2010)
Nature
, vol.467
, Issue.7312
, pp. 179-184
-
-
Lee, B.H.1
Lee, M.J.2
Park, S.3
Oh, D.C.4
Elsasser, S.5
Chen, P.C.6
-
273
-
-
0033536163
-
Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
-
10408445
-
Schenk D, Barbour R, Dunn W, Gordon G, Grajeda H, Guido T et al (1999) Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400(6740):173-177
-
(1999)
Nature
, vol.400
, Issue.6740
, pp. 173-177
-
-
Schenk, D.1
Barbour, R.2
Dunn, W.3
Gordon, G.4
Grajeda, H.5
Guido, T.6
-
274
-
-
0033835996
-
Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
-
10932230
-
Bard F, Cannon C, Barbour R, Burke RL, Games D, Grajeda H et al (2000) Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat Med 6(8):916-919
-
(2000)
Nat Med
, vol.6
, Issue.8
, pp. 916-919
-
-
Bard, F.1
Cannon, C.2
Barbour, R.3
Burke, R.L.4
Games, D.5
Grajeda, H.6
-
275
-
-
0034700471
-
A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease
-
11140685
-
Janus C, Pearson J, McLaurin J, Mathews PM, Jiang Y, Schmidt SD et al (2000) A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease. Nature 408(6815):979-982
-
(2000)
Nature
, vol.408
, Issue.6815
, pp. 979-982
-
-
Janus, C.1
Pearson, J.2
McLaurin, J.3
Mathews, P.M.4
Jiang, Y.5
Schmidt, S.D.6
-
276
-
-
0035902619
-
Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease
-
11438712 37524
-
DeMattos RB, Bales KR, Cummins DJ, Dodart JC, Paul SM, Holtzman DM (2001) Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 98(15):8850-8855
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, Issue.15
, pp. 8850-8855
-
-
DeMattos, R.B.1
Bales, K.R.2
Cummins, D.J.3
Dodart, J.C.4
Paul, S.M.5
Holtzman, D.M.6
-
277
-
-
58149129243
-
Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain
-
18953056, PT 12
-
Boche D, Zotova E, Weller RO, Love S, Neal JW, Pickering RM et al (2008) Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain. Brain 131(Pt 12):3299-3310
-
(2008)
Brain
, vol.131
, pp. 3299-3310
-
-
Boche, D.1
Zotova, E.2
Weller, R.O.3
Love, S.4
Neal, J.W.5
Pickering, R.M.6
-
278
-
-
34548146119
-
Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements
-
17715348
-
Asuni AA, Boutajangout A, Quartermain D, Sigurdsson EM (2007) Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements. J Neurosci 27(34):9115-9129
-
(2007)
J Neurosci
, vol.27
, Issue.34
, pp. 9115-9129
-
-
Asuni, A.A.1
Boutajangout, A.2
Quartermain, D.3
Sigurdsson, E.M.4
-
279
-
-
77954656871
-
Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice
-
20546729
-
Boimel M, Grigoriadis N, Lourbopoulos A, Haber E, Abramsky O, Rosenmann H (2010) Efficacy and safety of immunization with phosphorylated tau against neurofibrillary tangles in mice. Exp Neurol 224(2):472-485
-
(2010)
Exp Neurol
, vol.224
, Issue.2
, pp. 472-485
-
-
Boimel, M.1
Grigoriadis, N.2
Lourbopoulos, A.3
Haber, E.4
Abramsky, O.5
Rosenmann, H.6
-
280
-
-
78650065372
-
Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model
-
21147995 3135981
-
Boutajangout A, Quartermain D, Sigurdsson EM (2010) Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model. J Neurosci 30(49):16559-16566
-
(2010)
J Neurosci
, vol.30
, Issue.49
, pp. 16559-16566
-
-
Boutajangout, A.1
Quartermain, D.2
Sigurdsson, E.M.3
-
281
-
-
79960563632
-
Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain
-
21644996 3366469
-
Boutajangout A, Ingadottir J, Davies P, Sigurdsson EM (2011) Passive immunization targeting pathological phospho-tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain. J Neurochem 118(4):658-667
-
(2011)
J Neurochem
, vol.118
, Issue.4
, pp. 658-667
-
-
Boutajangout, A.1
Ingadottir, J.2
Davies, P.3
Sigurdsson, E.M.4
|