Rapid Restoration of Cognition in Alzheimer's Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ

Neuron

Volumn 59, Issue 1, 2008, Pages 43-55

  Adlard, Paul A ^a,b   Cherny, Robert A ^a,b,d   Finkelstein, David I ^a,b   Gautier, Elisabeth ^d   Robb, Elysia ^a   Cortes, Mikhalina ^a   Volitakis, Irene ^a   Liu, Xiang ^a   Smith, Jeffrey P ^a   Perez, Keyla ^a,b   Laughton, Katrina ^a,b   Li, Qiao Xin ^a,b   Charman, Susan A ^e   Nicolazzo, Joseph A ^e   Wilkins, Simon ^a,b   Deleva, Karolina ^a   Lynch, Toni ^a   Kok, Gaik ^d   Ritchie, Craig W ^f   Tanzi, Rudolph E ^g   Cappai, Roberto ^a,b,c   Masters, Colin L ^a,b   Barnham, Kevin J ^a,b,c   Bush, Ashley I ^a,b   more..

^a FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d Prana Biotechnology Ltd   (Australia)

^e MONASH UNIVERSITY   (Australia)

^f ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^g MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

CELLBIO; HUMDISEASE; MOLNEURO

Indexed keywords

8 QUINOLINOL DERIVATIVE; AMYLOID BETA PROTEIN; CLIOQUINOL; COPPER; IONOPHORE; IRON; MANGANESE; PBT2; ZINC;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MEMBRANE PERMEABILITY; METAL BINDING; MOUSE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANALYSIS OF VARIANCE; ANIMALS; BEHAVIOR, ANIMAL; CELL LINE, TUMOR; CLIOQUINOL; COGNITION; COPPER; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; HUMANS; HYDROXYQUINOLINES; LONG-TERM POTENTIATION; MAZE LEARNING; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEUROBLASTOMA; PEPTIDE FRAGMENTS; PRESENILIN-1; ZINC;

EID: 46149107512     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuron.2008.06.018     Document Type: Article

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