Pseudophosphorylation of tau at serine 422 inhibits caspase cleavage: In vitro evidence and implications for tangle formation in vivo

Journal of Neurochemistry

Volumn 97, Issue 4, 2006, Pages 1005-1014

  Guillozet Bongaarts, Angela L ^a,b   Cahill, Michael E ^a   Cryns, Vincent L ^a   Reynolds, Matthew R ^a   Berry, Robert W ^a   Binder, Lester I ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b RUSH MEDICAL COLLEGE   (United States)

Author keywords

Alzheimer's disease; Apoptosis; Neurofibrillary tangle; Neuropathology; Proteolysis

Indexed keywords

ANTIBODY; ASPARTIC ACID; CASPASE; CASPASE 3; EPITOPE; SERINE; TAU PROTEIN;

AGED; AGING; ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; ENZYME ACTIVATION; ENZYME REGULATION; FEMALE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MALE; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; NEUROPROTECTION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PSEUDOPHOSPHORYLATION;

AGED; AGED, 80 AND OVER; AGING; ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ANTIBODIES; APOPTOSIS; ASPARTIC ACID; BINDING SITES; CASPASE 3; CASPASES; CEREBRAL CORTEX; EPITOPES; FEMALE; HUMANS; MALE; NERVE DEGENERATION; NEUROFIBRILLARY TANGLES; NEURONS; PEPTIDE HYDROLASES; PHOSPHORYLATION; SERINE; TAU PROTEINS;

EID: 33646080573     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.03784.x     Document Type: Article

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