-
1
-
-
0034718571
-
Structure, microtubule interactions, and paired helical filament aggregation by tau mutants of frontotemporal dementias
-
Barghorn S, Zheng-Fischhofer Q, Ackmann M, Biernat J, von Bergen M, Mandelkow E, Mandelkow E (2000) Structure, microtubule interactions, and paired helical filament aggregation by tau mutants of frontotemporal dementias. Biochemistry 39:11714-11721.
-
(2000)
Biochemistry
, vol.39
, pp. 11714-11721
-
-
Barghorn, S.1
Zheng-Fischhofer, Q.2
Ackmann, M.3
Biernat, J.4
Von Bergen, M.5
Mandelkow, E.6
Mandelkow, E.7
-
2
-
-
0033059975
-
Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau
-
Bugiani O, Murrell JR, Giaccone G, Hasegawa M, Ghigo G, Tabaton M, Morbin M, Primavera A, Carella F, Solaro C, Grisoli M, Savoiardo MG, Spillantini F, Tagliavini M, Goedert M, Ghetti B (1999) Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau. J Neuropathol Exp Neurol 58:667-677.
-
(1999)
J Neuropathol Exp Neurol
, vol.58
, pp. 667-677
-
-
Bugiani, O.1
Murrell, J.R.2
Giaccone, G.3
Hasegawa, M.4
Ghigo, G.5
Tabaton, M.6
Morbin, M.7
Primavera, A.8
Carella, F.9
Solaro, C.10
Grisoli, M.11
Savoiardo, M.G.12
Spillantini, F.13
Tagliavini, M.14
Goedert, M.15
Ghetti, B.16
-
3
-
-
0032573083
-
Pathogenic implications of mutations in the tau gene in pallidoponto- nigral degeneration and related neurodegenerative disorders linked to chromosome 17
-
Clark LN, Poorkaj P, Wszolek Z, Geschwind DH, Nasreddine ZS, Miller B, Li D, Payami H, Awert F, Markopoulou K, Andreadis A, D'Souza I, Lee VM-Y, Reed L, Trojanowski JQ, Zhukareva V, Bird T, Schellenberg G, Wilhelmsen KC (1998) Pathogenic implications of mutations in the tau gene in pallidoponto- nigral degeneration and related neurodegenerative disorders linked to chromosome 17. Proc Natl Acad Sci USA 95:13103-13107.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 13103-13107
-
-
Clark, L.N.1
Poorkaj, P.2
Wszolek, Z.3
Geschwind, D.H.4
Nasreddine, Z.S.5
Miller, B.6
Li, D.7
Payami, H.8
Awert, F.9
Markopoulou, K.10
Andreadis, A.11
D'Souza, I.12
Lee, V.M.-Y.13
Reed, L.14
Trojanowski, J.Q.15
Zhukareva, V.16
Bird, T.17
Schellenberg, G.18
Wilhelmsen, K.C.19
-
4
-
-
0035937481
-
Effects of FTDP-17 mutations on the in vitro phosphorylation of tau by glycogen synthase kinase 3β identified by mass spectrometry demonstrate certain mutations exert long-range conformational changes
-
Connell JW, Gibb GM, Betts JC, Blackstock JC, Gallo J, Lovestone S, Hutton M, Anderton BH (2001) Effects of FTDP-17 mutations on the in vitro phosphorylation of tau by glycogen synthase kinase 3β identified by mass spectrometry demonstrate certain mutations exert long-range conformational changes. FEBS Lett 493:40-44.
-
(2001)
FEBS Lett
, vol.493
, pp. 40-44
-
-
Connell, J.W.1
Gibb, G.M.2
Betts, J.C.3
Blackstock, J.C.4
Gallo, J.5
Lovestone, S.6
Hutton, M.7
Anderton, B.H.8
-
5
-
-
0033850080
-
Abnormal tau-containing filaments in neurodegenerative diseases
-
Crowther RA, Goedert M (2000) Abnormal tau-containing filaments in neurodegenerative diseases. J Struct Biol 130:271-279.
-
(2000)
J Struct Biol
, vol.130
, pp. 271-279
-
-
Crowther, R.A.1
Goedert, M.2
-
6
-
-
0033545946
-
Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements
-
D'Souza I, Poorkaj P, Hong M, Nochlin D, Lee VM-Y, Bird TD, Schellenberg GD (1999) Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative RNA splicing regulatory elements. Proc Natl Acad Sci USA 96:5598-5603.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 5598-5603
-
-
D'Souza, I.1
Poorkaj, P.2
Hong, M.3
Nochlin, D.4
Lee, V.M.-Y.5
Bird, T.D.6
Schellenberg, G.D.7
-
7
-
-
0033002879
-
A mutation at codon 279 (N279K) in exon 10 of the tau gene causes a tauopathy with dementia and supranuclear palsy
-
Delisle MB, Murrell JR, Richardson R, Trofatter JA, Rascol O, Soulajes X, Mohr M, Calvas P, Ghetti B (1999) A mutation at codon 279 (N279K) in exon 10 of the tau gene causes a tauopathy with dementia and supranuclear palsy. Acta Neuropathol (Berl) 98:62-77.
-
(1999)
Acta Neuropathol (Berl)
, vol.98
, pp. 62-77
-
-
Delisle, M.B.1
Murrell, J.R.2
Richardson, R.3
Trofatter, J.A.4
Rascol, O.5
Soulajes, X.6
Mohr, M.7
Calvas, P.8
Ghetti, B.9
-
8
-
-
0037088687
-
Functional characterization of FTDP-17 tau gene mutations through their effects on Xenopus oocyte maturation
-
Delobel P, Flament S, Hamdane M, Jakes R, Rousseau A, Delacourte A, Vilain JP, Goedert M, Buee L (2002) Functional characterization of FTDP-17 tau gene mutations through their effects on Xenopus oocyte maturation. J Biol Chem 277:9199-9205.
-
(2002)
J Biol Chem
, vol.277
, pp. 9199-9205
-
-
Delobel, P.1
Flament, S.2
Hamdane, M.3
Jakes, R.4
Rousseau, A.5
Delacourte, A.6
Vilain, J.P.7
Goedert, M.8
Buee, L.9
-
9
-
-
7344220963
-
Segregation of a missense mutation in the microtubule-associated protein tau gene with familial frontotemporal dementia and Parkinsonism
-
Dumanchin C, Camuzat A, Campion D, Verpillat P, Hannequin D, Dubois B, Saugier-Veber P, Martin C, Penet C, Charbonnier F, Agid Y, Frebourg T, Brice A (1998) Segregation of a missense mutation in the microtubule-associated protein tau gene with familial frontotemporal dementia and Parkinsonism. Hum Mol Genet 7:1825-1829.
-
(1998)
Hum Mol Genet
, vol.7
, pp. 1825-1829
-
-
Dumanchin, C.1
Camuzat, A.2
Campion, D.3
Verpillat, P.4
Hannequin, D.5
Dubois, B.6
Saugier-Veber, P.7
Martin, C.8
Penet, C.9
Charbonnier, F.10
Agid, Y.11
Frebourg, T.12
Brice, A.13
-
10
-
-
0035808361
-
Tau filament formation in transgenic mice expressing P301L tau
-
Götz J, Chen F, Barmettler R, Nitsch RM (2001) tau filament formation in transgenic mice expressing P301L tau. J Biol Chem 276:529-534.
-
(2001)
J Biol Chem
, vol.276
, pp. 529-534
-
-
Götz, J.1
Chen, F.2
Barmettler, R.3
Nitsch, R.M.4
-
11
-
-
0033591225
-
5′ splice site mutations in tau associated with the inherited dementia FTDP-17 affect a stem-loop structure that regulates alternative splicing of exon 10
-
Grover A, Houlden H, Baker M, Adamson J, Lewis J, Prihar G, Pickering-Brown S, Duff K, Hutton M (1999) 5′ splice site mutations in tau associated with the inherited dementia FTDP-17 affect a stem-loop structure that regulates alternative splicing of exon 10. J Biol Chem 274:15134-15143.
-
(1999)
J Biol Chem
, vol.274
, pp. 15134-15143
-
-
Grover, A.1
Houlden, H.2
Baker, M.3
Adamson, J.4
Lewis, J.5
Prihar, G.6
Pickering-Brown, S.7
Duff, K.8
Hutton, M.9
-
12
-
-
0032561415
-
Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly
-
Hasegawa M, Smith MJ, Goedert M (1998) Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly. FEBS Lett 437:207-210.
-
(1998)
FEBS Lett
, vol.437
, pp. 207-210
-
-
Hasegawa, M.1
Smith, M.J.2
Goedert, M.3
-
13
-
-
0033060662
-
FTDP-17 mutations N279K and S305N in tau produce increased splicing of exon 10
-
Hasegawa M, Smith MJ, Iijima M, Tabira T, Goedert M (1999) FTDP-17 mutations N279K and S305N in tau produce increased splicing of exon 10. FEBS Lett 443:93-96.
-
(1999)
FEBS Lett
, vol.443
, pp. 93-96
-
-
Hasegawa, M.1
Smith, M.J.2
Iijima, M.3
Tabira, T.4
Goedert, M.5
-
14
-
-
0030748390
-
Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons
-
Hong M, Lee VM-Y (1997) Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons. J Biol Chem 272:19547-19553.
-
(1997)
J Biol Chem
, vol.272
, pp. 19547-19553
-
-
Hong, M.1
Lee, V.M.-Y.2
-
15
-
-
0032484089
-
Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17
-
Hong M, Zhukareva V, Vogelsberg-Ragaglia V, Wszolek Z, Reed L, Miller BI, Geschwind DH, Bird TD, McKeel D, Goate A, Morris JC, Wilhelmsen KC, Schellenberg GD, Trojanowski JQ, Lee VM-Y (1998) Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17. Science 282:1914-1917.
-
(1998)
Science
, vol.282
, pp. 1914-1917
-
-
Hong, M.1
Zhukareva, V.2
Vogelsberg-Ragaglia, V.3
Wszolek, Z.4
Reed, L.5
Miller, B.I.6
Geschwind, D.H.7
Bird, T.D.8
McKeel, D.9
Goate, A.10
Morris, J.C.11
Wilhelmsen, K.C.12
Schellenberg, G.D.13
Trojanowski, J.Q.14
Lee, V.M.-Y.15
-
16
-
-
0032543684
-
Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
-
Hutton M, Lendon CL, Rizzu P, Baker M, Froelich S, Houlden H, Pickering-Brown S, Chakraverty S, Isaacs A, Grover A, Hackett J, Adamson J, Lincoln S, Dickson D, Davies P, Reed L, Trojanowski JQ, Petersen RC, Stevens M, de Graaff E, Wauters E, van Baren J, Hillebrand M, Joosse M, Kwon JM, Nowotny P, Heutink P (1998) Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17. Nature 393:702-705.
-
(1998)
Nature
, vol.393
, pp. 702-705
-
-
Hutton, M.1
Lendon, C.L.2
Rizzu, P.3
Baker, M.4
Froelich, S.5
Houlden, H.6
Pickering-Brown, S.7
Chakraverty, S.8
Isaacs, A.9
Grover, A.10
Hackett, J.11
Adamson, J.12
Lincoln, S.13
Dickson, D.14
Davies, P.15
Reed, L.16
Trojanowski, J.Q.17
Petersen, R.C.18
Stevens, M.19
De Graaff, E.20
Wauters, E.21
Van Baren, J.22
Hillebrand, M.23
Joosse, M.24
Kwon, J.M.25
Nowotny, P.26
Heutink, P.27
more..
-
17
-
-
0033230886
-
Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform
-
Ishihara T, Hong M, Zhang B, Nakagawa Y, Lee MK, Trojanowski JQ, Lee VM-Y (1999) Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform. Neuron 24:751-762.
-
(1999)
Neuron
, vol.24
, pp. 751-762
-
-
Ishihara, T.1
Hong, M.2
Zhang, B.3
Nakagawa, Y.4
Lee, M.K.5
Trojanowski, J.Q.6
Lee, V.M.-Y.7
-
18
-
-
0035882526
-
Attenuated neurodegenerative disease phenotype in tau transgenic mouse lacking neurofilaments 1
-
Ishihara T, Higuchi M, Zhang B, Yoshiyama Y, Hong M, Trojanowski JQ, Lee VM-Y (2001a) Attenuated neurodegenerative disease phenotype in tau transgenic mouse lacking neurofilaments 1. J Neurosci 21:6026-6035.
-
(2001)
J Neurosci
, vol.21
, pp. 6026-6035
-
-
Ishihara, T.1
Higuchi, M.2
Zhang, B.3
Yoshiyama, Y.4
Hong, M.5
Trojanowski, J.Q.6
Lee, V.M.-Y.7
-
19
-
-
0035134081
-
Age-dependent induction of congophilic neurofibrillary tau inclusions in tau transgenic mice
-
Ishihara T, Zhang B, Higuchi M, Yoshiyama Y, Trojanowski JQ, Lee VM-Y (2001b) Age-dependent induction of congophilic neurofibrillary tau inclusions in tau transgenic mice. Am J Pathol 158:555-562.
-
(2001)
Am J Pathol
, vol.158
, pp. 555-562
-
-
Ishihara, T.1
Zhang, B.2
Higuchi, M.3
Yoshiyama, Y.4
Trojanowski, J.Q.5
Lee, V.M.-Y.6
-
20
-
-
0036759121
-
Unhampered prion neuroinvasion despite impaired fast axonal transport in transgenic mice overexpressing four-repeat tau
-
Künzi V, Glatzel M, Nakano MY, Greber UF, Leuven FV, Aguzzi A (2002) Unhampered prion neuroinvasion despite impaired fast axonal transport in transgenic mice overexpressing four-repeat tau. J Neurosci 22:7471-7477.
-
(2002)
J Neurosci
, vol.22
, pp. 7471-7477
-
-
Künzi, V.1
Glatzel, M.2
Nakano, M.Y.3
Greber, U.F.4
Leuven, F.V.5
Aguzzi, A.6
-
21
-
-
0025904444
-
A68: A major subunit of paired helical filaments and derivatized forms of normal tau
-
Lee VM-Y, Balin BJ, Otvos Jr L, Trojanowski JQ (1991) A68: a major subunit of paired helical filaments and derivatized forms of normal tau. Science 251:675-678.
-
(1991)
Science
, vol.251
, pp. 675-678
-
-
Lee, V.M.-Y.1
Balin, B.J.2
Otvos Jr., L.3
Trojanowski, J.Q.4
-
23
-
-
0034426011
-
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein
-
Lewis J, McGowan E, Rockwood J, Melrose H, Nacharaju P, van Slegtenhorst M, Gwinn-Hardy K, Paul MM, Baker M, Yu X, Duff K, Hardy J, Corral A, Lin WL, Yen SH, Dickson DW, Davies P, Hutton M (2000) Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nat Genet 25:402-405.
-
(2000)
Nat Genet
, vol.25
, pp. 402-405
-
-
Lewis, J.1
McGowan, E.2
Rockwood, J.3
Melrose, H.4
Nacharaju, P.5
Van Slegtenhorst, M.6
Gwinn-Hardy, K.7
Paul, M.M.8
Baker, M.9
Yu, X.10
Duff, K.11
Hardy, J.12
Corral, A.13
Lin, W.L.14
Yen, S.H.15
Dickson, D.W.16
Davies, P.17
Hutton, M.18
-
24
-
-
0035680685
-
FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and tau filaments in forebrain
-
Lim F, Hernández F, Lucas JJ, Gómez-Ramos P, Morán MA, Ávila J (2001) FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and tau filaments in forebrain. Mol Cell Neurosci 18:702-714.
-
(2001)
Mol Cell Neurosci
, vol.18
, pp. 702-714
-
-
Lim, F.1
Hernández, F.2
Lucas, J.J.3
Gómez-Ramos, P.4
Morán, M.A.5
Ávila, J.6
-
25
-
-
0029994754
-
Phosphorylation of tau by glycogen synthase kinase-3 beta in intact mammalian cells: The effects on the organization and stability of microtubules
-
Lovestone S, Hartley CL, Pearce J, Anderton BH (1996) Phosphorylation of tau by glycogen synthase kinase-3 beta in intact mammalian cells: the effects on the organization and stability of microtubules. Neuroscience 73:1145-1157.
-
(1996)
Neuroscience
, vol.73
, pp. 1145-1157
-
-
Lovestone, S.1
Hartley, C.L.2
Pearce, J.3
Anderton, B.H.4
-
26
-
-
0029588380
-
Three distinct axonal transport rates for tau, tubulin, and other microtubule-associated proteins: Evedence for dynamic interactions of tau with microtubules in vivo
-
Mercken M, Fisher I, Kosik KS, Nixon RA (1995) Three distinct axonal transport rates for tau, tubulin, and other microtubule-associated proteins: evedence for dynamic interactions of tau with microtubules in vivo. J Neurosci 15:8259-8267.
-
(1995)
J Neurosci
, vol.15
, pp. 8259-8267
-
-
Mercken, M.1
Fisher, I.2
Kosik, K.S.3
Nixon, R.A.4
-
27
-
-
0035131614
-
Molecular analysis of mutant and wild-type tau deposited in the brain affected by the FTDP-17 R406W mutation
-
Miyasaka T, Morishima-Kawashima M, Ravid R, Heutink P, van Swieten JC, Nagashima K, Ihara Y (2001) Molecular analysis of mutant and wild-type tau deposited in the brain affected by the FTDP-17 R406W mutation. Am J Pathol 158:373-379.
-
(2001)
Am J Pathol
, vol.158
, pp. 373-379
-
-
Miyasaka, T.1
Morishima-Kawashima, M.2
Ravid, R.3
Heutink, P.4
Van Swieten, J.C.5
Nagashima, K.6
Ihara, Y.7
-
28
-
-
0032763203
-
Tau gene mutation G389R causes a tauopathy with abundant pick body-like inclusions and axonal deposits
-
Murrell JR, Spillantini MG, Zolo P, Guazzelli M, Smith MJ, Hasegawa M, Redi F, Crowther RA, Pietrini P, Ghetti B, Goedert M (1999) tau gene mutation G389R causes a tauopathy with abundant pick body-like inclusions and axonal deposits. J Neuropathol Exp Neurol 58:1207-1226.
-
(1999)
J Neuropathol Exp Neurol
, vol.58
, pp. 1207-1226
-
-
Murrell, J.R.1
Spillantini, M.G.2
Zolo, P.3
Guazzelli, M.4
Smith, M.J.5
Hasegawa, M.6
Redi, F.7
Crowther, R.A.8
Pietrini, P.9
Ghetti, B.10
Goedert, M.11
-
29
-
-
0342368837
-
The FTDP-17-linked mutation R406W abolishes the interaction of phosphorylated tau with microtubules
-
Perez M, Lim F, Arrasate M, Avila J (2000) The FTDP-17-linked mutation R406W abolishes the interaction of phosphorylated tau with microtubules. J Neurochem 74:2583-2589.
-
(2000)
J Neurochem
, vol.74
, pp. 2583-2589
-
-
Perez, M.1
Lim, F.2
Arrasate, M.3
Avila, J.4
-
30
-
-
0033669232
-
Pick's disease is associated with mutations in the tau gene
-
Pickering-Brown S, Baker M, Yen SH, Liu WK, Hasegawa M, Cairns N, Lantos PL, Rossor M, Iwatsubo T, Davies Y, Allsop D, Furlong R, Owen F, Hardy J, Mann D, Hutton M (2000) Pick's disease is associated with mutations in the tau gene. Ann Neurol 48:859-867.
-
(2000)
Ann Neurol
, vol.48
, pp. 859-867
-
-
Pickering-Brown, S.1
Baker, M.2
Yen, S.H.3
Liu, W.K.4
Hasegawa, M.5
Cairns, N.6
Lantos, P.L.7
Rossor, M.8
Iwatsubo, T.9
Davies, Y.10
Allsop, D.11
Furlong, R.12
Owen, F.13
Hardy, J.14
Mann, D.15
Hutton, M.16
-
31
-
-
14444284106
-
Tau is a candidate gene for chromosome 17 frontotemporal dementia
-
Poorkaj P, Bird TD, Wijsman E, Nemens E, Garruto RM, Anderson L, Andreadis A, Wiederholt WC, Raskind M, Schellenberg GD (1998) tau is a candidate gene for chromosome 17 frontotemporal dementia. Ann Neurol 43:815-825.
-
(1998)
Ann Neurol
, vol.43
, pp. 815-825
-
-
Poorkaj, P.1
Bird, T.D.2
Wijsman, E.3
Nemens, E.4
Garruto, R.M.5
Anderson, L.6
Andreadis, A.7
Wiederholt, W.C.8
Raskind, M.9
Schellenberg, G.D.10
-
32
-
-
0342803685
-
Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein
-
Probst A, Gotz J, Wiederhold KH, Tolnay M, Mistl C, Jaton AL, Lee VM-Y, Trojanowski JQ, Ishihara T, Hong M, Jakes R, Crowther RA, Spillantini MG, Burki K, Goedert M (2000) Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein. Acta Neuropathol 99:469-481.
-
(2000)
Acta Neuropathol
, vol.99
, pp. 469-481
-
-
Probst, A.1
Gotz, J.2
Wiederhold, K.H.3
Tolnay, M.4
Mistl, C.5
Jaton, A.L.6
Lee, V.M.-Y.7
Trojanowski, J.Q.8
Ishihara, T.9
Hong, M.10
Jakes, R.11
Crowther, R.A.12
Spillantini, M.G.13
Burki, K.14
Goedert, M.15
-
33
-
-
0030826625
-
Autosomal dominant dementia with widespread neurofibrillary tangles
-
Reed LA, Grabowski TJ, Schmidt ML, Morris JC, Goate A, Solodkin A, Van Hoesen GW, Schelper RL, Talbot CJ, Wragg MA, Trojanowski JQ (1997) Autosomal dominant dementia with widespread neurofibrillary tangles. Ann Neurol 42:564-572.
-
(1997)
Ann Neurol
, vol.42
, pp. 564-572
-
-
Reed, L.A.1
Grabowski, T.J.2
Schmidt, M.L.3
Morris, J.C.4
Goate, A.5
Solodkin, A.6
Van Hoesen, G.W.7
Schelper, R.L.8
Talbot, C.J.9
Wragg, M.A.10
Trojanowski, J.Q.11
-
34
-
-
0033763736
-
Tau gene mutation K257T causes a tauopathy similar to Pick's disease
-
Rizzini C, Goedert M, Hodges JR, Smith MJ, Jakes R, Hills R, Xuereb JH, Crowther RA, Spillantini MG (2000) tau gene mutation K257T causes a tauopathy similar to Pick's disease. J Neuropathol Exp Neurol 59:990-1001.
-
(2000)
J Neuropathol Exp Neurol
, vol.59
, pp. 990-1001
-
-
Rizzini, C.1
Goedert, M.2
Hodges, J.R.3
Smith, M.J.4
Jakes, R.5
Hills, R.6
Xuereb, J.H.7
Crowther, R.A.8
Spillantini, M.G.9
-
35
-
-
0033070197
-
High prevalence of mutations in the microtubule-associated protein tau in a population study of frontotemporal dementia in the Netherlands
-
Rizzu P, Van Swieten JC, Joosse M, Hasegawa M, Stevens M, Tibben A, Niermeijer MF, Hillebrand M, Ravid R, Oostra BA, Goedert M, van Duijn CM, Heutink P (1999) High prevalence of mutations in the microtubule-associated protein tau in a population study of frontotemporal dementia in The Netherlands. Am J Hum Genet 64:414-421.
-
(1999)
Am J Hum Genet
, vol.64
, pp. 414-421
-
-
Rizzu, P.1
Van Swieten, J.C.2
Joosse, M.3
Hasegawa, M.4
Stevens, M.5
Tibben, A.6
Niermeijer, M.F.7
Hillebrand, M.8
Ravid, R.9
Oostra, B.A.10
Goedert, M.11
Van Duijn, C.M.12
Heutink, P.13
-
36
-
-
0034193290
-
Missense point mutations of tau to segregate with FTDP-17 exhibit site-specific effects on microtubule structure in COS cells: A novel action of R406W mutation
-
Sahara N, Tomiyama T, Mori H (2000) Missense point mutations of tau to segregate with FTDP-17 exhibit site-specific effects on microtubule structure in COS cells: a novel action of R406W mutation. J Neurosci Res 60:380-387.
-
(2000)
J Neurosci Res
, vol.60
, pp. 380-387
-
-
Sahara, N.1
Tomiyama, T.2
Mori, H.3
-
37
-
-
0032560487
-
Mutation in the tau gene in familial multiple system tauopathy with presenile dementia
-
Spillantini MG, Murrell JR, Goedert M, Farlow MR, Klug A, Ghetti B (1998) Mutation in the tau gene in familial multiple system tauopathy with presenile dementia. Proc Natl Acad Sci USA 95:7737-7741.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 7737-7741
-
-
Spillantini, M.G.1
Murrell, J.R.2
Goedert, M.3
Farlow, M.R.4
Klug, A.5
Ghetti, B.6
-
38
-
-
0033663879
-
A novel tau mutation (N296N) in familial dementia with swollen achromatic neurons and corticobasal inclusion bodies
-
Spillantini MG, Yoshida H, Rizzini C, Lantos PL, Khan N, Rossor MN, Goedert M, Brown J (2000) A novel tau mutation (N296N) in familial dementia with swollen achromatic neurons and corticobasal inclusion bodies. Ann Neurol 48:939-943.
-
(2000)
Ann Neurol
, vol.48
, pp. 939-943
-
-
Spillantini, M.G.1
Yoshida, H.2
Rizzini, C.3
Lantos, P.L.4
Khan, N.5
Rossor, M.N.6
Goedert, M.7
Brown, J.8
-
39
-
-
0032786370
-
Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein
-
Spittaels K, Van den Haute C, Van Dorpe J, Bruynseels K, Vandezande K, Laenen I, Geerts H, Mercken M, Sciot R, Van Lommel A, Loos R, Van Leuven F (1999) Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein. Am J Pathol 155:2153-2165.
-
(1999)
Am J Pathol
, vol.155
, pp. 2153-2165
-
-
Spittaels, K.1
Van Den Haute, C.2
Van Dorpe, J.3
Bruynseels, K.4
Vandezande, K.5
Laenen, I.6
Geerts, H.7
Mercken, M.8
Sciot, R.9
Van Lommel, A.10
Loos, R.11
Van Leuven, F.12
-
40
-
-
0037128935
-
Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress
-
Stamer K, Vogel R, Thies E, Mandelkow E, Mandelkow EM (2002) tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress. J Cell Biol 156:1051-1063.
-
(2002)
J Cell Biol
, vol.156
, pp. 1051-1063
-
-
Stamer, K.1
Vogel, R.2
Thies, E.3
Mandelkow, E.4
Mandelkow, E.M.5
-
41
-
-
0034093228
-
Progressive supranuclear palsy pathology caused by a novel silent mutation in exon 10 of the tau gene: Expansion of the disease phenotype caused by tau gene mutations
-
Stanford PM, Halliday GM, Brooks WS, Kwok JB, Storey CE, Creasey H, Morris JG, Fulham MJ, Schofield PR (2000) Progressive supranuclear palsy pathology caused by a novel silent mutation in exon 10 of the tau gene: expansion of the disease phenotype caused by tau gene mutations. Brain 123:880-893.
-
(2000)
Brain
, vol.123
, pp. 880-893
-
-
Stanford, P.M.1
Halliday, G.M.2
Brooks, W.S.3
Kwok, J.B.4
Storey, C.E.5
Creasey, H.6
Morris, J.G.7
Fulham, M.J.8
Schofield, P.R.9
-
42
-
-
0036138044
-
Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau
-
Tanemura K, Murayama M, Akagi T, Hashikawa T, Tominaga T, Ichikawa M, Yamaguchi H, Takashima A (2002) Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau. J Neurosci 22:133-141.
-
(2002)
J Neurosci
, vol.22
, pp. 133-141
-
-
Tanemura, K.1
Murayama, M.2
Akagi, T.3
Hashikawa, T.4
Tominaga, T.5
Ichikawa, M.6
Yamaguchi, H.7
Takashima, A.8
-
43
-
-
0037108953
-
Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau
-
Tatebayashi Y, Miyasaka T, Chui D-H, Akagi T, Mishima K-I, Iwasaki K, Fujiwara M, Tanemura K, Murayama M, Ishiguro K, Planel E, Sato S, Hashikawa T, Takashima A (2002) tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau. Proc Natl Acad Sci USA 99:13896-13901.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 13896-13901
-
-
Tatebayashi, Y.1
Miyasaka, T.2
Chui, D.-H.3
Akagi, T.4
Mishima, K.-I.5
Iwasaki, K.6
Fujiwara, M.7
Tanemura, K.8
Murayama, M.9
Ishiguro, K.10
Planel, E.11
Sato, S.12
Hashikawa, T.13
Takashima, A.14
-
44
-
-
0029052277
-
Overexpression of the human NFM subunit in transgenic mice modifies the level of endogenous NFL and the phosphorylation state of NFH subunits
-
Tu PH, Elder G, Lazzarini RA, Nelson D, Trojanowski JQ, Lee VM-Y (1995) Overexpression of the human NFM subunit in transgenic mice modifies the level of endogenous NFL and the phosphorylation state of NFH subunits. J Cell Biol 129:1629-1640.
-
(1995)
J Cell Biol
, vol.129
, pp. 1629-1640
-
-
Tu, P.H.1
Elder, G.2
Lazzarini, R.A.3
Nelson, D.4
Trojanowski, J.Q.5
Lee, V.M.-Y.6
-
45
-
-
0029966363
-
Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions
-
Tu PH, Raju P, Robinson KA, Gurney ME, Trojanowski JQ, Lee VM-Y (1996) Transgenic mice carrying a human mutant superoxide dismutase transgene develop neuronal cytoskeletal pathology resembling human amyotrophic lateral sclerosis lesions. Proc Natl Acad Sci USA 93:3155-3160.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 3155-3160
-
-
Tu, P.H.1
Raju, P.2
Robinson, K.A.3
Gurney, M.E.4
Trojanowski, J.Q.5
Lee, V.M.-Y.6
-
46
-
-
0036703743
-
The slow axonal transport of the microtubule-associated protein tau and the transport rates of different isoforms and mutants in cultured neurons
-
Utton MA, Connell J, Asuni AA, Slegtenhorst MV, Hutton M, Silva RD, Lees AJ, Miller CCJ, Anderton BH (2002) The slow axonal transport of the microtubule-associated protein tau and the transport rates of different isoforms and mutants in cultured neurons. J Neurosci 22:6394-6400.
-
(2002)
J Neurosci
, vol.22
, pp. 6394-6400
-
-
Utton, M.A.1
Connell, J.2
Asuni, A.A.3
Slegtenhorst, M.V.4
Hutton, M.5
Silva, R.D.6
Lees, A.J.7
Miller, C.C.J.8
Anderton, B.H.9
-
47
-
-
0032880430
-
Phenotypic variation in hereditary frontotemporal dementia with tau mutations
-
Van Swieten JC, Stevens M, Rosso SM, Rizzu P, Joosse M, de Koning I, Kamphorst W, Ravid R, Spillantini MG, Niermeijer MF, Heutink P (1999) Phenotypic variation in hereditary frontotemporal dementia with tau mutations. Ann Neurol 46:617-626.
-
(1999)
Ann Neurol
, vol.46
, pp. 617-626
-
-
Van Swieten, J.C.1
Stevens, M.2
Rosso, S.M.3
Rizzu, P.4
Joosse, M.5
De Koning, I.6
Kamphorst, W.7
Ravid, R.8
Spillantini, M.G.9
Niermeijer, M.F.10
Heutink, P.11
-
48
-
-
0033529304
-
Structure of tau exon 10 splicing regulatory element RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17
-
Varani L, Hasegawa M, Spillantini MG, Smith MJ, Murrell JR, Ghetti B, Klug A, Goedert M, Varani G (1999) Structure of tau exon 10 splicing regulatory element RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17. Proc Natl Acad Sci USA 96:8229-8234.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 8229-8234
-
-
Varani, L.1
Hasegawa, M.2
Spillantini, M.G.3
Smith, M.J.4
Murrell, J.R.5
Ghetti, B.6
Klug, A.7
Goedert, M.8
Varani, G.9
-
49
-
-
0033638377
-
Distinct FTDP-17 missense mutations in tau produce tau aggregates and other pathological phenotypes in transfected CHO cells
-
Vogelsberg-Ragaglia V, Bruce J, Richter-Landsberg C, Zhang B, Hong M, Trojanowski JQ, Lee VM-Y (2000) Distinct FTDP-17 missense mutations in tau produce tau aggregates and other pathological phenotypes in transfected CHO cells Mol Biol Cell 11:4093-4104.
-
(2000)
Mol Biol Cell
, vol.11
, pp. 4093-4104
-
-
Vogelsberg-Ragaglia, V.1
Bruce, J.2
Richter-Landsberg, C.3
Zhang, B.4
Hong, M.5
Trojanowski, J.Q.6
Lee, V.M.-Y.7
-
50
-
-
0033546987
-
A mutation in the microtubule-associated protein tau in pallido-nigro-luysian degeneration
-
Yasuda M, Kawamata T, Komure O, Kuno S, D'Souza I, Poorkaj P, Kawai J, Tanimukai S, Yamamoto Y, Hasegawa H, Sasahara M, Hazama F, Schellenberg GD, Tanaka C (1999) A mutation in the microtubule-associated protein tau in pallido-nigro-luysian degeneration. Neurology 53:864-868.
-
(1999)
Neurology
, vol.53
, pp. 864-868
-
-
Yasuda, M.1
Kawamata, T.2
Komure, O.3
Kuno, S.4
D'Souza, I.5
Poorkaj, P.6
Kawai, J.7
Tanimukai, S.8
Yamamoto, Y.9
Hasegawa, H.10
Sasahara, M.11
Hazama, F.12
Schellenberg, G.D.13
Tanaka, C.14
-
51
-
-
0034074542
-
A novel mutation at posititon +12 in the intron following exon 10 of the tau gene in familial frontotemporal dementia (FTD-Kumamoto)
-
Yasuda M, Takamatsu J, D'Souza I, Crowther RA, Kawamata T, Hasegawa M, Hasegawa H, Spillantini MG, Tanimukai S, Poorkaj P, Varani L, Varani G, Iwatsubo T, Goedert M, Schellenberg DG, Tanaka C (2000) A novel mutation at posititon +12 in the intron following exon 10 of the tau gene in familial frontotemporal dementia (FTD-Kumamoto). Ann Neurol 47:422-429.
-
(2000)
Ann Neurol
, vol.47
, pp. 422-429
-
-
Yasuda, M.1
Takamatsu, J.2
D'Souza, I.3
Crowther, R.A.4
Kawamata, T.5
Hasegawa, M.6
Hasegawa, H.7
Spillantini, M.G.8
Tanimukai, S.9
Poorkaj, P.10
Varani, L.11
Varani, G.12
Iwatsubo, T.13
Goedert, M.14
Schellenberg, D.G.15
Tanaka, C.16
-
52
-
-
0030817291
-
Neurofilaments and orthograde transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutation
-
Zhang B, Tu P, Abtahian F, Trojanowski JQ, Lee VM-Y (1997) Neurofilaments and orthograde transport are reduced in ventral root axons of transgenic mice that express human SOD1 with a G93A mutation. J Cell Biol 139:1307-1315.
-
(1997)
J Cell Biol
, vol.139
, pp. 1307-1315
-
-
Zhang, B.1
Tu, P.2
Abtahian, F.3
Trojanowski, J.Q.4
Lee, V.M.-Y.5
|