Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 1, 2005, Pages 227-231

  Zhang, Bin ^a   Maiti, Arpita ^c   Shively, Sharon ^a   Lakhani, Fara ^c   McDonald Jones, Gaye ^c   Bruce, Jennifer ^a   Lee, Edward B ^a   Xie, Sharon X ^b   Joyce, Sonali ^a   Li, Chi ^a   Toleikis, Philip M ^c   Lee, Virginia M Y ^a   Trojanowski, John Q ^a,d  

^a Institute on Aging   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c Angiotech Pharmaceuticals Inc   (Canada)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Neurodegeneration; Paxceed; Therapy; Transgenic mice; Ventral root

Indexed keywords

PACLITAXEL; TAU PROTEIN; TUBULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG DOSE REGIMEN; DRUG MEGADOSE; HYPOTHESIS; LOW DRUG DOSE; MICROTUBULE; MOTOR DYSFUNCTION; MOUSE; NERVE DEGENERATION; NERVE FIBER; NERVE FIBER TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN STABILITY; SHAM FEEDING; SPINAL NERVE; TRANSGENIC MOUSE;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; AXONS; MICE; MICE, TRANSGENIC; MICROTUBULES; PACLITAXEL; SPINAL CORD; TAU PROTEINS;

ANIMALIA; MUS MUSCULUS;

EID: 19944429064     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0406361102     Document Type: Article

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