Sodium selenate specifically activates PP2A phosphatase, dephosphorylates tau and reverses memory deficits in an Alzheimer's disease model

Journal of Clinical Neuroscience

Volumn 17, Issue 8, 2010, Pages 1025-1033

  Corcoran, Niall M ^a,b   Martin, Daniel ^a   Hutter Paier, Birgit ^c   Windisch, Manfred ^c   Nguyen, Thanh ^a   Nheu, Lina ^a   Sundstrom, Lars E ^d   Costello, Anthony J ^a,b   Hovens, Christopher M ^a,b  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b Velacor Therapeutics Pty Ltd   (Australia)

^c JSW Life Sciences GmbH   (Austria)

^d Capsant Neurotechnologies Ltd   (United Kingdom)

Author keywords

Alzheimer's disease; Dementia; PP2A; Sodium selenate; Tau

Indexed keywords

PHOSPHATASE; PROTEIN PP2A; SELENATE; TAU PROTEIN; UNCLASSIFIED DRUG; PHOSPHOPROTEIN PHOSPHATASE 2; SELENIC ACID; SELENIUM DERIVATIVE;

ALZHEIMER DISEASE; AMNESIA; AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HIPPOCAMPUS; HUMAN; HUMAN CELL; LEARNING; MALE; MAZE TEST; MEMORY; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; TRANSGENIC MOUSE; ANALYSIS OF VARIANCE; ANIMAL; CELL CULTURE; DISEASE MODEL; DRUG EFFECTS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MEMORY DISORDERS; METABOLISM; ORGAN CULTURE TECHNIQUE; PATHOPHYSIOLOGY; PHOSPHORYLATION; RAT; ROTAROD TEST; TUMOR CELL LINE; WESTERN BLOTTING; WISTAR RAT;

ALZHEIMER DISEASE; ANALYSIS OF VARIANCE; ANIMALS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELLS, CULTURED; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; HUMANS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; ORGAN CULTURE TECHNIQUES; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; RATS; RATS, WISTAR; ROTAROD PERFORMANCE TEST; SELENIUM COMPOUNDS; TAU PROTEINS; SELENIC ACID;

EID: 77954085078     PISSN: 09675868     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jocn.2010.04.020     Document Type: Article

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