Hyperdynamic microtubules, cognitive deficits, and pathology are improved in tau transgenic mice with low doses of the microtubule-stabilizing agent BMS-241027

Journal of Neuroscience

Volumn 32, Issue 21, 2012, Pages 7137-7145

  Barten, Donna M ^a   Fanara, Patrizia ^b   Andorfer, Cathy ^c   Hoque, Nina ^a   Anne Wong, P Y ^b   Husted, Kristofor H ^b   Cadelina, Gregory W ^a   DeCarr, Lynn B ^a   Yang, Ling ^a   Liu, Victoria ^b   Fessler, Chancy ^b   Protassio, Joan ^b   Riff, Timothy ^b   Turner, Holly ^b   Janus, Christopher G ^c   Sankaranarayanan, Sethu ^a   Polson, Craig ^a   Meredith, Jere E ^a   Gray, Gemma ^c   Hanna, Amanda ^c   Olson, Richard E ^a   Kim, Soong Hoon ^a   Vite, Gregory D ^a   Lee, Francis Y ^a   Albright, Charles F ^a   more..

^a BRISTOL MYERS SQUIBB   (United States)

^b KINEMED INC   (United States)

^c MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TUBULIN; DOXYCYCLINE; EPOTHILONE D; MICROTUBULE ASSOCIATED PROTEIN 2; TAU PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CELL LOSS; COGNITIVE DEFECT; CONTROLLED STUDY; FEMALE; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; LOW DRUG DOSE; MALE; MASS SPECTROMETRY; MAZE TEST; MICROTUBULE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TAUOPATHY; TRANSGENIC MOUSE; WESTERN BLOTTING;

ANIMALS; BRAIN; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXYCYCLINE; DRUG EVALUATION, PRECLINICAL; EPOTHILONES; FEMALE; HIPPOCAMPUS; MALE; MAZE LEARNING; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROTUBULES; NERVE DEGENERATION; TAU PROTEINS; TAUOPATHIES; TUBULIN MODULATORS;

EID: 84861313192     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0188-12.2012     Document Type: Article

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