The carboxy-terminal fragment of inhibitor-2 of protein phosphatase-2A induces Alzheimer disease pathology and cognitive impairment

FASEB Journal

Volumn 24, Issue 11, 2010, Pages 4420-4432

  Wang, Xiaochuan ^a,c   Blanchard, Julie ^a   Kohlbrenner, Erik ^b   Clement, Nathalie ^b,d   Linden, R Michael ^b,e   Radu, Aurelian ^b   Grundke Iqbal, Inge ^a   Iqbal, Khalid ^a  

^a NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^d UNIVERSITY OF FLORIDA   (United States)

^e KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

A ; Adeno associated virus induced expression; Glycogen synthase kinase 3 ; Hyperphosphorylation of tau; Neurofibrillary degeneration; Nontransgenic rat model of Alzheimer disease; SET

Indexed keywords

AMYLOID BETA PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; ENHANCED GREEN FLUORESCENT PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; PHOSPHOPROTEIN PHOSPHATASE 2A; SERINE; TAU PROTEIN;

ADENOVIRUS; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; CARBOXY TERMINAL SEQUENCE; COGNITIVE DEFECT; CONTROLLED STUDY; ENZYME ACTIVITY; MAZE TEST; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SPATIAL MEMORY;

ADENOVIRIDAE; ALZHEIMER DISEASE; ANIMALS; CARRIER PROTEINS; CELL LINE; COGNITION DISORDERS; DENDRITES; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; GLYCOGEN SYNTHASE KINASE 3; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HUMANS; MICE; NEURONS; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; SYNAPSES; TAU PROTEINS;

ADENO-ASSOCIATED VIRUS; ANIMALIA; RATTUS;

EID: 78649859760     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.10-158477     Document Type: Article

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