Reducing endogenous tau ameliorates amyloid β-induced deficits in an Alzheimer's disease mouse model

Science

Volumn 316, Issue 5825, 2007, Pages 750-754

  Roberson, Erik D ^a   Scearce Levie, Kimberly ^a   Palop, Jorge J ^a   Yan, Fengrong ^a   Cheng, Irene H ^a   Wu, Tiffany ^a   Gerstein, Hilary ^a   Yu, Gui Qiu ^a   Mucke, Lennart ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BRAIN PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; TAU PROTEIN;

DISEASE TREATMENT; NERVOUS SYSTEM DISORDER; PROTEIN; RODENT;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR DISORDER; BRAIN DYSFUNCTION; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE ASSOCIATION; EXCITOTOXICITY; LOCOMOTION; MAZE TEST; MOUSE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; AXONS; CONVULSANTS; DISEASE MODELS, ANIMAL; EXCITATORY AMINO ACID AGONISTS; EXPLORATORY BEHAVIOR; HIPPOCAMPUS; HUMANS; KAINIC ACID; MAZE LEARNING; MEMORY; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOTOR ACTIVITY; PENTYLENETETRAZOLE; PHOSPHORYLATION; SEIZURES; TAU PROTEINS;

MUS; MUS MUSCULUS;

EID: 34248181511     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1141736     Document Type: Article

References (33)

1. R. Tanzi, L. Bertram, Cell 120, 545 (2005).
2. J. Lewis et al., Science 293, 1487 (2001).
3. M. Rapoport, H. N. Dawson, L. I. Binder, M. P. Vitek, A. Ferreira, Proc. Natl. Acad. Sci. U.S.A. 99, 6364 (2002).
4. S. Oddo, L. Billings, J. P. Kesslak, D. H. Cribbs, F. M. LaFerla, Neuron 43, 321 (2004).
5. C. X. Gong, F. Liu, I. Grundke-Iqbal, K. Igbal, J. Neural Transm. 112, 813 (2005).
6. K. Iqbal et al., Biochim. Biophys. Acta 1739, 198 (2005).
7. W. H. Stoothoff, G. V. Johnson, Biochim. Biophys. Acta 1739, 280 (2005).
8. I. Khlistunova et al., J. Biol. Chem. 281, 1205 (2006).
9. C. A. Dickey et al., FASEB J. 20, 753 (2006).
10. A. J. Myers et al., Hum. Mol. Genet. 14, 2399 (2005).
11. L. Mucke et al., J. Neurosci. 20, 4050 (2000).
12. H. N. Dawson et al., J. Cell Sci. 114, 1179 (2001).
13. Materials and methods are available as supporting material on Science Online.
14. J. J. Palop et al., Proc. Natl. Acad. Sci. U.S.A. 100, 9572 (2003).
15. D. T. Kobayashi, K. S. Chen, Genes Brain Behav. 4, 173 (2005).
16. O. Steward, J. Loesche, W. C. Horton, Brain Res. Bull. 2, 41 (1977).
17. K. K. Hsiao et al., Neuron 15, 1203 (1995).
18. J. Chin et al., J. Neurosci. 24, 4692 (2004).
19. S. Lesné et al., Nature 440, 352 (2006).
20. E. Planel et al., J. Neurosci. 24, 2401 (2004).
21. S. Y. Park, A. Ferreira, J. Neurosci. 25, 5365 (2005).
22. T. Liu et al., J. Neurochem. 88, 554 (2004).
23. K. SantaCruz et al., Science 309, 476 (2005).
24. R. B. Knowles et al., Proc. Natl. Acad. Sci. U.S.A. 96, 5274 (1999).
25. J. W. Geddes et al., Science 230, 1179 (1985).
26. M. P. Mattson, Nature 430, 631 (2004).
27. J. W. Olney, D. F. Wozniak, N. 8. Farber, Arch. Neurol. 54, 1234 (1997).
28. J. C. Amatniek et al., Epilepsia 47, 867 (2006).
29. R. A. Del Vecchio, L. H. Gold, S. J. Novick, G. Wong, L. A. Hyde, Neurosci. Lett. 367, 164 (2004).
30. J. J. Palop, J. Chin, L. Mucke, Nature 443, 768 (2006).
31. J. R. Lupski, Not. Genet. 38, 974 (2006).
32. F. Holsboer, Curr. Opin. Investig. Drugs 4, 46 (2003).
33. We thank M. Vitek and H. Dawson for tau knockout mice; P. Seubert and P. Davies for antibodies; H. Solanoy, X. Wang, and Y. Zhou for technical assistance; C. McCullough for advice on statistics; D. McPherson and L. Manuntag for administrative support; and G. Howard and S. Ordway for editorial review. L.M. received consulting fees from Merck and honoraria from Amgen, Elan, and Pfizer. E.D.R. received consulting fees from Rinat Neuroscience. Supported by NIH grants AG01138S and AG022074 (L.M.), MH070588 (K.S.L), and NS054811 (E.D.R); the Giannini Foundation (E.D.R.); the S.D. Bechtel Jr. Young Investigator Award (E.D.R.); and the NIH National Center for Research Resources grant RR18928-01.