메뉴 건너뛰기




Volumn , Issue , 2011, Pages

Modelling tauopathies in Drosophila: Insights from the fruit fly

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; CHAPERONE; ISOPROTEIN; TAU PROTEIN;

EID: 84855535702     PISSN: None     EISSN: 20900252     Source Type: Journal    
DOI: 10.4061/2011/598157     Document Type: Review
Times cited : (12)

References (108)
  • 3
    • 0025904444 scopus 로고
    • A68: A major subunit of paired helical filaments and derivatized forms of normal tau
    • Lee V. M. Y., Balin B. J., Otvos L., Trojanowski J. Q., A68: a major subunit of paired helical filaments and derivatized forms of normal tau Science 1991 251 4994 675 678 (Pubitemid 21916893)
    • (1991) Science , vol.251 , Issue.4994 , pp. 675-678
    • Lee, V.M.-Y.1    Balin, B.J.2    Otvos Jr., L.3    Trojanowski, J.Q.4
  • 4
    • 0034282067 scopus 로고    scopus 로고
    • Conformational change as one of the earliest alterations of tau in Alzheimer's disease
    • Weaver C. L., Espinoza M., Kress Y., Davies P., Conformational change as one of the earliest alterations of tau in Alzheimer's disease Neurobiology of Aging 2000 21 5 719 727
    • (2000) Neurobiology of Aging , vol.21 , Issue.5 , pp. 719-727
    • Weaver, C.L.1    Espinoza, M.2    Kress, Y.3    Davies, P.4
  • 5
    • 0024745894 scopus 로고
    • Multiple isoforms of human microtubule-associated protein tau: Sequences and localization in neurofibrillary tangles of Alzheimer's disease
    • Goedert M., Spillantini M. G., Jakes R., Rutherford D., Crowther R. A., Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease Neuron 1989 3 4 519 526
    • (1989) Neuron , vol.3 , Issue.4 , pp. 519-526
    • Goedert, M.1    Spillantini, M.G.2    Jakes, R.3    Rutherford, D.4    Crowther, R.A.5
  • 6
    • 0031949084 scopus 로고    scopus 로고
    • Frontotemporal dementia and Parkinsonism linked to chromosome 17: A new group of tauopathies
    • Spillantini M. G., Bird T. D., Ghetti B., Frontotemporal dementia and Parkinsonism linked to chromosome 17: a new group of tauopathies Brain Pathology 1998 8 2 387 402 (Pubitemid 28186074)
    • (1998) Brain Pathology , vol.8 , Issue.2 , pp. 387-402
    • Spillantini, M.G.1    Bird, T.D.2    Ghetti, B.3
  • 9
    • 77953675879 scopus 로고    scopus 로고
    • Probing the biology of Alzheimer's disease in mice
    • Ashe K. H., Zahs K. R., Probing the biology of Alzheimer's disease in mice Neuron 2010 66 5 631 645
    • (2010) Neuron , vol.66 , Issue.5 , pp. 631-645
    • Ashe, K.H.1    Zahs, K.R.2
  • 10
    • 79960284291 scopus 로고    scopus 로고
    • The power and richness of modelling tauopathies in Drosophila
    • Papanikolopoulou K., Skoulakis E. M. C., The power and richness of modelling tauopathies in Drosophila Molecular Neurobiology 2011 44 1 122 133
    • (2011) Molecular Neurobiology , vol.44 , Issue.1 , pp. 122-133
    • Papanikolopoulou, K.1    Skoulakis, E.M.C.2
  • 11
    • 65449156394 scopus 로고    scopus 로고
    • SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans
    • Guthrie C. R., Schellenberg G. D., Kraemer B. C., SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans Human Molecular Genetics 2009 18 10 1825 1838
    • (2009) Human Molecular Genetics , vol.18 , Issue.10 , pp. 1825-1838
    • Guthrie, C.R.1    Schellenberg, G.D.2    Kraemer, B.C.3
  • 12
    • 79955749505 scopus 로고    scopus 로고
    • Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery
    • Pandey U. B., Nichols C. D., Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery Pharmacological Reviews 2011 63 2 411 436
    • (2011) Pharmacological Reviews , vol.63 , Issue.2 , pp. 411-436
    • Pandey, U.B.1    Nichols, C.D.2
  • 13
    • 10644276290 scopus 로고    scopus 로고
    • Drosophila, the golden bug, emerges as a tool for human genetics
    • DOI 10.1038/nrg1503
    • Bier E., Drosophila, the golden bug, emerges as a tool for human genetics Nature Reviews Genetics 2005 6 1 9 23 (Pubitemid 39657894)
    • (2005) Nature Reviews Genetics , vol.6 , Issue.1 , pp. 9-23
    • Bier, E.1
  • 14
    • 33749242234 scopus 로고    scopus 로고
    • Drosophila in the study of neurodegenerative disease
    • DOI 10.1016/j.neuron.2006.09.025, PII S089662730600732X
    • Marsh J. L., Thompson L. M., Drosophila in the study of neurodegenerative disease Neuron 2006 52 1 169 178 (Pubitemid 44479830)
    • (2006) Neuron , vol.52 , Issue.1 , pp. 169-178
    • Marsh, J.L.1    Thompson, L.M.2
  • 15
    • 77950458277 scopus 로고    scopus 로고
    • Transgenic Drosophila models of Alzheimer's disease and tauopathies
    • Iijima-Ando K., Iijima K., Transgenic Drosophila models of Alzheimer's disease and tauopathies Brain Structure and Function 2010 214 2-3 245 262
    • (2010) Brain Structure and Function , vol.214 , Issue.23 , pp. 245-262
    • Iijima-Ando, K.1    Iijima, K.2
  • 17
    • 77954366328 scopus 로고    scopus 로고
    • Disruption of lysosome function promotes tumor growth and metastasis in Drosophila
    • Chi C., Zhu H., Han M., Zhuang Y., Wu X., Xu T., Disruption of lysosome function promotes tumor growth and metastasis in Drosophila Journal of Biological Chemistry 2010 285 28 21817 21823
    • (2010) Journal of Biological Chemistry , vol.285 , Issue.28 , pp. 21817-21823
    • Chi, C.1    Zhu, H.2    Han, M.3    Zhuang, Y.4    Wu, X.5    Xu, T.6
  • 18
    • 33750006528 scopus 로고    scopus 로고
    • Drosophila melanogaster neurobiology, neuropharmacology, and how the fly can inform central nervous system drug discovery
    • DOI 10.1016/j.pharmthera.2006.05.012, PII S0163725806001124
    • Nichols C. D., Drosophila melanogaster neurobiology, neuropharmacology, and how the fly can inform central nervous system drug discovery Pharmacology and Therapeutics 2006 112 3 677 700 (Pubitemid 44573493)
    • (2006) Pharmacology and Therapeutics , vol.112 , Issue.3 , pp. 677-700
    • Nichols, C.D.1
  • 19
    • 0027160708 scopus 로고
    • Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    • Brand A. H., Perrimon N., Targeted gene expression as a means of altering cell fates and generating dominant phenotypes Development 1993 118 2 401 415 (Pubitemid 23214028)
    • (1993) Development , vol.118 , Issue.2 , pp. 401-415
    • Brand, A.H.1    Perrimon, N.2
  • 20
    • 33750508956 scopus 로고    scopus 로고
    • Refined spatial manipulation of neuronal function by combinatorial restriction of transgene expression
    • DOI 10.1016/j.neuron.2006.08.028, PII S089662730600674X
    • Luan H., Peabody N. C., Vinson C., White B. H., Refined spatial manipulation of neuronal function by combinatorial restriction of transgene expression Neuron 2006 52 3 425 436 (Pubitemid 44667428)
    • (2006) Neuron , vol.52 , Issue.3 , pp. 425-436
    • Luan, H.1    Peabody, N.C.2    Vinson, CharlesR.3    White, B.H.4
  • 21
    • 4444277115 scopus 로고    scopus 로고
    • Refining GAL4-driven transgene expression in Drosophila with a GAL80 enhancer-trap
    • DOI 10.1002/gene.20051
    • Suster M. L., Seugnet L., Bate M., Sokolowski M. B., Refining GAL4-driven transgene expression in Drosophila with a GAL80 enhancer-trap Genesis 2004 39 4 240 245 (Pubitemid 39201545)
    • (2004) Genesis , vol.39 , Issue.4 , pp. 240-245
    • Suster, M.L.1    Seugnet, L.2    Bate, M.3    Sokolowski, M.B.4
  • 22
    • 0345168202 scopus 로고    scopus 로고
    • Spatiotemporal rescue of memory dysfunction in drosophila
    • DOI 10.1126/science.1089035
    • McGuire S. E., Le P. T., Osborn A. J., Matsumoto K., Davis R. L., Spatiotemporal rescue of memory dysfunction in Drosophila Science 2003 302 5651 1765 1768 (Pubitemid 37505740)
    • (2003) Science , vol.302 , Issue.5651 , pp. 1765-1768
    • McGuire, S.E.1    Le, P.T.2    Osborn, A.J.3    Matsumoto, K.4    Davis, R.L.5
  • 24
    • 40849136610 scopus 로고    scopus 로고
    • Spatial and temporal control of gene expression in drosophila using the inducible geneSwitch GAL4 system. I. Screen for larval nervous system drivers
    • DOI 10.1534/genetics.107.081968
    • Nicholson L., Singh G. K., Osterwalder T., Roman G. W., Davis R. L., Keshishian H., Spatial and temporal control of gene expression in Drosophila using the inducible geneSwitch GAL4 system. I. Screen for larval nervous system drivers Genetics 2008 178 1 215 234 (Pubitemid 351398742)
    • (2008) Genetics , vol.178 , Issue.1 , pp. 215-234
    • Nicholson, L.1    Singh, G.K.2    Osterwalder, T.3    Roman, G.W.4    Davis, R.L.5    Keshishian, H.6
  • 25
    • 78649723354 scopus 로고    scopus 로고
    • Glial fibrillary tangles and JAK/STAT-mediated glial and neuronal cell death in a Drosophila model of glial tauopathy
    • Colodner K. J., Feany M. B., Glial fibrillary tangles and JAK/STAT-mediated glial and neuronal cell death in a Drosophila model of glial tauopathy Journal of Neuroscience 2010 30 48 16102 16113
    • (2010) Journal of Neuroscience , vol.30 , Issue.48 , pp. 16102-16113
    • Colodner, K.J.1    Feany, M.B.2
  • 28
    • 0036741796 scopus 로고    scopus 로고
    • GAL4 system in Drosophila: A fly geneticist's Swiss army knife
    • Duffy J. B., GAL4 system in Drosophila: a fly geneticist's Swiss army knife Genesis 2002 34 1-2 1 15
    • (2002) Genesis , vol.34 , Issue.12 , pp. 1-15
    • Duffy, J.B.1
  • 29
    • 0037118247 scopus 로고    scopus 로고
    • Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila
    • DOI 10.1016/S0896-6273(02)00706-7
    • Jackson G. R., Wiedau-Pazos M., Sang T. K., Wagle N., Brown C. A., Massachi S., Geschwind D. H., Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila Neuron 2002 34 4 509 519 (Pubitemid 34628749)
    • (2002) Neuron , vol.34 , Issue.4 , pp. 509-519
    • Jackson, G.R.1    Wiedau-Pazos, M.2    Sang, T.-K.3    Wagle, N.4    Brown, C.A.5    Massachi, S.6    Geschwind, D.H.7
  • 30
    • 33947286683 scopus 로고    scopus 로고
    • Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo
    • DOI 10.1038/ncb1528, PII NCB1528
    • Fulga T. A., Elson-Schwab I., Khurana V., Steinhilb M. L., Spires T. L., Hyman B. T., Feany M. B., Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo Nature Cell Biology 2007 9 2 139 148 (Pubitemid 46420856)
    • (2007) Nature Cell Biology , vol.9 , Issue.2 , pp. 139-148
    • Fulga, T.A.1    Elson-Schwab, I.2    Khurana, V.3    Steinhilb, M.L.4    Spires, T.L.5    Hyman, B.T.6    Feany, M.B.7
  • 32
    • 0346361872 scopus 로고    scopus 로고
    • Genetic modifiers of tauopathy in drosophila
    • Shulman J. M., Feany M. B., Genetic modifiers of tauopathy in Drosophila Genetics 2003 165 3 1233 1242 (Pubitemid 38020245)
    • (2003) Genetics , vol.165 , Issue.3 , pp. 1233-1242
    • Shulman, J.M.1    Feany, M.B.2
  • 33
    • 33744994326 scopus 로고    scopus 로고
    • Biochemical investigation of Tau protein phosphorylation status and its solubility properties in Drosophila
    • DOI 10.1016/j.bbrc.2006.05.112, PII S0006291X06011399
    • Chau K. W. K., Chan W. Y., Shaw P. C., Chan H. Y. E., Biochemical investigation of tau protein phosphorylation status and its solubility properties in Drosophila Biochemical and Biophysical Research Communications 2006 346 1 150 159 (Pubitemid 43865979)
    • (2006) Biochemical and Biophysical Research Communications , vol.346 , Issue.1 , pp. 150-159
    • Chau, K.W.-K.1    Chan, W.-Y.2    Shaw, P.C.3    Chan, H.-Y.E.4
  • 34
    • 33749473333 scopus 로고    scopus 로고
    • Inhibition of proteasome and shaggy/glycogen synthase kinase-3β kinase prevents clearance of phosphorylated tau in Drosophila
    • DOI 10.1002/jnr.21006
    • Blard O., Frébourg T., Campion D., Lecourtois M., Inhibition of proteasome and shaggy/glycogen synthase kinase-3 kinase prevents clearance of phosphorylated tau in Drosophila Journal of Neuroscience Research 2006 84 5 1107 1115 (Pubitemid 44521055)
    • (2006) Journal of Neuroscience Research , vol.84 , Issue.5 , pp. 1107-1115
    • Blard, O.1    Frebourg, T.2    Campion, D.3    Lecourtois, M.4
  • 35
    • 34047106848 scopus 로고    scopus 로고
    • Cytoskeleton proteins are modulators of mutant tau-induced neurodegeneration in Drosophila
    • DOI 10.1093/hmg/ddm011
    • Blard O., Feuillette S., Bou J., Chaumette B., Frébourg T., Campion D., Lecourtois M., Cytoskeleton proteins are modulators of mutant tau-induced neurodegeneration in Drosophila Human Molecular Genetics 2007 16 5 555 566 (Pubitemid 46522618)
    • (2007) Human Molecular Genetics , vol.16 , Issue.5 , pp. 555-566
    • Blard, O.1    Feuillette, S.2    Bou, J.3    Chaumette, B.4    Frebourg, T.5    Campion, D.6    Lecourtois, M.7
  • 36
    • 77950940279 scopus 로고    scopus 로고
    • Drosophila models of human tauopathies indicate that tau protein toxicity in vivo is mediated by soluble cytosolic phosphorylated forms of the protein
    • Feuillette S., Miguel L., Frébourg T., Campion D., Lecourtois M., Drosophila models of human tauopathies indicate that tau protein toxicity in vivo is mediated by soluble cytosolic phosphorylated forms of the protein Journal of Neurochemistry 2010 113 4 895 903
    • (2010) Journal of Neurochemistry , vol.113 , Issue.4 , pp. 895-903
    • Feuillette, S.1    Miguel, L.2    Frébourg, T.3    Campion, D.4    Lecourtois, M.5
  • 37
    • 57649203362 scopus 로고    scopus 로고
    • Dissociation of tau toxicity and phosphorylation: Role of GSK-3 , MARK and Cdk5 in a Drosophila model
    • Chatterjee S., Sang T. K., Lawless G. M., Jackson G. R., Dissociation of tau toxicity and phosphorylation: role of GSK-3, MARK and Cdk5 in a Drosophila model Human Molecular Genetics 2009 18 1 164 177
    • (2009) Human Molecular Genetics , vol.18 , Issue.1 , pp. 164-177
    • Chatterjee, S.1    Sang, T.K.2    Lawless, G.M.3    Jackson, G.R.4
  • 39
    • 22244450095 scopus 로고    scopus 로고
    • Aberrant lysosomal carbohydrate storage accompanies endocytic defects and neurodegeneration in Drosophila benchwarmer
    • DOI 10.1083/jcb.200412001
    • Dermaut B., Norga K. K., Kania A., Verstreken P., Pan H., Zhou Y., Callaerts P., Bellen H. J., Aberrant lysosomal carbohydrate storage accompanies endocytic defects and neurodegeneration in Drosophila benchwarmer Journal of Cell Biology 2005 170 1 127 139 (Pubitemid 40994102)
    • (2005) Journal of Cell Biology , vol.170 , Issue.1 , pp. 127-139
    • Dermaut, B.1    Norga, K.K.2    Kania, A.3    Verstreken, P.4    Pan, H.5    Zhou, Y.6    Callaerts, P.7    Bellen, H.J.8
  • 40
    • 31944434543 scopus 로고    scopus 로고
    • TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model
    • DOI 10.1016/j.cub.2005.12.042, PII S0960982206010256
    • Khurana V., Lu Y., Steinhilb M. L., Oldham S., Shulman J. M., Feany M. B., TOR-mediated cell-cycle activation causes neurodegeneration in a Drosophila tauopathy model Current Biology 2006 16 3 230 241 (Pubitemid 43190222)
    • (2006) Current Biology , vol.16 , Issue.3 , pp. 230-241
    • Khurana, V.1    Lu, Y.2    Steinhilb, M.L.3    Oldham, S.4    Shulman, J.M.5    Feany, M.B.6
  • 41
    • 77957254409 scopus 로고    scopus 로고
    • Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease
    • Iijima K., Gatt A., Iijima-Ando K., Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease Human Molecular Genetics 2010 19 15 2947 2957
    • (2010) Human Molecular Genetics , vol.19 , Issue.15 , pp. 2947-2957
    • Iijima, K.1    Gatt, A.2    Iijima-Ando, K.3
  • 42
    • 34247615021 scopus 로고    scopus 로고
    • Study of tauopathies by comparing Drosophila and human tau in Drosophila
    • DOI 10.1007/s00441-007-0401-y
    • Chen X., Li Y., Huang J., Cao D., Yang G., Liu W., Lu H., Guo A., Study of tauopathies by comparing Drosophila and human tau in Drosophila Cell and Tissue Research 2007 329 1 169 178 (Pubitemid 46686106)
    • (2007) Cell and Tissue Research , vol.329 , Issue.1 , pp. 169-178
    • Chen, X.1    Li, Y.2    Huang, J.3    Cao, D.4    Yang, G.5    Liu, W.6    Lu, H.7    Guo, A.8
  • 43
    • 1542358895 scopus 로고    scopus 로고
    • PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila
    • DOI 10.1016/S0092-8674(04)00170-9, PII S0092867404001709
    • Nishimura I., Yang Y., Lu B., PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila Cell 2004 116 5 671 682 (Pubitemid 38326726)
    • (2004) Cell , vol.116 , Issue.5 , pp. 671-682
    • Nishimura, I.1    Yang, Y.2    Lu, B.3
  • 44
    • 35949001344 scopus 로고    scopus 로고
    • Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila
    • DOI 10.1371/journal.pgen.0030177
    • Bilen J., Bonini N. M., Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila PLoS Genetics 2007 3 10, article e177 1950 1964 (Pubitemid 350072059)
    • (2007) PLoS Genetics , vol.3 , Issue.10 , pp. 1950-1964
    • Bilen, J.1    Bonini, N.M.2
  • 45
    • 33746892301 scopus 로고    scopus 로고
    • Cell type-specific processing of human Tau proteins in Drosophila
    • DOI 10.1016/j.febslet.2006.07.045, PII S0014579306008787
    • Grammenoudi S., Kosmidis S., Skoulakis E. M. C., Cell type-specific processing of human tau proteins in Drosophila FEBS Letters 2006 580 19 4602 4606 (Pubitemid 44189378)
    • (2006) FEBS Letters , vol.580 , Issue.19 , pp. 4602-4606
    • Grammenoudi, S.1    Kosmidis, S.2    Skoulakis, E.M.C.3
  • 46
    • 33846448743 scopus 로고    scopus 로고
    • Activation of PAR-1 kinase and stimulation of tau phosphorylation by diverse signals require the tumor suppressor protein LKB1
    • DOI 10.1523/JNEUROSCI.5094-06.2007
    • Wang J. W., Imai Y., Lu B., Activation of PAR-1 kinase and stimulation of tau phosphorylation by diverse signals require the tumor suppressor protein LKB1 Journal of Neuroscience 2007 27 3 574 581 (Pubitemid 46143761)
    • (2007) Journal of Neuroscience , vol.27 , Issue.3 , pp. 574-581
    • Wang, J.-W.1    Imai, Y.2    Lu, B.3
  • 48
    • 27744600579 scopus 로고    scopus 로고
    • Over-expression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions
    • DOI 10.1016/j.nbd.2005.05.029, PII S0969996105001622
    • Chee F. C., Mudher A., Cuttle M. F., Newman T. A., MacKay D., Lovestone S., Shepherd D., Over-expression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions Neurobiology of Disease 2005 20 3 918 928 (Pubitemid 41619367)
    • (2005) Neurobiology of Disease , vol.20 , Issue.3 , pp. 918-928
    • Chee, F.C.1    Mudher, A.2    Cuttle, M.F.3    Newman, T.A.4    MacKay, D.5    Lovestone, S.6    Shepherd, D.7
  • 49
    • 34548317186 scopus 로고    scopus 로고
    • A comparison of the neuronal dysfunction caused by Drosophila tau and human tau in a Drosophila model of tauopathies
    • DOI 10.1007/s10158-007-0052-4
    • Ubhi K. K., Shaibah H., Newman T. A., Shepherd D., Mudher A., A comparison of the neuronal dysfunction caused by Drosophila tau and human tau in a Drosophila model of tauopathies Invertebrate Neuroscience 2007 7 3 165 171 (Pubitemid 47339788)
    • (2007) Invertebrate Neuroscience , vol.7 , Issue.3 , pp. 165-171
    • Ubhi, K.K.1    Shaibah, H.2    Newman, T.A.3    Shepherd, D.4    Mudher, A.5
  • 50
    • 0034716223 scopus 로고    scopus 로고
    • Tau and tau reporters disrupt central projections of sensory neurons in Drosophila
    • Williams D. W., Tyrer M., Shepherd D., Tau and tau reporters disrupt central projections of sensory neurons in Drosophila Journal of Comparative Neurology 2000 428 4 630 640
    • (2000) Journal of Comparative Neurology , vol.428 , Issue.4 , pp. 630-640
    • Williams, D.W.1    Tyrer, M.2    Shepherd, D.3
  • 51
    • 2542590202 scopus 로고    scopus 로고
    • Learning and memory deficits upon TAU accumulation in Drosophila mushroom body neurons
    • DOI 10.1101/lm.70804
    • Mershin A., Pavlopoulos E., Fitch O., Braden B. C., Nanopoulos D. V., Skoulakis E. M. C., Learning and memory deficits upon TAU accumulation in Drosophila mushroom body neurons Learning and Memory 2004 11 3 277 287 (Pubitemid 38697893)
    • (2004) Learning and Memory , vol.11 , Issue.3 , pp. 277-287
    • Mershin, A.1    Pavlopoulos, E.2    Fitch, O.3    Braden, B.C.4    Nanopoulos, D.V.5    Skoulakis, E.M.C.6
  • 52
    • 77957377567 scopus 로고    scopus 로고
    • LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3
    • Lin C. H., Tsai P. I., Wu R. M., Chien C. T., LRRK2 G2019S mutation induces dendrite degeneration through mislocalization and phosphorylation of tau by recruiting autoactivated GSK3 Journal of Neuroscience 2010 30 39 13138 13149
    • (2010) Journal of Neuroscience , vol.30 , Issue.39 , pp. 13138-13149
    • Lin, C.H.1    Tsai, P.I.2    Wu, R.M.3    Chien, C.T.4
  • 54
    • 78149411188 scopus 로고    scopus 로고
    • Soluble hyper-phosphorylated tau causes microtubule breakdown and functionally compromises normal tau in vivo
    • Cowan C. M., Bossing T., Page A., Shepherd D., Mudher A., Soluble hyper-phosphorylated tau causes microtubule breakdown and functionally compromises normal tau in vivo Acta Neuropathologica 2010 120 5 593 604
    • (2010) Acta Neuropathologica , vol.120 , Issue.5 , pp. 593-604
    • Cowan, C.M.1    Bossing, T.2    Page, A.3    Shepherd, D.4    Mudher, A.5
  • 56
    • 33846080531 scopus 로고    scopus 로고
    • Oxidative stress mediates tau-induced neurodegeneration in Drosophila
    • DOI 10.1172/JCI28769
    • Dias-Santagata D., Fulga T. A., Duttaroy A., Feany M. B., Oxidative stress mediates tau-induced neurodegeneration in Drosophila Journal of Clinical Investigation 2007 117 1 236 245 (Pubitemid 46055207)
    • (2007) Journal of Clinical Investigation , vol.117 , Issue.1 , pp. 236-245
    • Dias-Santagata, D.1    Fulga, T.A.2    Duttaroy, A.3    Feany, M.B.4
  • 57
    • 77958529500 scopus 로고    scopus 로고
    • The unfolded protein response protects from tau neurotoxicity in vivo
    • Loewen C. A., Feany M. B., The unfolded protein response protects from tau neurotoxicity in vivo PLoS ONE 2010 5 9
    • (2010) PLoS ONE , vol.5 , Issue.9
    • Loewen, C.A.1    Feany, M.B.2
  • 58
    • 0033529031 scopus 로고    scopus 로고
    • Neuronal overexpression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport
    • DOI 10.1016/S0960-9822(99)80215-2
    • Torroja L., Chu H., Kotovsky I., White K., Neuronal overexpression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport Current Biology 1999 9 9 489 492 (Pubitemid 29228622)
    • (1999) Current Biology , vol.9 , Issue.9 , pp. 489-492
    • Torroja, L.1    Chu, H.2    Kotovsky, I.3    White, K.4
  • 59
    • 74949109318 scopus 로고    scopus 로고
    • Differential effects of tau on the integrity and function of neurons essential for learning in Drosophila
    • Kosmidis S., Grammenoudi S., Papanikolopoulou K., Skoulakis E. M. C., Differential effects of tau on the integrity and function of neurons essential for learning in Drosophila Journal of Neuroscience 2010 30 2 464 477
    • (2010) Journal of Neuroscience , vol.30 , Issue.2 , pp. 464-477
    • Kosmidis, S.1    Grammenoudi, S.2    Papanikolopoulou, K.3    Skoulakis, E.M.C.4
  • 60
    • 77958459087 scopus 로고    scopus 로고
    • Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathies
    • Falzone T. L., Gunawardena S., McCleary D., Reis G. F., Goldstein L. S., Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathies Human Molecular Genetics 2010 19 22 4399 4408
    • (2010) Human Molecular Genetics , vol.19 , Issue.22 , pp. 4399-4408
    • Falzone, T.L.1    Gunawardena, S.2    McCleary, D.3    Reis, G.F.4    Goldstein, L.S.5
  • 61
    • 18244384190 scopus 로고    scopus 로고
    • Disruption of the MAP1B-related protein FUTSCH leads to changes in the neuronal cytoskeleton, axonal transport defects, and progressive neurodegeneration in Drosophila
    • DOI 10.1091/mbc.E04-11-1004
    • da Cruz A. B., Schwrzel M., Schulze S., Niyyati M., Heisenberg M., Kretzschmar D., Disruption of the MAP1B-related protein FUTSCH leads to changes in the neuronal cytoskeleton, axonal transport defects, and progressive neurodegeneration in Drosophila Molecular Biology of the Cell 2005 16 5 2433 2442 (Pubitemid 40632224)
    • (2005) Molecular Biology of the Cell , vol.16 , Issue.5 , pp. 2433-2442
    • Da Cruz, A.B.1    Schwarzel, M.2    Schulze, S.3    Niyyati, M.4    Heisenberg, M.5    Kretzschmar, D.6
  • 62
    • 67149083217 scopus 로고    scopus 로고
    • Aversive phototaxic suppression: Evaluation of a short-term memory assay in Drosophila melanogaster
    • Seugnet L., Suzuki Y., Stidd R., Shaw P. J., Aversive phototaxic suppression: evaluation of a short-term memory assay in Drosophila melanogaster Genes, Brain and Behavior 2009 8 4 377 389
    • (2009) Genes, Brain and Behavior , vol.8 , Issue.4 , pp. 377-389
    • Seugnet, L.1    Suzuki, Y.2    Stidd, R.3    Shaw, P.J.4
  • 63
    • 80052641987 scopus 로고    scopus 로고
    • Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease
    • Kerr F., Augustin H., Piper M. D. W., Gandy C., Allen M. J., Lovestone S., Partridge L., Dietary restriction delays aging, but not neuronal dysfunction, in Drosophila models of Alzheimer's disease Neurobiology of Aging 2011 32 11 1977 1989
    • (2011) Neurobiology of Aging , vol.32 , Issue.11 , pp. 1977-1989
    • Kerr, F.1    Augustin, H.2    Piper, M.D.W.3    Gandy, C.4    Allen, M.J.5    Lovestone, S.6    Partridge, L.7
  • 64
    • 3242733807 scopus 로고    scopus 로고
    • Spatiotemporal gene expression targeting with the TARGET and gene-switch systems in Drosophila
    • McGuire S. E., Mao Z., Davis R. L., Spatiotemporal gene expression targeting with the TARGET and gene-switch systems in Drosophila Science's STKE 2004 2004 220 pl6
    • (2004) Science's STKE , vol.2004 , Issue.220 , pp. 6
    • McGuire, S.E.1    Mao, Z.2    Davis, R.L.3
  • 67
    • 45149093564 scopus 로고    scopus 로고
    • Identification of novel genes that modify phenotypes induced by Alzheimer's -amyloid overexpression in Drosophila
    • Cao W., Song H. J., Gangi T., Kelkar A., Antani I., Garza D., Konsolaki M., Identification of novel genes that modify phenotypes induced by Alzheimer's -amyloid overexpression in Drosophila Genetics 2008 178 3 1457 1471
    • (2008) Genetics , vol.178 , Issue.3 , pp. 1457-1471
    • Cao, W.1    Song, H.J.2    Gangi, T.3    Kelkar, A.4    Antani, I.5    Garza, D.6    Konsolaki, M.7
  • 70
    • 81855205443 scopus 로고    scopus 로고
    • On the role of v-ATPase V0a1-dependent degradation in Alzheimer disease
    • Williamson W. R., Hiesinger P. R., On the role of v-ATPase V0a1-dependent degradation in Alzheimer disease Communicative and Integrative Biology 2010 3 6 604 607
    • (2010) Communicative and Integrative Biology , vol.3 , Issue.6 , pp. 604-607
    • Williamson, W.R.1    Hiesinger, P.R.2
  • 72
    • 0033103536 scopus 로고    scopus 로고
    • Mosaic analysis with a repressible neurotechnique cell marker for studies of gene function in neuronal morphogenesis
    • Lee T., Luo L., Mosaic analysis with a repressible neurotechnique cell marker for studies of gene function in neuronal morphogenesis Neuron 1999 22 3 451 461 (Pubitemid 29159845)
    • (1999) Neuron , vol.22 , Issue.3 , pp. 451-461
    • Lee, T.1    Luo, L.2
  • 73
    • 39849110726 scopus 로고    scopus 로고
    • The GSK3 hypothesis of Alzheimer's disease
    • DOI 10.1111/j.1471-4159.2007.05194.x
    • Hooper C., Killick R., Lovestone S., The GSK3 hypothesis of Alzheimer's disease Journal of Neurochemistry 2008 104 6 1433 1439 (Pubitemid 351316776)
    • (2008) Journal of Neurochemistry , vol.104 , Issue.6 , pp. 1433-1439
    • Hooper, C.1    Killick, R.2    Lovestone, S.3
  • 74
    • 77952549902 scopus 로고    scopus 로고
    • A exacerbates the neuronal dysfunction caused by human tau expression in a Drosophila model of Alzheimer's disease
    • Folwell J., Cowan C. M., Ubhi K. K., Shiabh H., Newman T. A., Shepherd D., Mudher A., A exacerbates the neuronal dysfunction caused by human tau expression in a Drosophila model of Alzheimer's disease Experimental Neurology 2010 223 2 401 409
    • (2010) Experimental Neurology , vol.223 , Issue.2 , pp. 401-409
    • Folwell, J.1    Cowan, C.M.2    Ubhi, K.K.3    Shiabh, H.4    Newman, T.A.5    Shepherd, D.6    Mudher, A.7
  • 75
    • 37049027122 scopus 로고    scopus 로고
    • Tau phosphorylation sites work in concert to promote neurotoxicity in vivo
    • DOI 10.1091/mbc.E07-04-0327
    • Steinhilb M. L., Dias-Santagata D., Fulga T. A., Felch D. L., Feany M. B., Tau phosphorylation sites work in concert to promote neurotoxicity in vivo Molecular Biology of the Cell 2007 18 12 5060 5068 (Pubitemid 350246705)
    • (2007) Molecular Biology of the Cell , vol.18 , Issue.12 , pp. 5060-5068
    • Steinhilb, M.L.1    Dias-Santagata, D.2    Fulga, T.A.3    Felch, D.L.4    Feany, M.B.5
  • 76
    • 0034814018 scopus 로고    scopus 로고
    • Identification and characterization of the Drosophila tau homolog
    • DOI 10.1016/S0925-4773(01)00487-7, PII S0925477301004877
    • Heidary G., Fortini M. E., Identification and characterization of the Drosophila tau homolog Mechanisms of Development 2001 108 1-2 171 178 (Pubitemid 32923065)
    • (2001) Mechanisms of Development , vol.108 , Issue.1-2 , pp. 171-178
    • Heidary, G.1    Fortini, M.E.2
  • 77
    • 33644777597 scopus 로고    scopus 로고
    • Development of Drosophila motoneurons: Specification and morphology
    • DOI 10.1016/j.semcdb.2005.11.007, PII S1084952105001217
    • Landgraf M., Thor S., Development of Drosophila motoneurons: specification and morphology Seminars in Cell and Developmental Biology 2006 17 1 3 11 (Pubitemid 43344457)
    • (2006) Seminars in Cell and Developmental Biology , vol.17 , Issue.1 , pp. 3-11
    • Landgraf, M.1    Thor, S.2
  • 79
    • 79959392915 scopus 로고    scopus 로고
    • Turning males on: Activation of male courtship behavior in Drosophila melanogaster
    • Pan Y., Robinett C. C., Baker B. S., Turning males on: activation of male courtship behavior in Drosophila melanogaster PLoS ONE 2011 6 6
    • (2011) PLoS ONE , vol.6 , Issue.6
    • Pan, Y.1    Robinett, C.C.2    Baker, B.S.3
  • 80
    • 80052261680 scopus 로고    scopus 로고
    • Serotonin receptor activity is necessary for olfactory learning and memory in Drosophila melanogaster
    • Johnson O., Becnel J., Nichols C. D., Serotonin receptor activity is necessary for olfactory learning and memory in Drosophila melanogaster Neuroscience 2011 192 372 381
    • (2011) Neuroscience , vol.192 , pp. 372-381
    • Johnson, O.1    Becnel, J.2    Nichols, C.D.3
  • 81
    • 44949233367 scopus 로고    scopus 로고
    • Social interaction-mediated lifespan extension of Drosophila Cu/Zn superoxide dismutase mutants
    • DOI 10.1073/pnas.0711127105
    • Ruan H., Wu C. F., Social interaction-mediated lifespan extension of Drosophila Cu/Zn superoxide dismutase mutants Proceedings of the National Academy of Sciences of the United States of America 2008 105 21 7506 7510 (Pubitemid 351830048)
    • (2008) Proceedings of the National Academy of Sciences of the United States of America , vol.105 , Issue.21 , pp. 7506-7510
    • Ruan, H.1    Wu, C.-F.2
  • 82
    • 79959657391 scopus 로고    scopus 로고
    • Social regulation of aggression by pheromonal activation of Or65a olfactory neurons in Drosophila
    • Liu W., Liang X., Gong J., Yang Z., Zhang Y. H., Zhang J. X., Rao Y., Social regulation of aggression by pheromonal activation of Or65a olfactory neurons in Drosophila Nature Neuroscience 2011 14 7 896 902
    • (2011) Nature Neuroscience , vol.14 , Issue.7 , pp. 896-902
    • Liu, W.1    Liang, X.2    Gong, J.3    Yang, Z.4    Zhang, Y.H.5    Zhang, J.X.6    Rao, Y.7
  • 83
    • 34848896268 scopus 로고    scopus 로고
    • The fruit fly Drosophila melanogaster favors dim light and times its activity peaks to early dawn and late dusk
    • DOI 10.1177/0748730407306198
    • Rieger D., Fraunholz C., Popp J., Bichler D., Dittmann R., Helfrich-Frster C., The fruit fly Drosophila melanogaster favors dim light and times its activity peaks to early dawn and late dusk Journal of Biological Rhythms 2007 22 5 387 399 (Pubitemid 47507060)
    • (2007) Journal of Biological Rhythms , vol.22 , Issue.5 , pp. 387-399
    • Rieger, D.1    Fraunholz, C.2    Popp, J.3    Bichler, D.4    Dittmann, R.5    Helfrich-Forster, C.6
  • 91
    • 77956587739 scopus 로고    scopus 로고
    • A oligomers cause localized Ca2 + elevation, missorting of endogenous tau into dendrites, tau phosphorylation, and destruction of microtubules and spines
    • Zempel H., Thies E., Mandelkow E., Mandelkow E. M., A oligomers cause localized Ca2 + elevation, missorting of endogenous tau into dendrites, tau phosphorylation, and destruction of microtubules and spines Journal of Neuroscience 2010 30 36 11938 11950
    • (2010) Journal of Neuroscience , vol.30 , Issue.36 , pp. 11938-11950
    • Zempel, H.1    Thies, E.2    Mandelkow, E.3    Mandelkow, E.M.4
  • 92
    • 0025269152 scopus 로고
    • Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
    • DeKosky S. T., Scheff S. W., Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity Annals of Neurology 1990 27 5 457 464 (Pubitemid 20149963)
    • (1990) Annals of Neurology , vol.27 , Issue.5 , pp. 457-464
    • DeKosky, S.T.1    Scheff, S.W.2
  • 94
    • 37149046340 scopus 로고    scopus 로고
    • Hyperphosphorylated tau in parahippocampal cortex impairs place learning in aged mice expressing wild-type human tau
    • DOI 10.1038/sj.emboj.7601917, PII 7601917
    • Kimura T., Yamashita S., Fukuda T., Park J. M., Murayama M., Mizoroki T., Yoshiike Y., Sahara N., Takashima A., Hyperphosphorylated tau in parahippocampal cortex impairs place learning in aged mice expressing wild-type human tau EMBO Journal 2007 26 24 5143 5152 (Pubitemid 350261280)
    • (2007) EMBO Journal , vol.26 , Issue.24 , pp. 5143-5152
    • Kimura, T.1    Yamashita, S.2    Fukuda, T.3    Park, J.-M.4    Murayama, M.5    Mizoroki, T.6    Yoshiike, Y.7    Sahara, N.8    Takashima, A.9
  • 95
    • 0033561207 scopus 로고    scopus 로고
    • Lithium reduces tau phosphorylation: Effects in living cells and in neurons at therapeutic concentrations
    • DOI 10.1016/S0006-3223(98)00183-8, PII S0006322398001838
    • Lovestone S., Davis D. R., Webster M. T., Kaech S., Brion J. P., Matus A., Anderton B. H., Lithium reduces tau phosphorylation: effects in living cells and in neurons at therapeutic concentrations Biological Psychiatry 1999 45 8 995 1003 (Pubitemid 29219620)
    • (1999) Biological Psychiatry , vol.45 , Issue.8 , pp. 995-1003
    • Lovestone, S.1    Davis, D.R.2    Webster, M.-T.3    Kaech, S.4    Brion, J.-P.5    Matus, A.6    Anderton, B.H.7
  • 96
    • 0025614352 scopus 로고
    • Evidence for decreased transport of tryptophan hydroxylase in Alzheimer's disease
    • Burke W. J., Park D. H., Chung H. D., Marshall G. L., Haring J. H., Joh T. H., Evidence for decreased transport of tryptophan hydroxylase in Alzheimer's disease Brain Research 1990 537 1-2 83 87
    • (1990) Brain Research , vol.537 , Issue.12 , pp. 83-87
    • Burke, W.J.1    Park, D.H.2    Chung, H.D.3    Marshall, G.L.4    Haring, J.H.5    Joh, T.H.6
  • 98
    • 0031012497 scopus 로고    scopus 로고
    • Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: Sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau
    • Alonso A. D. C., Grundke-Iqbal I., Barra H. S., Iqbal K., Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau Proceedings of the National Academy of Sciences of the United States of America 1997 94 1 298 303
    • (1997) Proceedings of the National Academy of Sciences of the United States of America , vol.94 , Issue.1 , pp. 298-303
    • Alonso, A.D.C.1    Grundke-Iqbal, I.2    Barra, H.S.3    Iqbal, K.4
  • 99
    • 0042697305 scopus 로고    scopus 로고
    • Triple-transgenic model of Alzheimer's Disease with plaques and tangles: Intracellular Aβ and synaptic dysfunction
    • DOI 10.1016/S0896-6273(03)00434-3
    • Oddo S., Caccamo A., Shepherd J. D., Murphy M. P., Golde T. E., Kayed R., Metherate R., Mattson M. P., Akbari Y., LaFerla F. M., Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular A and synaptic dysfunction Neuron 2003 39 3 409 421 (Pubitemid 36937044)
    • (2003) Neuron , vol.39 , Issue.3 , pp. 409-421
    • Oddo, S.1    Caccamo, A.2    Shepherd, J.D.3    Murphy, M.P.4    Golde, T.E.5    Kayed, R.6    Metherate, R.7    Mattson, M.P.8    Akbari, Y.9    LaFerla, F.M.10
  • 101
    • 0028362458 scopus 로고
    • A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads
    • DOI 10.1007/s004010050124
    • Braak E., Braaak H., Mandelkow E. M., A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads Acta Neuropathologica 1994 87 6 554 567 (Pubitemid 24158408)
    • (1994) Acta Neuropathologica , vol.87 , Issue.6 , pp. 554-567
    • Braak, E.1    Braaak, H.2    Mandelkow, E.-M.3
  • 102
    • 30944433816 scopus 로고    scopus 로고
    • Tauopathies: Recent insights into old diseases
    • Delacourte A., Tauopathies: recent insights into old diseases Folia Neuropathologica 2005 43 4 244 257 (Pubitemid 43109283)
    • (2005) Folia Neuropathologica , vol.43 , Issue.4 , pp. 244-257
    • Delacourte, A.1
  • 103
    • 33947099463 scopus 로고    scopus 로고
    • Connecting cell-cycle activation to neurodegeneration in Drosophila
    • DOI 10.1016/j.bbadis.2006.10.007, PII S092544390600216X
    • Khurana V., Feany M. B., Connecting cell-cycle activation to neurodegeneration in Drosophila Biochimica et Biophysica ActaMolecular Basis of Disease 2007 1772 4 446 456 (Pubitemid 46402965)
    • (2007) Biochimica et Biophysica Acta - Molecular Basis of Disease , vol.1772 , Issue.4 , pp. 446-456
    • Khurana, V.1    Feany, M.B.2
  • 106
    • 0035829720 scopus 로고    scopus 로고
    • Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila
    • DOI 10.1016/S0896-6273(01)00496-2
    • Gunawardena S., Goldstein L. S. B., Disruption of axonal transport and neuronal viability by amyloid precursor protein mutations in Drosophila Neuron 2001 32 3 389 401 (Pubitemid 33082041)
    • (2001) Neuron , vol.32 , Issue.3 , pp. 389-401
    • Gunawardena, S.1    Goldstein, L.S.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.