-
1
-
-
61349201380
-
Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers
-
10.1038/nature07761 19242475
-
Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. J Lauren, DA Gimbel, HB Nygaard, JW Gilbert, SM Strittmatter, Nature 2009 457 1128 1132 10.1038/nature07761 19242475
-
(2009)
Nature
, vol.457
, pp. 1128-1132
-
-
Lauren, J.1
Gimbel, D.A.2
Nygaard, H.B.3
Gilbert, J.W.4
Strittmatter, S.M.5
-
2
-
-
84866065959
-
Alzheimer amyloid-beta oligomer bound to postsynaptic prion protein activates Fyn to impair neurons
-
10.1038/nn.3178 22820466
-
Alzheimer amyloid-beta oligomer bound to postsynaptic prion protein activates Fyn to impair neurons. JW Um, HB Nygaard, JK Heiss, MA Kostylev, M Stagi, A Vortmeyer, T Wisniewski, EC Gunther, SM Strittmatter, Nat Neurosci 2012 15 1227 1235 10.1038/nn.3178 22820466
-
(2012)
Nat Neurosci
, vol.15
, pp. 1227-1235
-
-
Um, J.W.1
Nygaard, H.B.2
Heiss, J.K.3
Kostylev, M.A.4
Stagi, M.5
Vortmeyer, A.6
Wisniewski, T.7
Gunther, E.C.8
Strittmatter, S.M.9
-
3
-
-
84884200967
-
Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer Aβ oligomer bound to cellular prion protein
-
10.1016/j.neuron.2013.06.036 24012003
-
Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer Aβ oligomer bound to cellular prion protein. JW Um, AC Kaufman, M Kostylev, JK Heiss, M Stagi, H Takahashi, ME Kerrisk, A Vortmeyer, T Wisniewski, AJ Koleske, EC Gunther, HB Nygaard, SM Strittmatter, Neuron 2013 79 887 902 10.1016/j.neuron.2013.06.036 24012003
-
(2013)
Neuron
, vol.79
, pp. 887-902
-
-
Um, J.W.1
Kaufman, A.C.2
Kostylev, M.3
Heiss, J.K.4
Stagi, M.5
Takahashi, H.6
Kerrisk, M.E.7
Vortmeyer, A.8
Wisniewski, T.9
Koleske, A.J.10
Gunther, E.C.11
Nygaard, H.B.12
Strittmatter, S.M.13
-
4
-
-
84869992747
-
The complex PrP(c)-Fyn couples human oligomeric Aβ with pathological tau changes in Alzheimer's disease
-
10.1523/JNEUROSCI.1858-12.2012
-
The complex PrP(c)-Fyn couples human oligomeric Aβ with pathological tau changes in Alzheimer's disease. M Larson, MA Sherman, F Amar, M Nuvolone, JA Schneider, DA Bennett, A Aguzzi, SE Lesne, J Neurosci 2012 32 16857a 16871a 10.1523/JNEUROSCI.1858-12.2012
-
(2012)
J Neurosci
, vol.32
-
-
Larson, M.1
Sherman, M.A.2
Amar, F.3
Nuvolone, M.4
Schneider, J.A.5
Bennett, D.A.6
Aguzzi, A.7
Lesne, S.E.8
-
5
-
-
0031439247
-
Cellular functions regulated by SRC family kinases
-
DOI 10.1146/annurev.cellbio.13.1.513
-
Cellular functions regulated by Src family kinases. SM Thomas, JS Brugge, Annu Rev Cell Dev Biol 1997 13 513 609 10.1146/annurev.cellbio.13.1.513 9442882 (Pubitemid 28034534)
-
(1997)
Annual Review of Cell and Developmental Biology
, vol.13
, pp. 513-609
-
-
Thomas, S.M.1
Brugge, J.S.2
-
6
-
-
0035374609
-
The hunting of the Src
-
DOI 10.1038/35073094
-
The hunting of the Src. GS Martin, Nat Rev Mol Cell Biol 2001 2 467 475 10.1038/35073094 11389470 (Pubitemid 33680585)
-
(2001)
Nature Reviews Molecular Cell Biology
, vol.2
, Issue.6
, pp. 467-474
-
-
Martin, G.S.1
-
7
-
-
7944223078
-
Structure and regulation of Src family kinases
-
DOI 10.1038/sj.onc.1208081
-
Structure and regulation of Src family kinases. TJ Boggon, MJ Eck, Oncogene 2004 23 7918 7927 10.1038/sj.onc.1208081 15489910 (Pubitemid 39468851)
-
(2004)
Oncogene
, vol.23
, Issue.48 REV. ISS. 7
, pp. 7918-7927
-
-
Boggon, T.J.1
Eck, M.J.2
-
8
-
-
0031452274
-
Structures of Src-family tyrosine kinases
-
DOI 10.1016/S0959-440X(97)80146-7
-
Structures of Src-family tyrosine kinases. F Sicheri, J Kuriyan, Curr Opin Struct Biol 1997 7 777 785 10.1016/S0959-440X(97)80146-7 9434895 (Pubitemid 28025103)
-
(1997)
Current Opinion in Structural Biology
, vol.7
, Issue.6
, pp. 777-785
-
-
Sicheri, F.1
Kuriyan, J.2
-
9
-
-
33947659355
-
Homology modeling of human Fyn kinase structure: Discovery of rosmarinic acid as a new Fyn kinase inhibitor and in Silico study of its possible binding modes
-
DOI 10.1021/jm0607202
-
Homology modeling of human Fyn kinase structure: discovery of rosmarinic acid as a new Fyn kinase inhibitor and in silico study of its possible binding modes. D Jelic, B Mildner, S Kostrun, K Nujic, D Verbanac, O Culic, R Antolovic, W Brandt, J Med Chem 2007 50 1090 1100 10.1021/jm0607202 17315853 (Pubitemid 46496310)
-
(2007)
Journal of Medicinal Chemistry
, vol.50
, Issue.6
, pp. 1090-1100
-
-
Jelic, D.1
Mildner, B.2
Kostrun, S.3
Nujic, K.4
Verbanac, D.5
Culic, O.6
Antolovic, R.7
Brandt, W.8
-
10
-
-
81855168411
-
Fyn, a potential target for Alzheimer's disease
-
21799250
-
Fyn, a potential target for Alzheimer's disease. K Yang, J Belrose, CH Trepanier, G Lei, MF Jackson, JF MacDonald, J Alzheimers Dis 2011 27 243 252 21799250
-
(2011)
J Alzheimers Dis
, vol.27
, pp. 243-252
-
-
Yang, K.1
Belrose, J.2
Trepanier, C.H.3
Lei, G.4
Jackson, M.F.5
Macdonald, J.F.6
-
11
-
-
0036432267
-
Identification of an alternatively spliced isoform of the fyn tyrosine kinase
-
DOI 10.1016/S0006-291X(02)02510-X, PII S0006291X0202510X
-
Identification of an alternatively spliced isoform of the fyn tyrosine kinase. JF Goldsmith, CG Hall, TP Atkinson, Biochem Biophys Res Commun 2002 298 501 504 10.1016/S0006-291X(02)02510-X 12408980 (Pubitemid 35333686)
-
(2002)
Biochemical and Biophysical Research Communications
, vol.298
, Issue.4
, pp. 501-504
-
-
Goldsmith, J.F.1
Hall, C.G.2
Atkinson, T.P.3
-
12
-
-
0024751217
-
Expression of a novel form of the fyn proto-oncogene in hematopoietic cells
-
2488273
-
Expression of a novel form of the fyn proto-oncogene in hematopoietic cells. MP Cooke, RM Perlmutter, New Biol 1989 1 66 74 2488273
-
(1989)
New Biol
, vol.1
, pp. 66-74
-
-
Cooke, M.P.1
Perlmutter, R.M.2
-
13
-
-
79958252836
-
From axon-glial signalling to myelination: The integrating role of oligodendroglial Fyn kinase
-
10.1007/s00018-010-0616-z 21207100
-
From axon-glial signalling to myelination: the integrating role of oligodendroglial Fyn kinase. EM Kramer-Albers, R White, Cell Mol Life Sci 2011 68 2003 2012 10.1007/s00018-010-0616-z 21207100
-
(2011)
Cell Mol Life Sci
, vol.68
, pp. 2003-2012
-
-
Kramer-Albers, E.M.1
White, R.2
-
14
-
-
0037025303
-
Striatal enriched phosphatase 61 dephosphorylates Fyn at phosphotyrosine 420
-
DOI 10.1074/jbc.M111683200
-
Striatal enriched phosphatase 61 dephosphorylates Fyn at phosphotyrosine 420. TH Nguyen, J Liu, PJ Lombroso, J Biol Chem 2002 277 24274 24279 10.1074/jbc.M111683200 11983687 (Pubitemid 34951945)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.27
, pp. 24274-24279
-
-
Nguyen, T.-H.1
Liu, J.2
Lombroso, P.J.3
-
15
-
-
0032211806
-
Fyn, a Src family tyrosine kinase
-
DOI 10.1016/S1357-2725(98)00089-2, PII S1357272598000892
-
Fyn, a Src family tyrosine kinase. MD Resh, Int J Biochem Cell Biol 1998 30 1159 1162 10.1016/S1357-2725(98)00089-2 9839441 (Pubitemid 28515659)
-
(1998)
International Journal of Biochemistry and Cell Biology
, vol.30
, Issue.11
, pp. 1159-1162
-
-
Resh, M.D.1
-
16
-
-
0034721678
-
Signal-processing machines at the postsynaptic density
-
10.1126/science.290.5492.750 11052931
-
Signal-processing machines at the postsynaptic density. MB Kennedy, Science 2000 290 750 754 10.1126/science.290.5492.750 11052931
-
(2000)
Science
, vol.290
, pp. 750-754
-
-
Kennedy, M.B.1
-
17
-
-
0035808467
-
Characterization of Fyn-mediated tyrosine phosphorylation sites on GluRε2 (NR2B) subunit of the N-methyl-D-aspartate receptor
-
DOI 10.1074/jbc.M008085200
-
Characterization of Fyn-mediated tyrosine phosphorylation sites on GluR epsilon 2 (NR2B) subunit of the N-methyl-D-aspartate receptor. T Nakazawa, S Komai, T Tezuka, C Hisatsune, H Umemori, K Semba, M Mishina, T Manabe, T Yamamoto, J Biol Chem 2001 276 693 699 11024032 (Pubitemid 32050862)
-
(2001)
Journal of Biological Chemistry
, vol.276
, Issue.1
, pp. 693-699
-
-
Nakazawa, T.1
Komai, S.2
Tezuka, T.3
Hisatsune, C.4
Umemori, H.5
Semba, K.6
Mishina, M.7
Manabe, T.8
Yamamoto, T.9
-
18
-
-
0032459183
-
Higher seizure susceptibility and enhanced tyrosine phosphorylation of N-methyl-D-aspartate receptor subunit 2B in fyn transgenic mice
-
Higher seizure susceptibility and enhanced tyrosine phosphorylation of N-methyl-D-aspartate receptor subunit 2B in fyn transgenic mice. N Kojima, H Ishibashi, K Obata, ER Kandel, Learn Mem 1998 5 429 445 10489260 (Pubitemid 29108875)
-
(1998)
Learning and Memory
, vol.5
, Issue.6
, pp. 429-445
-
-
Kojima, N.1
Ishibashi, H.2
Obata, K.3
Kandel, E.R.4
-
19
-
-
0027092647
-
Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice
-
Impaired long-term potentiation, spatial learning, and hippocampal development in fyn mutant mice. SG Grant, TJ O'Dell, KA Karl, PL Stein, P Soriano, ER Kandel, Science 1992 258 1903 1910 10.1126/science.1361685 1361685 (Pubitemid 23026728)
-
(1992)
Science
, vol.258
, Issue.5090
, pp. 1903-1910
-
-
Grant, S.G.N.1
O'Dell, T.J.2
Karl, K.A.3
Stein, P.L.4
Soriano, P.5
Kandel, E.R.6
-
20
-
-
24644491679
-
The synaptic localization of NR2B-containing NMDA receptors is controlled by interactions with PDZ proteins and AP-2
-
DOI 10.1016/j.neuron.2005.08.016, PII S0896627305006914
-
The synaptic localization of NR2B-containing NMDA receptors is controlled by interactions with PDZ proteins and AP-2. K Prybylowski, K Chang, N Sans, L Kan, S Vicini, RJ Wenthold, Neuron 2005 47 845 857 10.1016/j.neuron.2005.08.016 16157279 (Pubitemid 41266951)
-
(2005)
Neuron
, vol.47
, Issue.6
, pp. 845-857
-
-
Prybylowski, K.1
Chang, K.2
Sans, N.3
Kan, L.4
Vicini, S.5
Wenthold, R.J.6
-
21
-
-
0028889715
-
NMDA receptor subunits epsilon 1 (NR2A) and epsilon 2 (NR2B) are substrates for Fyn in the postsynaptic density fraction isolated from the rat brain
-
10.1006/bbrc.1995.2662 7488151
-
NMDA receptor subunits epsilon 1 (NR2A) and epsilon 2 (NR2B) are substrates for Fyn in the postsynaptic density fraction isolated from the rat brain. T Suzuki, K Okumura-Noji, Biochem Biophys Res Commun 1995 216 582 588 10.1006/bbrc.1995.2662 7488151
-
(1995)
Biochem Biophys Res Commun
, vol.216
, pp. 582-588
-
-
Suzuki, T.1
Okumura-Noji, K.2
-
22
-
-
0033578855
-
Long-term potentiation - A decade of progress?
-
DOI 10.1126/science.285.5435.1870
-
Long-term potentiation-a decade of progress? RC Malenka, RA Nicoll, Science 1999 285 1870 1874 10.1126/science.285.5435.1870 10489359 (Pubitemid 29444608)
-
(1999)
Science
, vol.285
, Issue.5435
, pp. 1870-1874
-
-
Malenka, R.C.1
Nicoll, R.A.2
-
23
-
-
4544373236
-
Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression
-
DOI 10.1523/JNEUROSCI.1697-04.2004
-
Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression. PV Massey, BE Johnson, PR Moult, YP Auberson, MW Brown, E Molnar, GL Collingridge, ZI Bashir, J Neurosci 2004 24 7821 7828 10.1523/JNEUROSCI.1697-04.2004 15356193 (Pubitemid 39215685)
-
(2004)
Journal of Neuroscience
, vol.24
, Issue.36
, pp. 7821-7828
-
-
Massey, P.V.1
Johnson, B.E.2
Moult, P.R.3
Auberson, Y.P.4
Brown, M.W.5
Molnar, E.6
Collingridge, G.L.7
Bashir, Z.I.8
-
24
-
-
50549100670
-
Activation of Fyn tyrosine kinase in the mouse dorsal hippocampus is essential for contextual fear conditioning
-
10.1111/j.1460-9568.2008.06405.x 18691323
-
Activation of Fyn tyrosine kinase in the mouse dorsal hippocampus is essential for contextual fear conditioning. T Isosaka, K Hattori, S Kida, T Kohno, T Nakazawa, T Yamamoto, T Yagi, S Yuasa, Eur J Neurosci 2008 28 973 981 10.1111/j.1460-9568.2008.06405.x 18691323
-
(2008)
Eur J Neurosci
, vol.28
, pp. 973-981
-
-
Isosaka, T.1
Hattori, K.2
Kida, S.3
Kohno, T.4
Nakazawa, T.5
Yamamoto, T.6
Yagi, T.7
Yuasa, S.8
-
25
-
-
0032898671
-
Enhanced synaptic transmission and reduced threshold for LTP induction in fyn-transgenic mice
-
DOI 10.1046/j.1460-9568.1999.00407.x
-
Enhanced synaptic transmission and reduced threshold for LTP induction in fyn-transgenic mice. YF Lu, N Kojima, K Tomizawa, A Moriwaki, M Matsushita, K Obata, H Matsui, Eur J Neurosci 1999 11 75 82 10.1046/j.1460-9568.1999.00407.x 9987012 (Pubitemid 29012312)
-
(1999)
European Journal of Neuroscience
, vol.11
, Issue.1
, pp. 75-82
-
-
Lu, Y.-F.1
-
26
-
-
80052848693
-
Decreased dendritic spine density and abnormal spine morphology in Fyn knockout mice
-
21872217
-
Decreased dendritic spine density and abnormal spine morphology in Fyn knockout mice. LW Babus, EM Little, KE Keenoy, SS Minami, E Chen, JM Song, J Caviness, SY Koo, DT Pak, GW Rebeck, RS Turner, HS Hoe, Brain Res 2011 1415 96 102 21872217
-
(2011)
Brain Res
, vol.1415
, pp. 96-102
-
-
Babus, L.W.1
Little, E.M.2
Keenoy, K.E.3
Minami, S.S.4
Chen, E.5
Song, J.M.6
Caviness, J.7
Koo, S.Y.8
Pak, D.T.9
Rebeck, G.W.10
Turner, R.S.11
Hoe, H.S.12
-
27
-
-
0027976632
-
Initial events of myelination involve Fyn tyrosine kinase signalling
-
DOI 10.1038/367572a0
-
Initial events of myelination involve Fyn tyrosine kinase signalling. H Umemori, S Sato, T Yagi, S Aizawa, T Yamamoto, Nature 1994 367 572 576 10.1038/367572a0 7509042 (Pubitemid 24055518)
-
(1994)
Nature
, vol.367
, Issue.6463
, pp. 572-576
-
-
Umemori, H.1
Sato, S.2
Yagi, T.3
Aizawa, S.4
Yamamoto, T.5
-
28
-
-
0035869609
-
A unique role for Fyn in CNS myelination
-
A unique role for Fyn in CNS myelination. BR Sperber, EA Boyle-Walsh, MJ Engleka, P Gadue, AC Peterson, PL Stein, SS Scherer, FA McMorris, J Neurosci 2001 21 2039 2047 11245687 (Pubitemid 32221386)
-
(2001)
Journal of Neuroscience
, vol.21
, Issue.6
, pp. 2039-2047
-
-
Sperber, B.R.1
Boyle-Walsh, E.A.2
Engleka, M.J.3
Gadue, P.4
Peterson, A.C.5
Stein, P.L.6
Scherer, S.S.7
McMorris, F.A.8
-
29
-
-
0027447602
-
The protein tyrosine kinase, fyn, in Alzheimer's disease pathology
-
The protein tyrosine kinase, fyn, in Alzheimer's disease pathology. SK Shirazi, JG Wood, Neuroreport 1993 4 435 437 10.1097/00001756-199304000-00024 8388744 (Pubitemid 23116742)
-
(1993)
NeuroReport
, vol.4
, Issue.4
, pp. 435-437
-
-
Shirazi, S.K.1
Wood, J.G.2
-
30
-
-
0028978360
-
Physiological levels of beta-amyloid increase tyrosine phosphorylation and cytosolic calcium
-
10.1016/0006-8993(95)00282-U 7552293
-
Physiological levels of beta-amyloid increase tyrosine phosphorylation and cytosolic calcium. YQ Luo, N Hirashima, YH Li, DL Alkon, T Sunderland, R Etcheberrigaray, B Wolozin, Brain Res 1995 681 65 74 10.1016/0006-8993(95)00282- U 7552293
-
(1995)
Brain Res
, vol.681
, pp. 65-74
-
-
Luo, Y.Q.1
Hirashima, N.2
Li, Y.H.3
Alkon, D.L.4
Sunderland, T.5
Etcheberrigaray, R.6
Wolozin, B.7
-
31
-
-
0037387147
-
A cell surface receptor complex for fibrillar β-amyloid mediates microglial activation
-
A cell surface receptor complex for fibrillar beta-amyloid mediates microglial activation. ME Bamberger, ME Harris, DR McDonald, J Husemann, GE Landreth, J Neurosci 2003 23 2665 2674 12684452 (Pubitemid 36418601)
-
(2003)
Journal of Neuroscience
, vol.23
, Issue.7
, pp. 2665-2674
-
-
Bamberger, M.E.1
Harris, M.E.2
McDonald, D.R.3
Husemann, J.4
Landreth, G.E.5
-
32
-
-
0037439642
-
Aberrant activation of focal adhesion proteins mediates fibrillar amyloid β-induced neuronal dystrophy
-
Aberrant activation of focal adhesion proteins mediates fibrillar amyloid beta-induced neuronal dystrophy. EA Grace, J Busciglio, J Neurosci 2003 23 493 502 12533609 (Pubitemid 36139548)
-
(2003)
Journal of Neuroscience
, vol.23
, Issue.2
, pp. 493-502
-
-
Grace, E.A.1
Busciglio, J.2
-
33
-
-
0035297712
-
Targeting small A β oligomers: The solution to an Alzheimer's disease conundrum?
-
DOI 10.1016/S0166-2236(00)01749-5, PII S0166223600017495
-
Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum? WL Klein, GA Krafft, CE Finch, Trends Neurosci 2001 24 219 224 10.1016/S0166-2236(00)01749-5 11250006 (Pubitemid 32204378)
-
(2001)
Trends in Neurosciences
, vol.24
, Issue.4
, pp. 219-224
-
-
Klein, W.L.1
Krafft, G.A.2
Finch, C.E.3
-
34
-
-
11544279355
-
1-42 are potent central nervous system neurotoxins
-
DOI 10.1073/pnas.95.11.6448
-
Diffusible, nonfibrillar ligands derived from Aβ§ssub§1- 42§esub§ are potent central nervous system neurotoxins. MP Lambert, AK Barlow, BA Chromy, C Edwards, R Freed, M Liosatos, TE Morgan, I Rozovsky, B Trommer, KL Viola, P Wals, C Zhang, CE Finch, GA Krafft, WL Klein, Proc Natl Acad Sci U S A 1998 95 6448 6453 10.1073/pnas.95.11.6448 9600986 (Pubitemid 28249033)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.11
, pp. 6448-6453
-
-
Lambert, M.P.1
Barlow, A.K.2
Chromy, B.A.3
Edwards, C.4
Freed, R.5
Liosatos, M.6
Morgan, T.E.7
Rozovsky, I.8
Trommer, B.9
Viola, K.L.10
Wals, P.11
Zhang, C.12
Finch, C.E.13
Krafft, G.A.14
Klein, W.L.15
-
35
-
-
77956197815
-
Interaction between human prion protein and amyloid-beta (Aβ) oligomers: Role of N-terminal residues
-
10.1074/jbc.M110.145516 20576610
-
Interaction between human prion protein and amyloid-beta (Aβ) oligomers: role of N-terminal residues. S Chen, SP Yadav, WK Surewicz, J Biol Chem 2010 285 26377 26383 10.1074/jbc.M110.145516 20576610
-
(2010)
J Biol Chem
, vol.285
, pp. 26377-26383
-
-
Chen, S.1
Yadav, S.P.2
Surewicz, W.K.3
-
36
-
-
77956165325
-
Prion protein and Aβ-related synaptic toxicity impairment
-
10.1002/emmm.201000082 20665634
-
Prion protein and Aβ-related synaptic toxicity impairment. AM Calella, M Farinelli, M Nuvolone, O Mirante, R Moos, J Falsig, IM Mansuy, A Aguzzi, EMBO Mol Med 2010 2 306 314 10.1002/emmm.201000082 20665634
-
(2010)
EMBO Mol Med
, vol.2
, pp. 306-314
-
-
Calella, A.M.1
Farinelli, M.2
Nuvolone, M.3
Mirante, O.4
Moos, R.5
Falsig, J.6
Mansuy, I.M.7
Aguzzi, A.8
-
37
-
-
76649093635
-
Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein
-
10.1073/pnas.0911829107 20133875
-
Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein. C Balducci, M Beeg, M Stravalaci, A Bastone, A Sclip, E Biasini, L Tapella, L Colombo, C Manzoni, T Borsello, R Chiesa, M Gobbi, M Salmona, G Forloni, Proc Natl Acad Sci U S A 2010 107 2295 2300 10.1073/pnas.0911829107 20133875
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 2295-2300
-
-
Balducci, C.1
Beeg, M.2
Stravalaci, M.3
Bastone, A.4
Sclip, A.5
Biasini, E.6
Tapella, L.7
Colombo, L.8
Manzoni, C.9
Borsello, T.10
Chiesa, R.11
Gobbi, M.12
Salmona, M.13
Forloni, G.14
-
38
-
-
77955617917
-
The prion protein as a receptor for amyloid-beta
-
discussion E4-E5 10.1038/nature09217 20703260
-
The prion protein as a receptor for amyloid-beta. HW Kessels, LN Nguyen, S Nabavi, R Malinow, Nature 2010 466 3 E4 discussion E4-E5 10.1038/nature09217 20703260
-
(2010)
Nature
, vol.466
-
-
Kessels, H.W.1
Nguyen, L.N.2
Nabavi, S.3
Malinow, R.4
-
39
-
-
79960660843
-
Ablation of cellular prion protein does not ameliorate abnormal neural network activity or cognitive dysfunction in the J20 line of human amyloid precursor protein transgenic mice
-
10.1523/JNEUROSCI.1459-11.2011 21775587
-
Ablation of cellular prion protein does not ameliorate abnormal neural network activity or cognitive dysfunction in the J20 line of human amyloid precursor protein transgenic mice. M Cisse, PE Sanchez, DH Kim, K Ho, GQ Yu, L Mucke, J Neurosci 2011 31 10427 10431 10.1523/JNEUROSCI.1459-11.2011 21775587
-
(2011)
J Neurosci
, vol.31
, pp. 10427-10431
-
-
Cisse, M.1
Sanchez, P.E.2
Kim, D.H.3
Ho, K.4
Yu, G.Q.5
Mucke, L.6
-
40
-
-
79956110918
-
The cellular prion protein mediates neurotoxic signalling of beta-sheet-rich conformers independent of prion replication
-
10.1038/emboj.2011.86 21441896
-
The cellular prion protein mediates neurotoxic signalling of beta-sheet-rich conformers independent of prion replication. UK Resenberger, A Harmeier, AC Woerner, JL Goodman, V Muller, R Krishnan, RM Vabulas, HA Kretzschmar, S Lindquist, FU Hartl, G Multhaup, KF Winklhofer, J Tatzelt, EMBO J 2011 30 2057 2070 10.1038/emboj.2011.86 21441896
-
(2011)
EMBO J
, vol.30
, pp. 2057-2070
-
-
Resenberger, U.K.1
Harmeier, A.2
Woerner, A.C.3
Goodman, J.L.4
Muller, V.5
Krishnan, R.6
Vabulas, R.M.7
Kretzschmar, H.A.8
Lindquist, S.9
Hartl, F.U.10
Multhaup, G.11
Winklhofer, K.F.12
Tatzelt, J.13
-
41
-
-
80055071341
-
Amyloid-beta-induced synapse damage is mediated via cross-linkage of cellular prion proteins
-
10.1074/jbc.M111.248724 21900234
-
Amyloid-beta-induced synapse damage is mediated via cross-linkage of cellular prion proteins. C Bate, A Williams, J Biol Chem 2011 286 37955 37963 10.1074/jbc.M111.248724 21900234
-
(2011)
J Biol Chem
, vol.286
, pp. 37955-37963
-
-
Bate, C.1
Williams, A.2
-
42
-
-
80755143595
-
Aβ inhibition of ionic conductance in mouse basal forebrain neurons is dependent upon the cellular prion protein PrPC
-
10.1523/JNEUROSCI.4367-11.2011 22072680
-
Aβ inhibition of ionic conductance in mouse basal forebrain neurons is dependent upon the cellular prion protein PrPC. K Alier, L Ma, J Yang, D Westaway, JH Jhamandas, J Neurosci 2011 31 16292 16297 10.1523/JNEUROSCI.4367- 11.2011 22072680
-
(2011)
J Neurosci
, vol.31
, pp. 16292-16297
-
-
Alier, K.1
Ma, L.2
Yang, J.3
Westaway, D.4
Jhamandas, J.H.5
-
43
-
-
77957778860
-
Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an Alzheimer's disease model mouse
-
10.1186/1471-2202-11-130 20946660
-
Anti-PrPC monoclonal antibody infusion as a novel treatment for cognitive deficits in an Alzheimer's disease model mouse. E Chung, Y Ji, Y Sun, RJ Kascsak, RB Kascsak, PD Mehta, SM Strittmatter, T Wisniewski, BMC Neurosci 2010 11 130 10.1186/1471-2202-11-130 20946660
-
(2010)
BMC Neurosci
, vol.11
, pp. 130
-
-
Chung, E.1
Ji, Y.2
Sun, Y.3
Kascsak, R.J.4
Kascsak, R.B.5
Mehta, P.D.6
Strittmatter, S.M.7
Wisniewski, T.8
-
44
-
-
77951876319
-
Memory impairment in transgenic Alzheimer mice requires cellular prion protein
-
10.1523/JNEUROSCI.0395-10.2010 20445063
-
Memory impairment in transgenic Alzheimer mice requires cellular prion protein. DA Gimbel, HB Nygaard, EE Coffey, EC Gunther, J Lauren, ZA Gimbel, SM Strittmatter, J Neurosci 2010 30 6367 6374 10.1523/JNEUROSCI.0395-10.2010 20445063
-
(2010)
J Neurosci
, vol.30
, pp. 6367-6374
-
-
Gimbel, D.A.1
Nygaard, H.B.2
Coffey, E.E.3
Gunther, E.C.4
Lauren, J.5
Gimbel, Z.A.6
Strittmatter, S.M.7
-
45
-
-
84863011560
-
Cellular prion protein is essential for oligomeric amyloid-beta-induced neuronal cell death
-
10.1093/hmg/ddr542 22100763
-
Cellular prion protein is essential for oligomeric amyloid-beta-induced neuronal cell death. W Kudo, HP Lee, WQ Zou, X Wang, G Perry, X Zhu, MA Smith, RB Petersen, HG Lee, Hum Mol Genet 2012 21 1138 1144 10.1093/hmg/ddr542 22100763
-
(2012)
Hum Mol Genet
, vol.21
, pp. 1138-1144
-
-
Kudo, W.1
Lee, H.P.2
Zou, W.Q.3
Wang, X.4
Perry, G.5
Zhu, X.6
Smith, M.A.7
Petersen, R.B.8
Lee, H.G.9
-
46
-
-
84863116075
-
Aβ neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-D-aspartate receptors
-
10.1073/pnas.1110789109 22307640
-
Aβ neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-D-aspartate receptors. H You, S Tsutsui, S Hameed, TJ Kannanayakal, L Chen, P Xia, JD Engbers, SA Lipton, PK Stys, GW Zamponi, Proc Natl Acad Sci U S A 2012 109 1737 1742 10.1073/pnas.1110789109 22307640
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 1737-1742
-
-
You, H.1
Tsutsui, S.2
Hameed, S.3
Kannanayakal, T.J.4
Chen, L.5
Xia, P.6
Engbers, J.D.7
Lipton, S.A.8
Stys, P.K.9
Zamponi, G.W.10
-
47
-
-
79955393816
-
Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain
-
10.1074/jbc.M110.199356 21393248
-
Amyloid-beta42 interacts mainly with insoluble prion protein in the Alzheimer brain. WQ Zou, X Xiao, J Yuan, G Puoti, H Fujioka, X Wang, S Richardson, X Zhou, R Zou, S Li, X Zhu, PL McGeer, J McGeehan, G Kneale, DE Rincon-Limas, P Fernandez-Funez, HG Lee, MA Smith, RB Petersen, JP Guo, J Biol Chem 2011 286 15095 15105 10.1074/jbc.M110.199356 21393248
-
(2011)
J Biol Chem
, vol.286
, pp. 15095-15105
-
-
Zou, W.Q.1
Xiao, X.2
Yuan, J.3
Puoti, G.4
Fujioka, H.5
Wang, X.6
Richardson, S.7
Zhou, X.8
Zou, R.9
Li, S.10
Zhu, X.11
McGeer, P.L.12
McGeehan, J.13
Kneale, G.14
Rincon-Limas, D.E.15
Fernandez-Funez, P.16
Lee, H.G.17
Smith, M.A.18
Petersen, R.B.19
Guo, J.P.20
more..
-
48
-
-
79958249995
-
Interaction between prion protein and toxic amyloid beta assemblies can be therapeutically targeted at multiple sites
-
21654636
-
Interaction between prion protein and toxic amyloid beta assemblies can be therapeutically targeted at multiple sites. DB Freir, AJ Nicoll, I Klyubin, S Panico, JM McDonald, E Risse, EA Asante, MA Farrow, RB Sessions, HR Saibil, AR Clarke, MJ Rowan, DM Walsh, J Collinge, Nat Commun 2011 2 336 21654636
-
(2011)
Nat Commun
, vol.2
, pp. 336
-
-
Freir, D.B.1
Nicoll, A.J.2
Klyubin, I.3
Panico, S.4
McDonald, J.M.5
Risse, E.6
Asante, E.A.7
Farrow, M.A.8
Sessions, R.B.9
Saibil, H.R.10
Clarke, A.R.11
Rowan, M.J.12
Walsh, D.M.13
Collinge, J.14
-
49
-
-
79956302348
-
Alzheimer's disease brain-derived amyloid-beta-mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion protein
-
10.1523/JNEUROSCI.6500-10.2011 21593310
-
Alzheimer's disease brain-derived amyloid-beta-mediated inhibition of LTP in vivo is prevented by immunotargeting cellular prion protein. AE Barry, I Klyubin, JM McDonald, AJ Mably, MA Farrell, M Scott, DM Walsh, MJ Rowan, J Neurosci 2011 31 7259 7263 10.1523/JNEUROSCI.6500-10.2011 21593310
-
(2011)
J Neurosci
, vol.31
, pp. 7259-7263
-
-
Barry, A.E.1
Klyubin, I.2
McDonald, J.M.3
Mably, A.J.4
Farrell, M.A.5
Scott, M.6
Walsh, D.M.7
Rowan, M.J.8
-
50
-
-
1842731881
-
SRC kinases: A hub for NMDA receptor regulation
-
Src kinases: a hub for NMDA receptor regulation. MW Salter, LV Kalia, Nat Rev 2004 5 317 328 (Pubitemid 38478658)
-
(2004)
Nature Reviews Neuroscience
, vol.5
, Issue.4
, pp. 317-328
-
-
Salter, M.W.1
Kalia, L.V.2
-
51
-
-
33846633336
-
Aβ oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease
-
DOI 10.1523/JNEUROSCI.3501-06.2007
-
Aβ oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. PN Lacor, MC Buniel, PW Furlow, AS Clemente, PT Velasco, M Wood, KL Viola, WL Klein, J Neurosci 2007 27 796 807 10.1523/JNEUROSCI.3501-06.2007 17251419 (Pubitemid 46174498)
-
(2007)
Journal of Neuroscience
, vol.27
, Issue.4
, pp. 796-807
-
-
Lacor, P.N.1
Buniel, M.C.2
Furlow, P.W.3
Clemente, A.S.4
Velasco, P.T.5
Wood, M.6
Viola, K.L.7
Klein, W.L.8
-
52
-
-
49149124343
-
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory
-
10.1038/nm1782 18568035
-
Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory. GM Shankar, S Li, TH Mehta, A Garcia-Munoz, NE Shepardson, I Smith, FM Brett, MA Farrell, MJ Rowan, CA Lemere, CM Regan, DM Walsh, BL Sabatini, DJ Selkoe, Nat Med 2008 14 837 842 10.1038/nm1782 18568035
-
(2008)
Nat Med
, vol.14
, pp. 837-842
-
-
Shankar, G.M.1
Li, S.2
Mehta, T.H.3
Garcia-Munoz, A.4
Shepardson, N.E.5
Smith, I.6
Brett, F.M.7
Farrell, M.A.8
Rowan, M.J.9
Lemere, C.A.10
Regan, C.M.11
Walsh, D.M.12
Sabatini, B.L.13
Selkoe, D.J.14
-
53
-
-
33947314641
-
Natural oligomers of the Alzheimer amyloid-β protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway
-
DOI 10.1523/JNEUROSCI.4970-06.2007
-
Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. GM Shankar, BL Bloodgood, M Townsend, DM Walsh, DJ Selkoe, BL Sabatini, J Neurosci 2007 27 2866 2875 10.1523/JNEUROSCI.4970-06.2007 17360908 (Pubitemid 46438992)
-
(2007)
Journal of Neuroscience
, vol.27
, Issue.11
, pp. 2866-2875
-
-
Shankar, G.M.1
Bloodgood, B.L.2
Townsend, M.3
Walsh, D.M.4
Selkoe, D.J.5
Sabatini, B.L.6
-
54
-
-
0037174618
-
Alzheimer's disease is a synaptic failure
-
DOI 10.1126/science.1074069
-
Alzheimer's disease is a synaptic failure. DJ Selkoe, Science 2002 298 789 791 10.1126/science.1074069 12399581 (Pubitemid 35231524)
-
(2002)
Science
, vol.298
, Issue.5594
, pp. 789-791
-
-
Selkoe, D.J.1
-
55
-
-
34248181511
-
Reducing endogenous tau ameliorates amyloid β-induced deficits in an Alzheimer's disease mouse model
-
DOI 10.1126/science.1141736
-
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model. ED Roberson, K Scearce-Levie, JJ Palop, F Yan, IH Cheng, T Wu, H Gerstein, GQ Yu, L Mucke, Science 2007 316 750 754 10.1126/science.1141736 17478722 (Pubitemid 46717684)
-
(2007)
Science
, vol.316
, Issue.5825
, pp. 750-754
-
-
Roberson, E.D.1
Scearce-Levie, K.2
Palop, J.J.3
Yan, F.4
Cheng, I.H.5
Wu, T.6
Gerstein, H.7
Yu, G.-Q.8
Mucke, L.9
-
56
-
-
77956504025
-
Tyrosine phosphorylation of tau accompanies disease progression in transgenic mouse models of tauopathy
-
10.1111/j.1365-2990.2010.01103.x 20609109
-
Tyrosine phosphorylation of tau accompanies disease progression in transgenic mouse models of tauopathy. K Bhaskar, GA Hobbs, SH Yen, G Lee, Neuropathol Appl Neurobiol 2010 36 462 477 10.1111/j.1365-2990.2010.01103.x 20609109
-
(2010)
Neuropathol Appl Neurobiol
, vol.36
, pp. 462-477
-
-
Bhaskar, K.1
Hobbs, G.A.2
Yen, S.H.3
Lee, G.4
-
57
-
-
27444437758
-
Disease-related modifications in tau affect the interaction between Fyn and tau
-
DOI 10.1074/jbc.M505895200
-
Disease-related modifications in tau affect the interaction between Fyn and Tau. K Bhaskar, SH Yen, G Lee, J Biol Chem 2005 280 35119 35125 10.1074/jbc.M505895200 16115884 (Pubitemid 41532698)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.42
, pp. 35119-35125
-
-
Bhaskar, K.1
Yen, S.-H.2
Lee, G.3
-
58
-
-
12144288564
-
Phosphorylation of tau by fyn: Implications for alzheimer's disease
-
DOI 10.1523/JNEUROSCI.4162-03.2004
-
Phosphorylation of tau by fyn: implications for Alzheimer's disease. G Lee, R Thangavel, VM Sharma, JM Litersky, K Bhaskar, SM Fang, LH Do, A Andreadis, G Van Hoesen, H Ksiezak-Reding, J Neurosci 2004 24 2304 2312 10.1523/JNEUROSCI.4162-03.2004 14999081 (Pubitemid 38314562)
-
(2004)
Journal of Neuroscience
, vol.24
, Issue.9
, pp. 2304-2312
-
-
Lee, G.1
Thangavel, R.2
Sharma, V.M.3
Litersky, J.M.4
Bhaskar, K.5
Fang, S.M.6
Do, L.H.7
Andreadis, A.8
Van Hoesen, G.9
Ksiezak-Reding, H.10
-
59
-
-
0344505849
-
Tau interacts with src-family non-receptor tyrosine kinases
-
Tau interacts with src-family non-receptor tyrosine kinases. G Lee, ST Newman, DL Gard, H Band, G Panchamoorthy, J Cell Sci 1998 111 3167 3177 9763511 (Pubitemid 28532427)
-
(1998)
Journal of Cell Science
, vol.111
, Issue.21
, pp. 3167-3177
-
-
Lee, G.1
Todd Newman, S.2
Gard, D.L.3
Band, H.4
Panchamoorthy, G.5
-
60
-
-
78651506630
-
Amyloid-beta/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease
-
10.1523/JNEUROSCI.4152-10.2011 21228179
-
Amyloid-beta/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease. ED Roberson, B Halabisky, JW Yoo, J Yao, J Chin, F Yan, T Wu, P Hamto, N Devidze, GQ Yu, JJ Palop, JL Noebels, L Mucke, J Neurosci 2011 31 700 711 10.1523/JNEUROSCI.4152-10.2011 21228179
-
(2011)
J Neurosci
, vol.31
, pp. 700-711
-
-
Roberson, E.D.1
Halabisky, B.2
Yoo, J.W.3
Yao, J.4
Chin, J.5
Yan, F.6
Wu, T.7
Hamto, P.8
Devidze, N.9
Yu, G.Q.10
Palop, J.J.11
Noebels, J.L.12
Mucke, L.13
-
61
-
-
77955322042
-
Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models
-
10.1016/j.cell.2010.06.036 20655099
-
Dendritic function of tau mediates amyloid-beta toxicity in Alzheimer's disease mouse models. LM Ittner, YD Ke, F Delerue, M Bi, A Gladbach, J van Eersel, H Wolfing, BC Chieng, MJ Christie, IA Napier, A Eckert, M Staufenbiel, E Hardeman, J Götz, Cell 2010 142 387 397 10.1016/j.cell.2010.06.036 20655099
-
(2010)
Cell
, vol.142
, pp. 387-397
-
-
Ittner, L.M.1
Ke, Y.D.2
Delerue, F.3
Bi, M.4
Gladbach, A.5
Van Eersel, J.6
Wolfing, H.7
Chieng, B.C.8
Christie, M.J.9
Napier, I.A.10
Eckert, A.11
Staufenbiel, M.12
Hardeman, E.13
Götz, J.14
-
62
-
-
78049448191
-
SNPs associated with cerebrospinal fluid phospho-tau levels influence rate of decline in Alzheimer's disease
-
10.1371/journal.pgen.1001101 20862329
-
SNPs associated with cerebrospinal fluid phospho-tau levels influence rate of decline in Alzheimer's disease. C Cruchaga, JS Kauwe, K Mayo, N Spiegel, S Bertelsen, P Nowotny, AR Shah, R Abraham, P Hollingworth, D Harold, MM Owen, J Williams, S Lovestone, ER Peskind, G Li, JB Leverenz, D Galasko, JC Morris, AM Fagan, DM Holtzman, AM Goate, Alzheimer's Disease Neuroimaging Initiative, PLoS Genet 2010 6 1001101 10.1371/journal.pgen.1001101 20862329
-
(2010)
PLoS Genet
, vol.6
, pp. 51001101
-
-
Cruchaga, C.1
Kauwe, J.S.2
Mayo, K.3
Spiegel, N.4
Bertelsen, S.5
Nowotny, P.6
Shah, A.R.7
Abraham, R.8
Hollingworth, P.9
Harold, D.10
Owen, M.M.11
Williams, J.12
Lovestone, S.13
Peskind, E.R.14
Li, G.15
Leverenz, J.B.16
Galasko, D.17
Morris, J.C.18
Fagan, A.M.19
Holtzman, D.M.20
Goate, A.M.21
Disease Neuroimaging Initiative, A.22
more..
-
63
-
-
84866328064
-
Tau phosphorylation pathway genes and cerebrospinal fluid tau levels in Alzheimer's disease
-
10.1002/ajmg.b.32094 22927204
-
Tau phosphorylation pathway genes and cerebrospinal fluid tau levels in Alzheimer's disease. LM Bekris, S Millard, F Lutz, G Li, DR Galasko, MR Farlow, JF Quinn, JA Kaye, JB Leverenz, DW Tsuang, CE Yu, ER Peskind, Am J Med Genet B Neuropsychiatr Genet 2012 159B 874 883 10.1002/ajmg.b.32094 22927204
-
(2012)
Am J Med Genet B Neuropsychiatr Genet
, vol.159
, pp. 874-883
-
-
Bekris, L.M.1
Millard, S.2
Lutz, F.3
Li, G.4
Galasko, D.R.5
Farlow, M.R.6
Quinn, J.F.7
Kaye, J.A.8
Leverenz, J.B.9
Tsuang, D.W.10
Yu, C.E.11
Peskind, E.R.12
-
64
-
-
2442711560
-
Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice
-
DOI 10.1523/JNEUROSCI.0277-04.2004
-
Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice. J Chin, JJ Palop, GQ Yu, N Kojima, E Masliah, L Mucke, J Neurosci 2004 24 4692 4697 10.1523/JNEUROSCI.0277- 04.2004 15140940 (Pubitemid 38656624)
-
(2004)
Journal of Neuroscience
, vol.24
, Issue.19
, pp. 4692-4697
-
-
Chin, J.1
Palop, J.J.2
Yu, G.-Q.3
Kojima, N.4
Masliah, E.5
Mucke, L.6
-
65
-
-
27144489060
-
Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease
-
DOI 10.1523/JNEUROSCI.2980-05.2005
-
Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease. J Chin, JJ Palop, J Puolivali, C Massaro, N Bien-Ly, H Gerstein, K Scearce-Levie, E Masliah, L Mucke, J Neurosci 2005 25 9694 9703 10.1523/JNEUROSCI.2980-05.2005 16237174 (Pubitemid 41510910)
-
(2005)
Journal of Neuroscience
, vol.25
, Issue.42
, pp. 9694-9703
-
-
Chin, J.1
Palop, J.J.2
Puolivali, J.3
Massaro, C.4
Bien-Ly, N.5
Gerstein, H.6
Scearce-Levie, K.7
Masliah, E.8
Mucke, L.9
-
66
-
-
84856974150
-
Fyn knock-down increases Abeta, decreases phospho-tau, and worsens spatial learning in 3xTg-AD mice
-
e15-e24 21782287
-
Fyn knock-down increases Abeta, decreases phospho-tau, and worsens spatial learning in 3xTg-AD mice. SS Minami, TG Clifford, HS Hoe, Y Matsuoka, GW Rebeck, Neurobiol Aging 2012 33 825 e15-e24 21782287
-
(2012)
Neurobiol Aging
, vol.33
, pp. 825
-
-
Minami, S.S.1
Clifford, T.G.2
Hoe, H.S.3
Matsuoka, Y.4
Rebeck, G.W.5
-
67
-
-
78650491806
-
Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model
-
10.1073/pnas.1013543107 20956308
-
Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model. Y Zhang, P Kurup, J Xu, N Carty, SM Fernandez, HB Nygaard, C Pittenger, P Greengard, SM Strittmatter, AC Nairn, PJ Lombroso, Proc Natl Acad Sci U S A 2010 107 19014 19019 10.1073/pnas.1013543107 20956308
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 19014-19019
-
-
Zhang, Y.1
Kurup, P.2
Xu, J.3
Carty, N.4
Fernandez, S.M.5
Nygaard, H.B.6
Pittenger, C.7
Greengard, P.8
Strittmatter, S.M.9
Nairn, A.C.10
Lombroso, P.J.11
-
68
-
-
84861805073
-
Inhibition of Src kinase activity attenuates amyloid associated microgliosis in a murine model of Alzheimer's disease
-
10.1186/1742-2094-9-117
-
Inhibition of Src kinase activity attenuates amyloid associated microgliosis in a murine model of Alzheimer's disease. G Dhawan, CK Combs, J Neuroinflamm 2012 9 117 10.1186/1742-2094-9-117
-
(2012)
J Neuroinflamm
, vol.9
, pp. 117
-
-
Dhawan, G.1
Combs, C.K.2
-
69
-
-
60149094000
-
Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling
-
19208690
-
Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling. AS Baer, YA Syed, SU Kang, D Mitteregger, R Vig, C Ffrench-Constant, RJ Franklin, F Altmann, G Lubec, MR Kotter, Brain 2009 132 465 481 19208690
-
(2009)
Brain
, vol.132
, pp. 465-481
-
-
Baer, A.S.1
Syed, Y.A.2
Kang, S.U.3
Mitteregger, D.4
Vig, R.5
Ffrench-Constant, C.6
Franklin, R.J.7
Altmann, F.8
Lubec, G.9
Kotter, M.R.10
-
70
-
-
0026669001
-
Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn
-
10.1016/0092-8674(92)90309-Z 1516132
-
Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn. MW Appleby, JA Gross, MP Cooke, SD Levin, X Qian, RM Perlmutter, Cell 1992 70 751 763 10.1016/0092-8674(92)90309-Z 1516132
-
(1992)
Cell
, vol.70
, pp. 751-763
-
-
Appleby, M.W.1
Gross, J.A.2
Cooke, M.P.3
Levin, S.D.4
Qian, X.5
Perlmutter, R.M.6
-
71
-
-
0035881584
-
+ T cells into the Th2 subset
-
Impairment in the expression and activity of Fyn during differentiation of naive CD4§ssup§+§esup§ T cells into the Th2 subset. T Tamura, O Igarashi, A Hino, H Yamane, S Aizawa, T Kato, H Nariuchi, J Immunol 2001 167 1962 1969 11489976 (Pubitemid 32747501)
-
(2001)
Journal of Immunology
, vol.167
, Issue.4
, pp. 1962-1969
-
-
Tamura, T.1
Igarashi, O.2
Hino, A.3
Yamane, H.4
Aizawa, S.5
Kato, T.6
Nariuchi, H.7
-
72
-
-
46249134182
-
Analysis of fyn function in hemostasis and αllbβ3-integrin signaling
-
DOI 10.1242/jcs.014076
-
Analysis of Fyn function in hemostasis and alphaIIbbeta3-integrin signaling. KB Reddy, DM Smith, EF Plow, J Cell Sci 2008 121 1641 1648 10.1242/jcs.014076 18430780 (Pubitemid 351911821)
-
(2008)
Journal of Cell Science
, vol.121
, Issue.10
, pp. 1641-1648
-
-
Reddy, K.B.1
Smith, D.M.2
Plow, E.F.3
-
73
-
-
79957803165
-
Masitinib as an adjunct therapy for mild-to-moderate Alzheimer's disease: A randomised, placebo-controlled phase 2 trial
-
10.1186/alzrt75 21504563
-
Masitinib as an adjunct therapy for mild-to-moderate Alzheimer's disease: a randomised, placebo-controlled phase 2 trial. F Piette, J Belmin, H Vincent, N Schmidt, S Pariel, M Verny, C Marquis, J Mely, L Hugonot-Diener, JP Kinet, P Dubreuil, A Moussy, O Hermine, Alzheimers Res Ther 2011 3 16 10.1186/alzrt75 21504563
-
(2011)
Alzheimers Res Ther
, vol.3
, pp. 16
-
-
Piette, F.1
Belmin, J.2
Vincent, H.3
Schmidt, N.4
Pariel, S.5
Verny, M.6
Marquis, C.7
Mely, J.8
Hugonot-Diener, L.9
Kinet, J.P.10
Dubreuil, P.11
Moussy, A.12
Hermine, O.13
-
74
-
-
33750491945
-
N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy] -5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor
-
DOI 10.1021/jm060434q
-
N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methylpiperazin-1-yl)ethoxy] -5-(tetrahydro-2H-pyran-4-yloxy)quinazolin-4-amine, a novel, highly selective, orally available, dual-specific c-Src/Abl kinase inhibitor. LF Hennequin, J Allen, J Breed, J Curwen, M Fennell, TP Green, C Lambert-van der Brempt, R Morgentin, RA Norman, A Olivier, L Otterbein, PA Plé N Warin, G Costello, J Med Chem 2006 49 6465 6488 10.1021/jm060434q 17064066 (Pubitemid 44657442)
-
(2006)
Journal of Medicinal Chemistry
, vol.49
, Issue.22
, pp. 6465-6488
-
-
Hennequin, L.F.1
Allen, J.2
Breed, J.3
Curwen, J.4
Fennell, M.5
Green, T.P.6
Lambert-Van Der Brempt, C.7
Morgentin, R.8
Norman, R.A.9
Olivier, A.10
Otterbein, L.11
Ple, P.A.12
Warin, N.13
Costello, G.14
-
75
-
-
84879088504
-
Phase II study of the Src kinase inhibitor saracatinib (AZD0530) in metastatic melanoma
-
10.1007/s10637-012-9897-4 23151808
-
Phase II study of the Src kinase inhibitor saracatinib (AZD0530) in metastatic melanoma. TC Gangadhar, JI Clark, T Karrison, TF Gajewski, Invest New Drugs 2013 31 769 773 10.1007/s10637-012-9897-4 23151808
-
(2013)
Invest New Drugs
, vol.31
, pp. 769-773
-
-
Gangadhar, T.C.1
Clark, J.I.2
Karrison, T.3
Gajewski, T.F.4
-
76
-
-
84855748821
-
Phase II trial of saracatinib (AZD0530), an oral SRC-inhibitor for the treatment of patients with hormone receptor-negative metastatic breast cancer
-
10.1016/j.clbc.2011.03.021 21729667
-
Phase II trial of saracatinib (AZD0530), an oral SRC-inhibitor for the treatment of patients with hormone receptor-negative metastatic breast cancer. A Gucalp, JA Sparano, J Caravelli, J Santamauro, S Patil, A Abbruzzi, C Pellegrino, J Bromberg, C Dang, M Theodoulou, J Massague, L Norton, C Hudis, TA Traina, Clin Breast Cancer 2011 11 306 311 10.1016/j.clbc.2011.03.021 21729667
-
(2011)
Clin Breast Cancer
, vol.11
, pp. 306-311
-
-
Gucalp, A.1
Sparano, J.A.2
Caravelli, J.3
Santamauro, J.4
Patil, S.5
Abbruzzi, A.6
Pellegrino, C.7
Bromberg, J.8
Dang, C.9
Theodoulou, M.10
Massague, J.11
Norton, L.12
Hudis, C.13
Traina, T.A.14
-
77
-
-
84863792706
-
A phase II trial of the Src kinase inhibitor saracatinib (AZD0530) in patients with metastatic or locally advanced gastric or gastro esophageal junction (GEJ) adenocarcinoma: A trial of the PMH phase II consortium
-
10.1007/s10637-011-9650-4 21400081
-
A phase II trial of the Src kinase inhibitor saracatinib (AZD0530) in patients with metastatic or locally advanced gastric or gastro esophageal junction (GEJ) adenocarcinoma: a trial of the PMH phase II consortium. HJ Mackay, HJ Au, E McWhirter, T Alcindor, A Jarvi, K MacAlpine, L Wang, JJ Wright, AM Oza, Invest New Drugs 2012 30 1158 1163 10.1007/s10637-011-9650-4 21400081
-
(2012)
Invest New Drugs
, vol.30
, pp. 1158-1163
-
-
Mackay, H.J.1
Au, H.J.2
McWhirter, E.3
Alcindor, T.4
Jarvi, A.5
Macalpine, K.6
Wang, L.7
Wright, J.J.8
Oza, A.M.9
-
78
-
-
79851495693
-
Phase II study of saracatinib (AZD0530) for patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC)
-
21273606
-
Phase II study of saracatinib (AZD0530) for patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC). MG Fury, S Baxi, R Shen, KW Kelly, BL Lipson, D Carlson, H Stambuk, S Haque, DG Pfister, Anticancer Res 2011 31 249 253 21273606
-
(2011)
Anticancer Res
, vol.31
, pp. 249-253
-
-
Fury, M.G.1
Baxi, S.2
Shen, R.3
Kelly, K.W.4
Lipson, B.L.5
Carlson, D.6
Stambuk, H.7
Haque, S.8
Pfister, D.G.9
-
79
-
-
84862018553
-
A phase I/II study of the Src inhibitor saracatinib (AZD0530) in combination with gemcitabine in advanced pancreatic cancer
-
10.1007/s10637-010-9611-3 21170669
-
A phase I/II study of the Src inhibitor saracatinib (AZD0530) in combination with gemcitabine in advanced pancreatic cancer. DJ Renouf, MJ Moore, D Hedley, S Gill, D Jonker, E Chen, D Walde, R Goel, B Southwood, I Gauthier, W Walsh, L McIntosh, L Seymour, Invest New Drugs 2012 30 779 786 10.1007/s10637-010-9611-3 21170669
-
(2012)
Invest New Drugs
, vol.30
, pp. 779-786
-
-
Renouf, D.J.1
Moore, M.J.2
Hedley, D.3
Gill, S.4
Jonker, D.5
Chen, E.6
Walde, D.7
Goel, R.8
Southwood, B.9
Gauthier, I.10
Walsh, W.11
McIntosh, L.12
Seymour, L.13
|