-
1
-
-
0022744803
-
Abnormal phosphorylation of the microtubule-associated protein tau in Alzheimer cytoskeletal pathology
-
Grundke-Iqbal I, Iqbal K, Tung YC, Quinlan M, Wisniewski HM, Binder LI (1986) Abnormal phosphorylation of the microtubule-associated protein tau in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci U S A 83, 4913-4917.
-
(1986)
Proc Natl Acad Sci U S A
, vol.83
, pp. 4913-4917
-
-
Grundke-Iqbal, I.1
Iqbal, K.2
Tung, Y.C.3
Quinlan, M.4
Wisniewski, H.M.5
Binder, L.I.6
-
2
-
-
0025904444
-
A68: A major subunit of the paired helical filaments and derivatized forms of normal tau
-
Lee VM, Balin BJ, Otvos LJ, Trojanowski JQ (1991) A68: A major subunit of the paired helical filaments and derivatized forms of normal tau. Science 251, 675-678.
-
(1991)
Science
, vol.251
, pp. 675-678
-
-
Lee, V.M.1
Balin, B.J.2
Otvos, L.J.3
Trojanowski, J.Q.4
-
3
-
-
69449093036
-
Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology
-
Polydoro M, Acker CM, Duff K, Castillo PE, Davies P (2009) Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology. J Neurosci 29, 10741-10749.
-
(2009)
J Neurosci
, vol.29
, pp. 10741-10749
-
-
Polydoro, M.1
Acker, C.M.2
Duff, K.3
Castillo, P.E.4
Davies, P.5
-
4
-
-
22344438508
-
Tau suppression in a neurodegenerative mouse model improves memory function
-
Santacruz K, Lewis J, Spires T, Paulson J,Kotilinek L, Ingelsson M, Guimaraes A, DeTure M, Ramsden M, McGowan E, Forster C, Yue M, Orne J, Janus C, Mariash A, Kuskowski M, Hyman B, Hutton M, Ashe KH (2005) Tau suppression in a neurodegenerative mouse model improves memory function. Science 309, 476-481.
-
(2005)
Science
, vol.309
, pp. 476-481
-
-
Santacruz, K.1
Lewis, J.2
Spires, T.3
Paulson, J.4
Kotilinek, L.5
Ingelsson, M.6
Guimaraes, A.7
Deture, M.8
Ramsden, M.9
McGowan, E.10
Forster, C.11
Yue, M.12
Orne, J.13
Janus, C.14
Mariash, A.15
Kuskowski, M.16
Hyman, B.17
Hutton, M.18
Ashe, K.H.19
-
5
-
-
33744818219
-
Assessments of the accumulation severities of amyloid betaprotein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains
-
Zhou XW, Li X, Bjorkdahl C, Sjogren MJ, Alafuzoff I, Soininen H, Grundke-Iqbal I, Iqbal K, Winblad B, Pei JJ (2006) Assessments of the accumulation severities of amyloid betaprotein and hyperphosphorylated tau in the medial temporal cortex of control and Alzheimer's brains. Neurobiol Dis 22, 657-668.
-
(2006)
Neurobiol Dis
, vol.22
, pp. 657-668
-
-
Zhou, X.W.1
Li, X.2
Bjorkdahl, C.3
Sjogren, M.J.4
Alafuzoff, I.5
Soininen, H.6
Grundke-Iqbal, I.7
Iqbal, K.8
Winblad, B.9
Pei, J.J.10
-
6
-
-
33747425620
-
GSK-3 is essential in the pathogenesis of Alzheimer's disease
-
Takashima A (2006) GSK-3 is essential in the pathogenesis of Alzheimer's disease. J Alzheimers Dis 9, 309-317.
-
(2006)
J Alzheimers Dis
, vol.9
, pp. 309-317
-
-
Takashima, A.1
-
7
-
-
67349142329
-
Mechanisms of tau-induced neurodegeneration
-
Iqbal K, Liu F, Gong CX, Alonso Adel C, Grundke-Iqbal I (2009) Mechanisms of tau-induced neurodegeneration. Acta Neuropathol 118, 53-69.
-
(2009)
Acta Neuropathol
, vol.118
, pp. 53-69
-
-
Iqbal, K.1
Liu, F.2
Gong, C.X.3
Alonso Adel, C.4
Grundke-Iqbal, I.5
-
8
-
-
0028902487
-
Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and-2B
-
Wang JZ, Gong CX, Zaidi T, Grundke-Iqbal I, Iqbal K (1995) Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and-2B. J Biol Chem 270, 4854-4860.
-
(1995)
J Biol Chem
, vol.270
, pp. 4854-4860
-
-
Wang, J.Z.1
Gong, C.X.2
Zaidi, T.3
Grundke-Iqbal, I.4
Iqbal, K.5
-
9
-
-
0034088846
-
Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease
-
Gong CX, Lidsky T, Wegiel J, Zuck L, Grundke-Iqbal I, Iqbal K (2000) Phosphorylation of microtubule-associated protein tau is regulated by protein phosphatase 2A in mammalian brain. Implications for neurofibrillary degeneration in Alzheimer's disease. J Biol Chem 275, 5535-5544.
-
(2000)
J Biol Chem
, vol.275
, pp. 5535-5544
-
-
Gong, C.X.1
Lidsky, T.2
Wegiel, J.3
Zuck, L.4
Grundke-Iqbal, I.5
Iqbal, K.6
-
10
-
-
78649859760
-
The carboxyterminal fragment of inhibitor-2 of protein phosphatase-2A induces Alzheimer disease pathology and cognitive impairment
-
Wang X, Blanchard J, Kohlbrenner E, Clement N, Linden RM, Radu A, Grundke-Iqbal I, Iqbal K (2010) The carboxyterminal fragment of inhibitor-2 of protein phosphatase-2A induces Alzheimer disease pathology and cognitive impairment. FASEB J 24, 4420-4432.
-
(2010)
FASEB J
, vol.24
, pp. 4420-4432
-
-
Wang, X.1
Blanchard, J.2
Kohlbrenner, E.3
Clement, N.4
Linden, R.M.5
Radu, A.6
Grundke-Iqbal, I.7
Iqbal, K.8
-
11
-
-
27644478606
-
Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation
-
Liu F, Grundke-Iqbal I, Iqbal K, Gong CX (2005) Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation. Eur J Neurosci 22, 1942-1950.
-
(2005)
Eur J Neurosci
, vol.22
, pp. 1942-1950
-
-
Liu, F.1
Grundke-Iqbal, I.2
Iqbal, K.3
Gong, C.X.4
-
12
-
-
0035851175
-
Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice
-
Kins S, Crameri A, Evans DR, Hemmings BA, Nitsch RM, Gotz J (2001) Reduced protein phosphatase 2A activity induces hyperphosphorylation and altered compartmentalization of tau in transgenic mice. J Biol Chem 276, 38193-38200.
-
(2001)
J Biol Chem
, vol.276
, pp. 38193-38200
-
-
Kins, S.1
Crameri, A.2
Evans, D.R.3
Hemmings, B.A.4
Nitsch, R.M.5
Gotz, J.6
-
13
-
-
0029113874
-
Phosphatase activity toward abnormally phosphorylated tau: Decrease in Alzheimer disease brain
-
Gong CX, Shaikh S,Wang JZ, Zaidi T, Grundke-Iqbal I, Iqbal K(1995) Phosphatase activity toward abnormally phosphorylated tau: Decrease in Alzheimer disease brain. J Neurochem 65, 732-738.
-
(1995)
J Neurochem
, vol.65
, pp. 732-738
-
-
Gong, C.X.1
Shaikh, S.2
Wang, J.Z.3
Zaidi, T.4
Grundke-Iqbal, I.5
Iqbal, K.6
-
14
-
-
41149086325
-
Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology
-
Liu R, Zhou XW, Tanila H, Bjorkdahl C, Wang JZ, Guan ZZ, Cao Y, Gustafsson JA, Winblad B, Pei JJ (2008) Phosphorylated PP2A (tyrosine 307) is associated with Alzheimer neurofibrillary pathology. J Cell Mol Med 12, 241-257.
-
(2008)
J Cell Mol Med
, vol.12
, pp. 241-257
-
-
Liu, R.1
Zhou, X.W.2
Tanila, H.3
Bjorkdahl, C.4
Wang, J.Z.5
Guan, Z.Z.6
Cao, Y.7
Gustafsson, J.A.8
Winblad, B.9
Pei, J.J.10
-
15
-
-
84870481575
-
Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation
-
Xiong Y, Jing XP, Zhou XW, Wang XL, Yang Y, Sun XY, Qiu M, Cao FY, Lu YM, Liu R, Wang JZ (2013) Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation. Neurobiol Aging 34, 745-756.
-
(2013)
Neurobiol Aging
, vol.34
, pp. 745-756
-
-
Xiong, Y.1
Jing, X.P.2
Zhou, X.W.3
Wang, X.L.4
Yang, Y.5
Sun, X.Y.6
Qiu, M.7
Cao, F.Y.8
Lu, Y.M.9
Liu, R.10
Wang, J.Z.11
-
16
-
-
79959736543
-
Glycogen synthase kinase-3-regulates Tyr307 phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src
-
Yao XQ, Zhang XX,YinYY, Liu B, Luo DJ, Liu D, Chen NN, Ni ZF,Wang X,Wang Q,Wang JZ, Liu GP (2011) Glycogen synthase kinase-3-regulates Tyr307 phosphorylation of protein phosphatase-2A via protein tyrosine phosphatase 1B but not Src. Biochem J 437, 335-344.
-
(2011)
Biochem J
, vol.437
, pp. 335-344
-
-
Yao, X.Q.1
Zhang, X.X.2
Yin, Y.Y.3
Liu, B.4
Luo, D.J.5
Liu, D.6
Chen, N.N.7
Ni, Z.F.8
Wang, X.9
Wang, Q.10
Wang, J.Z.11
Liu, G.P.12
-
17
-
-
51649119364
-
Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus
-
Zhang CE, Tian Q,Wei W, Peng JH, Liu GP, Zhou XW,Wang Q, Wang DW, Wang JZ (2008) Homocysteine induces tau phosphorylation by inactivating protein phosphatase 2A in rat hippocampus. Neurobiol Aging 29, 1654-1665.
-
(2008)
Neurobiol Aging
, vol.29
, pp. 1654-1665
-
-
Zhang, C.E.1
Tian, Q.2
Wei, W.3
Peng, J.H.4
Liu, G.P.5
Zhou, X.W.6
Wang, Q.7
Wang, D.W.8
Wang, J.Z.9
-
18
-
-
63849199824
-
The NMN/NaMN adenylyltransferase (NMNAT) protein family
-
Lau C, Niere M, Ziegler M (2009) The NMN/NaMN adenylyltransferase (NMNAT) protein family. Front Biosci 14, 410-431.
-
(2009)
Front Biosci
, vol.14
, pp. 410-431
-
-
Lau, C.1
Niere, M.2
Ziegler, M.3
-
19
-
-
78650071674
-
Expression, localization, and biochemical characterization of nicotinamide mononucleotide adenylyltransferase 2
-
Mayer PR, Huang N, Dewey CM, Dries DR, Zhang H, Yu G (2010) Expression, localization, and biochemical characterization of nicotinamide mononucleotide adenylyltransferase 2. J Biol Chem 285, 40387-40396.
-
(2010)
J Biol Chem
, vol.285
, pp. 40387-40396
-
-
Mayer, P.R.1
Huang, N.2
Dewey, C.M.3
Dries, D.R.4
Zhang, H.5
Yu, G.6
-
20
-
-
0036031865
-
Identification of a novel human nicotinamide mononucleotide adenylyltransferase
-
Raffaelli N, Sorci L, Amici A, Emanuelli M, Mazzola F, Magni G (2002) Identification of a novel human nicotinamide mononucleotide adenylyltransferase. Biochem Biophys Res Commun 297, 835-840.
-
(2002)
Biochem Biophys Res Commun
, vol.297
, pp. 835-840
-
-
Raffaelli, N.1
Sorci, L.2
Amici, A.3
Emanuelli, M.4
Mazzola, F.5
Magni, G.6
-
21
-
-
0038644836
-
Structural characterization of a human cytosolic NMN/NaMN adenylyltransferase and implication in human NAD biosynthesis
-
Zhang X, Kurnasov OV, Karthikeyan S, Grishin NV, Osterman AL, Zhang H (2003) Structural characterization of a human cytosolic NMN/NaMN adenylyltransferase and implication in human NAD biosynthesis. J Biol Chem 278, 13503-13511.
-
(2003)
J Biol Chem
, vol.278
, pp. 13503-13511
-
-
Zhang, X.1
Kurnasov, O.V.2
Karthikeyan, S.3
Grishin, N.V.4
Osterman, A.L.5
Zhang, H.6
-
22
-
-
27744501798
-
Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms
-
Berger F, Lau C, Dahlmann M, Ziegler M (2005) Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms. J Biol Chem 280, 36334-36341.
-
(2005)
J Biol Chem
, vol.280
, pp. 36334-36341
-
-
Berger, F.1
Lau, C.2
Dahlmann, M.3
Ziegler, M.4
-
23
-
-
77954617977
-
Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons
-
Gilley J, Coleman MP (2010) Endogenous Nmnat2 is an essential survival factor for maintenance of healthy axons. PLoS Biol 8, e1000300.
-
(2010)
PLoS Biol
, vol.8
-
-
Gilley, J.1
Coleman, M.P.2
-
24
-
-
33845477523
-
Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity
-
Zhai RG, Cao Y, Hiesinger PR, Zhou Y, Mehta SQ, Schulze KL, Verstreken P, Bellen HJ (2006) Drosophila NMNAT maintains neural integrity independent of its NAD synthesis activity. PLoS Biol 4, e416.
-
(2006)
PLoS Biol
, vol.4
-
-
Zhai, R.G.1
Cao, Y.2
Hiesinger, P.R.3
Zhou, Y.4
Mehta, S.Q.5
Schulze, K.L.6
Verstreken, P.7
Bellen, H.J.8
-
25
-
-
42249103603
-
NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration
-
Zhai RG, Zhang F, Hiesinger PR, Cao Y, Haueter CM, Bellen HJ (2008) NAD synthase NMNAT acts as a chaperone to protect against neurodegeneration. Nature 452, 887-891.
-
(2008)
Nature
, vol.452
, pp. 887-891
-
-
Zhai, R.G.1
Zhang, F.2
Hiesinger, P.R.3
Cao, Y.4
Haueter, C.M.5
Bellen, H.J.6
-
26
-
-
44949233176
-
Nmnat delays axonal degeneration caused by mitochondrial and oxidative stress
-
Press C, Milbrandt J (2008) Nmnat delays axonal degeneration caused by mitochondrial and oxidative stress. J Neurosci 28, 4861-4871.
-
(2008)
J Neurosci
, vol.28
, pp. 4861-4871
-
-
Press, C.1
Milbrandt, J.2
-
27
-
-
84859624394
-
A novel Drosophila model of nerve injury reveals an essential role of Nmnat in maintaining axonal integrity
-
Fang Y, Soares L, Teng X, Geary M, Bonini NM (2012) A novel Drosophila model of nerve injury reveals an essential role of Nmnat in maintaining axonal integrity. Curr Biol 22, 590-595.
-
(2012)
Curr Biol
, vol.22
, pp. 590-595
-
-
Fang, Y.1
Soares, L.2
Teng, X.3
Geary, M.4
Bonini, N.M.5
-
28
-
-
66249146403
-
Transgenic mice expressing the Nmnat1 protein manifest robust delay in axonal degeneration in vivo
-
SasakiY,Vohra BP, Baloh RH, Milbrandt J (2009) Transgenic mice expressing the Nmnat1 protein manifest robust delay in axonal degeneration in vivo. J Neurosci 29, 6526-6534.
-
(2009)
J Neurosci
, vol.29
, pp. 6526-6534
-
-
Sasaki, Y.1
Vohra, B.P.2
Baloh, R.H.3
Milbrandt, J.4
-
29
-
-
84855389519
-
CREB-activity and nmnat2 transcription are downregulated prior to neurodegeneration, while NMNAT2 overexpression is neuroprotective, in a mouse model of human tauopathy
-
Ljungberg MC, Ali YO, Zhu J, Wu CS, Oka K, Zhai RG, Lu HC(2012) CREB-activity and nmnat2 transcription are downregulated prior to neurodegeneration, while NMNAT2 overexpression is neuroprotective, in a mouse model of human tauopathy. Hum Mol Genet 21, 251-267.
-
(2012)
Hum Mol Genet
, vol.21
, pp. 251-267
-
-
Ljungberg, M.C.1
Ali, Y.O.2
Zhu, J.3
Wu, C.S.4
Oka, K.5
Zhai, R.G.6
Lu, H.C.7
-
30
-
-
84855368532
-
NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy
-
Ali YO, Ruan K, Zhai RG (2012) NMNAT suppresses tau-induced neurodegeneration by promoting clearance of hyperphosphorylated tau oligomers in a Drosophila model of tauopathy. Hum Mol Genet 21, 237-250.
-
(2012)
Hum Mol Genet
, vol.21
, pp. 237-250
-
-
Ali, Y.O.1
Ruan, K.2
Zhai, R.G.3
-
31
-
-
84861192034
-
AGEs induce Alzheimer-like tau pathology and memory deficit via RAGE-mediated GSK-3 activation
-
Li XH, Lv BL, Xie JZ, Liu J, Zhou XW,Wang JZ (2012)AGEs induce Alzheimer-like tau pathology and memory deficit via RAGE-mediated GSK-3 activation. Neurobiol Aging 33, 1400-1410.
-
(2012)
Neurobiol Aging
, vol.33
, pp. 1400-1410
-
-
Li, X.H.1
Lv, B.L.2
Xie, J.Z.3
Liu, J.4
Zhou, X.W.5
Wang, J.Z.6
-
32
-
-
77049107343
-
Acetyl-L-carnitine attenuates okadaic acid induced tau hyperphosphorylation and spatial memory impairment in rats
-
Yin YY, Liu H, Cong XB, Liu Z,Wang Q,Wang JZ, Zhu LQ (2010) Acetyl-L-carnitine attenuates okadaic acid induced tau hyperphosphorylation and spatial memory impairment in rats. J Alzheimers Dis 19, 735-746.
-
(2010)
J Alzheimers Dis
, vol.19
, pp. 735-746
-
-
Yin, Y.Y.1
Liu, H.2
Cong, X.B.3
Liu, Z.4
Wang, Q.5
Wang, J.Z.6
Zhu, L.Q.7
-
33
-
-
80051789852
-
Acetyl-L-carnitine ameliorates spatial memory deficits induced by inhibition of phosphoinositol-3 kinase and protein kinase C
-
Jiang X, Tian Q, Wang Y, Zhou XW, Xie JZ, Wang JZ, Zhu LQ (2011) Acetyl-L-carnitine ameliorates spatial memory deficits induced by inhibition of phosphoinositol-3 kinase and protein kinase C. J Neurochem 118, 864-878.
-
(2011)
J Neurochem
, vol.118
, pp. 864-878
-
-
Jiang, X.1
Tian, Q.2
Wang, Y.3
Zhou, X.W.4
Xie, J.Z.5
Wang, J.Z.6
Zhu, L.Q.7
-
34
-
-
79960739369
-
Upregulation of AKT attenuates amyloid-induced cell apoptosis
-
Yin G, Li LY, Qu M, Luo HB, Wang JZ, Zhou XW (2011) Upregulation of AKT attenuates amyloid-induced cell apoptosis. J Alzheimers Dis 25, 337-345.
-
(2011)
J Alzheimers Dis
, vol.25
, pp. 337-345
-
-
Yin, G.1
Li, L.Y.2
Qu, M.3
Luo, H.B.4
Wang, J.Z.5
Zhou, X.W.6
-
35
-
-
84863154673
-
EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation
-
Yang Y, Shu X, Liu D, Shang Y, Wu Y, Pei L, Xu X, Tian Q, Zhang J, Qian K, Wang YX, Petralia RS, Tu W, Zhu LQ, Wang JZ, Lu Y (2012) EPAC null mutation impairs learning and social interactions via aberrant regulation of miR-124 and Zif268 translation. Neuron 73, 774-788.
-
(2012)
Neuron
, vol.73
, pp. 774-788
-
-
Yang, Y.1
Shu, X.2
Liu, D.3
Shang, Y.4
Wu, Y.5
Pei, L.6
Xu, X.7
Tian, Q.8
Zhang, J.9
Qian, K.10
Wang, Y.X.11
Petralia, R.S.12
Tu, W.13
Zhu, L.Q.14
Wang, J.Z.15
Lu, Y.16
-
36
-
-
79960925152
-
Nmnat exerts neuroprotective effects in dendrites and axons
-
Wen Y, Parrish JZ, He R, Zhai RG, Kim MD (2011) Nmnat exerts neuroprotective effects in dendrites and axons. Mol Cell Neurosci 48, 1-8.
-
(2011)
Mol Cell Neurosci
, vol.48
, pp. 1-8
-
-
Wen, Y.1
Parrish, J.Z.2
He, R.3
Zhai, R.G.4
Kim, M.D.5
-
37
-
-
77957740998
-
Targeting NMNAT1 to axons and synapses transforms its neuroprotective potency in vivo
-
Babetto E, Beirowski B, Janeckova L, Brown R, Gilley J, Thomson D, Ribchester RR, Coleman MP (2010) Targeting NMNAT1 to axons and synapses transforms its neuroprotective potency in vivo. J Neurosci 30, 13291-13304.
-
(2010)
J Neurosci
, vol.30
, pp. 13291-13304
-
-
Babetto, E.1
Beirowski, B.2
Janeckova, L.3
Brown, R.4
Gilley, J.5
Thomson, D.6
Ribchester, R.R.7
Coleman, M.P.8
-
38
-
-
65649126738
-
Nicotinamide mononucleotide adenylyl transferase-mediated axonal protection requires enzymatic activity but not increased levels of neuronal nicotinamide adenine dinucleotide
-
Sasaki Y, Vohra BP, Lund FE, Milbrandt J (2009) Nicotinamide mononucleotide adenylyl transferase-mediated axonal protection requires enzymatic activity but not increased levels of neuronal nicotinamide adenine dinucleotide. J Neurosci 29, 5525-5535.
-
(2009)
J Neurosci
, vol.29
, pp. 5525-5535
-
-
Sasaki, Y.1
Vohra, B.P.2
Lund, F.E.3
Milbrandt, J.4
-
39
-
-
4043165678
-
Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration
-
Araki T, Sasaki Y, Milbrandt J (2004) Increased nuclear NAD biosynthesis and SIRT1 activation prevent axonal degeneration. Science 305, 1010-1013.
-
(2004)
Science
, vol.305
, pp. 1010-1013
-
-
Araki, T.1
Sasaki, Y.2
Milbrandt, J.3
-
40
-
-
82755168795
-
Nicotinamide mononucleotide adenylyl transferase 1 protects against acute neurodegeneration in developing CNS by inhibiting excitotoxic-necrotic cell death
-
Verghese PB, Sasaki Y, Yang D, Stewart F, Sabar F, Finn MB, Wroge CM,Mennerick S, Neil JJ, Milbrandt J, Holtzman DM (2011) Nicotinamide mononucleotide adenylyl transferase 1 protects against acute neurodegeneration in developing CNS by inhibiting excitotoxic-necrotic cell death. Proc Natl Acad Sci U S A 108, 19054-19059.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 19054-19059
-
-
Verghese, P.B.1
Sasaki, Y.2
Yang, D.3
Stewart, F.4
Sabar, F.5
Finn, M.B.6
Wroge, C.M.7
Mennerick, S.8
Neil, J.J.9
Milbrandt, J.10
Holtzman, D.M.11
-
41
-
-
0036771832
-
AbetaPP induces cdk5-dependent tau hyperphosphorylation in transgenic mice Tg2576
-
Otth C, Concha II, Arendt T, Stieler J, Schliebs R, González- Billault C, Maccioni RB (2002) AbetaPP induces cdk5-dependent tau hyperphosphorylation in transgenic mice Tg2576. J Alzheimers Dis 4, 417-430.
-
(2002)
J Alzheimers Dis
, vol.4
, pp. 417-430
-
-
Otth, C.1
Concha, I.I.2
Arendt, T.3
Stieler, J.4
Schliebs, R.5
González- Billault, C.6
Maccioni, R.B.7
-
42
-
-
11144356498
-
Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein e and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease
-
Kawarabayashi T, Shoji M, Younkin LH,Wen-Lang L, Dickson DW, Murakami T, Matsubara E, Abe K, Ashe KH, Younkin SG (2004) Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's disease. J Neurosci 24, 3801-3809.
-
(2004)
J Neurosci
, vol.24
, pp. 3801-3809
-
-
Kawarabayashi, T.1
Shoji, M.2
Younkin, L.H.3
Wen-Lang, L.4
Dickson, D.W.5
Murakami, T.6
Matsubara, E.7
Abe, K.8
Ashe, K.H.9
Younkin, S.G.10
-
43
-
-
84876412066
-
Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model
-
doi: 10.1159-000338152
-
Flunkert S, Hierzer M, Löffler T, Rabl R, Neddens J, Duller S, Schofield EL, Ward MA, Posch M, Jungwirth H, Windisch M, Hutter-Paier B (2012) Elevated levels of soluble total and hyperphosphorylated tau result in early behavioral deficits and distinct changes in brain pathology in a new tau transgenic mouse model. Neurodegener Dis, doi: 10.1159-000338152.
-
(2012)
Neurodegener Dis
-
-
Flunkert, S.1
Hierzer, M.2
Löffler, T.3
Rabl, R.4
Neddens, J.5
Duller, S.6
Schofield, E.L.7
Ward, M.A.8
Posch, M.9
Jungwirth, H.10
Windisch, M.11
Hutter-Paier, B.12
-
44
-
-
0024592297
-
Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism
-
Haystead TA, Sim AT, Carling D, Honnor RC, Tsukitani Y, Cohen P, Hardie DG (1989) Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism. Nature 337, 78-81.
-
(1989)
Nature
, vol.337
, pp. 78-81
-
-
Haystead, T.A.1
Sim, A.T.2
Carling, D.3
Honnor, R.C.4
Tsukitani, Y.5
Cohen, P.6
Hardie, D.G.7
-
45
-
-
0024361302
-
An improved procedure for identifying and quantitating protein phosphatases in mammalian tissues
-
Cohen P, Klumpp S, Schelling DL (1989) An improved procedure for identifying and quantitating protein phosphatases in mammalian tissues. FEBS Lett 250, 596-600.
-
(1989)
FEBS Lett
, vol.250
, pp. 596-600
-
-
Cohen, P.1
Klumpp, S.2
Schelling, D.L.3
-
46
-
-
80053181515
-
Hyperphosphorylation of autoantigenic targets of paraproteins is due to inactivation of PP2A
-
Preuss KD, Pfreundschuh M, Fadle N, Regitz E, Raudies S, Murwaski N, Ahlgrimm M, Bittenbring J, Klotz M, Schäfer KH, Held G, Neumann F, Grass S (2011) Hyperphosphorylation of autoantigenic targets of paraproteins is due to inactivation of PP2A. Blood 118, 3340-3346.
-
(2011)
Blood
, vol.118
, pp. 3340-3346
-
-
Preuss, K.D.1
Pfreundschuh, M.2
Fadle, N.3
Regitz, E.4
Raudies, S.5
Murwaski, N.6
Ahlgrimm, M.7
Bittenbring, J.8
Klotz, M.9
Schäfer, K.H.10
Held, G.11
Neumann, F.12
Grass, S.13
-
47
-
-
0026786471
-
Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation
-
Chen J, Martin BL, Brautigan DL (1992) Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation. Science 257, 1261-1264.
-
(1992)
Science
, vol.257
, pp. 1261-1264
-
-
Chen, J.1
Martin, B.L.2
Brautigan, D.L.3
-
48
-
-
33744926927
-
The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons
-
MacDonald JM, Beach MG, Porpiglia E, Sheehan AE,Watts RJ, Freeman MR (2006) The Drosophila cell corpse engulfment receptor Draper mediates glial clearance of severed axons. Neuron 50, 869-881.
-
(2006)
Neuron
, vol.50
, pp. 869-881
-
-
Macdonald, J.M.1
Beach, M.G.2
Porpiglia, E.3
Sheehan, A.E.4
Watts, R.J.5
Freeman, M.R.6
-
49
-
-
0029416987
-
Dephosphorylation of fetal-tau and paired helical filament-tau by protein phosphatase 1 and 2A and calcineurin
-
Yamamoto H, Hasegawa M, Ono T, Tashima K, Ihara Y, Miyamoto E(1995) Dephosphorylation of fetal-tau and paired helical filament-tau by protein phosphatase 1 and 2A and calcineurin. J Biochem 118, 1224-1231.
-
(1995)
J Biochem
, vol.118
, pp. 1224-1231
-
-
Yamamoto, H.1
Hasegawa, M.2
Ono, T.3
Tashima, K.4
Ihara, Y.5
Miyamoto, E.6
-
50
-
-
84857073309
-
Regulation of mitochondrial transport and inter-microtubule spacing by tau phosphorylation at the sites hyperphosphorylated in Alzheimer's disease
-
Shahpasand K, Uemura I, Saito T, Asano T, Hata K, Shibata K, Toyoshima Y, Hasegawa M, Hisanaga S (2012) Regulation of mitochondrial transport and inter-microtubule spacing by tau phosphorylation at the sites hyperphosphorylated in Alzheimer's disease. J Neurosci 32, 2430-2441.
-
(2012)
J Neurosci
, vol.32
, pp. 2430-2441
-
-
Shahpasand, K.1
Uemura, I.2
Saito, T.3
Asano, T.4
Hata, K.5
Shibata, K.6
Toyoshima, Y.7
Hasegawa, M.8
Hisanaga, S.9
-
51
-
-
77957256216
-
Phosphorylation of tau at Thr212, Thr231, and Ser262 combined causes neurodegeneration
-
Alonso AD, Di Clerico J, Li B, Corbo CP, Alaniz ME, Grundke-Iqbal I, Iqbal K (2010) Phosphorylation of tau at Thr212, Thr231, and Ser262 combined causes neurodegeneration. J Biol Chem 285, 30851-30860.
-
(2010)
J Biol Chem
, vol.285
, pp. 30851-30860
-
-
Alonso, A.D.1
Di Clerico, J.2
Li, B.3
Corbo, C.P.4
Alaniz, M.E.5
Grundke-Iqbal, I.6
Iqbal, K.7
-
52
-
-
58149267462
-
Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau
-
Green KN, Steffan JS, Martinez-Coria H, Sun X, Schreiber SS, Thompson LM, LaFerla FM(2008) Nicotinamide restores cognition in Alzheimer's disease transgenic mice via a mechanism involving sirtuin inhibition and selective reduction of Thr231-phosphotau. J Neurosci 28, 11500-11510.
-
(2008)
J Neurosci
, vol.28
, pp. 11500-11510
-
-
Green, K.N.1
Steffan, J.S.2
Martinez-Coria, H.3
Sun, X.4
Schreiber, S.S.5
Thompson, L.M.6
Laferla, F.M.7
-
53
-
-
77957254409
-
Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease
-
Iijima K, Gatt A, Iijima-Ando K (2010) Tau Ser262 phosphorylation is critical for Abeta42-induced tau toxicity in a transgenic Drosophila model of Alzheimer's disease. Hum Mol Genet 19, 2947-2957.
-
(2010)
Hum Mol Genet
, vol.19
, pp. 2947-2957
-
-
Iijima, K.1
Gatt, A.2
Iijima-Ando, K.3
-
54
-
-
0028237871
-
Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts
-
Chen J, Parsons S, Brautigan DL (1994) Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts. J Biol Chem 269, 7957-7962.
-
(1994)
J Biol Chem
, vol.269
, pp. 7957-7962
-
-
Chen, J.1
Parsons, S.2
Brautigan, D.L.3
-
55
-
-
44849144122
-
I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A
-
Chen S, Li B, Grundke-Iqbal I, IqbalK(2008) I1PP2A affects tau phosphorylation via association with the catalytic subunit of protein phosphatase 2A. J Biol Chem 283, 10513-10521.
-
(2008)
J Biol Chem
, vol.283
, pp. 10513-10521
-
-
Chen, S.1
Li, B.2
Grundke-Iqbal, I.3
Iqbal, K.4
-
56
-
-
33745370049
-
Involvement of I2PP2A in the abnormal hyperphosphorylation of tau and its reversal by Memantine
-
Chohan MO, Khatoon S, Iqbal IG, Iqbal K (2006) Involvement of I2PP2A in the abnormal hyperphosphorylation of tau and its reversal by Memantine. FEBS Lett 580, 3973-3979.
-
(2006)
FEBS Lett
, vol.580
, pp. 3973-3979
-
-
Chohan, M.O.1
Khatoon, S.2
Iqbal, I.G.3
Iqbal, K.4
-
57
-
-
67949102025
-
Src kinase up-regulates the ERK cascade through inactivation of protein phosphatase 2A following cerebral ischemia
-
Hu X, Wu X, Xu J, Zhou J, Han X, Guo J (2009) Src kinase up-regulates the ERK cascade through inactivation of protein phosphatase 2A following cerebral ischemia. BMC Neurosci 10, 74.
-
(2009)
BMC Neurosci
, vol.10
, pp. 74
-
-
Hu, X.1
Wu, X.2
Xu, J.3
Zhou, J.4
Han, X.5
Guo, J.6
-
58
-
-
14944350207
-
Role of protein phosphatase 2A in mGluR5-regulated MEK/ERK phosphorylation in neurons
-
Mao L, Yang L, Arora A, Choe ES, Zhang G, Liu Z, Fibuch EE, Wang JQ (2005) Role of protein phosphatase 2A in mGluR5-regulated MEK/ERK phosphorylation in neurons. J Biol Chem 280, 12602-12610.
-
(2005)
J Biol Chem
, vol.280
, pp. 12602-12610
-
-
Mao, L.1
Yang, L.2
Arora, A.3
Choe, E.S.4
Zhang, G.5
Liu, Z.6
Fibuch, E.E.7
Wang, J.Q.8
-
59
-
-
84859592010
-
WldS prevents axon degeneration through increased mitochondrial flux and enhanced mitochondrial Ca2+ buffering
-
Avery MA, Rooney TM, Pandya JD,Wishart TM, Gillingwater TH, Geddes JW, Sullivan PG, Freeman MR (2012) WldS prevents axon degeneration through increased mitochondrial flux and enhanced mitochondrial Ca2+ buffering. Curr Biol 22, 596-600.
-
(2012)
Curr Biol
, vol.22
, pp. 596-600
-
-
Avery, M.A.1
Rooney, T.M.2
Pandya, J.D.3
Wishart, T.M.4
Gillingwater, T.H.5
Geddes, J.W.6
Sullivan, P.G.7
Freeman, M.R.8
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