Abnormal hyperphosphorylation of tau: Sites, regulation, and molecular mechanism of neurofibrillary degeneration

Journal of Alzheimer's Disease

Volumn 33, Issue SUPPL. 1, 2013, Pages

  Wang, Jian Zhi ^a   Xia, Yi Yuan ^a   Grundke Iqbal, Inge ^b   Iqbal, Khalid ^b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

Author keywords

Alzheimer's disease; neurofibrillary degeneration; post translational modifications of tau; protein kinases; protein phosphatases; tau phosphorylation

Indexed keywords

ADENYLATE KINASE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CASEIN KINASE I; CASEIN KINASE II; CASPASE 2; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 5; GLYCOGEN SYNTHASE KINASE 3BETA; MESSENGER RNA PRECURSOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROLINE DIRECTED PROTEIN KINASE; PROTEIN KINASE; PROTEIN KINASE B; PROTEIN KINASE C; PROTEIN KINASE N; PROTEIN P110; PROTEIN SERINE KINASE; PROTEIN SERINE THREONINE KINASE; S6 KINASE; SERINE; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; STRESS ACTIVATED PROTEIN KINASE; TAU PROTEIN; TAU TUBULIN KINASE; THREONINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ACETYLATION; ALZHEIMER DISEASE; APOPTOSIS; BINDING SITE; BRAIN; CARBOXY TERMINAL SEQUENCE; CELL SURVIVAL; CELL TRANSPORT; CHROMOSOME 17; CLINICAL RESEARCH; CYTOPLASM; CYTOSOL; DEMENTIA; ENZYME INHIBITION; GLUCOSE METABOLISM; HIBERNATION; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MICROTUBULE; MICROTUBULE ASSEMBLY; MOLECULAR MECHANICS; NERVE CELL; NERVE DEGENERATION; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; NICK END LABELING; NITRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN GLYCOSYLATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN POLYMERIZATION; PROTEIN PROCESSING; RECEPTOR DOWN REGULATION; REVIEW; UBIQUITINATION;

EID: 84872551783     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2012-129031     Document Type: Review

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