-
1
-
-
0031012497
-
Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau
-
Alonso A.D., Grundke-Iqbal I., Barra H.S., Iqbal K. Abnormal phosphorylation of tau and the mechanism of Alzheimer neurofibrillary degeneration: sequestration of microtubule-associated proteins 1 and 2 and the disassembly of microtubules by the abnormal tau. Proc. Natl. Acad. Sci. U. S. A. 1997, 94:298-303.
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 298-303
-
-
Alonso, A.D.1
Grundke-Iqbal, I.2
Barra, H.S.3
Iqbal, K.4
-
2
-
-
0344517353
-
Lithium protects cultured neurons against beta-amyloid-induced neurodegeneration
-
Alvarez G., Munoz-Montano J.R., Satrustegui J., Avila J., Bogonez E., Diaz-Nido J. Lithium protects cultured neurons against beta-amyloid-induced neurodegeneration. FEBS Lett. 1999, 453:260-264.
-
(1999)
FEBS Lett.
, vol.453
, pp. 260-264
-
-
Alvarez, G.1
Munoz-Montano, J.R.2
Satrustegui, J.3
Avila, J.4
Bogonez, E.5
Diaz-Nido, J.6
-
3
-
-
33646906138
-
Über eigenartige Krankheitsfälle des späteren Alters. Zbl. ges
-
Alzheimer A. Über eigenartige Krankheitsfälle des späteren Alters. Zbl. ges. Neuroñ. Psych. 1911, 4:356-385.
-
(1911)
Neuroñ. Psych.
, vol.4
, pp. 356-385
-
-
Alzheimer, A.1
-
4
-
-
1642289188
-
Role of tau protein in both physiological and pathological conditions
-
Avila J., Lucas J.J., Perez M., Hernandez F. Role of tau protein in both physiological and pathological conditions. Physiol. Rev. 2004, 84:361-384.
-
(2004)
Physiol. Rev.
, vol.84
, pp. 361-384
-
-
Avila, J.1
Lucas, J.J.2
Perez, M.3
Hernandez, F.4
-
5
-
-
3343005434
-
PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations
-
Baki L., Shioi J., Wen P., Shao Z., Schwarzman A., Gama-Sosa M., Neve R., Robakis N.K. PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutations. EMBO J. 2004, 23:2586-2596.
-
(2004)
EMBO J.
, vol.23
, pp. 2586-2596
-
-
Baki, L.1
Shioi, J.2
Wen, P.3
Shao, Z.4
Schwarzman, A.5
Gama-Sosa, M.6
Neve, R.7
Robakis, N.K.8
-
6
-
-
10944241542
-
Tau alteration and neuronal degeneration in tauopathies: mechanisms and models
-
Brandt R., Hundelt M., Shahani N. Tau alteration and neuronal degeneration in tauopathies: mechanisms and models. Biochim. Biophys. Acta 2005, 1739:331-354.
-
(2005)
Biochim. Biophys. Acta
, vol.1739
, pp. 331-354
-
-
Brandt, R.1
Hundelt, M.2
Shahani, N.3
-
7
-
-
0028986916
-
Beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding
-
Busciglio J., Lorenzo A., Yeh J., Yankner B.A. beta-amyloid fibrils induce tau phosphorylation and loss of microtubule binding. Neuron 1995, 14:879-888.
-
(1995)
Neuron
, vol.14
, pp. 879-888
-
-
Busciglio, J.1
Lorenzo, A.2
Yeh, J.3
Yankner, B.A.4
-
8
-
-
0036942289
-
Proteasome-mediated degradation of tau proteins occurs independently of the chymotrypsin-like activity by a nonprocessive pathway
-
Cardozo C., Michaud C. Proteasome-mediated degradation of tau proteins occurs independently of the chymotrypsin-like activity by a nonprocessive pathway. Arch. Biochem. Biophys. 2002, 408:103-110.
-
(2002)
Arch. Biochem. Biophys.
, vol.408
, pp. 103-110
-
-
Cardozo, C.1
Michaud, C.2
-
9
-
-
60849092552
-
The cochaperone BAG2 sweeps paired helical filament-insoluble tau from the microtubule
-
Carrettiero D.C., Hernandez I., Neveu P., Papagiannakopoulos T., Kosik K.S. The cochaperone BAG2 sweeps paired helical filament-insoluble tau from the microtubule. J. Neurosci. 2009, 29:2151-2161.
-
(2009)
J. Neurosci.
, vol.29
, pp. 2151-2161
-
-
Carrettiero, D.C.1
Hernandez, I.2
Neveu, P.3
Papagiannakopoulos, T.4
Kosik, K.S.5
-
10
-
-
33746543634
-
Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells
-
Caruso A., Motolese M., Iacovelli L., Caraci F., Copani A., Nicoletti F., Terstappen G.C., Gaviraghi G., Caricasole A. Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells. J. Neurochem. 2006, 98:364-371.
-
(2006)
J. Neurochem.
, vol.98
, pp. 364-371
-
-
Caruso, A.1
Motolese, M.2
Iacovelli, L.3
Caraci, F.4
Copani, A.5
Nicoletti, F.6
Terstappen, G.C.7
Gaviraghi, G.8
Caricasole, A.9
-
11
-
-
0345171818
-
Apolipoprotein E and beta-amyloid (1-42) regulation of glycogen synthase kinase-3beta
-
Cedazo-Minguez A., Popescu B.O., Blanco-Millan J.M., Akterin S., Pei J.J., Winblad B., Cowburn R.F. Apolipoprotein E and beta-amyloid (1-42) regulation of glycogen synthase kinase-3beta. J. Neurochem. 2003, 87:1152-1164.
-
(2003)
J. Neurochem.
, vol.87
, pp. 1152-1164
-
-
Cedazo-Minguez, A.1
Popescu, B.O.2
Blanco-Millan, J.M.3
Akterin, S.4
Pei, J.J.5
Winblad, B.6
Cowburn, R.F.7
-
12
-
-
45849104800
-
LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3′s phosphorylation of beta-catenin
-
Cselenyi C.S., Jernigan K.K., Tahinci E., Thorne C.A., Lee L.A., Lee E. LRP6 transduces a canonical Wnt signal independently of Axin degradation by inhibiting GSK3′s phosphorylation of beta-catenin. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:8032-8037.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 8032-8037
-
-
Cselenyi, C.S.1
Jernigan, K.K.2
Tahinci, E.3
Thorne, C.A.4
Lee, L.A.5
Lee, E.6
-
13
-
-
33745827715
-
Site-specific phosphorylation and caspase cleavage differentially impact tau-microtubule interactions and tau aggregation
-
Ding H., Matthews T.A., Johnson G.V. Site-specific phosphorylation and caspase cleavage differentially impact tau-microtubule interactions and tau aggregation. J. Biol. Chem. 2006, 281:19107-19114.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 19107-19114
-
-
Ding, H.1
Matthews, T.A.2
Johnson, G.V.3
-
14
-
-
0022896901
-
Tau protein function in living cells
-
Drubin D.G., Kirschner M.W. Tau protein function in living cells. J. Cell Biol. 1986, 103:2739-2746.
-
(1986)
J. Cell Biol.
, vol.103
, pp. 2739-2746
-
-
Drubin, D.G.1
Kirschner, M.W.2
-
15
-
-
0032476645
-
Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease
-
Ebneth A., Godemann R., Stamer K., Illenberger S., Trinczek B., Mandelkow E. Overexpression of tau protein inhibits kinesin-dependent trafficking of vesicles, mitochondria, and endoplasmic reticulum: implications for Alzheimer's disease. J. Cell Biol. 1998, 143:777-794.
-
(1998)
J. Cell Biol.
, vol.143
, pp. 777-794
-
-
Ebneth, A.1
Godemann, R.2
Stamer, K.3
Illenberger, S.4
Trinczek, B.5
Mandelkow, E.6
-
16
-
-
33646922314
-
Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3
-
Engel T., Hernandez F., Avila J., Lucas J.J. Full reversal of Alzheimer's disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3. J. Neurosci. 2006, 26:5083-5090.
-
(2006)
J. Neurosci.
, vol.26
, pp. 5083-5090
-
-
Engel, T.1
Hernandez, F.2
Avila, J.3
Lucas, J.J.4
-
17
-
-
33746210131
-
Cooexpression of FTDP-17 tau and GSK-3beta in transgenic mice induce tau polymerization and neurodegeneration
-
Engel T., Lucas J.J., Gomez-Ramos P., Moran M.A., Avila J., Hernandez F. Cooexpression of FTDP-17 tau and GSK-3beta in transgenic mice induce tau polymerization and neurodegeneration. Neurobiol. Aging 2006, 27:1258-1268.
-
(2006)
Neurobiol. Aging
, vol.27
, pp. 1258-1268
-
-
Engel, T.1
Lucas, J.J.2
Gomez-Ramos, P.3
Moran, M.A.4
Avila, J.5
Hernandez, F.6
-
18
-
-
0035370372
-
Insulin/IGF signalling and ageing: seeing the bigger picture
-
Gems D., Partridge L. Insulin/IGF signalling and ageing: seeing the bigger picture. Curr. Opin. Genet. Dev. 2001, 11:287-292.
-
(2001)
Curr. Opin. Genet. Dev.
, vol.11
, pp. 287-292
-
-
Gems, D.1
Partridge, L.2
-
19
-
-
0021207461
-
Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein
-
Glenner G.G., Wong C.W. Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein. Biochem. Biophys. Res. Commun. 1984, 122:1131-1135.
-
(1984)
Biochem. Biophys. Res. Commun.
, vol.122
, pp. 1131-1135
-
-
Glenner, G.G.1
Wong, C.W.2
-
20
-
-
0023009658
-
Microtubule-associated protein tau. A component of Alzheimer paired helical filaments
-
Grundke-Iqbal I., Iqbal K., Quinlan M., Tung Y.C., Zaidi M.S., Wisniewski H.M. Microtubule-associated protein tau. A component of Alzheimer paired helical filaments. J. Biol. Chem. 1986, 261:6084-6089.
-
(1986)
J. Biol. Chem.
, vol.261
, pp. 6084-6089
-
-
Grundke-Iqbal, I.1
Iqbal, K.2
Quinlan, M.3
Tung, Y.C.4
Zaidi, M.S.5
Wisniewski, H.M.6
-
21
-
-
0022744803
-
Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology
-
Grundke-Iqbal I., Iqbal K., Tung Y.C., Quinlan M., Wisniewski H.M., Binder L.I. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc. Natl. Acad. Sci. U. S. A. 1986, 83:4913-4917.
-
(1986)
Proc. Natl. Acad. Sci. U. S. A.
, vol.83
, pp. 4913-4917
-
-
Grundke-Iqbal, I.1
Iqbal, K.2
Tung, Y.C.3
Quinlan, M.4
Wisniewski, H.M.5
Binder, L.I.6
-
22
-
-
0034626747
-
Genetic pathways that regulate ageing in model organisms
-
Guarente L., Kenyon C. Genetic pathways that regulate ageing in model organisms. Nature 2000, 408:255-262.
-
(2000)
Nature
, vol.408
, pp. 255-262
-
-
Guarente, L.1
Kenyon, C.2
-
23
-
-
61849088424
-
Tau phosphorylation: the therapeutic challenge for neurodegenerative disease
-
Hanger D.P., Anderton B.H., Noble W. Tau phosphorylation: the therapeutic challenge for neurodegenerative disease. Trends Mol. Med. 2009, 15:112-119.
-
(2009)
Trends Mol. Med.
, vol.15
, pp. 112-119
-
-
Hanger, D.P.1
Anderton, B.H.2
Noble, W.3
-
24
-
-
70349562237
-
GSK3 Inhibitors and Disease
-
Hernandez F., Nido J.D., Avila J., Villanueva N. GSK3 Inhibitors and Disease. Mini Rev. Med. Chem. 2009, 9:1024-1029.
-
(2009)
Mini Rev. Med. Chem.
, vol.9
, pp. 1024-1029
-
-
Hernandez, F.1
Nido, J.D.2
Avila, J.3
Villanueva, N.4
-
25
-
-
0027255817
-
Glycogen synthase kinase 3 beta is identical to tau protein kinase I generating several epitopes of paired helical filaments
-
Ishiguro K., Shiratsuchi A., Sato S., Omori A., Arioka M., Kobayashi S., Uchida T., Imahori K. Glycogen synthase kinase 3 beta is identical to tau protein kinase I generating several epitopes of paired helical filaments. FEBS Lett. 1993, 325:167-172.
-
(1993)
FEBS Lett.
, vol.325
, pp. 167-172
-
-
Ishiguro, K.1
Shiratsuchi, A.2
Sato, S.3
Omori, A.4
Arioka, M.5
Kobayashi, S.6
Uchida, T.7
Imahori, K.8
-
26
-
-
0037118247
-
Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila
-
Jackson G.R., Wiedau-Pazos M., Sang T.K., Wagle N., Brown C.A., Massachi S., Geschwind D.H. Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila. Neuron 2002, 34:509-519.
-
(2002)
Neuron
, vol.34
, pp. 509-519
-
-
Jackson, G.R.1
Wiedau-Pazos, M.2
Sang, T.K.3
Wagle, N.4
Brown, C.A.5
Massachi, S.6
Geschwind, D.H.7
-
27
-
-
0033558929
-
Sequence requirements for formation of conformational variants of tau similar to those found in Alzheimer's disease
-
Jicha G.A., Berenfeld B., Davies P. Sequence requirements for formation of conformational variants of tau similar to those found in Alzheimer's disease. J. Neurosci. Res. 1999, 55:713-723.
-
(1999)
J. Neurosci. Res.
, vol.55
, pp. 713-723
-
-
Jicha, G.A.1
Berenfeld, B.2
Davies, P.3
-
29
-
-
0442276554
-
The glamour and gloom of glycogen synthase kinase-3
-
Jope R.S., Johnson G.V. The glamour and gloom of glycogen synthase kinase-3. Trends Biochem. Sci. 2004, 29:95-102.
-
(2004)
Trends Biochem. Sci.
, vol.29
, pp. 95-102
-
-
Jope, R.S.1
Johnson, G.V.2
-
30
-
-
61349201380
-
Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers
-
Lauren J., Gimbel D.A., Nygaard H.B., Gilbert J.W., Strittmatter S.M. Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers. Nature 2009, 457:1128-1132.
-
(2009)
Nature
, vol.457
, pp. 1128-1132
-
-
Lauren, J.1
Gimbel, D.A.2
Nygaard, H.B.3
Gilbert, J.W.4
Strittmatter, S.M.5
-
31
-
-
17044435830
-
Tau phosphorylation in Alzheimer's disease: pathogen or protector?
-
Lee H.G., Perry G., Moreira P.I., Garrett M.R., Liu Q., Zhu X., Takeda A., Nunomura A., Smith M.A. Tau phosphorylation in Alzheimer's disease: pathogen or protector?. Trends Mol. Med. 2005, 11:164-169.
-
(2005)
Trends Mol. Med.
, vol.11
, pp. 164-169
-
-
Lee, H.G.1
Perry, G.2
Moreira, P.I.3
Garrett, M.R.4
Liu, Q.5
Zhu, X.6
Takeda, A.7
Nunomura, A.8
Smith, M.A.9
-
32
-
-
65249113325
-
The insulin/Akt signaling pathway is targeted by intracellular beta-amyloid
-
Lee H.K., Kumar P., Fu Q., Rosen K.M., Querfurth H.W. The insulin/Akt signaling pathway is targeted by intracellular beta-amyloid. Mol. Biol. Cell 2009, 20:1533-1544.
-
(2009)
Mol. Biol. Cell
, vol.20
, pp. 1533-1544
-
-
Lee, H.K.1
Kumar, P.2
Fu, Q.3
Rosen, K.M.4
Querfurth, H.W.5
-
33
-
-
0035680685
-
FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and Tau filaments in forebrain
-
Lim F., Hernandez F., Lucas J.J., Gomez-Ramos P., Moran M.A., Avila J. FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and Tau filaments in forebrain. Mol. Cell Neurosci. 2001, 18:702-714.
-
(2001)
Mol. Cell Neurosci.
, vol.18
, pp. 702-714
-
-
Lim, F.1
Hernandez, F.2
Lucas, J.J.3
Gomez-Ramos, P.4
Moran, M.A.5
Avila, J.6
-
34
-
-
7744227096
-
Glycogen synthase kinase-3beta phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis
-
Linseman D.A., Butts B.D., Precht T.A., Phelps R.A., Le S.S., Laessig T.A., Bouchard R.J., Florez-McClure M.L., Heidenreich K.A. Glycogen synthase kinase-3beta phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis. J. Neurosci. 2004, 24:9993-10002.
-
(2004)
J. Neurosci.
, vol.24
, pp. 9993-10002
-
-
Linseman, D.A.1
Butts, B.D.2
Precht, T.A.3
Phelps, R.A.4
Le, S.S.5
Laessig, T.A.6
Bouchard, R.J.7
Florez-McClure, M.L.8
Heidenreich, K.A.9
-
35
-
-
0035863188
-
Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice
-
Lucas J.J., Hernandez F., Gomez-Ramos P., Moran M.A., Hen R., Avila J. Decreased nuclear beta-catenin, tau hyperphosphorylation and neurodegeneration in GSK-3beta conditional transgenic mice. EMBO J. 2001, 20:27-39.
-
(2001)
EMBO J.
, vol.20
, pp. 27-39
-
-
Lucas, J.J.1
Hernandez, F.2
Gomez-Ramos, P.3
Moran, M.A.4
Hen, R.5
Avila, J.6
-
36
-
-
44049089139
-
Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling
-
Magdesian M.H., Carvalho M.M., Mendes F.A., Saraiva L.M., Juliano M.A., Juliano L., Garcia-Abreu J., Ferreira S.T. Amyloid-beta binds to the extracellular cysteine-rich domain of Frizzled and inhibits Wnt/beta-catenin signaling. J. Biol. Chem. 2008, 283:9359-9368.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 9359-9368
-
-
Magdesian, M.H.1
Carvalho, M.M.2
Mendes, F.A.3
Saraiva, L.M.4
Juliano, M.A.5
Juliano, L.6
Garcia-Abreu, J.7
Ferreira, S.T.8
-
37
-
-
54249140068
-
GSK-3 inhibitors: a ray of hope for the treatment of Alzheimer's disease?
-
Martinez A., Perez D.I. GSK-3 inhibitors: a ray of hope for the treatment of Alzheimer's disease?. J. Alzheimers Dis. 2008, 15:181-191.
-
(2008)
J. Alzheimers Dis.
, vol.15
, pp. 181-191
-
-
Martinez, A.1
Perez, D.I.2
-
38
-
-
0012510759
-
Amyloid plaque core protein in Alzheimer disease and Down syndrome
-
Masters C.L., Simms G., Weinman N.A., Multhaup G., McDonald B.L., Beyreuther K. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc. Natl. Acad. Sci. U. S. A. 1985, 82:4245-4249.
-
(1985)
Proc. Natl. Acad. Sci. U. S. A.
, vol.82
, pp. 4245-4249
-
-
Masters, C.L.1
Simms, G.2
Weinman, N.A.3
Multhaup, G.4
McDonald, B.L.5
Beyreuther, K.6
-
39
-
-
0027193036
-
Ubiquitin is conjugated with amino-terminally processed tau in paired helical filaments
-
Morishima-Kawashima M., Hasegawa M., Takio K., Suzuki M., Titani K., Ihara Y. Ubiquitin is conjugated with amino-terminally processed tau in paired helical filaments. Neuron 1993, 10:1151-1160.
-
(1993)
Neuron
, vol.10
, pp. 1151-1160
-
-
Morishima-Kawashima, M.1
Hasegawa, M.2
Takio, K.3
Suzuki, M.4
Titani, K.5
Ihara, Y.6
-
40
-
-
0028899714
-
Proline-directed and non-proline-directed phosphorylation of PHF-tau
-
Morishima-Kawashima M., Hasegawa M., Takio K., Suzuki M., Yoshida H., Titani K., Ihara Y. Proline-directed and non-proline-directed phosphorylation of PHF-tau. J. Biol. Chem. 1995, 270:823-829.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 823-829
-
-
Morishima-Kawashima, M.1
Hasegawa, M.2
Takio, K.3
Suzuki, M.4
Yoshida, H.5
Titani, K.6
Ihara, Y.7
-
42
-
-
21044449225
-
Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo
-
Noble W., Planel E., Zehr C., Olm V., Meyerson J., Suleman F., Gaynor K., Wang L., LaFrancois J., Feinstein B., Burns M., Krishnamurthy P., Wen Y., Bhat R., Lewis J., Dickson D., Duff K. Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:6990-6995.
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 6990-6995
-
-
Noble, W.1
Planel, E.2
Zehr, C.3
Olm, V.4
Meyerson, J.5
Suleman, F.6
Gaynor, K.7
Wang, L.8
LaFrancois, J.9
Feinstein, B.10
Burns, M.11
Krishnamurthy, P.12
Wen, Y.13
Bhat, R.14
Lewis, J.15
Dickson, D.16
Duff, K.17
-
43
-
-
0036118882
-
Formation of aberrant phosphotau fibrillar polymers in neural cultured cells
-
Perez M., Hernandez F., Gomez-Ramos A., Smith M., Perry G., Avila J. Formation of aberrant phosphotau fibrillar polymers in neural cultured cells. Eur. J. Biochem. 2002, 269:1484-1489.
-
(2002)
Eur. J. Biochem.
, vol.269
, pp. 1484-1489
-
-
Perez, M.1
Hernandez, F.2
Gomez-Ramos, A.3
Smith, M.4
Perry, G.5
Avila, J.6
-
44
-
-
0242720372
-
Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model
-
Perez M., Hernandez F., Lim F., Diaz-Nido J., Avila J. Chronic lithium treatment decreases mutant tau protein aggregation in a transgenic mouse model. J. Alzheimers Dis. 2003, 5:301-308.
-
(2003)
J. Alzheimers Dis.
, vol.5
, pp. 301-308
-
-
Perez, M.1
Hernandez, F.2
Lim, F.3
Diaz-Nido, J.4
Avila, J.5
-
45
-
-
0038292054
-
Prion peptide induces neuronal cell death through a pathway involving glycogen synthase kinase 3
-
Perez M., Rojo A.I., Wandosell F., Diaz-Nido J., Avila J. Prion peptide induces neuronal cell death through a pathway involving glycogen synthase kinase 3. Biochem. J. 2003, 372:129-136.
-
(2003)
Biochem. J.
, vol.372
, pp. 129-136
-
-
Perez, M.1
Rojo, A.I.2
Wandosell, F.3
Diaz-Nido, J.4
Avila, J.5
-
46
-
-
35548977583
-
The role of the VQIVYK peptide in tau protein phosphorylation
-
Perez M., Santa-Maria I., Tortosa E., Cuadros R., Del Valle M., Hernandez F., Moreno F.J., Avila J. The role of the VQIVYK peptide in tau protein phosphorylation. J. Neurochem. 2007, 103:1447-1460.
-
(2007)
J. Neurochem.
, vol.103
, pp. 1447-1460
-
-
Perez, M.1
Santa-Maria, I.2
Tortosa, E.3
Cuadros, R.4
Del Valle, M.5
Hernandez, F.6
Moreno, F.J.7
Avila, J.8
-
47
-
-
0029796168
-
Polymerization of tau into filaments in the presence of heparin: the minimal sequence required for tau-tau interaction
-
Perez M., Valpuesta J.M., Medina M., Montejo de Garcini E., Avila J. Polymerization of tau into filaments in the presence of heparin: the minimal sequence required for tau-tau interaction. J. Neurochem. 1996, 67:1183-1190.
-
(1996)
J. Neurochem.
, vol.67
, pp. 1183-1190
-
-
Perez, M.1
Valpuesta, J.M.2
Medina, M.3
Montejo de Garcini, E.4
Avila, J.5
-
48
-
-
11144356089
-
CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation
-
Petrucelli L., Dickson D., Kehoe K., Taylor J., Snyder H., Grover A., De Lucia M., McGowan E., Lewis J., Prihar G., Kim J., Dillmann W.H., Browne S.E., Hall A., Voellmy R., Tsuboi Y., Dawson T.M., Wolozin B., Hardy J., Hutton M. CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation. Hum. Mol. Genet. 2004, 13:703-714.
-
(2004)
Hum. Mol. Genet.
, vol.13
, pp. 703-714
-
-
Petrucelli, L.1
Dickson, D.2
Kehoe, K.3
Taylor, J.4
Snyder, H.5
Grover, A.6
De Lucia, M.7
McGowan, E.8
Lewis, J.9
Prihar, G.10
Kim, J.11
Dillmann, W.H.12
Browne, S.E.13
Hall, A.14
Voellmy, R.15
Tsuboi, Y.16
Dawson, T.M.17
Wolozin, B.18
Hardy, J.19
Hutton, M.20
more..
-
49
-
-
12144289492
-
Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: implications for Alzheimer's disease
-
Planel E., Miyasaka T., Launey T., Chui D.H., Tanemura K., Sato S., Murayama O., Ishiguro K., Tatebayashi Y., Takashima A. Alterations in glucose metabolism induce hypothermia leading to tau hyperphosphorylation through differential inhibition of kinase and phosphatase activities: implications for Alzheimer's disease. J. Neurosci. 2004, 24:2401-2411.
-
(2004)
J. Neurosci.
, vol.24
, pp. 2401-2411
-
-
Planel, E.1
Miyasaka, T.2
Launey, T.3
Chui, D.H.4
Tanemura, K.5
Sato, S.6
Murayama, O.7
Ishiguro, K.8
Tatebayashi, Y.9
Takashima, A.10
-
50
-
-
0031921466
-
Mutant genes in familial Alzheimer's disease and transgenic models
-
Price D.L., Sisodia S.S. Mutant genes in familial Alzheimer's disease and transgenic models. Annu. Rev. Neurosci. 1998, 21:479-505.
-
(1998)
Annu. Rev. Neurosci.
, vol.21
, pp. 479-505
-
-
Price, D.L.1
Sisodia, S.S.2
-
51
-
-
0037197836
-
Tau is essential to beta-amyloid-induced neurotoxicity
-
Rapoport M., Dawson H.N., Binder L.I., Vitek M.P., Ferreira A. Tau is essential to beta-amyloid-induced neurotoxicity. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:6364-6369.
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 6364-6369
-
-
Rapoport, M.1
Dawson, H.N.2
Binder, L.I.3
Vitek, M.P.4
Ferreira, A.5
-
52
-
-
34248181511
-
Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model
-
Roberson E.D., Scearce-Levie K., Palop J.J., Yan F., Cheng I.H., Wu T., Gerstein H., Yu G.Q., Mucke L. Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model. Science 2007, 316:750-754.
-
(2007)
Science
, vol.316
, pp. 750-754
-
-
Roberson, E.D.1
Scearce-Levie, K.2
Palop, J.J.3
Yan, F.4
Cheng, I.H.5
Wu, T.6
Gerstein, H.7
Yu, G.Q.8
Mucke, L.9
-
53
-
-
12144289142
-
Quinones facilitate the self-assembly of the phosphorylated tubulin binding region of tau into fibrillar polymers
-
Santa-Maria I., Hernandez F., Martin C.P., Avila J., Moreno F.J. Quinones facilitate the self-assembly of the phosphorylated tubulin binding region of tau into fibrillar polymers. Biochemistry 2004, 43:2888-2897.
-
(2004)
Biochemistry
, vol.43
, pp. 2888-2897
-
-
Santa-Maria, I.1
Hernandez, F.2
Martin, C.P.3
Avila, J.4
Moreno, F.J.5
-
54
-
-
54049111843
-
Association of GSK3B with Alzheimer disease and frontotemporal dementia
-
Schaffer B.A., Bertram L., Miller B.L., Mullin K., Weintraub S., Johnson N., Bigio E.H., Mesulam M., Wiedau-Pazos M., Jackson G.R., Cummings J.L., Cantor R.M., Levey A.I., Tanzi R.E., Geschwind D.H. Association of GSK3B with Alzheimer disease and frontotemporal dementia. Arch. Neurol. 2008, 65:1368-1374.
-
(2008)
Arch. Neurol.
, vol.65
, pp. 1368-1374
-
-
Schaffer, B.A.1
Bertram, L.2
Miller, B.L.3
Mullin, K.4
Weintraub, S.5
Johnson, N.6
Bigio, E.H.7
Mesulam, M.8
Wiedau-Pazos, M.9
Jackson, G.R.10
Cummings, J.L.11
Cantor, R.M.12
Levey, A.I.13
Tanzi, R.E.14
Geschwind, D.H.15
-
55
-
-
56349119351
-
Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis
-
Small S.A., Duff K. Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis. Neuron 2008, 60:534-542.
-
(2008)
Neuron
, vol.60
, pp. 534-542
-
-
Small, S.A.1
Duff, K.2
-
56
-
-
0027407565
-
Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease
-
Strittmatter W.J., Saunders A.M., Schmechel D., Pericak-Vance M., Enghild J., Salvesen G.S., Roses A.D. Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease. Proc. Natl. Acad. Sci. U. S. A. 1993, 90:1977-1981.
-
(1993)
Proc. Natl. Acad. Sci. U. S. A.
, vol.90
, pp. 1977-1981
-
-
Strittmatter, W.J.1
Saunders, A.M.2
Schmechel, D.3
Pericak-Vance, M.4
Enghild, J.5
Salvesen, G.S.6
Roses, A.D.7
-
57
-
-
13144265717
-
Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau
-
Takashima A., Murayama M., Murayama O., Kohno T., Honda T., Yasutake K., Nihonmatsu N., Mercken M., Yamaguchi H., Sugihara S., Wolozin B. Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau. Proc. Natl. Acad. Sci. U. S. A. 1998, 95:9637-9641.
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 9637-9641
-
-
Takashima, A.1
Murayama, M.2
Murayama, O.3
Kohno, T.4
Honda, T.5
Yasutake, K.6
Nihonmatsu, N.7
Mercken, M.8
Yamaguchi, H.9
Sugihara, S.10
Wolozin, B.11
-
58
-
-
0034727104
-
LDL-receptor-related proteins in Wnt signal transduction
-
Tamai K., Semenov M., Kato Y., Spokony R., Liu C., Katsuyama Y., Hess F., Saint-Jeannet J.P., He X. LDL-receptor-related proteins in Wnt signal transduction. Nature 2000, 407:530-535.
-
(2000)
Nature
, vol.407
, pp. 530-535
-
-
Tamai, K.1
Semenov, M.2
Kato, Y.3
Spokony, R.4
Liu, C.5
Katsuyama, Y.6
Hess, F.7
Saint-Jeannet, J.P.8
He, X.9
-
59
-
-
36348935683
-
Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway
-
Townsend M., Mehta T., Selkoe D.J. Soluble Abeta inhibits specific signal transduction cascades common to the insulin receptor pathway. J. Biol. Chem. 2007, 282:33305-33312.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 33305-33312
-
-
Townsend, M.1
Mehta, T.2
Selkoe, D.J.3
-
60
-
-
0034625060
-
Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure
-
von Bergen M., Friedhoff P., Biernat J., Heberle J., Mandelkow E.M., Mandelkow E. Assembly of tau protein into Alzheimer paired helical filaments depends on a local sequence motif ((306)VQIVYK(311)) forming beta structure. Proc. Natl. Acad. Sci. U. S. A. 2000, 97:5129-5134.
-
(2000)
Proc. Natl. Acad. Sci. U. S. A.
, vol.97
, pp. 5129-5134
-
-
von Bergen, M.1
Friedhoff, P.2
Biernat, J.3
Heberle, J.4
Mandelkow, E.M.5
Mandelkow, E.6
-
61
-
-
0028902487
-
Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and-2B
-
Wang J.Z., Gong C.X., Zaidi T., Grundke-Iqbal I., Iqbal K. Dephosphorylation of Alzheimer paired helical filaments by protein phosphatase-2A and-2B. J. Biol. Chem. 1995, 270:4854-4860.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 4854-4860
-
-
Wang, J.Z.1
Gong, C.X.2
Zaidi, T.3
Grundke-Iqbal, I.4
Iqbal, K.5
-
62
-
-
0008538685
-
A protein factor essential for microtubule assembly
-
Weingarten M.D., Lockwood A.H., Hwo S.Y., Kirschner M.W. A protein factor essential for microtubule assembly. Proc. Natl. Acad. Sci. U. S. A. 1975, 72:1858-1862.
-
(1975)
Proc. Natl. Acad. Sci. U. S. A.
, vol.72
, pp. 1858-1862
-
-
Weingarten, M.D.1
Lockwood, A.H.2
Hwo, S.Y.3
Kirschner, M.W.4
-
63
-
-
0025286104
-
Molecular cloning and expression of glycogen synthase kinase-3/factor A
-
Woodgett J.R. Molecular cloning and expression of glycogen synthase kinase-3/factor A. EMBO J. 1990, 9:2431-2438.
-
(1990)
EMBO J.
, vol.9
, pp. 2431-2438
-
-
Woodgett, J.R.1
|