Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

Nature

Volumn 408, Issue 6815, 2000, Pages 979-982

  Janus, Christopher ^a   Pearson, Jacqueline ^a   McLaurin, JoAnne ^a   Mathews, Paul M ^b   Jiang, Ying ^b   Schmidt, Stephen D ^b   Chishti, M Azhar ^a   Horne, Patrick ^a   Heslin, Donna ^a   French, Janet ^a   Mount, Howard T J ^a   Nixon, Ralph A ^b   Mercken, Marc ^c   Bergeron, Catherine ^a,d   Fraser, Paul E ^a   St George Hyslop, Peter ^a,d   Westaway, David ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c JANSSEN RESEARCH FOUNDATION   (Belgium)

^d TORONTO WESTERN HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN;

ALZHEIMER DISEASE; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; BRAIN LEVEL; COGNITION; CONTROLLED STUDY; DRUG EFFECT; HIPPOCAMPUS; HISTOPATHOLOGY; IMMUNIZATION; MOUSE; NONHUMAN; PATHOGENESIS; PLAQUE FORMING CELL; PRIORITY JOURNAL; PROTEIN PROCESSING; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID; AMYLOID BETA-PROTEIN; ANIMALS; CRICETINAE; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; HUMANS; MAZE LEARNING; MESOCRICETUS; MICE; MICE, INBRED C3H; MICE, TRANSGENIC; PEPTIDE FRAGMENTS; SENILE PLAQUES; VACCINATION;

ANIMALIA; MURINAE; MUS MUSCULUS;

EID: 0034700471     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/35050110     Document Type: Article

References (30)

1. Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease
2. Immunization with Aβ attenuates Alzheimer's disease-like pathology in the PDAPP mouse
3. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
4. Clinical trial designs for demonstrating disease-course-altering effects in dementia
5. Developments of a water-maze procedure for studying spatial learning in the rat
6. Variable-interval probe test as a tool for repeated measurements of spatial memory in the water maze
7. Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice
8. A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease. Donepezil study group
9. Early phenotypic changes in transgenic mice that over-express different mutants of amyloid precursor protein
10. Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models
11. Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer β-amyloid peptide
12. β-amyloid neurotoxicity requires fibril formation and is inhibited by Congo red
13. Amyloid β-protein fibrillogenesis. Structure and biological activity of protofibrillar intermediates
14. Protofibrillar intermediates of amyloid β-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons
15. Soluble pool of Aβ amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
16. Correlation between elevated levels of amyloid β-peptide in the brain and cognitive decline
17. High-level neuronal expression of Aβ1-42 in wild-type human amyloid protein precursor transgenic mice: Synaptotoxicity without plaque formation
18. Alzheimer's disease: Antibody clears senile plaques
19. A second cytotoxic proteolytic peptide derived from amyloid β-protein precursor
20. Phosphatidylinositol and inositol involvement in Alzheimer amyloid-beta fibril growth and arrest
21. Spatial learning in transgenic mice expressing human presenilin 1 (PS1) transgenes
22. Navigation in the water maze: The role of proximal and visual cues, path intergration, and magnetic field information
23. Effects of repeated disorientation on the acquisition of spatial tasks in rats: Dissociation between the appetetive radial arm maze and aversive water maze
24. Deficits in memory tasks of mice with CREB mutations depend on gene dosage
25. Hippocampal protein kinase C activity is reduced in poor spatial learners
26. Comparison of four staining methods on the detection of neuritic plaques
27. An increased percentage of long amytoid B protein secreted by Familial Amyloid β Protein Precursor (BAPP717) mutants
28. Mutant presenilins of Alzheimer's Disease increase production of 42 residue amyloid β-protein in both transfected cells and transgenic mice