Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation

Neurobiology of Aging

Volumn 34, Issue 3, 2013, Pages 745-756

  Xiong, Yan ^a   Jing, Xiao Peng ^a   Zhou, Xin Wen ^a,b   Wang, Xiu Lian ^a   Yang, Yang ^a   Sun, Xu Ying ^a   Qiu, Mei ^a   Cao, Fu Yuan ^a   Lu, You Ming ^a,b   Liu, Rong ^a,b   Wang, Jian Zhi ^a,b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Protein phosphatase 2A; Src; Tauopathy; Tyrosine phosphorylation; Zinc

Indexed keywords

CLIOQUINOL; PHENYLALANINE; PHOSPHOPROTEIN PHOSPHATASE 2A; TAU PROTEIN; ZINC;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG TOLERABILITY; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HIPPOCAMPUS; MALE; MOUSE; MUTATION; NEOCORTEX; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SITE DIRECTED MUTAGENESIS; TAUOPATHY; UPREGULATION;

ANIMALS; BRAIN; CELL LINE, TUMOR; HUMANS; MICE; MICE, TRANSGENIC; NEURONS; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; PYRIMIDINES; RATS; RATS, SPRAGUE-DAWLEY; SRC-FAMILY KINASES; TAU PROTEINS; TAUOPATHIES; TRACE ELEMENTS; TYROSINE; ZINC;

EID: 84870481575     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2012.07.003     Document Type: Article

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