Zinc stimulates tau S214 phosphorylation by the activation of Raf/mitogen-activated protein kinase-kinase/extracellular signal-regulated kinase pathway

NeuroReport

Volumn 22, Issue 16, 2011, Pages 839-844

  Kim, Insook ^a,c   Park, Eun Ji ^a   Seo, Jeho ^a   Ko, Suk Jin ^a   Lee, Jinu ^d   Kim, Chul Hoon ^a,b  

^a Yonsei University   (South Korea)

^b Yonsei University College of Medicine   (South Korea)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d Yonsei University   (South Korea)

Author keywords

Alzheimer's disease; extracellular signal regulated kinase; neurofibrillary tangle; phosphorylation; tau; tau kinases

Indexed keywords

ALANINE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PYRROLIDINE DITHIOCARBAMATE; RAF PROTEIN; SERINE; TAU PROTEIN; ZINC;

ALZHEIMER DISEASE; ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE MUTATION; HUMAN; HUMAN CELL; MICROTUBULE ASSEMBLY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

CELL LINE, TUMOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; MAP KINASE SIGNALING SYSTEM; MICROTUBULES; PHOSPHORYLATION; POLYMERIZATION; RAF KINASES; RAS PROTEINS; SERINE; TAU PROTEINS; ZINC;

EID: 80053627394     PISSN: 09594965     EISSN: 1473558X     Source Type: Journal    
DOI: 10.1097/WNR.0b013e32834c0a2d     Document Type: Article

References (25)

1. Ittner LM, Gotz J. Amyloid-beta and tau: a toxic pas de deux in Alzheimer's disease. Nat Rev Neurosci 2011; 12:65-72.
2. Drubin DG, Kirschner MW. Tau protein function in living cells. J Cell Biol 1986; 103:2739-2746. (Pubitemid 17008019)
3. Grundke-Iqbal I, Iqbal K, Quinlan M, Tung YC, Zaidi MS, Wisniewski HM. Microtubule-associated protein tau: a component of Alzheimer paired helical filaments. J Biol Chem 1986; 261:6084-6089. (Pubitemid 17207447)
4. Ballatore C, Lee VM, Trojanowski JQ. Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nat Rev Neurosci 2007; 8:663-672. (Pubitemid 47283144)
5. Mazanetz MP, Fischer PM. Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases. Nat Rev Drug Discov 2007; 6:464-479. (Pubitemid 47064569)
6. Cho JH, Johnson GV. Glycogen synthase kinase 3beta phosphorylates tau at both primed and unprimed sites: differential impact on microtubule binding. J Biol Chem 2003; 278:187-193. (Pubitemid 36043561)
7. Spittaels K, Van den Haute C, Van Dorpe J, Geerts H, Mercken M, Bruynseels K, et al. Glycogen synthase kinase-3beta phosphorylates protein tau and rescues the axonopathy in the central nervous system of human four-repeat tau transgenic mice. J Biol Chem 2000; 275:41340-41349. (Pubitemid 32054968)
8. Noble W, Olm V, Takata K, Casey E, Mary O, Meyerson J, et al. Cdk5 is a key factor in tau aggregation and tangle formation in vivo. Neuron 2003; 38:555-565. (Pubitemid 36645031)
9. Bitanihirwe BK, Cunningham MG. Zinc: the brain's dark horse. Synapse 2009; 63:1029-1049.
10. Danscher G, Jensen KB, Frederickson CJ, Kemp K, Andreasen A, Juhl S, et al. Increased amount of zinc in the hippocampus and amygdala of Alzheimer's diseased brains: a proton-induced X-ray emission spectroscopic analysis of cryostat sections from autopsy material. J Neurosci Methods 1997; 76:53-59. (Pubitemid 27405086)
11. Bush AI, Pettingell WH, Multhaup G, Paradis M, Vonsattel JP, Gusella JF, et al. Rapid induction of Alzheimer A beta amyloid formation by zinc. Science 1994; 265:1464-1467. (Pubitemid 24306803)
12. Cuajungco MP, Faget KY. Zinc takes the center stage: its paradoxical role in Alzheimer's disease. Brain Res Brain Res Rev 2003; 41:44-56. (Pubitemid 36044593)
13. Kim CH, Kim JH, Xu J, Hsu CY, Ahn YS. Pyrrolidine dithiocarbamate induces bovine cerebral endothelial cell death by increasing the intracellular zinc level. J Neurochem 1999; 72:1586-1592. (Pubitemid 29140832)
14. Biernat J, Gustke N, Drewes G, Mandelkow EM, Mandelkow E. Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding. Neuron 1993; 11:153-163. (Pubitemid 23222542)
15. He K, Aizenman E. ERK signaling leads to mitochondrial dysfunction in extracellular zinc-induced neurotoxicity. J Neurochem 2010; 114:452-461.
16. Kyoung Pyo H, Lovati E, Pasinetti GM, Ksiezak-Reding H. Phosphorylation of tau at THR212 and SER214 in human neuronal and glial cultures: the role of AKT. Neuroscience 2004; 127:649-658. (Pubitemid 38993168)
17. Hanger DP, Anderton BH, Noble W. Tau phosphorylation: the therapeutic challenge for neurodegenerative disease. Trends Mol Med 2009; 15:112-119.
18. Seo SR, Chong SA, Lee SI, Sung JY, Ahn YS, Chung KC, et al. Zn2+-induced ERK activation mediated by reactive oxygen species causes cell death in differentiated PC12 cells. J Neurochem 2001; 78:600-610. (Pubitemid 32729988)
19. Bruinsma JJ, Jirakulaporn T, Muslin AJ, Kornfeld K. Zinc ions and cation diffusion facilitator proteins regulate Ras-mediated signaling. Dev Cell 2002; 2:567-578. (Pubitemid 34538138)
20. Yoshida H, Goedert M. Sequential phosphorylation of tau protein by cAMP-dependent protein kinase and SAPK4/p38delta or JNK2 in the presence of heparin generates the AT100 epitope. J Neurochem 2006; 99:154-164. (Pubitemid 44395138)
21. Yoshida H, Hastie CJ, McLauchlan H, Cohen P, Goedert M. Phosphorylation of microtubule-associated protein tau by isoforms of c-Jun N-terminal kinase (JNK). J Neurochem 2004; 90:352-358. (Pubitemid 38938221)
22. Schneider A, Biernat J, von Bergen M, Mandelkow E, Mandelkow EM. Phosphorylation that detaches tau protein from microtubules (Ser262, Ser214) also protects it against aggregation into Alzheimer paired helical filaments. Biochemistry 1999; 38:3549-3558.
23. Yang YC, Lin CH, Lee EH. Serum-and glucocorticoid-inducible kinase 1 (SGK1) increases neurite formation through microtubule depolymerization by SGK1 and by SGK1 phosphorylation of tau. Mol Cell Biol 2006; 26:8357-8370. (Pubitemid 44748570)
24. Harris FM, Brecht WJ, Xu Q, Mahley RW, Huang Y. Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: modulation by zinc. J Biol Chem 2004; 279:44795-44801. (Pubitemid 39430890)
25. Wang CY, Wang T, Zheng W, Zhao BL, Danscher G, Chen YH, et al. Zinc overload enhances APP cleavage and Abeta deposition in the Alzheimer mouse brain. PLoS One 2010; 5:e15349.