Amyloid-β/fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of alzheimer's disease

Journal of Neuroscience

Volumn 31, Issue 2, 2011, Pages 700-711

  Roberson, Erik D ^a,b,c   Halabisky, Brian ^a,b,h   Yoo, Jong W ^d,e,f   Yao, Jinghua ^a   Chin, Jeannie ^a,b,i   Yan, Fengrong ^a   Wu, Tiffany ^a   Hamto, Patricia ^a   Devidze, Nino ^a   Yu, Gui Qiu ^a   Palop, Jorge J ^a,b   Noebels, Jeffrey L ^d,e,f,g   Mucke, Lennart ^a,b  

^a GLADSTONE INSTITUTE OF NEUROLOGICAL DISEASE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d Developmental Neurogenetics Laboratory   (United States)

^e Departments of Neurology   (United States)

^f Departments of Molecular and Human Genetics   (United States)

^g BAYLOR COLLEGE OF MEDICINE   (United States)

^h BRISTOL MYERS SQUIBB   (United States)

ⁱ THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN KINASE FYN; TAU PROTEIN;

ALZHEIMER DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; COGNITIVE DEFECT; CONTROLLED STUDY; DISEASE SEVERITY; ELECTROENCEPHALOGRAPHY; EPILEPTIC DISCHARGE; EXCITATORY POSTSYNAPTIC POTENTIAL; GENE OVEREXPRESSION; HIPPOCAMPUS; INHIBITORY POSTSYNAPTIC POTENTIAL; MORTALITY; MOUSE; NERVE CELL NETWORK; NEUROPROTECTION; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN INTERACTION; SEIZURE; SYNAPTIC TRANSMISSION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; ELECTROENCEPHALOGRAPHY; FEMALE; HIPPOCAMPUS; MALE; MICE; MICE, MUTANT STRAINS; NERVE NET; NEURONAL PLASTICITY; PROTO-ONCOGENE PROTEINS C-FYN; SEIZURES; SPECIES SPECIFICITY; SYNAPSES; SYNAPTIC TRANSMISSION; TAU PROTEINS;

EID: 78651506630     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4152-10.2011     Document Type: Article

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