-
1
-
-
0033850407
-
Tau protein isoforms, phosphorylation and role in neurodegenerative disorders
-
Buee, L., Bussiere, T., Buee-Scherrer, V., Delacourte, A. & Hof, P. R. Tau protein isoforms, phosphorylation and role in neurodegenerative disorders. Brain Res. Rev. 33, 95-130 (2000).
-
(2000)
Brain Res. Rev
, vol.33
, pp. 95-130
-
-
Buee, L.1
Bussiere, T.2
Buee-Scherrer, V.3
Delacourte, A.4
Hof, P.R.5
-
2
-
-
0028785525
-
Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain
-
Brandt, R., Leger, J. & Lee, G. Interaction of tau with the neural plasma membrane mediated by tau's amino-terminal projection domain. J. Cell Biol. 131, 1327-1340 (1995).
-
(1995)
J. Cell Biol
, vol.131
, pp. 1327-1340
-
-
Brandt, R.1
Leger, J.2
Lee, G.3
-
3
-
-
0040141570
-
Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments
-
Maas, T., Eidenmuller, J. & Brandt, R. Interaction of tau with the neural membrane cortex is regulated by phosphorylation at sites that are modified in paired helical filaments. J. Biol. Chem. 275, 15733-15740 (2000).
-
(2000)
J. Biol. Chem
, vol.275
, pp. 15733-15740
-
-
Maas, T.1
Eidenmuller, J.2
Brandt, R.3
-
4
-
-
33947286683
-
Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo
-
Fulga, T. A. et al. Abnormal bundling and accumulation of F-actin mediates tau-induced neuronal degeneration in vivo. Nature Cell Biol. 9, 139-148 (2007).
-
(2007)
Nature Cell Biol
, vol.9
, pp. 139-148
-
-
Fulga, T.A.1
-
5
-
-
10944228450
-
Tau and src family tyrosine kinases
-
Lee, G. Tau and src family tyrosine kinases. Biochim. Biophys. Acta 1739, 323-330 (2005).
-
(2005)
Biochim. Biophys. Acta
, vol.1739
, pp. 323-330
-
-
Lee, G.1
-
6
-
-
0024675418
-
The microtubule binding domain of tau protein
-
Lee, G., Neve, R. L. & Kosik, K. S. The microtubule binding domain of tau protein. Neuron 2, 1615-1624 (1989).
-
(1989)
Neuron
, vol.2
, pp. 1615-1624
-
-
Lee, G.1
Neve, R.L.2
Kosik, K.S.3
-
7
-
-
0022365608
-
The distribution of tau in the mammalian central nervous system
-
Binder, L. I., Frankfurter, A. & Rebhun, L. I. The distribution of tau in the mammalian central nervous system. J. Cell Biol. 101, 1371-1378 (1985).
-
(1985)
J. Cell Biol
, vol.101
, pp. 1371-1378
-
-
Binder, L.I.1
Frankfurter, A.2
Rebhun, L.I.3
-
8
-
-
0032484089
-
Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17
-
Hong, M. et al. Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17. Science 282, 1914-1917 (1998).
-
(1998)
Science
, vol.282
, pp. 1914-1917
-
-
Hong, M.1
-
9
-
-
4344572092
-
Microtubule structure and its stabilisation
-
Amos, L. A. Microtubule structure and its stabilisation. Org. Biomol. Chem. 2, 2153-2160 (2004).
-
(2004)
Org. Biomol. Chem
, vol.2
, pp. 2153-2160
-
-
Amos, L.A.1
-
10
-
-
0037413708
-
Repeat motifs of tau bind to the insides of microtubules in the absence of taxol
-
Kar, S., Fan, J., Smith, M. J., Goedert, M. & Amos, L. A. Repeat motifs of tau bind to the insides of microtubules in the absence of taxol. EMBO J. 22, 70-77 (2003).
-
(2003)
EMBO J
, vol.22
, pp. 70-77
-
-
Kar, S.1
Fan, J.2
Smith, M.J.3
Goedert, M.4
Amos, L.A.5
-
11
-
-
0037468616
-
Discodermolide interferes with the binding of tau protein to microtubules
-
Kar, S., Florence, G. J., Paterson, I. & Amos, L. A. Discodermolide interferes with the binding of tau protein to microtubules. FEBS Lett. 539, 34-36 (2003).
-
(2003)
FEBS Lett
, vol.539
, pp. 34-36
-
-
Kar, S.1
Florence, G.J.2
Paterson, I.3
Amos, L.A.4
-
12
-
-
0032938625
-
Assembly of paired helical filaments from mouse tau: Implications for the neurofibrillary pathology in transgenic mouse models for Alzheimer's disease
-
Kampers, T., Pangalos, M., Geerts, H., Wiech, H. & Mandelkow, E. Assembly of paired helical filaments from mouse tau: implications for the neurofibrillary pathology in transgenic mouse models for Alzheimer's disease. FEBS Lett. 451, 39-44 (1999).
-
(1999)
FEBS Lett
, vol.451
, pp. 39-44
-
-
Kampers, T.1
Pangalos, M.2
Geerts, H.3
Wiech, H.4
Mandelkow, E.5
-
13
-
-
13144265717
-
Presenilin 1 associates with glycogen synthase kinase-3β and its substrate tau
-
Takashima, A. et al. Presenilin 1 associates with glycogen synthase kinase-3β and its substrate tau. Proc. Natl Acad. Sci. USA 95, 9637-9641 (1998).
-
(1998)
Proc. Natl Acad. Sci. USA
, vol.95
, pp. 9637-9641
-
-
Takashima, A.1
-
14
-
-
85161742415
-
-
Kuret, J. et al. Evaluating triggers and enhancers of tau fibrillization. Microsc. Res. Tech. 67, 141-155 (2005). This review provides a model to rationalize the multistep pathway to tau fibril formation, as well as experimental methods for tau fibrillization assays.
-
Kuret, J. et al. Evaluating triggers and enhancers of tau fibrillization. Microsc. Res. Tech. 67, 141-155 (2005). This review provides a model to rationalize the multistep pathway to tau fibril formation, as well as experimental methods for tau fibrillization assays.
-
-
-
-
15
-
-
34447503455
-
-
Mazanetz, M. P. & Fischer, P. M. Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases. Nature Rev. Drug Discov. 6, 464-479 (2007). An up-to-date account of the role of specific kinases in tau-mediated neurodegeneration and their significance as targets for therapeutic intervention.
-
Mazanetz, M. P. & Fischer, P. M. Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases. Nature Rev. Drug Discov. 6, 464-479 (2007). An up-to-date account of the role of specific kinases in tau-mediated neurodegeneration and their significance as targets for therapeutic intervention.
-
-
-
-
16
-
-
10544236116
-
The microtubule-associated protein tau is extensively modified with O-linked N-acetylglucosamine
-
Arnold, C. S. et al. The microtubule-associated protein tau is extensively modified with O-linked N-acetylglucosamine. J. Biol. Chem. 271, 28741-28744 (1996).
-
(1996)
J. Biol. Chem
, vol.271
, pp. 28741-28744
-
-
Arnold, C.S.1
-
17
-
-
33646008860
-
Concurrent alterations of O-GlcNAcylation and phosphorylation of tau in mouse brains during fasting
-
Li, X., Lu, F., Wang, J.-Z. & Gong, C.-X. Concurrent alterations of O-GlcNAcylation and phosphorylation of tau in mouse brains during fasting. Eur. J. Neurosci. 23, 2078-2086 (2006).
-
(2006)
Eur. J. Neurosci
, vol.23
, pp. 2078-2086
-
-
Li, X.1
Lu, F.2
Wang, J.-Z.3
Gong, C.-X.4
-
18
-
-
3242739968
-
O-GlcNAcylation regulates phosphorylation of tau: A mechanism involved in Alzheimer's disease
-
Liu, F., Iqbal, K., Grundke-Iqbal, I., Hart, G. W. & Gong, C.-X. O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease. Proc. Natl Acad. Sci. USA 101, 10804-10809 (2004).
-
(2004)
Proc. Natl Acad. Sci. USA
, vol.101
, pp. 10804-10809
-
-
Liu, F.1
Iqbal, K.2
Grundke-Iqbal, I.3
Hart, G.W.4
Gong, C.-X.5
-
19
-
-
18544390506
-
Post-translational modifications of tau protein in Alzheimer's disease
-
Gong, C. X., Liu, F., Grundke-Iqbal, I. & Iqbal, K. Post-translational modifications of tau protein in Alzheimer's disease. J. Neural Transm. 112, 813-838 (2005).
-
(2005)
J. Neural Transm
, vol.112
, pp. 813-838
-
-
Gong, C.X.1
Liu, F.2
Grundke-Iqbal, I.3
Iqbal, K.4
-
20
-
-
0036051027
-
Glycoxidative stress creates a vicious cycle of neurodegeneration in Alzheimer's disease - a target for neuroprotective treatment strategies?
-
Münch, G., Deuther-Conrad, W. & Gasic-Milenkovic, J. Glycoxidative stress creates a vicious cycle of neurodegeneration in Alzheimer's disease - a target for neuroprotective treatment strategies? J. Neural Transm. 62 (Suppl.), 303-307 (2002).
-
(2002)
J. Neural Transm
, vol.62
, Issue.SUPPL.
, pp. 303-307
-
-
Münch, G.1
Deuther-Conrad, W.2
Gasic-Milenkovic, J.3
-
21
-
-
33744950091
-
Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation
-
Cripps, D. et al. Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation. J. Biol. Chem. 281, 10825-10838 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 10825-10838
-
-
Cripps, D.1
-
22
-
-
33744544785
-
Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and α-synuclein
-
Dorval, V. & Fraser, P. E. Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and α-synuclein. J. Biol. Chem. 281, 9919-9924 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 9919-9924
-
-
Dorval, V.1
Fraser, P.E.2
-
23
-
-
34249733176
-
SUMO on the road to neurodegeneration
-
Dorval, V. & Fraser, P. E. SUMO on the road to neurodegeneration. Biochim. Biophys. Acta 1773, 694-706 (2007).
-
(2007)
Biochim. Biophys. Acta
, vol.1773
, pp. 694-706
-
-
Dorval, V.1
Fraser, P.E.2
-
24
-
-
25944468064
-
Impaired tau protein function following nitration-induced oxidative stress in vitro and in vivo
-
Mailliot, C., Trojanowski, J. Q. & Lee, V. M. Impaired tau protein function following nitration-induced oxidative stress in vitro and in vivo. Neurobiol. Aging 23 (Suppl. 1), 415 (2002).
-
(2002)
Neurobiol. Aging
, vol.23
, Issue.SUPPL. 1
, pp. 415
-
-
Mailliot, C.1
Trojanowski, J.Q.2
Lee, V.M.3
-
25
-
-
33747401659
-
Tau phosphorylation and proteolysis: Insights and perspectives
-
Johnson, G. Tau phosphorylation and proteolysis: insights and perspectives. J. Alzheimers Dis. 9, 243-250 (2006).
-
(2006)
J. Alzheimers Dis
, vol.9
, pp. 243-250
-
-
Johnson, G.1
-
26
-
-
14244261725
-
-
Roy, S., Zhang, B., Lee, V. M.-Y. & Trojanowski, J. Q. Axonal transport defects: a common theme in neurodegenerative diseases. Acta Neuropathol. 109, 5-13 (2005). Reviews the biology of axonal transport and its role in neurodegenerative disease.
-
Roy, S., Zhang, B., Lee, V. M.-Y. & Trojanowski, J. Q. Axonal transport defects: a common theme in neurodegenerative diseases. Acta Neuropathol. 109, 5-13 (2005). Reviews the biology of axonal transport and its role in neurodegenerative disease.
-
-
-
-
27
-
-
10944273984
-
Pathways of tau fibrillization
-
Kuret, J. et al. Pathways of tau fibrillization. Biochim. Biophys. Acta 1739, 167-178 (2005).
-
(2005)
Biochim. Biophys. Acta
, vol.1739
, pp. 167-178
-
-
Kuret, J.1
-
28
-
-
3142514201
-
Protein aggregation and neurodegenerative disease
-
Ross, C. A. & Poirier, M. A. Protein aggregation and neurodegenerative disease. Nature Med. 10, S10-S17 (2004).
-
(2004)
Nature Med
, vol.10
-
-
Ross, C.A.1
Poirier, M.A.2
-
29
-
-
0034843039
-
Sequence of neurofibrillary changes in aging and Alzheimer's disease: A confocal study with phospho-tau antibody, AD2
-
Galvan, M., David, J. P., Delacourte, A., Luna, J. & Mena, R. Sequence of neurofibrillary changes in aging and Alzheimer's disease: a confocal study with phospho-tau antibody, AD2. J. Alzheimers Dis. 3, 417-425 (2001).
-
(2001)
J. Alzheimers Dis
, vol.3
, pp. 417-425
-
-
Galvan, M.1
David, J.P.2
Delacourte, A.3
Luna, J.4
Mena, R.5
-
30
-
-
33947691643
-
Granular tau oligomers as intermediates of tau filaments
-
Maeda, S. et al. Granular tau oligomers as intermediates of tau filaments. Biochemistry 46, 3856-3861 (2007).
-
(2007)
Biochemistry
, vol.46
, pp. 3856-3861
-
-
Maeda, S.1
-
31
-
-
33244456786
-
Increased levels of granular tau oligomers: An early sign of brain aging and Alzheimer's disease
-
Maeda, S. et al. Increased levels of granular tau oligomers: an early sign of brain aging and Alzheimer's disease. Neurosci. Res. 54, 197-201 (2006).
-
(2006)
Neurosci. Res
, vol.54
, pp. 197-201
-
-
Maeda, S.1
-
32
-
-
11144258263
-
Mutations causing neurodegenerative tauopathies
-
Goedert, M. & Jakes, R. Mutations causing neurodegenerative tauopathies. Biochim. Biophys. Acta 1739, 240-250 (2005).
-
(2005)
Biochim. Biophys. Acta
, vol.1739
, pp. 240-250
-
-
Goedert, M.1
Jakes, R.2
-
33
-
-
0035930625
-
Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local β-structure
-
von Bergen, M. et al. Mutations of tau protein in frontotemporal dementia promote aggregation of paired helical filaments by enhancing local β-structure. J. Biol. Chem. 276, 48165-48174 (2001).
-
(2001)
J. Biol. Chem
, vol.276
, pp. 48165-48174
-
-
von Bergen, M.1
-
34
-
-
0033011181
-
Accelerated filament formation from tau protein with specific FTDP-17 missense mutations
-
Nacharaju, P. et al. Accelerated filament formation from tau protein with specific FTDP-17 missense mutations. FEBS Lett. 447, 195-199 (1999).
-
(1999)
FEBS Lett
, vol.447
, pp. 195-199
-
-
Nacharaju, P.1
-
35
-
-
4844219627
-
Promotion of hyperphosphorylation by frontotemporal dementia tau mutations
-
Alonso Adel, C., Mederlyova, A., Novak, M., Grundke-Iqbal, I. & Iqbal, K. Promotion of hyperphosphorylation by frontotemporal dementia tau mutations. J. Biol. Chem. 279, 34873-34881 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, pp. 34873-34881
-
-
Alonso Adel, C.1
Mederlyova, A.2
Novak, M.3
Grundke-Iqbal, I.4
Iqbal, K.5
-
36
-
-
0033042978
-
Mutations in tau reduce its microtubule binding properties in intact cells and affect its phosphorylation
-
Dayanandan, R. et al. Mutations in tau reduce its microtubule binding properties in intact cells and affect its phosphorylation. FEBS Lett. 446, 228-232 (1999).
-
(1999)
FEBS Lett
, vol.446
, pp. 228-232
-
-
Dayanandan, R.1
-
37
-
-
33646198145
-
Tau therapeutic strategies for the treatment of Alzheimer's disease
-
Churcher, I. Tau therapeutic strategies for the treatment of Alzheimer's disease. Curr. Top. Med. Chem. 6, 579-595 (2006).
-
(2006)
Curr. Top. Med. Chem
, vol.6
, pp. 579-595
-
-
Churcher, I.1
-
38
-
-
21044449225
-
-
Noble, W. et al. Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo. Proc. Natl Acad. Sci. USA 102, 6990-6995 (2005). Study that validates GSK3β as a target for tau-directed therapies.
-
Noble, W. et al. Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo. Proc. Natl Acad. Sci. USA 102, 6990-6995 (2005). Study that validates GSK3β as a target for tau-directed therapies.
-
-
-
-
39
-
-
0038187674
-
GSK-3α regulates production of Alzheimer's disease amyloid-β peptides
-
Phiel, C. J., Wilson, C. A., Lee, V. M. Y. & Klein, P. S. GSK-3α regulates production of Alzheimer's disease amyloid-β peptides. Nature 423, 435-439 (2003).
-
(2003)
Nature
, vol.423
, pp. 435-439
-
-
Phiel, C.J.1
Wilson, C.A.2
Lee, V.M.Y.3
Klein, P.S.4
-
40
-
-
0036769791
-
Role of serine/threonine protein phosphatase in Alzheimer's disease
-
Tian, Q. & Wang, J. Role of serine/threonine protein phosphatase in Alzheimer's disease. Neurosignals 11, 262-269 (2002).
-
(2002)
Neurosignals
, vol.11
, pp. 262-269
-
-
Tian, Q.1
Wang, J.2
-
41
-
-
3142514196
-
Oxidative stress in neurodegeneration: Cause or consequence?
-
Andersen, J. K. Oxidative stress in neurodegeneration: cause or consequence? Nature Med. 5, S18-S25 (2004).
-
(2004)
Nature Med
, vol.5
-
-
Andersen, J.K.1
-
42
-
-
23744439419
-
Oxidative stress and neurodegeneration
-
Moreira, P. I. et al. Oxidative stress and neurodegeneration. Ann. NY Acad. Sci. 1043, 545-552 (2005).
-
(2005)
Ann. NY Acad. Sci
, vol.1043
, pp. 545-552
-
-
Moreira, P.I.1
-
43
-
-
33751218015
-
Tau-dependent microtubule disassembly initiated by prefibrillar β-amyloid
-
King, M. E. et al. Tau-dependent microtubule disassembly initiated by prefibrillar β-amyloid. J. Cell Biol. 175, 541-546 (2006).
-
(2006)
J. Cell Biol
, vol.175
, pp. 541-546
-
-
King, M.E.1
-
44
-
-
0037197836
-
-
Rapoport, M., Dawson, H. N., Binder, L. I., Vitek, M. P. & Ferreira, A. Tau is essential to β-amyloid-induced neurotoxicity. Proc. Natl Acad. Sci. USA 99, 6364-6369 (2002). Study that substantiates the notion that tau may be a mediator of upstream pathological events, namely Aβ-induced neurotoxicity.
-
Rapoport, M., Dawson, H. N., Binder, L. I., Vitek, M. P. & Ferreira, A. Tau is essential to β-amyloid-induced neurotoxicity. Proc. Natl Acad. Sci. USA 99, 6364-6369 (2002). Study that substantiates the notion that tau may be a mediator of upstream pathological events, namely Aβ-induced neurotoxicity.
-
-
-
-
45
-
-
19944383786
-
Tau modifiers as therapeutic targets for Alzheimer's disease
-
Liu, Q. et al. Tau modifiers as therapeutic targets for Alzheimer's disease. Biochim. Biophys. Acta 1739, 211-215 (2005).
-
(2005)
Biochim. Biophys. Acta
, vol.1739
, pp. 211-215
-
-
Liu, Q.1
-
46
-
-
0029114196
-
Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein τ controls the in vitro assembly of paired helical filaments
-
Schweers, O., Mandelkow, E., Biernat, J. & Mandelkow, E. Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein τ controls the in vitro assembly of paired helical filaments. Proc. Natl Acad. Sci. USA 92, 8463-8467 (1995).
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 8463-8467
-
-
Schweers, O.1
Mandelkow, E.2
Biernat, J.3
Mandelkow, E.4
-
47
-
-
21244486781
-
Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice
-
David, D. C. et al. Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice. J. Biol. Chem. 280, 23802-23814 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 23802-23814
-
-
David, D.C.1
-
48
-
-
33846047004
-
Pathways by which Aβ facilitates tau pathology
-
Blurton-Jones, M. & LaFerla, F. M. Pathways by which Aβ facilitates tau pathology. Curr. Alzheimer Res. 3, 437-448 (2006).
-
(2006)
Curr. Alzheimer Res
, vol.3
, pp. 437-448
-
-
Blurton-Jones, M.1
LaFerla, F.M.2
-
49
-
-
33144487701
-
Temporal profile of amyloid-β (Aβ) oligomerization in an in vivo model of Alzheimer disease: A link between Aβ and tau pathology
-
Oddo, S. et al. Temporal profile of amyloid-β (Aβ) oligomerization in an in vivo model of Alzheimer disease: a link between Aβ and tau pathology. J. Biol. Chem. 281, 1599-1604 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 1599-1604
-
-
Oddo, S.1
-
50
-
-
34248181511
-
-
Roberson, E. D. et al. Reducing endogenous tau ameliorates amyloid β-induced deficits in an Alzheimer's disease mouse model. Science 316, 750-754 (2007). Study that suggests the role tau might have as a mediator of neurodegeneration. This study also suggests that tau reduction may be therapeutically beneficial.
-
Roberson, E. D. et al. Reducing endogenous tau ameliorates amyloid β-induced deficits in an Alzheimer's disease mouse model. Science 316, 750-754 (2007). Study that suggests the role tau might have as a mediator of neurodegeneration. This study also suggests that tau reduction may be therapeutically beneficial.
-
-
-
-
51
-
-
0033969771
-
Muscle weakness, hyperactivity, and impairment in fear conditioning in tau-deficient mice
-
Ikegami, S., Harada, A. & Hirokawa, N. Muscle weakness, hyperactivity, and impairment in fear conditioning in tau-deficient mice. Neurosci. Lett. 279, 129-132 (2000).
-
(2000)
Neurosci. Lett
, vol.279
, pp. 129-132
-
-
Ikegami, S.1
Harada, A.2
Hirokawa, N.3
-
52
-
-
7044238416
-
Neurodegenerative diseases: A decade of discoveries paves the way for therapeutic breakthroughs
-
Forman, M. S., Trojanowski, J. Q. & Lee, V. M.-Y. Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs. Nature Med. 10, 1055-1063 (2004).
-
(2004)
Nature Med
, vol.10
, pp. 1055-1063
-
-
Forman, M.S.1
Trojanowski, J.Q.2
Lee, V.M.-Y.3
-
53
-
-
0142200946
-
Overview of protein aggregation in single, double, and triple neurodegenerative brain amyloidoses
-
Trojanowski, J. Q. & Mattson, M. P. Overview of protein aggregation in single, double, and triple neurodegenerative brain amyloidoses. Neuromolecular Med. 4, 1-6 (2003).
-
(2003)
Neuromolecular Med
, vol.4
, pp. 1-6
-
-
Trojanowski, J.Q.1
Mattson, M.P.2
-
54
-
-
0033639241
-
Novel method to quantify neuropil threads in brains from elders with or without cognitive impairment
-
Mitchell, T. W. et al. Novel method to quantify neuropil threads in brains from elders with or without cognitive impairment. J. Histochem. Cytochem. 48, 1627-1638 (2000).
-
(2000)
J. Histochem. Cytochem
, vol.48
, pp. 1627-1638
-
-
Mitchell, T.W.1
-
55
-
-
19044378780
-
Microtubule-stabilizing drugs for therapy of Alzheimer's disease and other neurodegenerative disorders with axonal transport impairments
-
Trojanowski, J. Q., Smith, A. B., Huryn, D. & Lee, V. M.-Y. Microtubule-stabilizing drugs for therapy of Alzheimer's disease and other neurodegenerative disorders with axonal transport impairments. Expert Opin. Pharmacother. 6, 683-686 (2005).
-
(2005)
Expert Opin. Pharmacother
, vol.6
, pp. 683-686
-
-
Trojanowski, J.Q.1
Smith, A.B.2
Huryn, D.3
Lee, V.M.-Y.4
-
56
-
-
0033230886
-
Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform
-
Ishihara, T. et al. Age-dependent emergence and progression of a tauopathy in transgenic mice overexpressing the shortest human tau isoform. Neuron 24, 751-762 (1999).
-
(1999)
Neuron
, vol.24
, pp. 751-762
-
-
Ishihara, T.1
-
57
-
-
19944429064
-
Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model
-
Zhang, B. et al. Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model. Proc. Natl Acad. Sci. USA 102, 227-231 (2005).
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 227-231
-
-
Zhang, B.1
-
58
-
-
0026740795
-
Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease
-
Arriagada, P. V., Growdon, J. H., Hedley-Whyte, E. T. & Hyman, B. T. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 42, 631-639 (1992).
-
(1992)
Neurology
, vol.42
, pp. 631-639
-
-
Arriagada, P.V.1
Growdon, J.H.2
Hedley-Whyte, E.T.3
Hyman, B.T.4
-
59
-
-
0026743110
-
Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease
-
Arriagada, P. V., Marzloff, K. & Hyman, B. T. Distribution of Alzheimer-type pathologic changes in nondemented elderly individuals matches the pattern in Alzheimer's disease. Neurology 42, 1681-1688 (1992).
-
(1992)
Neurology
, vol.42
, pp. 1681-1688
-
-
Arriagada, P.V.1
Marzloff, K.2
Hyman, B.T.3
-
60
-
-
22344438508
-
-
Santacruz, K. et al. Tau suppression in a neurodegenerative mouse model improves memory function. Science 309, 476-481 (2005). Interesting study that shows that suppression of tau improves memory function even though NFTs continue to grow.
-
Santacruz, K. et al. Tau suppression in a neurodegenerative mouse model improves memory function. Science 309, 476-481 (2005). Interesting study that shows that suppression of tau improves memory function even though NFTs continue to grow.
-
-
-
-
61
-
-
27744491956
-
Pathological tau: A loss of normal function or a gain in toxicity?
-
Trojanowski, J. Q. & Lee, V. M. Pathological tau: a loss of normal function or a gain in toxicity? Nature Neurosci. 8, 1136-1137 (2005).
-
(2005)
Nature Neurosci
, vol.8
, pp. 1136-1137
-
-
Trojanowski, J.Q.1
Lee, V.M.2
-
62
-
-
20044385920
-
-
Stokin, G. B. et al. Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science 307, 1282-1288 (2005). Together with reference 61, this study shows that axonal transport defects may be early pathological events in tau-mediated neurodegeneration.
-
Stokin, G. B. et al. Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease. Science 307, 1282-1288 (2005). Together with reference 61, this study shows that axonal transport defects may be early pathological events in tau-mediated neurodegeneration.
-
-
-
-
63
-
-
33846538660
-
-
Yoshiyama, Y. et al. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron 53, 337-351 (2007). Paper demonstrating that microgliosis and synaptic pathology may be the earliest manifestation of neurodegenerative tauopathies. The paper also suggests that abrogation of tau-induced microglial activation may be therapeutically beneficial.
-
Yoshiyama, Y. et al. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron 53, 337-351 (2007). Paper demonstrating that microgliosis and synaptic pathology may be the earliest manifestation of neurodegenerative tauopathies. The paper also suggests that abrogation of tau-induced microglial activation may be therapeutically beneficial.
-
-
-
-
64
-
-
10944231216
-
Transgenic animal models of tauopathies
-
Lee, V. M.-Y., Kenyon, T. K. & Trojanowski, J. Q. Transgenic animal models of tauopathies. Biochim. Biophys. Acta 1739, 251-259 (2005).
-
(2005)
Biochim. Biophys. Acta
, vol.1739
, pp. 251-259
-
-
Lee, V.M.-Y.1
Kenyon, T.K.2
Trojanowski, J.Q.3
-
65
-
-
33947729229
-
Biomarkers of neurodegeneration for diagnosis and monitoring therapeutics
-
Shaw, L. M., Korecka, M., Clark, C. M., Lee, V. M. & Trojanowski, J. Q. Biomarkers of neurodegeneration for diagnosis and monitoring therapeutics. Nature Rev. Drug Discov. 6, 295-303 (2007).
-
(2007)
Nature Rev. Drug Discov
, vol.6
, pp. 295-303
-
-
Shaw, L.M.1
Korecka, M.2
Clark, C.M.3
Lee, V.M.4
Trojanowski, J.Q.5
-
66
-
-
23044439880
-
Cyanine dye N744 inhibits tau fibrillization by blocking filament extension: Implications for the treatment of tauopathic neurodegenerative diseases
-
Necula, M., Chirita, C. N. & Kuret, J. Cyanine dye N744 inhibits tau fibrillization by blocking filament extension: implications for the treatment of tauopathic neurodegenerative diseases. Biochemistry 44, 10227-10237 (2005).
-
(2005)
Biochemistry
, vol.44
, pp. 10227-10237
-
-
Necula, M.1
Chirita, C.N.2
Kuret, J.3
-
67
-
-
20844432208
-
Screening for inhibitors of tau polymerization
-
Pickhardt, M. et al. Screening for inhibitors of tau polymerization. Curr. Alzheimer Res. 2, 219-226 (2005).
-
(2005)
Curr. Alzheimer Res
, vol.2
, pp. 219-226
-
-
Pickhardt, M.1
-
68
-
-
13544251748
-
Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells
-
Pickhardt, M. et al. Anthraquinones inhibit tau aggregation and dissolve Alzheimer's paired helical filaments in vitro and in cells. J. Biol. Chem. 280, 3628-3635 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 3628-3635
-
-
Pickhardt, M.1
-
69
-
-
14844303721
-
Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins
-
Taniguchi, S. et al. Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins. J. Biol. Chem. 280, 7614-7623 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 7614-7623
-
-
Taniguchi, S.1
-
70
-
-
33845192482
-
Congo red and protein aggregation in neurodegenerative diseases
-
Frid, P., Anisimov, S. V. & Popovic, N. Congo red and protein aggregation in neurodegenerative diseases. Brain Res. Rev. 53, 135-160 (2007).
-
(2007)
Brain Res. Rev
, vol.53
, pp. 135-160
-
-
Frid, P.1
Anisimov, S.V.2
Popovic, N.3
-
71
-
-
1542327644
-
Ligand-dependent inhibition and reversal of tau filament formation
-
Chirita, C., Necula, M. & Kuret, J. Ligand-dependent inhibition and reversal of tau filament formation. Biochemistry 43, 2879-2887 (2004).
-
(2004)
Biochemistry
, vol.43
, pp. 2879-2887
-
-
Chirita, C.1
Necula, M.2
Kuret, J.3
-
72
-
-
14644403123
-
Development of a fluorescent high throughput assay for tau aggregation
-
Liu, M., Ni, J., Kosik, K. S. & Yeh, L. A. Development of a fluorescent high throughput assay for tau aggregation. Assay Drug Dev. Technol. 2, 609-619 (2004).
-
(2004)
Assay Drug Dev. Technol
, vol.2
, pp. 609-619
-
-
Liu, M.1
Ni, J.2
Kosik, K.S.3
Yeh, L.A.4
-
73
-
-
0029742937
-
Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines
-
Wischik, C. M., Edwards, P. C., Lai, R. Y. K., Roth, M. & Harrington, C. R. Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines. Proc. Natl Acad. Sci. USA 93, 11213-11218 (1996).
-
(1996)
Proc. Natl Acad. Sci. USA
, vol.93
, pp. 11213-11218
-
-
Wischik, C.M.1
Edwards, P.C.2
Lai, R.Y.K.3
Roth, M.4
Harrington, C.R.5
-
74
-
-
33748588165
-
Inhibition of protein aggregation in vitro and in vivo by a natural osmoprotectant
-
Ignatova, Z. & Gierasch, L. M. Inhibition of protein aggregation in vitro and in vivo by a natural osmoprotectant. Proc. Natl Acad. Sci. USA 103, 13357-13361 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 13357-13361
-
-
Ignatova, Z.1
Gierasch, L.M.2
-
75
-
-
33847199377
-
-
Gotz, J. et al. A decade of tau transgenic animal models and beyond. Brain Pathol. 17, 91-103 (2007). An up-to-date account of tau transgenic animal models.
-
Gotz, J. et al. A decade of tau transgenic animal models and beyond. Brain Pathol. 17, 91-103 (2007). An up-to-date account of tau transgenic animal models.
-
-
-
-
76
-
-
33646126924
-
A decade of modeling Alzheimer's disease in transgenic mice
-
McGowan, E., Eriksen, J. & Hutton, M. A decade of modeling Alzheimer's disease in transgenic mice. Trends Genet. 22, 281-289 (2006).
-
(2006)
Trends Genet
, vol.22
, pp. 281-289
-
-
McGowan, E.1
Eriksen, J.2
Hutton, M.3
-
77
-
-
33750503415
-
Drug discovery in dementia: The role of rodent models
-
Van Dam, D. & De Deyn, P. P. Drug discovery in dementia: the role of rodent models. Nature Rev. Drug Discov. 5, 956-970 (2006).
-
(2006)
Nature Rev. Drug Discov
, vol.5
, pp. 956-970
-
-
Van Dam, D.1
De Deyn, P.P.2
-
78
-
-
33746652117
-
Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits
-
Schindowski, K. et al. Alzheimer's disease-like tau neuropathology leads to memory deficits and loss of functional synapses in a novel mutated tau transgenic mouse without any motor deficits. Am. J. Pathol. 169, 599-616 (2006).
-
(2006)
Am. J. Pathol
, vol.169
, pp. 599-616
-
-
Schindowski, K.1
-
79
-
-
34247876141
-
Therapies for Alzheimer's disease
-
Melnikova, I. Therapies for Alzheimer's disease. Nature Rev. Drug Discov. 6, 341-342 (2007).
-
(2007)
Nature Rev. Drug Discov
, vol.6
, pp. 341-342
-
-
Melnikova, I.1
-
80
-
-
28044460038
-
Quinoline and benzimidazole derivatives: Candidate probes for in vivo imaging of tau pathology in Alzheimer's disease
-
Okamura, N. et al. Quinoline and benzimidazole derivatives: candidate probes for in vivo imaging of tau pathology in Alzheimer's disease. J. Neurosci. 25, 10857-10862 (2005).
-
(2005)
J. Neurosci
, vol.25
, pp. 10857-10862
-
-
Okamura, N.1
-
81
-
-
12344273726
-
The blood-brain barrier: Bottleneck in brain drug development
-
Pardridge, W. M. The blood-brain barrier: bottleneck in brain drug development. NeuroRx 2, 3-14 (2005).
-
(2005)
NeuroRx
, vol.2
, pp. 3-14
-
-
Pardridge, W.M.1
-
82
-
-
0028965635
-
Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform
-
Gotz, J. et al. Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform. EMBO J. 14, 1304-1313 (1995).
-
(1995)
EMBO J
, vol.14
, pp. 1304-1313
-
-
Gotz, J.1
-
83
-
-
0032786370
-
Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein
-
Spittaels, K. et al. Prominent axonopathy in the brain and spinal cord of transgenic mice overexpressing four-repeat human tau protein. Am. J. Pathol. 155, 2153-2165 (1999).
-
(1999)
Am. J. Pathol
, vol.155
, pp. 2153-2165
-
-
Spittaels, K.1
-
84
-
-
0342803685
-
Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein
-
Probst, A. et al. Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein. Acta Neuropathol. 99, 469-481 (2000).
-
(2000)
Acta Neuropathol
, vol.99
, pp. 469-481
-
-
Probst, A.1
-
85
-
-
0035134081
-
Age-dependent induction of congophilic neurofibrillary tau inclusions in tau transgenic mice
-
Ishihara, T. et al. Age-dependent induction of congophilic neurofibrillary tau inclusions in tau transgenic mice. Am. J. Pathol. 158, 555-562 (2001).
-
(2001)
Am. J. Pathol
, vol.158
, pp. 555-562
-
-
Ishihara, T.1
-
86
-
-
0034426011
-
Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein
-
Lewis, J. et al. Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nature Genet. 25, 402-405 (2000).
-
(2000)
Nature Genet
, vol.25
, pp. 402-405
-
-
Lewis, J.1
-
87
-
-
0035808361
-
Tau filament formation in transgenic mice expressing P301L tau
-
Gotz, J., Chen, F., Barmettler, R. & Nitsch, R. M. Tau filament formation in transgenic mice expressing P301L tau. J. Biol. Chem. 276, 529-534 (2001).
-
(2001)
J. Biol. Chem
, vol.276
, pp. 529-534
-
-
Gotz, J.1
Chen, F.2
Barmettler, R.3
Nitsch, R.M.4
-
88
-
-
0034016093
-
Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes
-
Duff, K. et al. Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes. Neurobiol. Dis. 7, 87-98 (2000).
-
(2000)
Neurobiol. Dis
, vol.7
, pp. 87-98
-
-
Duff, K.1
-
89
-
-
0034948975
-
Oligodendroglial tau filament formation in transgenic mice expressing G272V tau
-
Gotz, J. et al. Oligodendroglial tau filament formation in transgenic mice expressing G272V tau. Eur. J. Neurosci. 13, 2131-2140 (2001).
-
(2001)
Eur. J. Neurosci
, vol.13
, pp. 2131-2140
-
-
Gotz, J.1
-
90
-
-
0036850725
-
Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein
-
Allen, B. et al. Abundant tau filaments and nonapoptotic neurodegeneration in transgenic mice expressing human P301S tau protein. J. Neurosci. 22, 9340-9351 (2002).
-
(2002)
J. Neurosci
, vol.22
, pp. 9340-9351
-
-
Allen, B.1
-
91
-
-
0035680685
-
FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and tau filaments in forebrain
-
Lim, F. et al. FTDP-17 mutations in tau transgenic mice provoke lysosomal abnormalities and tau filaments in forebrain. Mol. Cell Neurosci. 18, 702-714 (2001).
-
(2001)
Mol. Cell Neurosci
, vol.18
, pp. 702-714
-
-
Lim, F.1
-
92
-
-
0036138044
-
Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau
-
Tanemura, K. et al. Neurodegeneration with tau accumulation in a transgenic mouse expressing V337M human tau. J. Neurosci. 22, 133-141 (2002).
-
(2002)
J. Neurosci
, vol.22
, pp. 133-141
-
-
Tanemura, K.1
-
93
-
-
0037108953
-
Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau
-
Tatebayashi, Y. et al. Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau. Proc. Natl Acad. Sci. USA 99, 13896-13901 (2002).
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 13896-13901
-
-
Tatebayashi, Y.1
-
94
-
-
0033694470
-
Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord
-
Tesseur, I. et al. Prominent axonopathy and disruption of axonal transport in transgenic mice expressing human apolipoprotein E4 in neurons of brain and spinal cord. Am. J. Pathol. 157, 1495-1510 (2000).
-
(2000)
Am. J. Pathol
, vol.157
, pp. 1495-1510
-
-
Tesseur, I.1
-
95
-
-
12944268979
-
Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5
-
Ahlijanian, M. K. et al. Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5. Proc. Natl Acad. Sci. USA 97, 2910-2915 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 2910-2915
-
-
Ahlijanian, M.K.1
-
96
-
-
0034612256
-
Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice
-
Capsoni, S. et al. Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice. Proc. Natl Acad. Sci. USA 97, 6826-6831 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 6826-6831
-
-
Capsoni, S.1
-
97
-
-
0344845132
-
Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease
-
Oddo, S., Caccamo, A., Kitazawa, M., Tseng, B. P. & LaFerla, F. M. Amyloid deposition precedes tangle formation in a triple transgenic model of Alzheimer's disease. Neurobiol. Aging 24, 1063-1070 (2003).
-
(2003)
Neurobiol. Aging
, vol.24
, pp. 1063-1070
-
-
Oddo, S.1
Caccamo, A.2
Kitazawa, M.3
Tseng, B.P.4
LaFerla, F.M.5
-
98
-
-
0042697305
-
Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Aβ and synaptic dysfunction
-
Oddo, S. et al. Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Aβ and synaptic dysfunction. Neuron 39, 409-421 (2003).
-
(2003)
Neuron
, vol.39
, pp. 409-421
-
-
Oddo, S.1
-
99
-
-
34248142548
-
High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation
-
Crowe, A., Ballatore, C., Hyde, E., Trojanowski, J. Q. & Lee, V. M.-Y. High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation. Biochem. Biophys. Res. Commun. 358, 1-6 (2007).
-
(2007)
Biochem. Biophys. Res. Commun
, vol.358
, pp. 1-6
-
-
Crowe, A.1
Ballatore, C.2
Hyde, E.3
Trojanowski, J.Q.4
Lee, V.M.-Y.5
-
100
-
-
33847369469
-
The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins
-
Dickey, C. A. et al. The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins. J. Clin. Invest. 117, 648-658 (2007).
-
(2007)
J. Clin. Invest
, vol.117
, pp. 648-658
-
-
Dickey, C.A.1
-
102
-
-
34248354279
-
Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage
-
Matsuoka, Y. et al. Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage. J. Mol. Neurosci. 31, 165-170 (2007).
-
(2007)
J. Mol. Neurosci
, vol.31
, pp. 165-170
-
-
Matsuoka, Y.1
-
103
-
-
0036812560
-
From epidemiology to therapeutic trials with anti-inflammatory drugs in Alzheimer's disease: The role of NSAIDs and cyclooxygenase in β-amyloidosis and clinical dementia
-
Pasinetti, G. M. From epidemiology to therapeutic trials with anti-inflammatory drugs in Alzheimer's disease: the role of NSAIDs and cyclooxygenase in β-amyloidosis and clinical dementia. J. Alzheimers Dis. 4, 435-445 (2002).
-
(2002)
J. Alzheimers Dis
, vol.4
, pp. 435-445
-
-
Pasinetti, G.M.1
-
104
-
-
22144489808
-
Non-steroidal anti-inflammatory drugs (NSAIDs) and other anti-inflammatory agents in the treatment of neurodegenerative disease
-
Klegeris, A. & McGeer, P. L. Non-steroidal anti-inflammatory drugs (NSAIDs) and other anti-inflammatory agents in the treatment of neurodegenerative disease. Curr. Alzheimer Res. 2, 355-365 (2005).
-
(2005)
Curr. Alzheimer Res
, vol.2
, pp. 355-365
-
-
Klegeris, A.1
McGeer, P.L.2
-
105
-
-
26444475416
-
Novel therapeutic opportunities for Alzheimer's disease: Focus on nonsteroidal anti-inflammatory drugs
-
Townsend, K. P. & Pratico, D. Novel therapeutic opportunities for Alzheimer's disease: focus on nonsteroidal anti-inflammatory drugs. FASEB J. 19, 1592-1601 (2005).
-
(2005)
FASEB J
, vol.19
, pp. 1592-1601
-
-
Townsend, K.P.1
Pratico, D.2
|