Curcumin suppresses soluble Tau dinners and corrects molecular chaperone, synaptic, and behavioral deficits in aged human Tau transgenic mice

Journal of Biological Chemistry

Volumn 288, Issue 6, 2013, Pages 4056-4065

  Ma, Qiu Lan ^a,b   Zuo, Xiaohong ^a,c   Yang, Fusheng ^a   Ubeda, Oliver J ^a   Gant, Dana J ^a   Alaverdyan, Mher ^a   Teng, Edmond ^a   Hu, Shuxin ^a   Chen, Ping Ping ^a   Maiti, Panchanan ^a   Teter, Bruce ^a   Cole, Greg M ^a,b   Frautschy, Sally A ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

^c CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA AMYLOIDS; BINDING MOLECULES; COGNITIVE DEFICITS; CURCUMIN; CYTOSOLIC FRACTIONS; GAIN INSIGHT; HEAT SHOCK PROTEIN; HEAT SHOCK RESPONSE; IMMUNOBLOTS; MICROTUBULE STABILITY; MOLECULAR CHAPERONES; SYNAPTIC PROTEINS; TAU PATHOLOGY; TRANSGENE; TRANSGENIC MICE;

MAMMALS; PLANTS (BOTANY); PROTEINS;

DIMERS;

AMYLOID BETA PROTEIN; CHAPERONE; CURCUMIN; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 72; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 KINASE; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN KINASE; PROTEIN KINASE B; PROTEIN KINASE FYN; TAU PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL FOOD; ANIMAL MODEL; ARTICLE; BEHAVIOR DISORDER; CELL LOSS; CELL MEMBRANE; CONTROLLED STUDY; CYTOSOL; DENDRITIC CELL; DIMERIZATION; FEMALE; HIPPOCAMPUS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; MALE; MICROTUBULE; MOUSE; NERVE CELL; NERVE CELL STIMULATION; NONHUMAN; PERIKARYON; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; SOLUBILITY; SUPPLEMENTATION; SYNAPSE; SYNAPTIC DEFICIT; TAUOPATHY; TRANSGENE; TRANSGENIC MOUSE;

AGED; AGED, 80 AND OVER; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BEHAVIOR, ANIMAL; CURCUMIN; FEMALE; HEAT-SHOCK PROTEINS; HIPPOCAMPUS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MEMBRANE PROTEINS; MICE; MICE, TRANSGENIC; PROTEIN MULTIMERIZATION; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-FYN; RECEPTORS, N-METHYL-D-ASPARTATE; SOLUBILITY; SYNAPSES; TAU PROTEINS; TAUOPATHIES;

EID: 84873687399     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.393751     Document Type: Article

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