Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation

Journal of Biological Chemistry

Volumn 281, Issue 16, 2006, Pages 10825-10838

  Cripps, Diane ^a   Thomas, Stefani N ^a   Jeng, Young ^a   Yang, Frank ^b   Davies, Peter ^c   Yang, Austin J ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^c Micro Tech Scientific Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIODEGRADATION; BRAIN; MASS SPECTROMETRY; POLYPEPTIDES; PROTEINS;

ALZHEIMER DISEASE (AD); PAIRED HELICAL FILAMENTS (PHFS); PROTEIN PHOSPHORYLATION;

DISEASES;

LYSINE; MONOCLONAL ANTIBODY; POLYUBIQUITIN; TAU PROTEIN; UBIQUITIN;

ALZHEIMER DISEASE; ARTICLE; CONJUGATION; HUMAN; PAIRED HELICAL FILAMENT; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN PURIFICATION; TANDEM MASS SPECTROMETRY; UBIQUITINATION;

ALGORITHMS; ALZHEIMER DISEASE; AMINO ACID SEQUENCE; CHROMATOGRAPHY, LIQUID; HUMANS; IMMUNOBLOTTING; IMMUNOPRECIPITATION; LYSINE; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; NERVE DEGENERATION; NEUROFIBRILLARY TANGLES; PEPTIDES; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SERINE; SOLVENTS; TAU PROTEINS; THREONINE; TRYPSIN; UBIQUITIN;

EID: 33744950091     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M512786200     Document Type: Article

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