Site-specific dephosphorylation of tau protein at Ser202/Thr205 in response to microtubule depolymerization in cultured human neurons involves protein phosphatase 2A

Journal of Biological Chemistry

Volumn 271, Issue 10, 1996, Pages 5589-5594

  Merrick, Sandra E ^a   Demoise, David C ^a   Lee, Virginia M Y ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOPROTEIN PHOSPHATASE; TAU PROTEIN;

ALZHEIMER DISEASE; ARTICLE; DEPHOSPHORYLATION; DEPOLYMERIZATION; HUMAN; HUMAN CELL; MICROTUBULE; NEUROFIBRILLARY TANGLE; PRIORITY JOURNAL; PROTEIN ISOLATION; PROTEIN PHOSPHORYLATION;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; ANTIBODIES; AUTORADIOGRAPHY; BLOTTING, WESTERN; CELLS, CULTURED; COLCHICINE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EPITOPES; HUMANS; METHIONINE; MICROTUBULES; NEURONS; NOCODAZOLE; PHOSPHATES; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHORUS RADIOISOTOPES; SERINE; SULFUR RADIOISOTOPES; TAU PROTEINS; TERATOCARCINOMA; THREONINE; TUMOR CELLS, CULTURED;

EID: 0029669963     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.10.5589     Document Type: Article

References (68)

1. Lee, V M.-Y.,and Trojanowski, J. Q. (1992) Curr. Opin. Neurobiol. 2, 653-656
2. Goedert, M., Jakes, R., Crowther, R A., Six, J., Lubke, U., Vandermeeren, M., Cras, P., Trojanowski, J Q , and Lee, V. M.-Y. (1993) Proc Natl Acad. Sci. U. S. A. 90, 5066-5070
3. Trojanowski, J. Q , Schmidt, M. L., Shin, R.-W., Bramblett, G. T., Rao, D., and Lee, V. M.-Y. (1993) Brain. Pathol. 3, 45-54
4. Goedert, M., Wischik, C M., Crowther, R. A., Walker, J. E., and Klug, A. (1988) Pros Natl. Acad. Sci U. S. A. 85, 4051-4055
5. Wishik, C. M., Novak, M., Thogersen, H C , Edwards, P. C., Runswick, M. J., Jakes, R., Walker, J. E,. Milstein, C., Roth. M., and Hug, A. (1988) Proc. Natl. Acad Sci. U. S. A. 85, 4506-4510
6. Wischik, C M., Novak. M., Edwards, P. C , Klug, A., Tichelaar, W., and Crowther, R. A. (1988) Proc Natl Acad. Sci. U. S. A. 85, 4884-4888
7. Kondo, J., Honda, T , Mori, H., Hamada, Y , Miura, R., Ogawara, M., and Ihara, Y. (1988) Neuron 1, 827-834
8. Lee, V. M.-Y., Balin, B J , Otvos, L. J., and Trojanowski, J. Q. (1991) Science 251, 675-678
9. Weingarten, M D , Lackwood, A. H., Hwo, S.-Y., and Kirschner, M. W (1975) Proc Natl. Acad Sci. U. S. A. 72, 1858-1862
10. Himmler, A. (1989) Mol. Cell. Biol. 9, 1389-1396
11. Goedert, M , Spillantini, M. G., Potier, M. C., Ulrich, J., and Crowther, R. A. (1989) EMBO J. 8, 393-399
12. Goedert, M., Cohen, E S., Jakes, R., and Cohen, P. (1992) FFBS Lett. 312, 95-99
13. Hasegawa, M., Morishima-Kawashima, M., Takio, K., Suzuki, M., Titani, K , and Ihara. Y. (1992) J. Biol. Chem 267, 17047-17054
14. Watanabe, A., Hasegawa, M . Suzuki, M., Takio, K., Monshima-Kawashima, M , Titam, K., Arai, T., Kosik, K. S., and Ihara, Y. (1993) J. Biol. Chem. 268, 25712-25717
15. Goedert, M., Jakes, R., Crowther, R. A., Cohen, P., Vandermeeren, M., and Cras, P. (1994) Biochem. J 301, 871-877
16. Morishima-Kawashima, M., Hasegawa, M., Takio, K., Suzuki, M., Yoshida, H., Titani, K. and Ihara, Y. (1995) J. Biol. Chem. 270, 823-829
17. Mawal-Dewan, M., Henley, J , Van de Voorde, A., Trojanowski, J. Q., and Lee, V. M.-Y. (1994) J. Biol. Chem 269, 30981-30987
18. Matsuo, E S., Shin, R.-W , Billingsley, M. L., Van de Voorde, A., O'Connor, M., Trojanowski, J. Q., and Lee, V. M.-Y. (1994) Neuron 13, 989-1002
19. Lindwall, G., and Cole, R. D (1984) J Biol Chem. 259, 5301-5305
20. Bramblett, G. T., Goedert, M., Jakes, R., Merrick, S. E., Trojanowsb, J. Q , and Lee, V. M.-Y. (1993) Neuron 10, 1089-1099
21. Biernat, J , Gustke, N., Drewes, G., Mandelkow, E -M , and Mandelkow, E. (1993) Neuron 11, 153-163
22. Goedert, M., and Jakes, R. (1990) EMBO J 9, 4225-4230
23. Butner, K. A., and Kirschner, M W. (1991) J. Cell Biol. 115, 717-730
24. Gustke, N., Trinczek, B., Biernat, J., Mandelkow, E.-M., and Mandelkow, E. (1994) Biochemistry 33, 9511-9522
25. Goode, B. L , and Feinstein, S. C. (1994) J. Cell Biol. 124, 769-782
26. Yang, S. D., Yu, J. S., and Lai, Y. G. (1991) J. Protein Chem. 10, 171-181
27. Drewes, G , Lichtenberg-Kraag, B., Doring, F., Mandelkow, E.-M., Biernat, J., Goris, J., Doree, M., and Mandelkow, E. (1992) EMBO J. 11, 2131-2138
28. Hanger, D P., Hughes, K., Woodgett, J R., Brion, J. P., and Anderton, B. H. (1992) Neurosci. Lett. 147, 58-62
29. Ishiguro, K., Takamatsu, M , Tomizawa, K., Omori, A., Takahashi, M., Arioka, M., Uchida, T., and Imahori, K. (1992) J. Biol. Chem. 267, 10897-10901
30. Mandelkow, E.-M., Drewes, G., Biernat, J., Gustke, N., Van Lint, J., Vandenheede, J. R., and Mandelkow, E. (1992) FEBS Lett. 314, 315-321
31. Vulliet, R., Halloran, S. M., Braun, R. K., Smith, A. J., and Lee, G. (1992) J. Biol. Chem. 267, 22570-22574
32. Harris, K. A , Oyler, G. A., Doolittle, G. M , Vincent, I., Lehman, R. A., Kincaid, R. L., and Billingsley, M. L. (1993) Ann. Neurol. 33, 77-87
33. Paudel, H. K., Lew, J., Ali, Z., and Wang, J. H. (1993) J. Biol. Chem. 268, 23512-23518
34. Kobayashi, S., Ishiguro, K, Omori. A., Takamatsu, M., Arioka, M , Imahori, K., and Uchida, T. (1993) FEBS Lett. 335, 171-175
35. Baumann, K., Mandelkow, E.-M., Biernat, J., Piwnica-Worms, H., and Mandelkow, E (1993) FEBS Lett. 336, 417-424
36. Scott, C W., Spreen, R. C., Herman, J. L., Chow, F. P., Davison, M. D., Young, J., and Caputo, C. B. (1993) J. Biol. Chem. 268, 1166-1173
37. Steiner, B., Mandelkow, E.-M., Biernat, J., Gustke, N., Meyer, H. E , Schmit, B., Mieskes, G., Soling, H. D., Drechsel, D , Kirschner, M. W., Goedert, M., and Mandelkow, E. (1990) EMBO J. 9, 3539-3544
38. Correas, I., Diaz-Nido, J., and Avila, J. (1992) J. Biol. Chem. 267, 15721-15728
39. Lee, V. M.-Y , and Andrews, P. W. (1986) J. Neurosci. 6, 514-521
40. Pleasure, S. J., Page, C., and Lee, V. M.-Y. (1992) J. Neurosci 12, 1802-1815
41. Pleasure, S. J., and Lee, V M.-Y. (1993) J. Nearosci. Res. 35, 585-602
42. Bramblett, G. T., Trojanowski, J. Q., and Lee, V. M.-Y (1992) Lab Invest. 66, 212-222
43. Vallee, R B. (1982) J. Cell Biol. 92, 435-442
44. Wertkin, A. M., Turner, R. S., Pleasure, S. J., Golde, T. E., Younkin, S G., Trojanowski, J Q , and Lee, V. M.-Y. (1993) Proc. Natl. Acad. Sci U. S A 90, 9513-9517
45. Schiff, P. B., Fant, J., and Horwitz, S. B. (1979) Nature 277, 665-667
46. Smith, P. K., Krohn, R. I., Hermanson, G. T., Mallia, A. K., Gartner, F. H., Provenzano, M. D., Fujimoto, E. K., Goeke, N. M., Olson, B. J., and Klenk, D. C. (1985) Anal. Biochem 150, 76-85
47. Lee, V. M.-Y., Carden, M. J., Schlaepfer, W. W., and Trojanowski, J. Q. (1987) J. Neurosci. 7, 3474-3478
48. Binder, L. I., Frankfurter, A., and Rebhun, L. I. (1985) J. Cell Biol. 101, 1371-1378
49. Szendrei, G., Lee, V. M.-Y., and Otvos, L. (1993) J. Neurosci. Res. 34, 243-249
50. Greenberg, S. G., and Davies, P. (1990) Proc. Natl. Acad. Sci U.S.A. 87, 5827-5831
51. Greenberg, S. G., Davies, P., Schein, J D., and Binder, L. I. (1992) J. Biol. Chem. 267, 564-569
52. Lang, E., Szendrei, G. I, Lee, V M.-Y , and Otvos, L. (1992) Biochem Biophys. Res Commun. 187, 783-790
53. Otvos, L., Feiner, L., Lang, M., Vandermeeren E., Szendrei, M., and Lee, V. M.-Y. (1995) J. Neurosci. Res. 39, 669-673
54. Mercken, M., Lubke, U, Boons, J., Van de Voorde, A., Martin, J-J , and Gheuen, J (1992) Acta Neuropathol. 84, 265-272
55. Goedert, M., Jakes, R., and Vanmechelen, E. (1995) Neurosci. Lett. 189, 167-170
56. Trojanowski, J Q., Schuck, T., Schmidt, M. L., and Lee, V. M.-Y. (1989) J. Histochem Cytochem. 37, 209-215
57. Kosik, K. S., Orecchio, L. D., Binder, L., Trojanowski, J. Q., Lee, V. M.-Y., and Lee, G. (1988) Neuron 1, 817-825
58. Wolozin, B. L., Pruchnicki, A., Dickinson, D W., and Davies, P. (1986) Science 232, 648-650
59. Ksiezak-Reding, H., Chien, C. H., Lee, V. M.-Y., and Yen, S. H. (1990) J Neurosci. Res. 25, 412-419
60. Drechsel, D. N., Hyman, A. A , Cobb, M. H., and Kirschner, M. W. (1992) Mol. Biol Cell 3, 1141-1154
61. Liu, J., Farmer, J. D., Jr., Lane, W. S , Friedman, J., Weissman, I., and Schreiber, S L (1991) Cell 66, 807-815
62. Schreiber, S. L. (1991) Science 251, 283-287
63. Fruman, D. A , Klee, C B., Bierer, B. E., and Burakoff, S. J. (1992) Proc. Natl. Acad. Sci. U S. A 89, 3686-3690
64. Drubin, D., Kobayashi, S., and Kirschner, M. (1986) Ann. N. Y. Acad. Sci 466, 257-268
65. Sontag, E , Nunbhakdi-Craig, V., Bloom, G. S., and Mumby, M. C. (1995) J. Cell Bio. 128, 1131-1144
66. Mattson, M. P (1992) Brain Res 582, 107-118
67. Goedert, M., Cohen, E. S., Jakes, R., and Cohen, P. (1992) FEBS Lett. 312, 95-99
68. Drewes, G., Mandelkow, E.-M., Baumann, K., Goris, J, Merlevede, W., and Mandelkow, E. (1993) FEBS Lett. 336, 425-432