Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease

Journal of Neurochemistry

Volumn 85, Issue 1, 2003, Pages 115-122

  Keck, Susi ^a   Nitsch, Robert ^a   Grune, Tilman ^a   Ullrich, Oliver ^a  

^a HUMBOLDT UNIVERSITY   (Germany)

Author keywords

Oxidative stress; Paired helical filaments; Proteasome; Protein degradation; Protein oxidation; Tau

Indexed keywords

AMYLOID BETA PROTEIN; PROTEASOME INHIBITOR; RECOMBINANT PROTEIN; RECOMBINANT TAU PROTEIN; TAU PROTEIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; CORRELATION ANALYSIS; DISEASE ASSOCIATION; DISEASE SEVERITY; ENZYME SUBUNIT; HUMAN; IMMUNOPRECIPITATION; INCUBATION TIME; INHIBITION KINETICS; NERVE CELL DEGENERATION; NERVE CELL LESION; NERVE CELL NECROSIS; NEUROFIBRILLARY TANGLE; NEUROPATHOLOGY; OXIDATIVE STRESS; PAIRED HELICAL FILAMENT; PRECIPITATION; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; STATISTICAL SIGNIFICANCE;

EID: 0037381710     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.01642.x     Document Type: Article

References (33)

1. Bence N. F., Sampat R. M. and Kopito R. R. (2001) Impairment of the ubiquitin-proteasome system by protein aggregation. Science 292, 1552-1555.
2. Chung K. K., Zhang Y., Lim K. J., Tanaka Y., Huang H., Gao J., Ross C. A., Dawson V. L. and Dawson T. M. (2001) Parkin ubiquitinates the alpha-synuclein-interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease. Nat. Med. 7, 1144-1150.
3. Ciechanover A. (2001) Linking ubiquitin, parkin and synphilin-1. Nat. Med. 7, 1108-1109.
4. Ciechanover A., Orian A. and Schwartz A. L. (2000) Ubiquitin-mediated proteolysis: biological regulation via destruction. Bioessays 22, 442-451.
5. Cummings C. J., Reinstein E., Sun Y., Antalffy B., Jiang Y., Ciechanover A., Orr T., Beaudet A. L. and Zoghbi H. Y. (1999) Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice. Neuron 24, 879-892.
6. Davies K. J. (1987) Protein damage and degradation by oxygen radicals. I. General aspects. J. Biol. Chem. 262, 9895-9901.
7. Drubin D. and Kirschner M. (1986) Tau protein function in living cells. J. Cell Biol. 103, 2739-2746.
8. Drubin D., Reinstein S., Shooter E. and Kirschner M. (1985) Nerve growth factor-induced neurite outgrowth in PC12 cells involves the coordinate induction of microtubule assembly and assembly-promoting factors. J. Cell Biol. 101, 1799-1807.
9. Fernandez-Funez P., Nino-Rosales M. L., de-Gouyon B., She W. C., Luchak J. M., Martinez P., Turiegano E., Benito J., Capovilla M., Skinner P. J., McCall A., Canal I., Orr H. A. T., Zoghbi H. Y. and Botas J. (2000) Identification of genes that modify ataxin-1-induced neurodegeneration. Nature 408, 101-106.
10. Friedhoff P., Schneider A., Mandelkow E.-M. and Mandelkow E. (1998) Rapid assembly of Alzheimer-like paired helical filaments from microtubule-associated protein tau monitored by fluorescence in solution. Biochemistry 37, 10223-10230.
11. Grune T., Reinheckel T. and Davies K. J. (1997) Degradation of oxidized proteins in mammalian cells. FASEB J. 11, 526-534.
12. Giulivi C., Pacifici R. E. and Davies K. J. A. (1994) Arch. Biochem. Biophys. 311, 329-341.
13. Halliwell B. and Jenner P. (1998) Impaired clearance of oxidised proteins in neurodegenerative diseases. Lancet 351, 1510.
14. Hough R., Pratt G. and Rechsteiner M. (1987) Purification of two high molecular weight proteases from rabbit reticulocyte lysate. J. Biol. Chem. 262, 8303-8313.
15. Ingano L. A., Lentini K. M., Kovacs I., Tanzi R. E. and Kovacs D. M. (2000) Cytoplasmic presenilin aggregates in proteasome inhibitor-treated cells. Ann. NY Acad. Sci. 920, 259-260.
16. Keller J. N., Hanni K. B. and Markesbery W. R. (2000) Impaired proteasome function in Alzheimer's disease. J. Neurochem. 75, 436-439.
17. Lasch P., Petras T., Ullrich O., Backmann J., Naumann D. and Grune T. (2001) Hydrogen peroxide-induced structural alterations of RNAse A. J. Biol. Chem. 276, 9492-9502.
18. Lee V. M.-Y., Wang Y. and Trojanowski J. Q. (1999) Purification of paired helical filament tau and normal tau from human brain tissue. Meth. Enzymol. 309, 81-89.
19. Leroy E., Boyer R., Auburger G., Leube B., Ulm G., Mezey E., Harta G., Brownstein M. J., Jonnalagada S., Chernova T., Dehejia A., Lavedan C., Gasser T., Steinbach P. J., Wilkinson K. D. and Polymeropoulos M. H. (1998) The ubiquitin pathway in Parkinson's disease. Nature 395, 451-452.
20. Lopez-Salon M., Morelli L., Castano E. M., Soto E. F. and Pasquini J. M. (2000) Defective ubiquitination of cerebral proteins in Alzheimer's disease. J. Neurosci. Res. 62, 302-310.
21. Matsuo E. S., Shin R.-W., Billingsley M. L., Van DeVoorde A., O'Connor M., Trojanowski J. Q. and Lee V. M.-Y. (1994) Biopsy-derived adult human brain tau is phosphorylated at many of the same sites as Alzheimer's disease paired helical filament tau. Neuron 13, 989-1002.
22. Reinheckel T., Sitte N., Ullrich O., Kuckelkorn U., Davies K. J. and Grune T. (1998) Comparative resistance of the 20S and 26S proteasome to oxidative stress. Biochem. J. 335, 637-642.
23. Saigoh K., Wang Y. L., Suh J. G., Yamanishi T., Sakai Y., Kiyosawa H., Harada T., Ichihara N., Wakana S., Kikuchi T. and Wada K. (1999) Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice. Nat. Genet. 23, 47-51.
24. Schulz J. B. and Dichgans J. (1999) Molecular pathogenesis of movement disorders: are protein aggregates a common link in neuronal degeneration? Curr. Opin. Neurol. 12, 433-439.
25. Selkoe D. J. (1991) The molecular pathology of Alzheimer's disease. Neuron 6, 487-498.
26. Shringarpure R., Grune T., Sitte N. and Davies K. J. (2000) 4-Hydroxynonenal-modified amyloid-beta peptide inhibits the proteasome: possible importance in Alzheimer's disease. Cell. Mol. Life Sci. 57, 1802-1809.
27. Sitte N., Merker K., von Zglinicki T., Davies K. J. and Grune T. (2000) Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part II - aging of nondividing cells. FASEB J. 14, 2503-2510.
28. Smith M. A., Taneda S., Richey P. L., Miyata S., Yan S.-D., Stern D., Sayre L. M., Monnier V. M. and Perry G. (1994) Advanced Maillard reaction end products are associated with Alzheimer disease pathology. Proc. Natl Acad. Sci. USA 91, 5710-5714.
29. Smith M. A., Perry G., Richey P. L., Sayre L. M., Anderson V. E., Beal M. F. and Kowall N. (1996) Oxidative damage in Alzheimer's. Nature 382, 120-121.
30. Tanaka K., Suzuki T., Chiba T., Shimura H., Hattori N. and Mizuno Y. (2001) Parkin is linked to the ubiquitin pathway. J. Mol. Med. 79, 482-494.
31. Trojanowski J. and Lee V. M. Y. (1995) Phosphorylation of paired helical filament tau in Alzheimer's disease neurofibrillary lesions: focusing on phosphatases. FASEB J. 9, 1570-1576.
32. Yan S. D., Chen X., Schmidt A. M., Brett J., Godman G., Zou Y. S., Scott C. W., Caputo C., Frappier S. and Smith M. A. (1994) Glycated tau protein in Alzheimer's disease: a mechanism for induction of oxidant stress. Proc. Natl Acad. Sci. USA 91, 7787-7791.
33. Zwilling S., Konig H. and Wirth T. (1995) High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors. EMBO J. 14, 1198-1208.