Fenton chemistry and oxidative stress mediate the toxicity of the -amyloid peptide in a Drosophila model of Alzheimer's disease

European Journal of Neuroscience

Volumn 29, Issue 7, 2009, Pages 1335-1347

  Rival, Thomas ^a,b   Page, Richard M ^a   Chandraratna, Dhianjali S ^a,b   Sendall, Timothy J ^a,b   Ryder, Edward ^b   Liu, Beinan ^a,b   Lewis, Huw ^c   Rosahl, Thomas ^d   Hider, Robert ^e   Camargo, L M ^a,b   Shearman, Mark S ^d   Crowther, Damian C ^a,b   Lomas, David A ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^d MERCK RESEARCH LABORATORIES   (United States)

^e KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Aggregation; Chelation therapy; Hydroxy radical; Iron

Indexed keywords

AMYLOID BETA PEPTIDE[1-42]; AMYLOID BETA PROTEIN; CARBONYL DERIVATIVE; CATALASE; CLIOQUINOL; FERRITIN; HYDROGEN PEROXIDE; HYDROXYL RADICAL; IRON; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARCTIC; ARTICLE; CELL METABOLISM; CHELATION; CONTROLLED STUDY; DROSOPHILA; FENTON REACTION; GENETIC SCREENING; IN VIVO STUDY; IRON BINDING CAPACITY; LIFESPAN; LOCOMOTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL; WILD TYPE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; ANIMALS, GENETICALLY MODIFIED; APOFERRITINS; BRAIN; CLIOQUINOL; DISEASE MODELS, ANIMAL; DROSOPHILA; IRON; IRON CHELATING AGENTS; KAPLAN-MEIERS ESTIMATE; MOTOR ACTIVITY; MUTATION; NEURONS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATIVE STRESS; PEPTIDE FRAGMENTS; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE;

EID: 64049096553     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2009.06701.x     Document Type: Article

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