Novel diffusion barrier for axonal retention of Tau in neurons and its failure in neurodegeneration

EMBO Journal

Volumn 30, Issue 23, 2011, Pages 4825-4837

  Li, Xiaoyu ^a,c   Kumar, Yatender ^a,b   Zempel, Hans ^a,b   Mandelkow, Eva Maria ^a,b   Biernat, Jacek ^a,b   Mandelkow, Eckhard ^a,b  

^a MAX PLANCK UNIT FOR STRUCTURAL MOLECULAR BIOLOGY   (Germany)

^b GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^c UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Axon initial segment; Microtubules; Neuronal polarization; Tau protein

Indexed keywords

F ACTIN; MARK KINASE; PHOSPHOTRANSFERASE; TAU PROTEIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; AXON INITIAL SEGMENT; BLOOD BRAIN BARRIER; BRAIN NERVE CELL; EMBRYO; MICROTUBULE; NERVE DEGENERATION; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; RAT;

ACTINS; ALZHEIMER DISEASE; ANIMALS; AXONAL TRANSPORT; AXONS; CELL POLARITY; CELLS, CULTURED; CEREBRAL CORTEX; DENDRITES; GENETIC VECTORS; HUMANS; LUMINESCENT PROTEINS; MEMBRANE PROTEINS; MICROTUBULES; PHOSPHORYLATION; PHOTOCHEMISTRY; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, SPRAGUE-DAWLEY; TAU PROTEINS;

EID: 82455208974     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2011.376     Document Type: Article

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