Synaptic released zinc promotes tau hyperphosphorylation by inhibition of Protein Phosphatase 2A (PP2A)

Journal of Biological Chemistry

Volumn 287, Issue 14, 2012, Pages 11174-11182

  Sun, Xu Ying ^a   Wei, Yu Ping ^a   Xiong, Yan ^a   Wang, Xiao Chuan ^a,b   Xie, Ao Ji ^a   Wang, Xiu Lian ^a   Yang, Yang ^a   Wang, Qun ^a   Lu, You Ming ^a,b   Liu, Rong ^a,b   Wang, Jian Zhi ^a,b  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE; BRAIN SLICES; EXCITATORY SYNAPSIS; EXTRACELLULAR; HIPPOCAMPAL SLICE; HYPERPHOSPHORYLATED; HYPERPHOSPHORYLATION; NEUROFIBRILLARY TANGLES; PRE-TREATMENT; PROTEIN PHOSPHATASE 2A; SYNAPTIC TERMINALS; ZINC CHELATOR;

BRAIN; CHELATION; ENZYME ACTIVITY; PHOSPHORYLATION;

ZINC;

GLUTAMIC ACID; PHOSPHOPROTEIN PHOSPHATASE 2A; SERINE; TAU PROTEIN; THREONINE; ZINC;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPUS; MALE; NEUROMODULATION; NEUROPATHOLOGY; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; RAT; REGULATORY MECHANISM; SYNAPTIC TRANSMISSION; UPREGULATION; WESTERN BLOTTING; ZINC METABOLISM;

ALZHEIMER DISEASE; ANIMALS; ENZYME INHIBITORS; HIPPOCAMPUS; MALE; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; RATS; RATS, SPRAGUE-DAWLEY; SYNAPSES; SYNAPTIC TRANSMISSION; TAU PROTEINS; ZINC;

EID: 84859506934     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.309070     Document Type: Article

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