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Volumn 67, Issue 1, 2015, Pages 1-35

International union of basic and clinical pharmacology. XCI. structure, function, and pharmacology of acid-sensing ion channels and the epithelial Na+ channel

Author keywords

[No Author keywords available]

Indexed keywords

ACID SENSING ION CHANNEL; ACID SENSING ION CHANNEL BLOCKING AGENT; EPITHELIAL SODIUM CHANNEL; EPITHELIAL SODIUM CHANNEL BLOCKING AGENT; LIGAND; SODIUM;

EID: 84916201722     PISSN: 00316997     EISSN: 15210081     Source Type: Journal    
DOI: 10.1124/pr.114.009225.     Document Type: Article
Times cited : (230)

References (394)
  • 1
    • 0032515176 scopus 로고    scopus 로고
    • Protons activate brain Na+ channel 1 by inducing a conformational change that exposes a residue associated with neurodegeneration
    • Adams CM, Snyder PM, Price MP, and Welsh MJ (1998) Protons activate brain Na+ channel 1 by inducing a conformational change that exposes a residue associated with neurodegeneration. J Biol Chem 273:30204–30207.
    • (1998) J Biol Chem , vol.273 , pp. 30204-30207
    • Adams, C.M.1    Snyder, P.M.2    Price, M.P.3    Welsh, M.J.4
  • 2
    • 0032986088 scopus 로고    scopus 로고
    • Paradoxical stimulation of a DEG/ENaC channel by amiloride
    • Adams CM, Snyder PM, and Welsh MJ (1999) Paradoxical stimulation of a DEG/ENaC channel by amiloride. J Biol Chem 274:15500–15504.
    • (1999) J Biol Chem , vol.274 , pp. 15500-15504
    • Adams, C.M.1    Snyder, P.M.2    Welsh, M.J.3
  • 4
    • 33646757231 scopus 로고    scopus 로고
    • Dua Y, and Vohora D(2006) Anticonvulsant effect of amiloride in pentetrazole-induced status epilepticus in mice
    • Ali A, Pillai KP, Ahmad FJ, Dua Y, and Vohora D(2006) Anticonvulsant effect of amiloride in pentetrazole-induced status epilepticus in mice. Pharmacol Rep 58:242–245.
    • Pharmacol Rep , vol.58 , pp. 242-245
    • Ali, A.1    Pillai, K.P.2    Ahmad, F.J.3
  • 7
    • 0242496525 scopus 로고    scopus 로고
    • The extracellular domain determines the kinetics of desensitization in acid-sensitive ion channel 1
    • Coric T, Zhang P, Todorovic N, and Canessa CM (2003) The extracellular domain determines the kinetics of desensitization in acid-sensitive ion channel 1. J Biol Chem 278:45240–45247.
    • (2003) J Biol Chem , vol.278 , pp. 45240-45247
    • Coric, T.1    Zhang, P.2    Todorovic, N.3    Canessa, C.M.4
  • 10
    • 0033537829 scopus 로고    scopus 로고
    • The pretransmembrane 1 domain of acid-sensing ion channels participates in the ion pore
    • Coscoy S, de Weille JR, Lingueglia E, and Lazdunski M (1999) The pretransmembrane 1 domain of acid-sensing ion channels participates in the ion pore. J Biol Chem 274:10129–10132.
    • (1999) J Biol Chem , vol.274 , pp. 10129-10132
    • Coscoy, S.1    De Weille, J.R.2    Lingueglia, E.3    Lazdunski, M.4
  • 11
    • 0014038040 scopus 로고
    • Pyrazine diuretics. II. N-amidino-3-amino-5-substituted 6-halopyrazinecarboxamides
    • Cragoe EJ Jr, Woltersdorf OW Jr, Bicking JB, Kwong SF, and Jones JH (1967) Pyrazine diuretics. II. N-amidino-3-amino-5-substituted 6-halopyrazinecarboxamides. J Med Chem 10:66–75.
    • (1967) J Med Chem , vol.10 , pp. 66-75
    • Cragoe, E.J.1    Woltersdorf, O.W.2    Bicking, J.B.3    Kwong, S.F.4    Jones, J.H.5
  • 12
    • 33947715893 scopus 로고    scopus 로고
    • A conformation change in the extracellular domain that accompanies desensitization of acid-sensing ion channel (ASIC) 3
    • Cushman KA, Marsh-Haffner J, Adelman JP, and McCleskey EW (2007) A conformation change in the extracellular domain that accompanies desensitization of acid-sensing ion channel (ASIC) 3. J Gen Physiol 129:345–350.
    • (2007) J Gen Physiol , vol.129 , pp. 345-350
    • Cushman, K.A.1    Marsh-Haffner, J.2    Adelman, J.P.3    McCleskey, E.W.4
  • 15
    • 84864656610 scopus 로고    scopus 로고
    • Human ASIC3 channel dynamically adapts its activity to sense the extracellular pH in both acidic and alkaline directions
    • Delaunay A, Gasull X, Salinas M, Noël J, Friend V, Lingueglia E, and Deval E (2012) Human ASIC3 channel dynamically adapts its activity to sense the extracellular pH in both acidic and alkaline directions. Proc Natl Acad Sci USA 109:13124–13129.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 13124-13129
    • Delaunay, A.1    Gasull, X.2    Salinas, M.3    Noël, J.4    Friend, V.5    Lingueglia, E.6    Deval, E.7
  • 16
    • 84874292891 scopus 로고    scopus 로고
    • Gating transitions in the palm domain of ASIC1a
    • Della Vecchia MC, Rued AC, and Carattino MD (2013) Gating transitions in the palm domain of ASIC1a. J Biol Chem 288:5487–5495.
    • (2013) J Biol Chem , vol.288 , pp. 5487-5495
    • Della Vecchia, M.C.1    Rued, A.C.2    Carattino, M.D.3
  • 17
    • 0037379464 scopus 로고    scopus 로고
    • Effects of neuropeptide SF and related peptides on acid sensing ion channel 3 and sensory neuron excitability
    • Deval E, Baron A, Lingueglia E, Mazarguil H, Zajac JM, and Lazdunski M (2003) Effects of neuropeptide SF and related peptides on acid sensing ion channel 3 and sensory neuron excitability. Neuropharmacology 44:662–671.
    • (2003) Neuropharmacology , vol.44 , pp. 662-671
    • Deval, E.1    Baron, A.2    Lingueglia, E.3    Mazarguil, H.4    Zajac, J.M.5    Lazdunski, M.6
  • 18
    • 33644985209 scopus 로고    scopus 로고
    • Regulation of sensory neuron-specific acid-sensing ion channel 3 by the adaptor protein Na+/H+ exchanger regulatory factor-1
    • Deval E, Friend V, Thirant C, Salinas M, Jodar M, Lazdunski M, and Lingueglia E (2006) Regulation of sensory neuron-specific acid-sensing ion channel 3 by the adaptor protein Na+/H+ exchanger regulatory factor-1. J Biol Chem 281:1796–1807.
    • (2006) J Biol Chem , vol.281 , pp. 1796-1807
    • Deval, E.1    Friend, V.2    Thirant, C.3    Salinas, M.4    Jodar, M.5    Lazdunski, M.6    Lingueglia, E.7
  • 20
    • 2442599225 scopus 로고    scopus 로고
    • ASIC2bdependent regulation of ASIC3, an essential acid-sensing ion channel subunit in sensory neurons via the partner protein PICK-1
    • Deval E, Salinas M, Baron A, Lingueglia E, and Lazdunski M (2004) ASIC2bdependent regulation of ASIC3, an essential acid-sensing ion channel subunit in sensory neurons via the partner protein PICK-1. J Biol Chem 279:19531–19539.
    • (2004) J Biol Chem , vol.279 , pp. 19531-19539
    • Deval, E.1    Salinas, M.2    Baron, A.3    Lingueglia, E.4    Lazdunski, M.5
  • 21
    • 0035843979 scopus 로고    scopus 로고
    • Dependence of the acid-sensitive ion channel, ASIC1a, on extracellular Ca(2+) ions
    • de Weille J and Bassilana F (2001) Dependence of the acid-sensitive ion channel, ASIC1a, on extracellular Ca(2+) ions. Brain Res 900:277–281.
    • (2001) Brain Res , vol.900 , pp. 277-281
    • De Weille, J.1    Bassilana, F.2
  • 22
    • 0032555350 scopus 로고    scopus 로고
    • Identification, functional expression and chromosomal localisation of a sustained human protongated cation channel
    • de Weille JR, Bassilana F, Lazdunski M, and Waldmann R (1998) Identification, functional expression and chromosomal localisation of a sustained human protongated cation channel. FEBS Lett 433:257–260.
    • (1998) FEBS Lett , vol.433 , pp. 257-260
    • De Weille, J.R.1    Bassilana, F.2    Lazdunski, M.3    Waldmann, R.4
  • 23
    • 0036451193 scopus 로고    scopus 로고
    • The epithelial sodium channel (ENaC) is intracellularly located as a tetramer
    • Dijkink L, Hartog A, van Os CH, and Bindels RJ (2002) The epithelial sodium channel (ENaC) is intracellularly located as a tetramer. Pflugers Arch 444:549–555.
    • (2002) Pflugers Arch , vol.444 , pp. 549-555
    • Dijkink, L.1    Hartog, A.2    Van Os, C.H.3    Bindels, R.J.4
  • 24
  • 26
    • 68949212896 scopus 로고    scopus 로고
    • Protein complexes in snake venom
    • Doley R and Kini RM (2009) Protein complexes in snake venom. Cell Mol Life Sci 66: 2851–2871.
    • (2009) Cell Mol Life Sci , vol.66 , pp. 2851-2871
    • Doley, R.1    Kini, R.M.2
  • 27
    • 33644688683 scopus 로고    scopus 로고
    • Annexin II light chain p11 promotes functional expression of acid-sensing ion channel ASIC1a
    • Donier E, Rugiero F, Okuse K, and Wood JN (2005) Annexin II light chain p11 promotes functional expression of acid-sensing ion channel ASIC1a. J Biol Chem 280:38666–38672.
    • (2005) J Biol Chem , vol.280 , pp. 38666-38672
    • Donier, E.1    Rugiero, F.2    Okuse, K.3    Wood, J.N.4
  • 28
    • 45249113296 scopus 로고    scopus 로고
    • Mechanisms of non-steroid anti-inflammatory drugs action on ASICs expressed in hippocampal interneurons
    • Dorofeeva NA, Barygin OI, Staruschenko A, Bolshakov KV, and Magazanik LG (2008) Mechanisms of non-steroid anti-inflammatory drugs action on ASICs expressed in hippocampal interneurons. J Neurochem 106:429–441.
    • (2008) J Neurochem , vol.106 , pp. 429-441
    • Dorofeeva, N.A.1    Barygin, O.I.2    Staruschenko, A.3    Bolshakov, K.V.4    Magazanik, L.G.5
  • 29
    • 2442699006 scopus 로고    scopus 로고
    • Acid-sensing ion channels ASIC2 and ASIC3 do not contribute to mechanically activated currents in mammalian sensory neurones
    • Drew LJ, Rohrer DK, Price MP, Blaver KE, Cockayne DA, Cesare P, and Wood JN (2004) Acid-sensing ion channels ASIC2 and ASIC3 do not contribute to mechanically activated currents in mammalian sensory neurones. J Physiol 556:691–710.
    • (2004) J Physiol , vol.556 , pp. 691-710
    • Drew, L.J.1    Rohrer, D.K.2    Price, M.P.3    Blaver, K.E.4    Cockayne, D.A.5    Cesare, P.6    Wood, J.N.7
  • 30
    • 7244260316 scopus 로고    scopus 로고
    • Degenerin/epithelial Na+ channel proteins: Components of a vascular mechanosensor
    • Drummond HA, Gebremedhin D, and Harder DR (2004) Degenerin/epithelial Na+ channel proteins: components of a vascular mechanosensor. Hypertension 44: 643–648.
    • (2004) Hypertension , vol.44 , pp. 643-648
    • Drummond, H.A.1    Gebremedhin, D.2    Harder, D.R.3
  • 32
    • 84860351788 scopus 로고    scopus 로고
    • PI3-kinase/Akt pathway-regulated membrane insertion of acid-sensing ion channel 1a underlies BDNF-induced pain hypersensitivity
    • Duan B, Liu DS, Huang Y, Zeng WZ, Wang X, Yu H, Zhu MX, Chen ZY, and Xu TL (2012) PI3-kinase/Akt pathway-regulated membrane insertion of acid-sensing ion channel 1a underlies BDNF-induced pain hypersensitivity. J Neurosci 32:6351–6363.
    • (2012) J Neurosci , vol.32 , pp. 6351-6363
    • Duan, B.1    Liu, D.S.2    Huang, Y.3    Zeng, W.Z.4    Wang, X.5    Yu, H.6    Zhu, M.X.7    Chen, Z.Y.8    Xu, T.L.9
  • 33
    • 79951542315 scopus 로고    scopus 로고
    • Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis
    • Duan B, Wang YZ, Yang T, Chu XP, Yu Y, Huang Y, Cao H, Hansen J, Simon RP, and Zhu MX, et al. (2011) Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. J Neurosci 31:2101–2112.
    • (2011) J Neurosci , vol.31 , pp. 2101-2112
    • Duan, B.1    Wang, Y.Z.2    Yang, T.3    Chu, X.P.4    Yu, Y.5    Huang, Y.6    Cao, H.7    Hansen, J.8    Simon, R.P.9    Zhu, M.X.10
  • 34
    • 35348849742 scopus 로고    scopus 로고
    • Upregulation of acid-sensing ion channel ASIC1a in spinal dorsal horn neurons contributes to inflammatory pain hypersensitivity
    • Duan B, Wu LJ, Yu YQ, Ding Y, Jing L, Xu L, Chen J, and Xu TL (2007) Upregulation of acid-sensing ion channel ASIC1a in spinal dorsal horn neurons contributes to inflammatory pain hypersensitivity. J Neurosci 27:11139–11148.
    • (2007) J Neurosci , vol.27 , pp. 11139-11148
    • Duan, B.1    Wu, L.J.2    Yu, Y.Q.3    Ding, Y.4    Jing, L.5    Xu, L.6    Chen, J.7    Xu, T.L.8
  • 36
    • 0037085268 scopus 로고    scopus 로고
    • The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons
    • Duggan A, Garcia-Anoveros J, and Corey DP (2002) The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons. J Biol Chem 277: 5203–5208.
    • (2002) J Biol Chem , vol.277 , pp. 5203-5208
    • Duggan, A.1    Garcia-Anoveros, J.2    Corey, D.P.3
  • 37
    • 84867188744 scopus 로고    scopus 로고
    • Insight into DEG/ENaC channel gating from genetics and structure
    • Eastwood AL and Goodman MB (2012) Insight into DEG/ENaC channel gating from genetics and structure. Physiology (Bethesda) 27:282–290.
    • (2012) Physiology (Bethesda) , vol.27 , pp. 282-290
    • Eastwood, A.L.1    Goodman, M.B.2
  • 39
    • 0037634059 scopus 로고    scopus 로고
    • Recombinant production and solution structure of PcTx1, the specific peptide inhibitor of ASIC1a proton-gated cation channels
    • Escoubas P, Bernard C, Lambeau G, Lazdunski M, and Darbon H (2003) Recombinant production and solution structure of PcTx1, the specific peptide inhibitor of ASIC1a proton-gated cation channels. Protein Sci 12:1332–1343.
    • (2003) Protein Sci , vol.12 , pp. 1332-1343
    • Escoubas, P.1    Bernard, C.2    Lambeau, G.3    Lazdunski, M.4    Darbon, H.5
  • 44
    • 0032518665 scopus 로고    scopus 로고
    • The heterotetrameric architecture of the epithelial sodium channel (ENaC)
    • Firsov D, Gautschi I, Merillat AM, Rossier BC, and Schild L (1998) The heterotetrameric architecture of the epithelial sodium channel (ENaC). EMBO J 17: 344–352.
    • (1998) EMBO J , vol.17 , pp. 344-352
    • Firsov, D.1    Gautschi, I.2    Merillat, A.M.3    Rossier, B.C.4    Schild, L.5
  • 45
    • 0030451774 scopus 로고    scopus 로고
    • Cell surface expression of the epithelial Na channel and a mutant causing Liddle syndrome: A quantitative approach
    • Firsov D, Schild L, Gautschi I, Mérillat AM, Schneeberger E, and Rossier BC (1996) Cell surface expression of the epithelial Na channel and a mutant causing Liddle syndrome: a quantitative approach. Proc Natl Acad Sci USA 93:15370–15375.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 15370-15375
    • Firsov, D.1    Schild, L.2    Gautschi, I.3    Mérillat, A.M.4    Schneeberger, E.5    Rossier, B.C.6
  • 46
    • 36849009834 scopus 로고    scopus 로고
    • Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system
    • Friese MA, Craner MJ, Etzensperger R, Vergo S, Wemmie JA, Welsh MJ, Vincent A, and Fugger L (2007) Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system. Nat Med 13: 1483–1489.
    • (2007) Nat Med , vol.13 , pp. 1483-1489
    • Friese, M.A.1    Craner, M.J.2    Etzensperger, R.3    Vergo, S.4    Wemmie, J.A.5    Welsh, M.J.6    Vincent, A.7    Fugger, L.8
  • 47
    • 44349121823 scopus 로고    scopus 로고
    • Surface expression of epithelial Na channel protein in rat kidney
    • Frindt G, Ergonul Z, and Palmer LG (2008) Surface expression of epithelial Na channel protein in rat kidney. J Gen Physiol 131:617–627.
    • (2008) J Gen Physiol , vol.131 , pp. 617-627
    • Frindt, G.1    Ergonul, Z.2    Palmer, L.G.3
  • 48
    • 1642374813 scopus 로고    scopus 로고
    • Na channels in the rat connecting tubule
    • Frindt G and Palmer LG (2004) Na channels in the rat connecting tubule. Am J Physiol Renal Physiol 286:F669–F674.
    • (2004) Am J Physiol Renal Physiol , vol.286 , pp. F669-F674
    • Frindt, G.1    Palmer, L.G.2
  • 49
    • 68049088827 scopus 로고    scopus 로고
    • K+ secretion in the rat kidney: Na+ channeldependent and -independent mechanisms
    • Frindt G and Palmer LG (2009a) K+ secretion in the rat kidney: Na+ channeldependent and -independent mechanisms. Am J Physiol Renal Physiol 297: F389–F396.
    • (2009) Am J Physiol Renal Physiol , vol.297 , pp. F389-F396
    • Frindt, G.1    Palmer, L.G.2
  • 50
    • 70350719352 scopus 로고    scopus 로고
    • Surface expression of sodium channels and transporters in rat kidney: Effects of dietary sodium
    • Frindt G and Palmer LG (2009b) Surface expression of sodium channels and transporters in rat kidney: effects of dietary sodium. Am J Physiol Renal Physiol 297: F1249–F1255.
    • (2009) Am J Physiol Renal Physiol , vol.297 , pp. F1249-F1255
    • Frindt, G.1    Palmer, L.G.2
  • 51
    • 83455242931 scopus 로고    scopus 로고
    • Regulation of epithelial Na+ channels by adrenal steroids: Mineralocorticoid and glucocorticoid effects
    • Frindt G and Palmer LG (2012) Regulation of epithelial Na+ channels by adrenal steroids: mineralocorticoid and glucocorticoid effects. Am J Physiol Renal Physiol 302:F20–F26.
    • (2012) Am J Physiol Renal Physiol , vol.302 , pp. F20-F26
    • Frindt, G.1    Palmer, L.G.2
  • 52
    • 0027466605 scopus 로고
    • Feedback regulation of Na channels in rat CCT. II. Effects of inhibition of Na entry
    • Frindt G, Silver RB, Windhager EE, and Palmer LG (1993) Feedback regulation of Na channels in rat CCT. II. Effects of inhibition of Na entry. Am J Physiol 264: F565–F574.
    • (1993) Am J Physiol , vol.264 , pp. F565-F574
    • Frindt, G.1    Silver, R.B.2    Windhager, E.E.3    Palmer, L.G.4
  • 53
    • 0028937585 scopus 로고
    • Feedback regulation of Na channels in rat CCT. III. Response to cAMP
    • Frindt G, Silver RB, Windhager EE, and Palmer LG (1995) Feedback regulation of Na channels in rat CCT. III. Response to cAMP. Am J Physiol 268:F480–F489.
    • (1995) Am J Physiol , vol.268 , pp. F480-F489
    • Frindt, G.1    Silver, R.B.2    Windhager, E.E.3    Palmer, L.G.4
  • 54
    • 0017334057 scopus 로고
    • Current-voltage curve of sodium channels and concentration dependence of sodium permeability in frog skin
    • Fuchs W, Larsen EH, and Lindemann B (1977) Current-voltage curve of sodium channels and concentration dependence of sodium permeability in frog skin. J Physiol 267:137–166.
    • (1977) J Physiol , vol.267 , pp. 137-166
    • Fuchs, W.1    Larsen, E.H.2    Lindemann, B.3
  • 55
    • 0019817468 scopus 로고
    • New synthetic inhibitors of C1r, C1 esterase, thrombin, plasmin, kallikrein and trypsin
    • Fujii S and Hitomi Y (1981) New synthetic inhibitors of C1r, C1 esterase, thrombin, plasmin, kallikrein and trypsin. Biochim Biophys Acta 661:342–345.
    • (1981) Biochim Biophys Acta , vol.661 , pp. 342-345
    • Fujii, S.1    Hitomi, Y.2
  • 56
    • 0034489182 scopus 로고    scopus 로고
    • Acute differential regulation by corticosteroids of epithelial sodium channel subunit and Nedd4 mRNA levels in the distal colon
    • Fuller PJ, Brennan FE, and Burgess JS (2000) Acute differential regulation by corticosteroids of epithelial sodium channel subunit and Nedd4 mRNA levels in the distal colon. Pflugers Arch 441:94–101.
    • (2000) Pflugers Arch , vol.441 , pp. 94-101
    • Fuller, P.J.1    Brennan, F.E.2    Burgess, J.S.3
  • 57
    • 27844502151 scopus 로고    scopus 로고
    • Coupling between NMDA receptor and acid-sensing ion channel contributes to ischemic neuronal death
    • Gao J, Duan B, Wang DG, Deng XH, Zhang GY, Xu L, and Xu TL (2005) Coupling between NMDA receptor and acid-sensing ion channel contributes to ischemic neuronal death. Neuron 48:635–646.
    • (2005) Neuron , vol.48 , pp. 635-646
    • Gao, J.1    Duan, B.2    Wang, D.G.3    Deng, X.H.4    Zhang, G.Y.5    Xu, L.6    Xu, T.L.7
  • 58
    • 0030945484 scopus 로고    scopus 로고
    • Epithelial sodium channels: Function, structure, and regulation
    • Garty H and Palmer LG (1997) Epithelial sodium channels: function, structure, and regulation. Physiol Rev 77:359–396.
    • (1997) Physiol Rev , vol.77 , pp. 359-396
    • Garty, H.1    Palmer, L.G.2
  • 60
    • 0034284153 scopus 로고    scopus 로고
    • Serine proteases and brain damage - is there a link?
    • Gingrich MB and Traynelis SF (2000) Serine proteases and brain damage - is there a link? Trends Neurosci 23:399–407.
    • (2000) Trends Neurosci , vol.23 , pp. 399-407
    • Gingrich, M.B.1    Traynelis, S.F.2
  • 61
    • 67949092829 scopus 로고    scopus 로고
    • Pore architecture and ion sites in acidsensing ion channels and P2X receptors
    • Gonzales EB, Kawate T, and Gouaux E (2009) Pore architecture and ion sites in acidsensing ion channels and P2X receptors. Nature 460:599–604.
    • (2009) Nature , vol.460 , pp. 599-604
    • Gonzales, E.B.1    Kawate, T.2    Gouaux, E.3
  • 62
    • 77954656825 scopus 로고    scopus 로고
    • Osmolytes and ion transport modulators: New strategies for airway surface rehydration
    • Goralski JL, Boucher RC, and Button B (2010) Osmolytes and ion transport modulators: new strategies for airway surface rehydration. Curr Opin Pharmacol 10: 294–299.
    • (2010) Curr Opin Pharmacol , vol.10 , pp. 294-299
    • Goralski, J.L.1    Boucher, R.C.2    Button, B.3
  • 65
    • 84871430580 scopus 로고    scopus 로고
    • Toxin binding reveals two open state structures for one acid-sensing ion channel
    • Gründer S and Augustinowski K (2012) Toxin binding reveals two open state structures for one acid-sensing ion channel. Channels (Austin) 6:409–413.
    • (2012) Channels (Austin) , vol.6 , pp. 409-413
    • Gründer, S.1    Augustinowski, K.2
  • 66
    • 77954727554 scopus 로고    scopus 로고
    • Structure, function, and pharmacology of acid-sensing ion channels (ASICs): Focus on ASIC1a
    • Gründer S and Chen X (2010) Structure, function, and pharmacology of acid-sensing ion channels (ASICs): focus on ASIC1a. Int J Physiol Pathophysiol Pharmacol 2: 73–94.
    • (2010) Int J Physiol Pathophysiol Pharmacol , vol.2 , pp. 73-94
    • Gründer, S.1    Chen, X.2
  • 67
    • 84867750831 scopus 로고    scopus 로고
    • Subtype-specific modulation of acid-sensing ion channel (ASIC) function by 2-guanidine-4-methylquinazoline
    • Alijevic O and Kellenberger S (2012) Subtype-specific modulation of acid-sensing ion channel (ASIC) function by 2-guanidine-4-methylquinazoline. J Biol Chem 287: 36059–36070.
    • (2012) J Biol Chem , vol.287 , pp. 36059-36070
    • Alijevic, O.1    Kellenberger, S.2
  • 68
    • 0036711958 scopus 로고    scopus 로고
    • Modulation of ASIC channels in rat cerebellar Purkinje neurons by ischaemia-related signals
    • Allen NJ and Attwell D (2002) Modulation of ASIC channels in rat cerebellar Purkinje neurons by ischaemia-related signals. J Physiol 543:521–529.
    • (2002) J Physiol , vol.543 , pp. 521-529
    • Allen, N.J.1    Attwell, D.2
  • 70
    • 84864381348 scopus 로고    scopus 로고
    • Functional expression in Escherichia coli of the disulfide-rich sea anemone peptide APETx2, a potent blocker of acid-sensing ion channel 3
    • Anangi R, Rash LD, Mobli M, and King GF (2012) Functional expression in Escherichia coli of the disulfide-rich sea anemone peptide APETx2, a potent blocker of acid-sensing ion channel 3. Mar Drugs 10:1605–1618.
    • (2012) Mar Drugs , vol.10 , pp. 1605-1618
    • Anangi, R.1    Rash, L.D.2    Mobli, M.3    King, G.F.4
  • 71
    • 34347218655 scopus 로고    scopus 로고
    • Determination of epithelial Na+ channel subunit stoichiometry from single-channel conductances
    • Anantharam A and Palmer LG (2007) Determination of epithelial Na+ channel subunit stoichiometry from single-channel conductances. J Gen Physiol 130: 55–70.
    • (2007) J Gen Physiol , vol.130 , pp. 55-70
    • Anantharam, A.1    Palmer, L.G.2
  • 72
    • 33745761352 scopus 로고    scopus 로고
    • Open probability of the epithelial sodium channel is regulated by intracellular sodium
    • Anantharam A, Tian Y, and Palmer LG (2006) Open probability of the epithelial sodium channel is regulated by intracellular sodium. J Physiol 574:333–347.
    • (2006) J Physiol , vol.574 , pp. 333-347
    • Anantharam, A.1    Tian, Y.2    Palmer, L.G.3
  • 73
    • 33645465530 scopus 로고    scopus 로고
    • Activation of epithelial sodium channels by mouse channel activating proteases (mCAP) expressed in Xenopus oocytes requires catalytic activity of mCAP3 and mCAP2 but not mCAP1
    • Andreasen D, Vuagniaux G, Fowler-Jaeger N, Hummler E, and Rossier BC (2006) Activation of epithelial sodium channels by mouse channel activating proteases (mCAP) expressed in Xenopus oocytes requires catalytic activity of mCAP3 and mCAP2 but not mCAP1. J Am Soc Nephrol 17:968–976.
    • (2006) J am Soc Nephrol , vol.17 , pp. 968-976
    • Andreasen, D.1    Vuagniaux, G.2    Fowler-Jaeger, N.3    Hummler, E.4    Rossier, B.C.5
  • 75
    • 0037053376 scopus 로고    scopus 로고
    • The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons
    • Anzai N, Deval E, Schaefer L, Friend V, Lazdunski M, and Lingueglia E (2002) The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons. J Biol Chem 277:16655–16661.
    • (2002) J Biol Chem , vol.277 , pp. 16655-16661
    • Anzai, N.1    Deval, E.2    Schaefer, L.3    Friend, V.4    Lazdunski, M.5    Lingueglia, E.6
  • 77
    • 0035932944 scopus 로고    scopus 로고
    • DEG/ENaC ion channels involved in sensory transduction are modulated by cold temperature
    • Askwith CC, Benson CJ, Welsh MJ, and Snyder PM (2001) DEG/ENaC ion channels involved in sensory transduction are modulated by cold temperature. Proc Natl Acad Sci USA 98:6459–6463.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 6459-6463
    • Askwith, C.C.1    Benson, C.J.2    Welsh, M.J.3    Snyder, P.M.4
  • 78
    • 0033695107 scopus 로고    scopus 로고
    • Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels
    • Askwith CC, Cheng C, Ikuma M, Benson C, Price MP, and Welsh MJ (2000) Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channels. Neuron 26:133–141.
    • (2000) Neuron , vol.26 , pp. 133-141
    • Askwith, C.C.1    Cheng, C.2    Ikuma, M.3    Benson, C.4    Price, M.P.5    Welsh, M.J.6
  • 79
    • 0041464464 scopus 로고    scopus 로고
    • Epithelial Na+ channel mutants causing Liddle’s syndrome retain ability to respond to aldosterone and vasopressin
    • Auberson M, Hoffmann-Pochon N, Vandewalle A, Kellenberger S, and Schild L (2003) Epithelial Na+ channel mutants causing Liddle’s syndrome retain ability to respond to aldosterone and vasopressin. Am J Physiol Renal Physiol 285:F459–F471.
    • (2003) Am J Physiol Renal Physiol , vol.285 , pp. F459-F471
    • Auberson, M.1    Hoffmann-Pochon, N.2    Vandewalle, A.3    Kellenberger, S.4    Schild, L.5
  • 80
    • 0036828828 scopus 로고    scopus 로고
    • Alternative splicing and interaction with di- and polyvalent cations control the dynamic range of acidsensing ion channel 1 (ASIC1)
    • Babini E, Paukert M, Geisler HS, and Grunder S (2002) Alternative splicing and interaction with di- and polyvalent cations control the dynamic range of acidsensing ion channel 1 (ASIC1). J Biol Chem 277:41597–41603.
    • (2002) J Biol Chem , vol.277 , pp. 41597-41603
    • Babini, E.1    Paukert, M.2    Geisler, H.S.3    Grunder, S.4
  • 81
    • 0032900533 scopus 로고    scopus 로고
    • Molecular cloning and regional distribution of a human proton receptor subunit with biphasic functional properties
    • Babinski K, Lê KT, and Séguéla P (1999) Molecular cloning and regional distribution of a human proton receptor subunit with biphasic functional properties. J Neurochem 72:51–57.
    • (1999) J Neurochem , vol.72 , pp. 51-57
    • Babinski, K.1    Lê, K.T.2    Séguéla, P.3
  • 82
    • 84894105557 scopus 로고    scopus 로고
    • X-ray structure of acid-sensing ion channel 1-snake toxin complex reveals open state of a Na (+)-selective channel
    • Baconguis I, Bohlen CJ, Goehring A, Julius D, and Gouaux E (2014) X-ray structure of acid-sensing ion channel 1-snake toxin complex reveals open state of a Na (+)-selective channel. Cell 156:717–729.
    • (2014) Cell , vol.156 , pp. 717-729
    • Baconguis, I.1    Bohlen, C.J.2    Goehring, A.3    Julius, D.4    Gouaux, E.5
  • 83
    • 84866519244 scopus 로고    scopus 로고
    • Structural plasticity and dynamic selectivity of acid-sensing ion channel-spider toxin complexes
    • Baconguis I and Gouaux E (2012) Structural plasticity and dynamic selectivity of acid-sensing ion channel-spider toxin complexes. Nature 489:400–405.
    • (2012) Nature , vol.489 , pp. 400-405
    • Baconguis, I.1    Gouaux, E.2
  • 84
    • 27744496889 scopus 로고    scopus 로고
    • Vasopressin-V2 receptor stimulation reduces sodium excretion in healthy humans
    • Bankir L, Fernandes S, Bardoux P, Bouby N, and Bichet DG (2005) Vasopressin-V2 receptor stimulation reduces sodium excretion in healthy humans. J Am Soc Nephrol 16:1920–1928.
    • (2005) J am Soc Nephrol , vol.16 , pp. 1920-1928
    • Bankir, L.1    Fernandes, S.2    Bardoux, P.3    Bouby, N.4    Bichet, D.G.5
  • 85
    • 77951523610 scopus 로고    scopus 로고
    • The contact region between three domains of the extracellular loop of ASIC1a is critical for channel function
    • Bargeton B and Kellenberger S (2010) The contact region between three domains of the extracellular loop of ASIC1a is critical for channel function. J Biol Chem 285: 13816–13826.
    • (2010) J Biol Chem , vol.285 , pp. 13816-13826
    • Bargeton, B.1    Kellenberger, S.2
  • 86
    • 0037184973 scopus 로고    scopus 로고
    • Protein kinase C stimulates the acid-sensing ion channel ASIC2a via the PDZ domain-containing protein PICK1
    • Baron A, Deval E, Salinas M, Lingueglia E, Voilley N, and Lazdunski M (2002) Protein kinase C stimulates the acid-sensing ion channel ASIC2a via the PDZ domain-containing protein PICK1. J Biol Chem 277:50463–50468.
    • (2002) J Biol Chem , vol.277 , pp. 50463-50468
    • Baron, A.1    Deval, E.2    Salinas, M.3    Lingueglia, E.4    Voilley, N.5    Lazdunski, M.6
  • 87
    • 84885323818 scopus 로고    scopus 로고
    • Venom toxins in the exploration of molecular, physiological and pathophysiological functions of acid-sensing ion channels
    • Baron A, Diochot S, Salinas M, Deval E, Noël J, and Lingueglia E (2013) Venom toxins in the exploration of molecular, physiological and pathophysiological functions of acid-sensing ion channels. Toxicon 75:187–204.
    • (2013) Toxicon , vol.75 , pp. 187-204
    • Baron, A.1    Diochot, S.2    Salinas, M.3    Deval, E.4    Noël, J.5    Lingueglia, E.6
  • 89
    • 38949113205 scopus 로고    scopus 로고
    • Acid sensing ion channels in dorsal spinal cord neurons
    • Baron A, Voilley N, Lazdunski M, and Lingueglia E (2008) Acid sensing ion channels in dorsal spinal cord neurons. J Neurosci 28:1498–1508.
    • (2008) J Neurosci , vol.28 , pp. 1498-1508
    • Baron, A.1    Voilley, N.2    Lazdunski, M.3    Lingueglia, E.4
  • 94
    • 36248959309 scopus 로고    scopus 로고
    • Alveolar edema fluid clearance and acute lung injury
    • Berthiaume Y and Matthay MA (2007) Alveolar edema fluid clearance and acute lung injury. Respir Physiol Neurobiol 159:350–359.
    • (2007) Respir Physiol Neurobiol , vol.159 , pp. 350-359
    • Berthiaume, Y.1    Matthay, M.A.2
  • 96
    • 35348838445 scopus 로고    scopus 로고
    • Sodium self-inhibition of human epithelial sodium channel: Selectivity and affinity of the extracellular sodium sensing site
    • Bize V and Horisberger JD (2007) Sodium self-inhibition of human epithelial sodium channel: selectivity and affinity of the extracellular sodium sensing site. Am J Physiol Renal Physiol 293:F1137–F1146.
    • (2007) Am J Physiol Renal Physiol , vol.293 , pp. F1137-F1146
    • Bize, V.1    Horisberger, J.D.2
  • 97
    • 78751647166 scopus 로고    scopus 로고
    • Effect of a temperature increase in the nonnoxious range on proton-evoked ASIC and TRPV1 activity
    • Blanchard MG and Kellenberger S (2011) Effect of a temperature increase in the nonnoxious range on proton-evoked ASIC and TRPV1 activity. Pflugers Arch 461:123–139.
    • (2011) Pflugers Arch , vol.461 , pp. 123-139
    • Blanchard, M.G.1    Kellenberger, S.2
  • 98
    • 84858201111 scopus 로고    scopus 로고
    • Inhibition of voltage-gated Na(+) currents in sensory neurones by the sea anemone toxin APETx2
    • Blanchard MG, Rash LD, and Kellenberger S (2012) Inhibition of voltage-gated Na(+) currents in sensory neurones by the sea anemone toxin APETx2. Br J Pharmacol 165:2167–2177.
    • (2012) Br J Pharmacol , vol.165 , pp. 2167-2177
    • Blanchard, M.G.1    Rash, L.D.2    Kellenberger, S.3
  • 100
    • 84875982679 scopus 로고    scopus 로고
    • Inhibition of neuronal degenerin/epithelial Na+ channels by the multiple sclerosis drug 4-aminopyridine
    • Boiko N, Kucher V, Eaton BA, and Stockand JD (2013) Inhibition of neuronal degenerin/epithelial Na+ channels by the multiple sclerosis drug 4-aminopyridine. J Biol Chem 288:9418–9427.
    • (2013) J Biol Chem , vol.288 , pp. 9418-9427
    • Boiko, N.1    Kucher, V.2    Eaton, B.A.3    Stockand, J.D.4
  • 101
    • 84899747729 scopus 로고    scopus 로고
    • Restrictive expression of acidsensing ion channel 5 (asic5) in unipolar brush cells of the vestibulocerebellum
    • Boiko N, Kucher V, Wang B, and Stockand JD (2014) Restrictive expression of acidsensing ion channel 5 (asic5) in unipolar brush cells of the vestibulocerebellum. PLoS ONE 9:e91326.
    • (2014) Plos ONE , vol.9
    • Boiko, N.1    Kucher, V.2    Wang, B.3    Stockand, J.D.4
  • 102
    • 84891440020 scopus 로고    scopus 로고
    • Protonation controls ASIC1a activity via coordinated movements in multiple domains
    • Bonifacio G, Lelli CI, and Kellenberger S (2014) Protonation controls ASIC1a activity via coordinated movements in multiple domains. J Gen Physiol 143: 105–118.
    • (2014) J Gen Physiol , vol.143 , pp. 105-118
    • Bonifacio, G.1    Lelli, C.I.2    Kellenberger, S.3
  • 104
    • 34250207969 scopus 로고    scopus 로고
    • Epithelial Na+ channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the gamma-subunit
    • Bruns JB, Carattino MD, Sheng S, Maarouf AB, Weisz OA, Pilewski JM, Hughey RP, and Kleyman TR (2007) Epithelial Na+ channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the gamma-subunit. J Biol Chem 282:6153–6160.
    • (2007) J Biol Chem , vol.282 , pp. 6153-6160
    • Bruns, J.B.1    Carattino, M.D.2    Sheng, S.3    Maarouf, A.B.4    Weisz, O.A.5    Pilewski, J.M.6    Hughey, R.P.7    Kleyman, T.R.8
  • 105
    • 0029080413 scopus 로고
    • Relative expression of the human epithelial Na+ channel subunits in normal and cystic fibrosis airways
    • Burch LH, Talbot CR, Knowles MR, Canessa CM, Rossier BC, and Boucher RC (1995) Relative expression of the human epithelial Na+ channel subunits in normal and cystic fibrosis airways. Am J Physiol 269:C511–C518.
    • (1995) Am J Physiol , vol.269 , pp. C511-C518
    • Burch, L.H.1    Talbot, C.R.2    Knowles, M.R.3    Canessa, C.M.4    Rossier, B.C.5    Boucher, R.C.6
  • 107
    • 0027483065 scopus 로고
    • Epithelial sodium channel related to proteins involved in neurodegeneration
    • Canessa CM, Horisberger J-D, and Rossier BC (1993) Epithelial sodium channel related to proteins involved in neurodegeneration. Nature 361:467–470.
    • (1993) Nature , vol.361 , pp. 467-470
    • Canessa, C.M.1    Horisberger, J.-D.2    Rossier, B.C.3
  • 108
    • 0028252575 scopus 로고
    • Membrane topology of the epithelial sodium channel in intact cells
    • Canessa CM, Merillat AM, and Rossier BC (1994a) Membrane topology of the epithelial sodium channel in intact cells. Am J Physiol 267:C1682–C1690.
    • (1994) Am J Physiol , vol.267 , pp. C1682-C1690
    • Canessa, C.M.1    Merillat, A.M.2    Rossier, B.C.3
  • 110
    • 54449088865 scopus 로고    scopus 로고
    • Proteolytic processing of the epithelial sodium channel gamma subunit has a dominant role in channel activation
    • Carattino MD, Hughey RP, and Kleyman TR (2008) Proteolytic processing of the epithelial sodium channel gamma subunit has a dominant role in channel activation. J Biol Chem 283:25290–25295.
    • (2008) J Biol Chem , vol.283 , pp. 25290-25295
    • Carattino, M.D.1    Hughey, R.P.2    Kleyman, T.R.3
  • 112
    • 23644461777 scopus 로고    scopus 로고
    • Solution structure of APETx2, a specific peptide inhibitor of ASIC3 proton-gated channels
    • Chagot B, Escoubas P, Diochot S, Bernard C, Lazdunski M, and Darbon H (2005) Solution structure of APETx2, a specific peptide inhibitor of ASIC3 proton-gated channels. Protein Sci 14:2003–2010.
    • (2005) Protein Sci , vol.14 , pp. 2003-2010
    • Chagot, B.1    Escoubas, P.2    Diochot, S.3    Bernard, C.4    Lazdunski, M.5    Darbon, H.6
  • 113
    • 34547944617 scopus 로고    scopus 로고
    • A kinaseanchoring protein 150 and calcineurin are involved in regulation of acid-sensing ion channels ASIC1a and ASIC2a
    • Chai S, Li M, Lan J, Xiong ZG, Saugstad JA, and Simon RP (2007) A kinaseanchoring protein 150 and calcineurin are involved in regulation of acid-sensing ion channels ASIC1a and ASIC2a. J Biol Chem 282:22668–22677.
    • (2007) J Biol Chem , vol.282 , pp. 22668-22677
    • Chai, S.1    Li, M.2    Lan, J.3    Xiong, Z.G.4    Saugstad, J.A.5    Simon, R.P.6
  • 115
    • 0032546923 scopus 로고    scopus 로고
    • Mutations causing neurodegeneration in Caenorhabditis elegans drastically alter the pH sensitivity and inactivation of the mammalian H+-gated Na+ channel MDEG1
    • Champigny G, Voilley N, Waldmann R, and Lazdunski M (1998) Mutations causing neurodegeneration in Caenorhabditis elegans drastically alter the pH sensitivity and inactivation of the mammalian H+-gated Na+ channel MDEG1. J Biol Chem 273:15418–15422.
    • (1998) J Biol Chem , vol.273 , pp. 15418-15422
    • Champigny, G.1    Voilley, N.2    Waldmann, R.3    Lazdunski, M.4
  • 118
    • 84875794865 scopus 로고    scopus 로고
    • Neurosensory mechanotransduction through acidsensing ion channels
    • Chen CC and Wong CW (2013) Neurosensory mechanotransduction through acidsensing ion channels. J Cell Mol Med 17:337–349.
    • (2013) J Cell Mol Med , vol.17 , pp. 337-349
    • Chen, C.C.1    Wong, C.W.2
  • 119
    • 33947104112 scopus 로고    scopus 로고
    • Permeating protons contribute to tachyphylaxis of the acid-sensing ion channel (ASIC) 1a
    • Chen X and Gründer S (2007) Permeating protons contribute to tachyphylaxis of the acid-sensing ion channel (ASIC) 1a. J Physiol 579:657–670.
    • (2007) J Physiol , vol.579 , pp. 657-670
    • Chen, X.1    Gründer, S.2
  • 120
    • 22244439888 scopus 로고    scopus 로고
    • The tarantula toxin psalmotoxin 1 inhibits acid-sensing ion channel (ASIC) 1a by increasing its apparent H+ affinity
    • Chen X, Kalbacher H, and Gründer S (2005) The tarantula toxin psalmotoxin 1 inhibits acid-sensing ion channel (ASIC) 1a by increasing its apparent H+ affinity. J Gen Physiol 126:71–79.
    • (2005) J Gen Physiol , vol.126 , pp. 71-79
    • Chen, X.1    Kalbacher, H.2    Gründer, S.3
  • 121
    • 33644596215 scopus 로고    scopus 로고
    • Interaction of acid-sensing ion channel (ASIC) 1 with the tarantula toxin psalmotoxin 1 is state dependent
    • Chen X, Kalbacher H, and Gründer S (2006) Interaction of acid-sensing ion channel (ASIC) 1 with the tarantula toxin psalmotoxin 1 is state dependent. J Gen Physiol 127:267–276.
    • (2006) J Gen Physiol , vol.127 , pp. 267-276
    • Chen, X.1    Kalbacher, H.2    Gründer, S.3
  • 123
    • 34447507908 scopus 로고    scopus 로고
    • Potentiation of acid-sensing ion channels by sulfhydryl compounds
    • Cho JH and Askwith CC (2007) Potentiation of acid-sensing ion channels by sulfhydryl compounds. Am J Physiol Cell Physiol 292:C2161–C2174.
    • (2007) Am J Physiol Cell Physiol , vol.292 , pp. C2161-C2174
    • Cho, J.H.1    Askwith, C.C.2
  • 124
    • 0036023395 scopus 로고    scopus 로고
    • Na self inhibition of human epithelial Na channel: Temperature dependence and effect of extracellular proteases
    • Chraïbi A and Horisberger JD (2002) Na self inhibition of human epithelial Na channel: temperature dependence and effect of extracellular proteases. J Gen Physiol 120:133–145.
    • (2002) J Gen Physiol , vol.120 , pp. 133-145
    • Chraïbi, A.1    Horisberger, J.D.2
  • 125
    • 0031930649 scopus 로고    scopus 로고
    • Protease modulation of the activity of the epithelial sodium channel expressed in Xenopus oocytes
    • Chraïbi A, Vallet V, Firsov D, Hess SK, and Horisberger JD (1998) Protease modulation of the activity of the epithelial sodium channel expressed in Xenopus oocytes. J Gen Physiol 111:127–138.
    • (1998) J Gen Physiol , vol.111 , pp. 127-138
    • Chraïbi, A.1    Vallet, V.2    Firsov, D.3    Hess, S.K.4    Horisberger, J.D.5
  • 127
    • 33744981629 scopus 로고    scopus 로고
    • ASIC1a-specific modulation of acid-sensing ion channels in mouse cortical neurons by redox reagents
    • Chu XP, Close N, Saugstad JA, and Xiong ZG (2006) ASIC1a-specific modulation of acid-sensing ion channels in mouse cortical neurons by redox reagents. J Neurosci 26: 5329–5339.
    • (2006) J Neurosci , vol.26 , pp. 5329-5339
    • Chu, X.P.1    Close, N.2    Saugstad, J.A.3    Xiong, Z.G.4
  • 128
  • 131
    • 0242496525 scopus 로고    scopus 로고
    • The extracellular domain determines the kinetics of desensitization in acid-sensitive ion channel 1
    • Coric T, Zhang P, Todorovic N, and Canessa CM (2003) The extracellular domain determines the kinetics of desensitization in acid-sensitive ion channel 1. J Biol Chem 278:45240–45247.
    • (2003) J Biol Chem , vol.278 , pp. 45240-45247
    • Coric, T.1    Zhang, P.2    Todorovic, N.3    Canessa, C.M.4
  • 134
    • 0033537829 scopus 로고    scopus 로고
    • The pretransmembrane 1 domain of acid-sensing ion channels participates in the ion pore
    • Coscoy S, de Weille JR, Lingueglia E, and Lazdunski M (1999) The pretransmembrane 1 domain of acid-sensing ion channels participates in the ion pore. J Biol Chem 274:10129–10132.
    • (1999) J Biol Chem , vol.274 , pp. 10129-10132
    • Coscoy, S.1    De Weille, J.R.2    Lingueglia, E.3    Lazdunski, M.4
  • 135
    • 0014038040 scopus 로고
    • Pyrazine diuretics. II. N-amidino-3-amino-5-substituted 6-halopyrazinecarboxamides
    • Cragoe EJ Jr, Woltersdorf OW Jr, Bicking JB, Kwong SF, and Jones JH (1967) Pyrazine diuretics. II. N-amidino-3-amino-5-substituted 6-halopyrazinecarboxamides. J Med Chem 10:66–75.
    • (1967) J Med Chem , vol.10 , pp. 66-75
    • Cragoe, E.J.1    Woltersdorf, O.W.2    Bicking, J.B.3    Kwong, S.F.4    Jones, J.H.5
  • 136
    • 33947715893 scopus 로고    scopus 로고
    • A conformation change in the extracellular domain that accompanies desensitization of acid-sensing ion channel (ASIC) 3
    • Cushman KA, Marsh-Haffner J, Adelman JP, and McCleskey EW (2007) A conformation change in the extracellular domain that accompanies desensitization of acid-sensing ion channel (ASIC) 3. J Gen Physiol 129:345–350.
    • (2007) J Gen Physiol , vol.129 , pp. 345-350
    • Cushman, K.A.1    Marsh-Haffner, J.2    Adelman, J.P.3    McCleskey, E.W.4
  • 139
    • 84864656610 scopus 로고    scopus 로고
    • Human ASIC3 channel dynamically adapts its activity to sense the extracellular pH in both acidic and alkaline directions
    • Delaunay A, Gasull X, Salinas M, Noël J, Friend V, Lingueglia E, and Deval E (2012) Human ASIC3 channel dynamically adapts its activity to sense the extracellular pH in both acidic and alkaline directions. Proc Natl Acad Sci USA 109:13124–13129.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 13124-13129
    • Delaunay, A.1    Gasull, X.2    Salinas, M.3    Noël, J.4    Friend, V.5    Lingueglia, E.6    Deval, E.7
  • 140
    • 84874292891 scopus 로고    scopus 로고
    • Gating transitions in the palm domain of ASIC1a
    • Della Vecchia MC, Rued AC, and Carattino MD (2013) Gating transitions in the palm domain of ASIC1a. J Biol Chem 288:5487–5495.
    • (2013) J Biol Chem , vol.288 , pp. 5487-5495
    • Della Vecchia, M.C.1    Rued, A.C.2    Carattino, M.D.3
  • 141
    • 0037379464 scopus 로고    scopus 로고
    • Effects of neuropeptide SF and related peptides on acid sensing ion channel 3 and sensory neuron excitability
    • Deval E, Baron A, Lingueglia E, Mazarguil H, Zajac JM, and Lazdunski M (2003) Effects of neuropeptide SF and related peptides on acid sensing ion channel 3 and sensory neuron excitability. Neuropharmacology 44:662–671.
    • (2003) Neuropharmacology , vol.44 , pp. 662-671
    • Deval, E.1    Baron, A.2    Lingueglia, E.3    Mazarguil, H.4    Zajac, J.M.5    Lazdunski, M.6
  • 142
    • 33644985209 scopus 로고    scopus 로고
    • Regulation of sensory neuron-specific acid-sensing ion channel 3 by the adaptor protein Na+/H+ exchanger regulatory factor-1
    • Deval E, Friend V, Thirant C, Salinas M, Jodar M, Lazdunski M, and Lingueglia E (2006) Regulation of sensory neuron-specific acid-sensing ion channel 3 by the adaptor protein Na+/H+ exchanger regulatory factor-1. J Biol Chem 281:1796–1807.
    • (2006) J Biol Chem , vol.281 , pp. 1796-1807
    • Deval, E.1    Friend, V.2    Thirant, C.3    Salinas, M.4    Jodar, M.5    Lazdunski, M.6    Lingueglia, E.7
  • 144
    • 2442599225 scopus 로고    scopus 로고
    • ASIC2bdependent regulation of ASIC3, an essential acid-sensing ion channel subunit in sensory neurons via the partner protein PICK-1
    • Deval E, Salinas M, Baron A, Lingueglia E, and Lazdunski M (2004) ASIC2bdependent regulation of ASIC3, an essential acid-sensing ion channel subunit in sensory neurons via the partner protein PICK-1. J Biol Chem 279:19531–19539.
    • (2004) J Biol Chem , vol.279 , pp. 19531-19539
    • Deval, E.1    Salinas, M.2    Baron, A.3    Lingueglia, E.4    Lazdunski, M.5
  • 145
    • 0035843979 scopus 로고    scopus 로고
    • Dependence of the acid-sensitive ion channel, ASIC1a, on extracellular Ca(2+) ions
    • de Weille J and Bassilana F (2001) Dependence of the acid-sensitive ion channel, ASIC1a, on extracellular Ca(2+) ions. Brain Res 900:277–281.
    • (2001) Brain Res , vol.900 , pp. 277-281
    • De Weille, J.1    Bassilana, F.2
  • 146
    • 0032555350 scopus 로고    scopus 로고
    • Identification, functional expression and chromosomal localisation of a sustained human protongated cation channel
    • de Weille JR, Bassilana F, Lazdunski M, and Waldmann R (1998) Identification, functional expression and chromosomal localisation of a sustained human protongated cation channel. FEBS Lett 433:257–260.
    • (1998) FEBS Lett , vol.433 , pp. 257-260
    • De Weille, J.R.1    Bassilana, F.2    Lazdunski, M.3    Waldmann, R.4
  • 147
    • 0036451193 scopus 로고    scopus 로고
    • The epithelial sodium channel (ENaC) is intracellularly located as a tetramer
    • Dijkink L, Hartog A, van Os CH, and Bindels RJ (2002) The epithelial sodium channel (ENaC) is intracellularly located as a tetramer. Pflugers Arch 444:549–555.
    • (2002) Pflugers Arch , vol.444 , pp. 549-555
    • Dijkink, L.1    Hartog, A.2    Van Os, C.H.3    Bindels, R.J.4
  • 148
  • 150
    • 68949212896 scopus 로고    scopus 로고
    • Protein complexes in snake venom
    • Doley R and Kini RM (2009) Protein complexes in snake venom. Cell Mol Life Sci 66: 2851–2871.
    • (2009) Cell Mol Life Sci , vol.66 , pp. 2851-2871
    • Doley, R.1    Kini, R.M.2
  • 151
    • 33644688683 scopus 로고    scopus 로고
    • Annexin II light chain p11 promotes functional expression of acid-sensing ion channel ASIC1a
    • Donier E, Rugiero F, Okuse K, and Wood JN (2005) Annexin II light chain p11 promotes functional expression of acid-sensing ion channel ASIC1a. J Biol Chem 280:38666–38672.
    • (2005) J Biol Chem , vol.280 , pp. 38666-38672
    • Donier, E.1    Rugiero, F.2    Okuse, K.3    Wood, J.N.4
  • 152
    • 45249113296 scopus 로고    scopus 로고
    • Mechanisms of non-steroid anti-inflammatory drugs action on ASICs expressed in hippocampal interneurons
    • Dorofeeva NA, Barygin OI, Staruschenko A, Bolshakov KV, and Magazanik LG (2008) Mechanisms of non-steroid anti-inflammatory drugs action on ASICs expressed in hippocampal interneurons. J Neurochem 106:429–441.
    • (2008) J Neurochem , vol.106 , pp. 429-441
    • Dorofeeva, N.A.1    Barygin, O.I.2    Staruschenko, A.3    Bolshakov, K.V.4    Magazanik, L.G.5
  • 153
    • 2442699006 scopus 로고    scopus 로고
    • Acid-sensing ion channels ASIC2 and ASIC3 do not contribute to mechanically activated currents in mammalian sensory neurones
    • Drew LJ, Rohrer DK, Price MP, Blaver KE, Cockayne DA, Cesare P, and Wood JN (2004) Acid-sensing ion channels ASIC2 and ASIC3 do not contribute to mechanically activated currents in mammalian sensory neurones. J Physiol 556:691–710.
    • (2004) J Physiol , vol.556 , pp. 691-710
    • Drew, L.J.1    Rohrer, D.K.2    Price, M.P.3    Blaver, K.E.4    Cockayne, D.A.5    Cesare, P.6    Wood, J.N.7
  • 154
    • 7244260316 scopus 로고    scopus 로고
    • Degenerin/epithelial Na+ channel proteins: Components of a vascular mechanosensor
    • Drummond HA, Gebremedhin D, and Harder DR (2004) Degenerin/epithelial Na+ channel proteins: components of a vascular mechanosensor. Hypertension 44: 643–648.
    • (2004) Hypertension , vol.44 , pp. 643-648
    • Drummond, H.A.1    Gebremedhin, D.2    Harder, D.R.3
  • 156
    • 84860351788 scopus 로고    scopus 로고
    • PI3-kinase/Akt pathway-regulated membrane insertion of acid-sensing ion channel 1a underlies BDNF-induced pain hypersensitivity
    • Duan B, Liu DS, Huang Y, Zeng WZ, Wang X, Yu H, Zhu MX, Chen ZY, and Xu TL (2012) PI3-kinase/Akt pathway-regulated membrane insertion of acid-sensing ion channel 1a underlies BDNF-induced pain hypersensitivity. J Neurosci 32:6351–6363.
    • (2012) J Neurosci , vol.32 , pp. 6351-6363
    • Duan, B.1    Liu, D.S.2    Huang, Y.3    Zeng, W.Z.4    Wang, X.5    Yu, H.6    Zhu, M.X.7    Chen, Z.Y.8    Xu, T.L.9
  • 157
    • 79951542315 scopus 로고    scopus 로고
    • Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis
    • Duan B, Wang YZ, Yang T, Chu XP, Yu Y, Huang Y, Cao H, Hansen J, Simon RP, and Zhu MX, et al. (2011) Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis. J Neurosci 31:2101–2112.
    • (2011) J Neurosci , vol.31 , pp. 2101-2112
    • Duan, B.1    Wang, Y.Z.2    Yang, T.3    Chu, X.P.4    Yu, Y.5    Huang, Y.6    Cao, H.7    Hansen, J.8    Simon, R.P.9    Zhu, M.X.10
  • 158
    • 35348849742 scopus 로고    scopus 로고
    • Upregulation of acid-sensing ion channel ASIC1a in spinal dorsal horn neurons contributes to inflammatory pain hypersensitivity
    • Duan B, Wu LJ, Yu YQ, Ding Y, Jing L, Xu L, Chen J, and Xu TL (2007) Upregulation of acid-sensing ion channel ASIC1a in spinal dorsal horn neurons contributes to inflammatory pain hypersensitivity. J Neurosci 27:11139–11148.
    • (2007) J Neurosci , vol.27 , pp. 11139-11148
    • Duan, B.1    Wu, L.J.2    Yu, Y.Q.3    Ding, Y.4    Jing, L.5    Xu, L.6    Chen, J.7    Xu, T.L.8
  • 160
    • 0037085268 scopus 로고    scopus 로고
    • The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons
    • Duggan A, Garcia-Anoveros J, and Corey DP (2002) The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons. J Biol Chem 277: 5203–5208.
    • (2002) J Biol Chem , vol.277 , pp. 5203-5208
    • Duggan, A.1    Garcia-Anoveros, J.2    Corey, D.P.3
  • 161
    • 84867188744 scopus 로고    scopus 로고
    • Insight into DEG/ENaC channel gating from genetics and structure
    • Eastwood AL and Goodman MB (2012) Insight into DEG/ENaC channel gating from genetics and structure. Physiology (Bethesda) 27:282–290.
    • (2012) Physiology (Bethesda) , vol.27 , pp. 282-290
    • Eastwood, A.L.1    Goodman, M.B.2
  • 163
    • 0037634059 scopus 로고    scopus 로고
    • Recombinant production and solution structure of PcTx1, the specific peptide inhibitor of ASIC1a proton-gated cation channels
    • Escoubas P, Bernard C, Lambeau G, Lazdunski M, and Darbon H (2003) Recombinant production and solution structure of PcTx1, the specific peptide inhibitor of ASIC1a proton-gated cation channels. Protein Sci 12:1332–1343.
    • (2003) Protein Sci , vol.12 , pp. 1332-1343
    • Escoubas, P.1    Bernard, C.2    Lambeau, G.3    Lazdunski, M.4    Darbon, H.5
  • 168
    • 0032518665 scopus 로고    scopus 로고
    • The heterotetrameric architecture of the epithelial sodium channel (ENaC)
    • Firsov D, Gautschi I, Merillat AM, Rossier BC, and Schild L (1998) The heterotetrameric architecture of the epithelial sodium channel (ENaC). EMBO J 17: 344–352.
    • (1998) EMBO J , vol.17 , pp. 344-352
    • Firsov, D.1    Gautschi, I.2    Merillat, A.M.3    Rossier, B.C.4    Schild, L.5
  • 169
    • 0030451774 scopus 로고    scopus 로고
    • Cell surface expression of the epithelial Na channel and a mutant causing Liddle syndrome: A quantitative approach
    • Firsov D, Schild L, Gautschi I, Mérillat AM, Schneeberger E, and Rossier BC (1996) Cell surface expression of the epithelial Na channel and a mutant causing Liddle syndrome: a quantitative approach. Proc Natl Acad Sci USA 93:15370–15375.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 15370-15375
    • Firsov, D.1    Schild, L.2    Gautschi, I.3    Mérillat, A.M.4    Schneeberger, E.5    Rossier, B.C.6
  • 170
    • 36849009834 scopus 로고    scopus 로고
    • Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system
    • Friese MA, Craner MJ, Etzensperger R, Vergo S, Wemmie JA, Welsh MJ, Vincent A, and Fugger L (2007) Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system. Nat Med 13: 1483–1489.
    • (2007) Nat Med , vol.13 , pp. 1483-1489
    • Friese, M.A.1    Craner, M.J.2    Etzensperger, R.3    Vergo, S.4    Wemmie, J.A.5    Welsh, M.J.6    Vincent, A.7    Fugger, L.8
  • 171
    • 44349121823 scopus 로고    scopus 로고
    • Surface expression of epithelial Na channel protein in rat kidney
    • Frindt G, Ergonul Z, and Palmer LG (2008) Surface expression of epithelial Na channel protein in rat kidney. J Gen Physiol 131:617–627.
    • (2008) J Gen Physiol , vol.131 , pp. 617-627
    • Frindt, G.1    Ergonul, Z.2    Palmer, L.G.3
  • 172
    • 1642374813 scopus 로고    scopus 로고
    • Na channels in the rat connecting tubule
    • Frindt G and Palmer LG (2004) Na channels in the rat connecting tubule. Am J Physiol Renal Physiol 286:F669–F674.
    • (2004) Am J Physiol Renal Physiol , vol.286 , pp. F669-F674
    • Frindt, G.1    Palmer, L.G.2
  • 173
    • 68049088827 scopus 로고    scopus 로고
    • K+ secretion in the rat kidney: Na+ channeldependent and -independent mechanisms
    • Frindt G and Palmer LG (2009a) K+ secretion in the rat kidney: Na+ channeldependent and -independent mechanisms. Am J Physiol Renal Physiol 297: F389–F396.
    • (2009) Am J Physiol Renal Physiol , vol.297 , pp. F389-F396
    • Frindt, G.1    Palmer, L.G.2
  • 174
    • 70350719352 scopus 로고    scopus 로고
    • Surface expression of sodium channels and transporters in rat kidney: Effects of dietary sodium
    • Frindt G and Palmer LG (2009b) Surface expression of sodium channels and transporters in rat kidney: effects of dietary sodium. Am J Physiol Renal Physiol 297: F1249–F1255.
    • (2009) Am J Physiol Renal Physiol , vol.297 , pp. F1249-F1255
    • Frindt, G.1    Palmer, L.G.2
  • 175
    • 83455242931 scopus 로고    scopus 로고
    • Regulation of epithelial Na+ channels by adrenal steroids: Mineralocorticoid and glucocorticoid effects
    • Frindt G and Palmer LG (2012) Regulation of epithelial Na+ channels by adrenal steroids: mineralocorticoid and glucocorticoid effects. Am J Physiol Renal Physiol 302:F20–F26.
    • (2012) Am J Physiol Renal Physiol , vol.302 , pp. F20-F26
    • Frindt, G.1    Palmer, L.G.2
  • 176
    • 0027466605 scopus 로고
    • Feedback regulation of Na channels in rat CCT. II. Effects of inhibition of Na entry
    • Frindt G, Silver RB, Windhager EE, and Palmer LG (1993) Feedback regulation of Na channels in rat CCT. II. Effects of inhibition of Na entry. Am J Physiol 264: F565–F574.
    • (1993) Am J Physiol , vol.264 , pp. F565-F574
    • Frindt, G.1    Silver, R.B.2    Windhager, E.E.3    Palmer, L.G.4
  • 177
    • 0028937585 scopus 로고
    • Feedback regulation of Na channels in rat CCT. III. Response to cAMP
    • Frindt G, Silver RB, Windhager EE, and Palmer LG (1995) Feedback regulation of Na channels in rat CCT. III. Response to cAMP. Am J Physiol 268:F480–F489.
    • (1995) Am J Physiol , vol.268 , pp. F480-F489
    • Frindt, G.1    Silver, R.B.2    Windhager, E.E.3    Palmer, L.G.4
  • 178
    • 0017334057 scopus 로고
    • Current-voltage curve of sodium channels and concentration dependence of sodium permeability in frog skin
    • Fuchs W, Larsen EH, and Lindemann B (1977) Current-voltage curve of sodium channels and concentration dependence of sodium permeability in frog skin. J Physiol 267:137–166.
    • (1977) J Physiol , vol.267 , pp. 137-166
    • Fuchs, W.1    Larsen, E.H.2    Lindemann, B.3
  • 179
    • 0019817468 scopus 로고
    • New synthetic inhibitors of C1r, C1 esterase, thrombin, plasmin, kallikrein and trypsin
    • Fujii S and Hitomi Y (1981) New synthetic inhibitors of C1r, C1 esterase, thrombin, plasmin, kallikrein and trypsin. Biochim Biophys Acta 661:342–345.
    • (1981) Biochim Biophys Acta , vol.661 , pp. 342-345
    • Fujii, S.1    Hitomi, Y.2
  • 180
    • 0034489182 scopus 로고    scopus 로고
    • Acute differential regulation by corticosteroids of epithelial sodium channel subunit and Nedd4 mRNA levels in the distal colon
    • Fuller PJ, Brennan FE, and Burgess JS (2000) Acute differential regulation by corticosteroids of epithelial sodium channel subunit and Nedd4 mRNA levels in the distal colon. Pflugers Arch 441:94–101.
    • (2000) Pflugers Arch , vol.441 , pp. 94-101
    • Fuller, P.J.1    Brennan, F.E.2    Burgess, J.S.3
  • 181
    • 27844502151 scopus 로고    scopus 로고
    • Coupling between NMDA receptor and acid-sensing ion channel contributes to ischemic neuronal death
    • Gao J, Duan B, Wang DG, Deng XH, Zhang GY, Xu L, and Xu TL (2005) Coupling between NMDA receptor and acid-sensing ion channel contributes to ischemic neuronal death. Neuron 48:635–646.
    • (2005) Neuron , vol.48 , pp. 635-646
    • Gao, J.1    Duan, B.2    Wang, D.G.3    Deng, X.H.4    Zhang, G.Y.5    Xu, L.6    Xu, T.L.7
  • 182
    • 0030945484 scopus 로고    scopus 로고
    • Epithelial sodium channels: Function, structure, and regulation
    • Garty H and Palmer LG (1997) Epithelial sodium channels: function, structure, and regulation. Physiol Rev 77:359–396.
    • (1997) Physiol Rev , vol.77 , pp. 359-396
    • Garty, H.1    Palmer, L.G.2
  • 184
    • 0034284153 scopus 로고    scopus 로고
    • Serine proteases and brain damage - is there a link?
    • Gingrich MB and Traynelis SF (2000) Serine proteases and brain damage - is there a link? Trends Neurosci 23:399–407.
    • (2000) Trends Neurosci , vol.23 , pp. 399-407
    • Gingrich, M.B.1    Traynelis, S.F.2
  • 185
    • 67949092829 scopus 로고    scopus 로고
    • Pore architecture and ion sites in acidsensing ion channels and P2X receptors
    • Gonzales EB, Kawate T, and Gouaux E (2009) Pore architecture and ion sites in acidsensing ion channels and P2X receptors. Nature 460:599–604.
    • (2009) Nature , vol.460 , pp. 599-604
    • Gonzales, E.B.1    Kawate, T.2    Gouaux, E.3
  • 186
    • 77954656825 scopus 로고    scopus 로고
    • Osmolytes and ion transport modulators: New strategies for airway surface rehydration
    • Goralski JL, Boucher RC, and Button B (2010) Osmolytes and ion transport modulators: new strategies for airway surface rehydration. Curr Opin Pharmacol 10: 294–299.
    • (2010) Curr Opin Pharmacol , vol.10 , pp. 294-299
    • Goralski, J.L.1    Boucher, R.C.2    Button, B.3
  • 189
    • 84871430580 scopus 로고    scopus 로고
    • Toxin binding reveals two open state structures for one acid-sensing ion channel
    • Gründer S and Augustinowski K (2012) Toxin binding reveals two open state structures for one acid-sensing ion channel. Channels (Austin) 6:409–413.
    • (2012) Channels (Austin) , vol.6 , pp. 409-413
    • Gründer, S.1    Augustinowski, K.2
  • 190
    • 77954727554 scopus 로고    scopus 로고
    • Structure, function, and pharmacology of acid-sensing ion channels (ASICs): Focus on ASIC1a
    • Gründer S and Chen X (2010) Structure, function, and pharmacology of acid-sensing ion channels (ASICs): focus on ASIC1a. Int J Physiol Pathophysiol Pharmacol 2: 73–94.
    • (2010) Int J Physiol Pathophysiol Pharmacol , vol.2 , pp. 73-94
    • Gründer, S.1    Chen, X.2
  • 191
    • 0344743590 scopus 로고    scopus 로고
    • A mutation causing pseudohypoaldosteronism type 1 identifies a conserved glycine that is involved in the gating of the epithelial sodium channel
    • Gründer S, Firsov D, Chang SS, Jaeger NF, Gautschi I, Schild L, Lifton RP, and Rossier BC (1997) A mutation causing pseudohypoaldosteronism type 1 identifies a conserved glycine that is involved in the gating of the epithelial sodium channel. EMBO J 16:899–907.
    • (1997) EMBO J , vol.16 , pp. 899-907
    • Gründer, S.1    Firsov, D.2    Chang, S.S.3    Jaeger, N.F.4    Gautschi, I.5    Schild, L.6    Lifton, R.P.7    Rossier, B.C.8
  • 192
    • 0344701037 scopus 로고    scopus 로고
    • Amiloride and vertebrate gustatory responses to NaCl
    • Halpern BP (1998) Amiloride and vertebrate gustatory responses to NaCl. Neurosci Biobehav Rev 23:5–47.
    • (1998) Neurosci Biobehav Rev , vol.23 , pp. 5-47
    • Halpern, B.P.1
  • 193
    • 43149118602 scopus 로고    scopus 로고
    • Preferential assembly of epithelial sodium channel (ENaC) subunits in Xenopus oocytes: Role of furin-mediated endogenous proteolysis
    • Harris M, Garcia-Caballero A, Stutts MJ, Firsov D, and Rossier BC (2008) Preferential assembly of epithelial sodium channel (ENaC) subunits in Xenopus oocytes: role of furin-mediated endogenous proteolysis. J Biol Chem 283:7455–7463.
    • (2008) J Biol Chem , vol.283 , pp. 7455-7463
    • Harris, M.1    Garcia-Caballero, A.2    Stutts, M.J.3    Firsov, D.4    Rossier, B.C.5
  • 194
    • 1642524428 scopus 로고    scopus 로고
    • Timmermann DB, and Ahring PK (2004) pH Dependency and desensitization kinetics of heterologously expressed combinations of acid-sensing ion channel subunits
    • Hesselager M, Timmermann DB, and Ahring PK (2004) pH Dependency and desensitization kinetics of heterologously expressed combinations of acid-sensing ion channel subunits. J Biol Chem 279:11006–11015.
    • J Biol Chem , vol.279 , pp. 11006-11015
    • Hesselager, M.1
  • 195
    • 33745838632 scopus 로고    scopus 로고
    • Design, synthesis, and structure-activity relationships of novel 2-substituted pyrazinoylguanidine epithelial sodium channel blockers: Drugs for cystic fibrosis and chronic bronchitis
    • Hirsh AJ, Molino BF, Zhang J, Astakhova N, Geiss WB, Sargent BJ, Swenson BD, Usyatinsky A, Wyle MJ, and Boucher RC, et al. (2006) Design, synthesis, and structure-activity relationships of novel 2-substituted pyrazinoylguanidine epithelial sodium channel blockers: drugs for cystic fibrosis and chronic bronchitis. J Med Chem 49:4098–4115.
    • (2006) J Med Chem , vol.49 , pp. 4098-4115
    • Hirsh, A.J.1    Molino, B.F.2    Zhang, J.3    Astakhova, N.4    Geiss, W.B.5    Sargent, B.J.6    Swenson, B.D.7    Usyatinsky, A.8    Wyle, M.J.9    Boucher, R.C.10
  • 196
    • 41149164824 scopus 로고    scopus 로고
    • Pharmacological properties of N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N’-4-[4-(2,3-dihydroxypropoxy) phenyl]butyl-guanidine methanesulfonate (552-02), a novel epithelial sodium channel blocker with potential clinical efficacy for cystic fibrosis lung disease
    • Hirsh AJ, Zhang J, Zamurs A, Fleegle J, Thelin WR, Caldwell RA, Sabater JR, Abraham WM, Donowitz M, and Cha B, et al. (2008) Pharmacological properties of N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N’-4-[4-(2,3-dihydroxypropoxy) phenyl]butyl-guanidine methanesulfonate (552-02), a novel epithelial sodium channel blocker with potential clinical efficacy for cystic fibrosis lung disease. J Pharmacol Exp Ther 325:77–88.
    • (2008) J Pharmacol Exp Ther , vol.325 , pp. 77-88
    • Hirsh, A.J.1    Zhang, J.2    Zamurs, A.3    Fleegle, J.4    Thelin, W.R.5    Caldwell, R.A.6    Sabater, J.R.7    Abraham, W.M.8    Donowitz, M.9    Cha, B.10
  • 197
    • 84884284486 scopus 로고    scopus 로고
    • Does epithelial sodium channel hyperactivity contribute to cystic fibrosis lung disease?
    • Hobbs CA, Da Tan C, and Tarran R (2013) Does epithelial sodium channel hyperactivity contribute to cystic fibrosis lung disease? J Physiol 591:4377–4387.
    • (2013) J Physiol , vol.591 , pp. 4377-4387
    • Hobbs, C.A.1    Da Tan, C.2    Tarran, R.3
  • 199
    • 17444441690 scopus 로고    scopus 로고
    • Epithelial sodium channel: A ligand-gated channel? Nephron
    • Horisberger JD and Chraïbi A (2004) Epithelial sodium channel: a ligand-gated channel? Nephron, Physiol 96:37–41.
    • (2004) Physiol , vol.96 , pp. 37-41
    • Horisberger, J.D.1    Chraïbi, A.2
  • 200
    • 8744237238 scopus 로고    scopus 로고
    • PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current
    • Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, and Welsh MJ (2004) PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current. J Biol Chem 279:46962–46968.
    • (2004) J Biol Chem , vol.279 , pp. 46962-46968
    • Hruska-Hageman, A.M.1    Benson, C.J.2    Leonard, A.S.3    Price, M.P.4    Welsh, M.J.5
  • 201
    • 0036472120 scopus 로고    scopus 로고
    • Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the nonvoltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acidsensing ion channel)
    • Hruska-Hageman AM, Wemmie JA, Price MP, and Welsh MJ (2002) Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the nonvoltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acidsensing ion channel). Biochem J 361:443–450.
    • (2002) Biochem J , vol.361 , pp. 443-450
    • Hruska-Hageman, A.M.1    Wemmie, J.A.2    Price, M.P.3    Welsh, M.J.4
  • 206
    • 0034862157 scopus 로고    scopus 로고
    • Lactate enhances the acid-sensing Na+ channel on ischemia-sensing neurons
    • Immke DC and McCleskey EW (2001) Lactate enhances the acid-sensing Na+ channel on ischemia-sensing neurons. Nat Neurosci 4:869–870.
    • (2001) Nat Neurosci , vol.4 , pp. 869-870
    • Immke, D.C.1    McCleskey, E.W.2
  • 207
    • 0037427023 scopus 로고    scopus 로고
    • Protons open acid-sensing ion channels by catalyzing relief of Ca2+ blockade
    • Immke DC and McCleskey EW (2003) Protons open acid-sensing ion channels by catalyzing relief of Ca2+ blockade. Neuron 37:75–84.
    • (2003) Neuron , vol.37 , pp. 75-84
    • Immke, D.C.1    McCleskey, E.W.2
  • 208
    • 34548813656 scopus 로고    scopus 로고
    • Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH
    • Jasti J, Furukawa H, Gonzales EB, and Gouaux E (2007) Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pH. Nature 449:316–323.
    • (2007) Nature , vol.449 , pp. 316-323
    • Jasti, J.1    Furukawa, H.2    Gonzales, E.B.3    Gouaux, E.4
  • 209
    • 80052476803 scopus 로고    scopus 로고
    • Cysteine 149 in the extracellular finger domain of acid-sensing ion channel 1b subunit is critical for zinc-mediated inhibition
    • Jiang Q, Inoue K, Wu X, Papasian CJ, Wang JQ, Xiong ZG, and Chu XP (2011) Cysteine 149 in the extracellular finger domain of acid-sensing ion channel 1b subunit is critical for zinc-mediated inhibition. Neuroscience 193:89–99.
    • (2011) Neuroscience , vol.193 , pp. 89-99
    • Jiang, Q.1    Inoue, K.2    Wu, X.3    Papasian, C.J.4    Wang, J.Q.5    Xiong, Z.G.6    Chu, X.P.7
  • 211
    • 80055061673 scopus 로고    scopus 로고
    • The interaction between the first transmembrane domain and the thumb of ASIC1a is critical for its N-glycosylation and trafficking
    • Jing L, Jiang YQ, Jiang Q, Wang B, Chu XP, and Zha XM (2011) The interaction between the first transmembrane domain and the thumb of ASIC1a is critical for its N-glycosylation and trafficking. PLoS ONE 6:e26909.
    • (2011) Plos ONE , vol.6
    • Jing, L.1    Jiang, Y.Q.2    Jiang, Q.3    Wang, B.4    Chu, X.P.5    Zha, X.M.6
  • 213
    • 28044453285 scopus 로고    scopus 로고
    • The mechanosensitivity of mouse colon afferent fibers and their sensitization by inflammatory mediators require transient receptor potential vanilloid 1 and acid-sensing ion channel 3
    • Jones RC 3rd, Xu L, and Gebhart GF (2005) The mechanosensitivity of mouse colon afferent fibers and their sensitization by inflammatory mediators require transient receptor potential vanilloid 1 and acid-sensing ion channel 3. J Neurosci 25: 10981–10989.
    • (2005) J Neurosci , vol.25 , pp. 10981-10989
    • Jones, R.C.1    Xu, L.2    Gebhart, G.F.3
  • 215
    • 78650934293 scopus 로고    scopus 로고
    • Constraint-based, homology model of the extracellular domain of the epithelial Na+ channel a subunit reveals a mechanism of channel activation by proteases
    • Kashlan OB, Adelman JL, Okumura S, Blobner BM, Zuzek Z, Hughey RP, Kleyman TR, and Grabe M (2011) Constraint-based, homology model of the extracellular domain of the epithelial Na+ channel a subunit reveals a mechanism of channel activation by proteases. J Biol Chem 286:649–660.
    • (2011) J Biol Chem , vol.286 , pp. 649-660
    • Kashlan, O.B.1    Adelman, J.L.2    Okumura, S.3    Blobner, B.M.4    Zuzek, Z.5    Hughey, R.P.6    Kleyman, T.R.7    Grabe, M.8
  • 216
    • 80053374793 scopus 로고    scopus 로고
    • ENaC structure and function in the wake of a resolved structure of a family member
    • Kashlan OB and Kleyman TR (2011) ENaC structure and function in the wake of a resolved structure of a family member. Am J Physiol Renal Physiol 301: F684–F696.
    • (2011) Am J Physiol Renal Physiol , vol.301 , pp. F684-F696
    • Kashlan, O.B.1    Kleyman, T.R.2
  • 218
    • 14844320055 scopus 로고    scopus 로고
    • Intracellular thiolmediated modulation of epithelial sodium channel activity
    • Kellenberger S, Gautschi I, Pfister Y, and Schild L (2005) Intracellular thiolmediated modulation of epithelial sodium channel activity. J Biol Chem 280: 7739–7747.
    • (2005) J Biol Chem , vol.280 , pp. 7739-7747
    • Kellenberger, S.1    Gautschi, I.2    Pfister, Y.3    Schild, L.4
  • 219
    • 0033616609 scopus 로고    scopus 로고
    • A single point mutation in the pore region of the epithelial Na+ channel changes ion selectivity by modifying molecular sieving
    • Kellenberger S, Gautschi I, and Schild L (1999a) A single point mutation in the pore region of the epithelial Na+ channel changes ion selectivity by modifying molecular sieving. Proc Natl Acad Sci USA 96:4170–4175.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 4170-4175
    • Kellenberger, S.1    Gautschi, I.2    Schild, L.3
  • 220
    • 0036714466 scopus 로고    scopus 로고
    • An external site controls closing of the epithelial Na+ channel ENaC
    • Kellenberger S, Gautschi I, and Schild L (2002) An external site controls closing of the epithelial Na+ channel ENaC. J Physiol 543:413–424.
    • (2002) J Physiol , vol.543 , pp. 413-424
    • Kellenberger, S.1    Gautschi, I.2    Schild, L.3
  • 221
    • 0141457720 scopus 로고    scopus 로고
    • Mutations in the epithelial Na+ channel ENaC outer pore disrupt amiloride block by increasing its dissociation rate
    • Kellenberger S, Gautschi I, and Schild L (2003) Mutations in the epithelial Na+ channel ENaC outer pore disrupt amiloride block by increasing its dissociation rate. Mol Pharmacol 64:848–856.
    • (2003) Mol Pharmacol , vol.64 , pp. 848-856
    • Kellenberger, S.1    Gautschi, I.2    Schild, L.3
  • 223
    • 0036307827 scopus 로고    scopus 로고
    • Epithelial sodium channel/degenerin family of ion channels: A variety of functions for a shared structure
    • Kellenberger S and Schild L (2002) Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure. Physiol Rev 82:735–767.
    • (2002) Physiol Rev , vol.82 , pp. 735-767
    • Kellenberger, S.1    Schild, L.2
  • 224
    • 68949094195 scopus 로고    scopus 로고
    • ENaC at the cutting edge: Regulation of epithelial sodium channels by proteases
    • Kleyman TR, Carattino MD, and Hughey RP (2009) ENaC at the cutting edge: regulation of epithelial sodium channels by proteases. J Biol Chem 284:20447–20451.
    • (2009) J Biol Chem , vol.284 , pp. 20447-20451
    • Kleyman, T.R.1    Carattino, M.D.2    Hughey, R.P.3
  • 225
    • 0023807201 scopus 로고
    • Amiloride and its analogs as tools in the study of ion transport
    • Kleyman TR and Cragoe EJ Jr (1988) Amiloride and its analogs as tools in the study of ion transport. J Membr Biol 105:1–21.
    • (1988) J Membr Biol , vol.105 , pp. 1-21
    • Kleyman, T.R.1    Cragoe, E.J.2
  • 226
    • 0028281689 scopus 로고
    • Arginine vasopressin and forskolin regulate apical cell surface expression of epithelial Na+ channels in A6 cells
    • Kleyman TR, Ernst SA, and Coupaye-Gerard B (1994) Arginine vasopressin and forskolin regulate apical cell surface expression of epithelial Na+ channels in A6 cells. Am J Physiol 266:F506–F511.
    • (1994) Am J Physiol , vol.266 , pp. F506-F511
    • Kleyman, T.R.1    Ernst, S.A.2    Coupaye-Gerard, B.3
  • 230
    • 84894099742 scopus 로고    scopus 로고
    • Subunit-specific inhibition of acid sensing ion channels by stomatin-like protein 1
    • Kozlenkov A, Lapatsina L, Lewin GR, and Smith ES (2014) Subunit-specific inhibition of acid sensing ion channels by stomatin-like protein 1. J Physiol 592:557–569.
    • (2014) J Physiol , vol.592 , pp. 557-569
    • Kozlenkov, A.1    Lapatsina, L.2    Lewin, G.R.3    Smith, E.S.4
  • 231
    • 84889020105 scopus 로고    scopus 로고
    • Independent contribution of extracellular proton binding sites to ASIC1a activation
    • Krauson AJ, Rued AC, and Carattino MD (2013) Independent contribution of extracellular proton binding sites to ASIC1a activation. J Biol Chem 288:34375–34383.
    • (2013) J Biol Chem , vol.288 , pp. 34375-34383
    • Krauson, A.J.1    Rued, A.C.2    Carattino, M.D.3
  • 237
    • 84893867510 scopus 로고    scopus 로고
    • Pharmacological and electrophysiological characterization of the human bile acidsensitive ion channel (hBASIC)
    • Lefèvre CM, Diakov A, Haerteis S, Korbmacher C, Gründer S, and Wiemuth D (2014) Pharmacological and electrophysiological characterization of the human bile acidsensitive ion channel (hBASIC). Pflugers Arch 466:253–263.
    • (2014) Pflugers Arch , vol.466 , pp. 253-263
    • Lefèvre, C.M.1    Diakov, A.2    Haerteis, S.3    Korbmacher, C.4    Gründer, S.5    Wiemuth, D.6
  • 238
    • 84878686651 scopus 로고    scopus 로고
    • Subunit and frequency-dependent inhibition of acid sensing ion channels by local anesthetic tetracaine
    • Leng T, Lin J, Cottrell JE, and Xiong ZG (2013) Subunit and frequency-dependent inhibition of acid sensing ion channels by local anesthetic tetracaine. Mol Pain 9:27.
    • (2013) Mol Pain , vol.9
    • Leng, T.1    Lin, J.2    Cottrell, J.E.3    Xiong, Z.G.4
  • 239
    • 0037452601 scopus 로고    scopus 로고
    • Wemmie JA, and Welsh MJ (2003) cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1
    • Leonard AS, Yermolaieva O, Hruska-Hageman A, Askwith CC, Price MP, Wemmie JA, and Welsh MJ (2003) cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1. Proc Natl Acad Sci USA 100:2029–2034.
    • Proc Natl Acad Sci USA , vol.100 , pp. 2029-2034
    • Leonard, A.S.1    Yermolaieva, O.2    Hruska-Hageman, A.3    Askwith, C.C.4    Price, M.P.5
  • 240
    • 63249117189 scopus 로고    scopus 로고
    • Interaction of the aromatics Tyr-72/Trp-288 in the interface of the extracellular and transmembrane domains is essential for proton gating of acid-sensing ion channels
    • Li T, Yang Y, and Canessa CM (2009) Interaction of the aromatics Tyr-72/Trp-288 in the interface of the extracellular and transmembrane domains is essential for proton gating of acid-sensing ion channels. J Biol Chem 284:4689–4694.
    • (2009) J Biol Chem , vol.284 , pp. 4689-4694
    • Li, T.1    Yang, Y.2    Canessa, C.M.3
  • 241
    • 77957797513 scopus 로고    scopus 로고
    • Asn415 in the beta11-beta12 linker decreases proton-dependent desensitization of ASIC1
    • Li T, Yang Y, and Canessa CM (2010a) Asn415 in the beta11-beta12 linker decreases proton-dependent desensitization of ASIC1. J Biol Chem 285:31285–31291.
    • (2010) J Biol Chem , vol.285 , pp. 31285-31291
    • Li, T.1    Yang, Y.2    Canessa, C.M.3
  • 242
    • 77954611622 scopus 로고    scopus 로고
    • Leu85 in the beta1-beta2 linker of ASIC1 slows activation and decreases the apparent proton affinity by stabilizing a closed conformation
    • Li T, Yang Y, and Canessa CM (2010b) Leu85 in the beta1-beta2 linker of ASIC1 slows activation and decreases the apparent proton affinity by stabilizing a closed conformation. J Biol Chem 285:22706–22712.
    • (2010) J Biol Chem , vol.285 , pp. 22706-22712
    • Li, T.1    Yang, Y.2    Canessa, C.M.3
  • 243
    • 79960585260 scopus 로고    scopus 로고
    • Outlines of the pore in open and closed conformations describe the gating mechanism of ASIC1
    • Li T, Yang Y, and Canessa CM (2011a) Outlines of the pore in open and closed conformations describe the gating mechanism of ASIC1. Nat Commun 2:399.
    • (2011) Nat Commun , vol.2
    • Li, T.1    Yang, Y.2    Canessa, C.M.3
  • 244
    • 82755176257 scopus 로고    scopus 로고
    • The nonproton ligand sensing domain is required for paradoxical stimulation of ASIC3 channels by amiloride
    • Li WG, Yu Y, Huang C, Cao H, and Xu TL (2011b) The nonproton ligand sensing domain is required for paradoxical stimulation of ASIC3 channels by amiloride. J Biol Chem 286:42635–42646.
    • (2011) J Biol Chem , vol.286 , pp. 42635-42646
    • Li, W.G.1    Yu, Y.2    Huang, C.3    Cao, H.4    Xu, T.L.5
  • 245
    • 78649785634 scopus 로고    scopus 로고
    • ASIC3 channels integrate agmatine and multiple inflammatory signals through the nonproton ligand sensing domain
    • Li WG, Yu Y, Zhang ZD, Cao H, and Xu TL (2010c) ASIC3 channels integrate agmatine and multiple inflammatory signals through the nonproton ligand sensing domain. Mol Pain 6:88.
    • (2010) Mol Pain , vol.6
    • Li, W.G.1    Yu, Y.2    Zhang, Z.D.3    Cao, H.4    Xu, T.L.5
  • 246
    • 0001182641 scopus 로고
    • A familial renal disorder simulating primary aldosteronism but with negligible aldosterone secretion
    • Liddle GWBT and Coppage WS (1963) A familial renal disorder simulating primary aldosteronism but with negligible aldosterone secretion. Trans Assoc Am Physicians 76:199–213.
    • (1963) Trans Assoc am Physicians , vol.76 , pp. 199-213
    • Liddle, G.1    Coppage, W.S.2
  • 247
    • 77952365948 scopus 로고    scopus 로고
    • A combined computational and functional approach identifies new residues involved in pH-dependent gating of ASIC1a
    • Liechti LA, Bernèche S, Bargeton B, Iwaszkiewicz J, Roy S, Michielin O, and Kellenberger S (2010) A combined computational and functional approach identifies new residues involved in pH-dependent gating of ASIC1a. J Biol Chem 285:16315–16329.
    • (2010) J Biol Chem , vol.285 , pp. 16315-16329
    • Liechti, L.A.1    Bernèche, S.2    Bargeton, B.3    Iwaszkiewicz, J.4    Roy, S.5    Michielin, O.6    Kellenberger, S.7
  • 248
    • 79953183584 scopus 로고    scopus 로고
    • Inhibition of acid sensing ion channel currents by lidocaine in cultured mouse cortical neurons
    • Lin J, Chu X, Maysami S, Li M, Si H, Cottrell JE, Simon RP, and Xiong Z (2011) Inhibition of acid sensing ion channel currents by lidocaine in cultured mouse cortical neurons. Anesth Analg 112:977–981.
    • (2011) Anesth Analg , vol.112 , pp. 977-981
    • Lin, J.1    Chu, X.2    Maysami, S.3    Li, M.4    Si, H.5    Cottrell, J.E.6    Simon, R.P.7    Xiong, Z.8
  • 249
    • 0017348092 scopus 로고
    • Sodium-specific membrane channels of frog skin are pores: Current fluctuations reveal high turnover
    • Lindemann B and Van Driessche W (1977) Sodium-specific membrane channels of frog skin are pores: current fluctuations reveal high turnover. Science 195:292–294.
    • (1977) Science , vol.195 , pp. 292-294
    • Lindemann, B.1    Van Driessche, W.2
  • 250
    • 0029619234 scopus 로고
    • Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel
    • Lingueglia E, Champigny G, Lazdunski M, and Barbry P (1995) Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel. Nature 378:730–733.
    • (1995) Nature , vol.378 , pp. 730-733
    • Lingueglia, E.1    Champigny, G.2    Lazdunski, M.3    Barbry, P.4
  • 251
    • 33646489456 scopus 로고    scopus 로고
    • FMRFamide-gated sodium channel and ASIC channels: A new class of ionotropic receptors for FMRFamide and related peptides
    • Lingueglia E, Deval E, and Lazdunski M (2006) FMRFamide-gated sodium channel and ASIC channels: a new class of ionotropic receptors for FMRFamide and related peptides. Peptides 27:1138–1152.
    • (2006) Peptides , vol.27 , pp. 1138-1152
    • Lingueglia, E.1    Deval, E.2    Lazdunski, M.3
  • 253
    • 84866529319 scopus 로고    scopus 로고
    • Cannabinoids inhibit acid-sensing ion channel currents in rat dorsal root ganglion neurons
    • Liu YQ, Qiu F, Qiu CY, Cai Q, Zou P, Wu H, and Hu WP (2012) Cannabinoids inhibit acid-sensing ion channel currents in rat dorsal root ganglion neurons. PLoS ONE 7:e45531.
    • (2012) Plos ONE , vol.7
    • Liu, Y.Q.1    Qiu, F.2    Qiu, C.Y.3    Cai, Q.4    Zou, P.5    Wu, H.6    Hu, W.P.7
  • 258
    • 62949228127 scopus 로고    scopus 로고
    • Amiloride enhances the anticonvulsant action of various antiepileptic drugs in the mouse maximal electroshock seizure model
    • Luszczki JJ, Sawicka KM, Kozinska J, Dudra-Jastrzebska M, and Czuczwar SJ (2009) Amiloride enhances the anticonvulsant action of various antiepileptic drugs in the mouse maximal electroshock seizure model. J Neural Transm 116:57–66.
    • (2009) J Neural Transm , vol.116 , pp. 57-66
    • Luszczki, J.J.1    Sawicka, K.M.2    Kozinska, J.3    Dudra-Jastrzebska, M.4    Czuczwar, S.J.5
  • 260
    • 84880409755 scopus 로고    scopus 로고
    • Endothelin-1 inhibits sodium reabsorption by ET(A) and ET(B) receptors in the mouse cortical collecting duct
    • Lynch IJ, Welch AK, Kohan DE, Cain BD, and Wingo CS (2013) Endothelin-1 inhibits sodium reabsorption by ET(A) and ET(B) receptors in the mouse cortical collecting duct. Am J Physiol Renal Physiol 305:F568–F573.
    • (2013) Am J Physiol Renal Physiol , vol.305 , pp. F568-F573
    • Lynch, I.J.1    Welch, A.K.2    Kohan, D.E.3    Cain, B.D.4    Wingo, C.S.5
  • 261
    • 84855389998 scopus 로고    scopus 로고
    • A study of the hydration of the alkali metal ions in aqueous solution
    • Mähler J and Persson I (2012) A study of the hydration of the alkali metal ions in aqueous solution. Inorg Chem 51:425–438.
    • (2012) Inorg Chem , vol.51 , pp. 425-438
    • Mähler, J.1    Persson, I.2
  • 264
    • 84855282420 scopus 로고    scopus 로고
    • Angiotensin II increases activity of the epithelial Na+ channel (ENaC) in distal nephron additively to aldosterone
    • Mamenko M, Zaika O, Ilatovskaya DV, Staruschenko A, and Pochynyuk O (2012) Angiotensin II increases activity of the epithelial Na+ channel (ENaC) in distal nephron additively to aldosterone. J Biol Chem 287:660–671.
    • (2012) J Biol Chem , vol.287 , pp. 660-671
    • Mamenko, M.1    Zaika, O.2    Ilatovskaya, D.V.3    Staruschenko, A.4    Pochynyuk, O.5
  • 265
    • 0037115054 scopus 로고    scopus 로고
    • Proinflammatory mediators, stimulators of sensory neuron excitability via the expression of acid-sensing ion channels
    • Mamet J, Baron A, Lazdunski M, and Voilley N (2002) Proinflammatory mediators, stimulators of sensory neuron excitability via the expression of acid-sensing ion channels. J Neurosci 22:10662–10670.
    • (2002) J Neurosci , vol.22 , pp. 10662-10670
    • Mamet, J.1    Baron, A.2    Lazdunski, M.3    Voilley, N.4
  • 266
    • 1542781733 scopus 로고    scopus 로고
    • How nerve growth factor drives physiological and inflammatory expressions of acid-sensing ion channel 3 in sensory neurons
    • Mamet J, Lazdunski M, and Voilley N (2003) How nerve growth factor drives physiological and inflammatory expressions of acid-sensing ion channel 3 in sensory neurons. J Biol Chem 278:48907–48913.
    • (2003) J Biol Chem , vol.278 , pp. 48907-48913
    • Mamet, J.1    Lazdunski, M.2    Voilley, N.3
  • 267
    • 0032698749 scopus 로고    scopus 로고
    • Aldosteronemediated regulation of ENaC alpha, beta, and gamma subunit proteins in rat kidney
    • Masilamani S, Kim GH, Mitchell C, Wade JB, and Knepper MA (1999) Aldosteronemediated regulation of ENaC alpha, beta, and gamma subunit proteins in rat kidney. J Clin Invest 104:R19–R23.
    • (1999) J Clin Invest , vol.104 , pp. R19-R23
    • Masilamani, S.1    Kim, G.H.2    Mitchell, C.3    Wade, J.B.4    Knepper, M.A.5
  • 268
    • 84884996129 scopus 로고    scopus 로고
    • Effect of amiloride and spironolactone on renal tubular function and central blood pressure in patients with arterial hypertension during baseline conditions and after furosemide: A double-blinded, randomized, placebo-controlled crossover trial
    • Matthesen SK, Larsen T, Vase H, Lauridsen TG, Jensen JM, and Pedersen EB (2013) Effect of amiloride and spironolactone on renal tubular function and central blood pressure in patients with arterial hypertension during baseline conditions and after furosemide: a double-blinded, randomized, placebo-controlled crossover trial. Clin Exp Hypertens 35:313–324.
    • (2013) Clin Exp Hypertens , vol.35 , pp. 313-324
    • Matthesen, S.K.1    Larsen, T.2    Vase, H.3    Lauridsen, T.G.4    Jensen, J.M.5    Pedersen, E.B.6
  • 272
    • 19344375529 scopus 로고    scopus 로고
    • Extracellular trypsin increases ASIC1a selectivity for monovalent versus divalent cations
    • Neaga E, Amuzescu B, Dinu C, Macri B, Pena F, and Flonta M-L (2005) Extracellular trypsin increases ASIC1a selectivity for monovalent versus divalent cations. J Neurosci Methods 144:241–248.
    • (2005) J Neurosci Methods , vol.144 , pp. 241-248
    • Neaga, E.1    Amuzescu, B.2    Dinu, C.3    Macri, B.4    Pena, F.5    Flonta, M.-L.6
  • 273
    • 77950790731 scopus 로고    scopus 로고
    • Differential effects of temperature on acid-activated currents mediated by TRPV1 and ASIC channels in rat dorsal root ganglion neurons
    • Neelands TR, Zhang XF, McDonald H, and Puttfarcken P (2010) Differential effects of temperature on acid-activated currents mediated by TRPV1 and ASIC channels in rat dorsal root ganglion neurons. Brain Res 1329:55–66.
    • (2010) Brain Res , vol.1329 , pp. 55-66
    • Neelands, T.R.1    Zhang, X.F.2    McDonald, H.3    Puttfarcken, P.4
  • 274
    • 84868342564 scopus 로고    scopus 로고
    • Aldosterone-dependent and -independent regulation of the epithelial sodium channel (ENaC) in mouse distal nephron
    • Nesterov V, Dahlmann A, Krueger B, Bertog M, Loffing J, and Korbmacher C (2012) Aldosterone-dependent and -independent regulation of the epithelial sodium channel (ENaC) in mouse distal nephron. Am J Physiol Renal Physiol 303:F1289–F1299.
    • (2012) Am J Physiol Renal Physiol , vol.303 , pp. F1289-F1299
    • Nesterov, V.1    Dahlmann, A.2    Krueger, B.3    Bertog, M.4    Loffing, J.5    Korbmacher, C.6
  • 275
    • 46749138207 scopus 로고    scopus 로고
    • Amiloride delays the onset of pilocarpine-induced seizures in rats
    • N’Gouemo P (2008) Amiloride delays the onset of pilocarpine-induced seizures in rats. Brain Res 1222:230–232.
    • (2008) Brain Res , vol.1222 , pp. 230-232
    • N’Gouemo, P.1
  • 278
    • 0021206520 scopus 로고
    • Voltage-dependent block by amiloride and other monovalent cations of apical Na channels in the toad urinary bladder
    • Palmer LG (1984) Voltage-dependent block by amiloride and other monovalent cations of apical Na channels in the toad urinary bladder. J Membr Biol 80:153–165.
    • (1984) J Membr Biol , vol.80 , pp. 153-165
    • Palmer, L.G.1
  • 279
    • 0024594643 scopus 로고
    • Interactions of amiloride and small monovalent cations with the epithelial sodium channel. Inferences about the nature of the channel pore
    • Palmer LG and Andersen OS (1989) Interactions of amiloride and small monovalent cations with the epithelial sodium channel. Inferences about the nature of the channel pore. Biophys J 55:779–787.
    • (1989) Biophys J , vol.55 , pp. 779-787
    • Palmer, L.G.1    Andersen, O.S.2
  • 280
    • 59649083746 scopus 로고    scopus 로고
    • The two-membrane model of epithelial transport: Koefoed-Johnsen and Ussing (1958)
    • Palmer LG and Andersen OS (2008) The two-membrane model of epithelial transport: Koefoed-Johnsen and Ussing (1958). J Gen Physiol 132:607–612.
    • (2008) J Gen Physiol , vol.132 , pp. 607-612
    • Palmer, L.G.1    Andersen, O.S.2
  • 281
    • 1842321591 scopus 로고
    • Amiloride-sensitive Na channels from the apical membrane of the rat cortical collecting tubule
    • Palmer LG and Frindt G (1986) Amiloride-sensitive Na channels from the apical membrane of the rat cortical collecting tubule. Proc Natl Acad Sci USA 83:2767–2770.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 2767-2770
    • Palmer, L.G.1    Frindt, G.2
  • 282
    • 0030033429 scopus 로고    scopus 로고
    • Gating of Na channels in the rat cortical collecting tubule: Effects of voltage and membrane stretch
    • Palmer LG and Frindt G (1996) Gating of Na channels in the rat cortical collecting tubule: effects of voltage and membrane stretch. J Gen Physiol 107:35–45.
    • (1996) J Gen Physiol , vol.107 , pp. 35-45
    • Palmer, L.G.1    Frindt, G.2
  • 283
    • 34547897739 scopus 로고    scopus 로고
    • Na+ and K+ transport by the renal connecting tubule
    • Palmer LG and Frindt G (2007) Na+ and K+ transport by the renal connecting tubule. Curr Opin Nephrol Hypertens 16:477–483.
    • (2007) Curr Opin Nephrol Hypertens , vol.16 , pp. 477-483
    • Palmer, L.G.1    Frindt, G.2
  • 284
    • 84858291432 scopus 로고    scopus 로고
    • Regulation and dysregulation of epithelial Na+ channels
    • Palmer LG, Patel A, and Frindt G (2012) Regulation and dysregulation of epithelial Na+ channels. Clin Exp Nephrol 16:35–43.
    • (2012) Clin Exp Nephrol , vol.16 , pp. 35-43
    • Palmer, L.G.1    Patel, A.2    Frindt, G.3
  • 285
    • 73649085483 scopus 로고    scopus 로고
    • Conformational changes associated with proton-dependent gating of ASIC1a
    • Passero CJ, Okumura S, and Carattino MD (2009) Conformational changes associated with proton-dependent gating of ASIC1a. J Biol Chem 284:36473–36481.
    • (2009) J Biol Chem , vol.284 , pp. 36473-36481
    • Passero, C.J.1    Okumura, S.2    Carattino, M.D.3
  • 286
    • 5144227428 scopus 로고    scopus 로고
    • Identification of the Ca2+ blocking site of acid-sensing ion channel (ASIC) 1: Implications for channel gating
    • Paukert M, Babini E, Pusch M, and Gründer S (2004) Identification of the Ca2+ blocking site of acid-sensing ion channel (ASIC) 1: implications for channel gating. J Gen Physiol 124:383–394.
    • (2004) J Gen Physiol , vol.124 , pp. 383-394
    • Paukert, M.1    Babini, E.2    Pusch, M.3    Gründer, S.4
  • 287
    • 38049100869 scopus 로고    scopus 로고
    • SchindelinH, andGründer S (2008)Candidate amino acids involved in H+ gating of acid-sensing ion channel 1a
    • Paukert M, Chen X, Polleichtner G, SchindelinH, andGründer S (2008)Candidate amino acids involved in H+ gating of acid-sensing ion channel 1a. J Biol Chem 283:572–581.
    • J Biol Chem , vol.283 , pp. 572-581
    • Paukert, M.1    Chen, X.2    Polleichtner, G.3
  • 288
    • 84870325152 scopus 로고    scopus 로고
    • A natural point mutation changes both target selectivity and mechanism of action of sea anemone toxins
    • Peigneur S, Béress L, Möller C, Marí F, Forssmann WG, and Tytgat J (2012) A natural point mutation changes both target selectivity and mechanism of action of sea anemone toxins. FASEB J 26:5141–5151.
    • (2012) FASEB J , vol.26 , pp. 5141-5151
    • Peigneur, S.1    Béress, L.2    Möller, C.3    Marí, F.4    Forssmann, W.G.5    Tytgat, J.6
  • 289
    • 84867205076 scopus 로고    scopus 로고
    • Acid sensing ion channels regulate neuronal excitability by inhibiting BK potassium channels
    • Petroff E, Snitsarev V, Gong H, and Abboud FM (2012) Acid sensing ion channels regulate neuronal excitability by inhibiting BK potassium channels. Biochem Biophys Res Commun 426:511–515.
    • (2012) Biochem Biophys Res Commun , vol.426 , pp. 511-515
    • Petroff, E.1    Snitsarev, V.2    Gong, H.3    Abboud, F.M.4
  • 294
    • 33845897638 scopus 로고    scopus 로고
    • Prolonged activation of ASIC1a and the time window for neuroprotection in cerebral ischaemia
    • Pignataro G, Simon RP, and Xiong ZG (2007) Prolonged activation of ASIC1a and the time window for neuroprotection in cerebral ischaemia. Brain 130:151–158.
    • (2007) Brain , vol.130 , pp. 151-158
    • Pignataro, G.1    Simon, R.P.2    Xiong, Z.G.3
  • 295
    • 33748893261 scopus 로고    scopus 로고
    • Distinct ASIC currents are expressed in rat putative nociceptors and are modulated by nerve injury
    • Poirot O, Berta T, Decosterd I, and Kellenberger S (2006) Distinct ASIC currents are expressed in rat putative nociceptors and are modulated by nerve injury. J Physiol 576:215–234.
    • (2006) J Physiol , vol.576 , pp. 215-234
    • Poirot, O.1    Berta, T.2    Decosterd, I.3    Kellenberger, S.4
  • 296
    • 4644243948 scopus 로고    scopus 로고
    • Selective regulation of acid-sensing ion channel 1 by serine proteases
    • Poirot O, Vukicevic M, Boesch A, and Kellenberger S (2004) Selective regulation of acid-sensing ion channel 1 by serine proteases. J Biol Chem 279:38448–38457.
    • (2004) J Biol Chem , vol.279 , pp. 38448-38457
    • Poirot, O.1    Vukicevic, M.2    Boesch, A.3    Kellenberger, S.4
  • 300
    • 84862009509 scopus 로고    scopus 로고
    • Potentiation of acid-sensing ion channel activity by the activation of 5-HT₂ receptors in rat dorsal root ganglion neurons
    • Qiu F, Qiu CY, Liu YQ, Wu D, Li JD, and Hu WP (2012) Potentiation of acid-sensing ion channel activity by the activation of 5-HT₂ receptors in rat dorsal root ganglion neurons. Neuropharmacology 63:494–500.
    • (2012) Neuropharmacology , vol.63 , pp. 494-500
    • Qiu, F.1    Qiu, C.Y.2    Liu, Y.Q.3    Wu, D.4    Li, J.D.5    Hu, W.P.6
  • 301
    • 0033581885 scopus 로고    scopus 로고
    • Activation of the epithelial Na+ channel (ENaC) requires CFTR Cl- channel function
    • Reddy MM, Light MJ, and Quinton PM (1999) Activation of the epithelial Na+ channel (ENaC) requires CFTR Cl- channel function. Nature 402:301–304.
    • (1999) Nature , vol.402 , pp. 301-304
    • Reddy, M.M.1    Light, M.J.2    Quinton, P.M.3
  • 302
    • 0028332337 scopus 로고
    • Biochemical analysis of the membrane topology of the amiloride-sensitive Na+ channel
    • Renard S, Lingueglia E, Voilley N, Lazdunski M, and Barbry P (1994) Biochemical analysis of the membrane topology of the amiloride-sensitive Na+ channel. J Biol Chem 269:12981–12986.
    • (1994) J Biol Chem , vol.269 , pp. 12981-12986
    • Renard, S.1    Lingueglia, E.2    Voilley, N.3    Lazdunski, M.4    Barbry, P.5
  • 303
    • 67651092155 scopus 로고    scopus 로고
    • Clinical and molecular features of type 1 pseudohypoaldosteronism
    • Riepe FG (2009) Clinical and molecular features of type 1 pseudohypoaldosteronism. Horm Res 72:1–9.
    • (2009) Horm Res , vol.72 , pp. 1-9
    • Riepe, F.G.1
  • 306
    • 84890407542 scopus 로고    scopus 로고
    • Epithelial sodium channel (ENaC) and the control of blood pressure
    • Rossier BC (2014) Epithelial sodium channel (ENaC) and the control of blood pressure. Curr Opin Pharmacol 15:33–46.
    • (2014) Curr Opin Pharmacol , vol.15 , pp. 33-46
    • Rossier, B.C.1
  • 307
    • 64149083549 scopus 로고    scopus 로고
    • Activation of the epithelial sodium channel (ENaC) by serine proteases
    • Rossier BC and Stutts MJ (2009) Activation of the epithelial sodium channel (ENaC) by serine proteases. Annu Rev Physiol 71:361–379.
    • (2009) Annu Rev Physiol , vol.71 , pp. 361-379
    • Rossier, B.C.1    Stutts, M.J.2
  • 308
    • 0033855771 scopus 로고    scopus 로고
    • Regulation of the epithelial sodium channel (ENaC) by accessory proteins
    • Rotin D (2000) Regulation of the epithelial sodium channel (ENaC) by accessory proteins. Curr Opin Nephrol Hypertens 9:529–534.
    • (2000) Curr Opin Nephrol Hypertens , vol.9 , pp. 529-534
    • Rotin, D.1
  • 312
    • 0033199894 scopus 로고    scopus 로고
    • Cloning and functional expression of a novel degenerin-like Na+ channel gene in mammals
    • Sakai H, Lingueglia E, Champigny G, Mattei MG, and Lazdunski M (1999) Cloning and functional expression of a novel degenerin-like Na+ channel gene in mammals. J Physiol 519:323–333.
    • (1999) J Physiol , vol.519 , pp. 323-333
    • Sakai, H.1    Lingueglia, E.2    Champigny, G.3    Mattei, M.G.4    Lazdunski, M.5
  • 313
    • 84900389579 scopus 로고    scopus 로고
    • Binding site and inhibitory mechanism of the mambalgin-2 pain-relieving peptide on acid-sensing ion channel 1a
    • Salinas M, Besson T, Delettre Q, Diochot S, Boulakirba S, Douguet D, and Lingueglia E (2014) Binding site and inhibitory mechanism of the mambalgin-2 pain-relieving peptide on acid-sensing ion channel 1a. J Biol Chem 289:13363–13373.
    • (2014) J Biol Chem , vol.289 , pp. 13363-13373
    • Salinas, M.1    Besson, T.2    Delettre, Q.3    Diochot, S.4    Boulakirba, S.5    Douguet, D.6    Lingueglia, E.7
  • 314
    • 33644610311 scopus 로고    scopus 로고
    • The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a
    • Salinas M, Rash LD, Baron A, Lambeau G, Escoubas P, and Lazdunski M (2006) The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a. J Physiol 570:339–354.
    • (2006) J Physiol , vol.570 , pp. 339-354
    • Salinas, M.1    Rash, L.D.2    Baron, A.3    Lambeau, G.4    Escoubas, P.5    Lazdunski, M.6
  • 315
    • 62549093076 scopus 로고    scopus 로고
    • Native and recombinant ASIC1a receptors conduct negligible Ca2+ entry
    • Samways DS, Harkins AB, and Egan TM (2009) Native and recombinant ASIC1a receptors conduct negligible Ca2+ entry. Cell Calcium 45:319–325.
    • (2009) Cell Calcium , vol.45 , pp. 319-325
    • Samways, D.S.1    Harkins, A.B.2    Egan, T.M.3
  • 317
    • 11244269414 scopus 로고    scopus 로고
    • Analysis of the membrane topology of the acid-sensing ion channel 2a
    • Saugstad JA, Roberts JA, Dong J, Zeitouni S, and Evans RJ (2004) Analysis of the membrane topology of the acid-sensing ion channel 2a. J Biol Chem 279: 55514–55519.
    • (2004) J Biol Chem , vol.279 , pp. 55514-55519
    • Saugstad, J.A.1    Roberts, J.A.2    Dong, J.3    Zeitouni, S.4    Evans, R.J.5
  • 318
    • 0034646967 scopus 로고    scopus 로고
    • Molecular cloning, functional expression and chromosomal localization of an amiloridesensitive Na(+) channel from human small intestine
    • Schaefer L, Sakai H, Mattei M, Lazdunski M, and Lingueglia E (2000) Molecular cloning, functional expression and chromosomal localization of an amiloridesensitive Na(+) channel from human small intestine. FEBS Lett 471:205–210.
    • (2000) FEBS Lett , vol.471 , pp. 205-210
    • Schaefer, L.1    Sakai, H.2    Mattei, M.3    Lazdunski, M.4    Lingueglia, E.5
  • 319
    • 0025083637 scopus 로고
    • CAMP mediates the increase in apical membrane Na+ conductance produced in rat CCD by vasopressin
    • Schafer JA and Troutman SL (1990) cAMP mediates the increase in apical membrane Na+ conductance produced in rat CCD by vasopressin. Am J Physiol 259: F823–F831.
    • (1990) Am J Physiol , vol.259 , pp. F823-F831
    • Schafer, J.A.1    Troutman, S.L.2
  • 320
    • 0029046975 scopus 로고
    • A mutation in the epithelial sodium channel causing Liddle disease increases channel activity in the Xenopus laevis oocyte expression system
    • Schild L, Canessa CM, Shimkets RA, Gautschi I, Lifton RP, and Rossier BC (1995) A mutation in the epithelial sodium channel causing Liddle disease increases channel activity in the Xenopus laevis oocyte expression system. Proc Natl Acad Sci USA 92:5699–5703.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5699-5703
    • Schild, L.1    Canessa, C.M.2    Shimkets, R.A.3    Gautschi, I.4    Lifton, R.P.5    Rossier, B.C.6
  • 321
    • 0031017054 scopus 로고    scopus 로고
    • Identification of amino acid residues in the alpha, beta, and gamma subunits of the epithelial sodium channel (ENaC) involved in amiloride block and ion permeation
    • Schild L, Schneeberger E, Gautschi I, and Firsov D (1997) Identification of amino acid residues in the alpha, beta, and gamma subunits of the epithelial sodium channel (ENaC) involved in amiloride block and ion permeation. J Gen Physiol 109:15–26.
    • (1997) J Gen Physiol , vol.109 , pp. 15-26
    • Schild, L.1    Schneeberger, E.2    Gautschi, I.3    Firsov, D.4
  • 322
    • 59149099842 scopus 로고    scopus 로고
    • The cytoskeletal protein alpha-actinin regulates acid-sensing ion channel 1a through a C-terminal interaction
    • Schnizler MK, Schnizler K, Zha XM, Hall DD, Wemmie JA, Hell JW, and Welsh MJ (2009) The cytoskeletal protein alpha-actinin regulates acid-sensing ion channel 1a through a C-terminal interaction. J Biol Chem 284:2697–2705.
    • (2009) J Biol Chem , vol.284 , pp. 2697-2705
    • Schnizler, M.K.1    Schnizler, K.2    Zha, X.M.3    Hall, D.D.4    Wemmie, J.A.5    Hell, J.W.6    Welsh, M.J.7
  • 323
    • 84884585458 scopus 로고    scopus 로고
    • Novel small molecule epithelial sodium channel inhibitors as potential therapeutics in cystic fibrosis - a patent evaluation
    • Schoenberger M and Althaus M (2013) Novel small molecule epithelial sodium channel inhibitors as potential therapeutics in cystic fibrosis - a patent evaluation. Expert Opin Ther Pat 23:1383–1389.
    • (2013) Expert Opin Ther Pat , vol.23 , pp. 1383-1389
    • Schoenberger, M.1    Althaus, M.2
  • 325
    • 0036673386 scopus 로고    scopus 로고
    • Lactate, glucose and energy metabolism in the ischemic brain (Review)
    • Schurr A (2002) Lactate, glucose and energy metabolism in the ischemic brain (Review). Review Int J Mol Med 10:131–136.
    • (2002) Review Int J Mol Med , vol.10 , pp. 131-136
    • Schurr, A.1
  • 328
    • 0035941353 scopus 로고    scopus 로고
    • Second transmembrane domains of ENaC subunits contribute to ion permeation and selectivity
    • Sheng S, McNulty KA, Harvey JM, and Kleyman TR (2001) Second transmembrane domains of ENaC subunits contribute to ion permeation and selectivity. J Biol Chem 276:44091–44098.
    • (2001) J Biol Chem , vol.276 , pp. 44091-44098
    • Sheng, S.1    McNulty, K.A.2    Harvey, J.M.3    Kleyman, T.R.4
  • 329
    • 14844319275 scopus 로고    scopus 로고
    • Side chain orientation of residues lining the selectivity filter of epithelial Na+ channels
    • Sheng S, Perry CJ, Kashlan OB, and Kleyman TR (2005) Side chain orientation of residues lining the selectivity filter of epithelial Na+ channels. J Biol Chem 280: 8513–8522.
    • (2005) J Biol Chem , vol.280 , pp. 8513-8522
    • Sheng, S.1    Perry, C.J.2    Kashlan, O.B.3    Kleyman, T.R.4
  • 330
    • 0034708765 scopus 로고    scopus 로고
    • Characterization of the selectivity filter of the epithelial sodium channel
    • Sheng S, Li J, McNulty KA, Avery D, and Kleyman TR (2000) Characterization of the selectivity filter of the epithelial sodium channel. J Biol Chem 275:8572–8581.
    • (2000) J Biol Chem , vol.275 , pp. 8572-8581
    • Sheng, S.1    Li, J.2    McNulty, K.A.3    Avery, D.4    Kleyman, T.R.5
  • 331
    • 70350441287 scopus 로고    scopus 로고
    • Identification of protein domains that control proton and calcium sensitivity of ASIC1a
    • Sherwood T, Franke R, Conneely S, Joyner J, Arumugan P, and Askwith C (2009) Identification of protein domains that control proton and calcium sensitivity of ASIC1a. J Biol Chem 284:27899–27907.
    • (2009) J Biol Chem , vol.284 , pp. 27899-27907
    • Sherwood, T.1    Franke, R.2    Conneely, S.3    Joyner, J.4    Arumugan, P.5    Askwith, C.6
  • 332
    • 38349137692 scopus 로고    scopus 로고
    • Endogenous arginine-phenylalanine-amiderelated peptides alter steady-state desensitization of ASIC1a
    • Sherwood TW and Askwith CC (2008) Endogenous arginine-phenylalanine-amiderelated peptides alter steady-state desensitization of ASIC1a. J Biol Chem 283: 1818–1830.
    • (2008) J Biol Chem , vol.283 , pp. 1818-1830
    • Sherwood, T.W.1    Askwith, C.C.2
  • 333
    • 70449623627 scopus 로고    scopus 로고
    • Dynorphin opioid peptides enhance acidsensing ion channel 1a activity and acidosis-induced neuronal death
    • Sherwood TW and Askwith CC (2009) Dynorphin opioid peptides enhance acidsensing ion channel 1a activity and acidosis-induced neuronal death. J Neurosci 29:14371–14380.
    • (2009) J Neurosci , vol.29 , pp. 14371-14380
    • Sherwood, T.W.1    Askwith, C.C.2
  • 335
    • 79960024474 scopus 로고    scopus 로고
    • Heteromeric acidsensing ion channels (ASICs) composed of ASIC2b and ASIC1a display novel channel properties and contribute to acidosis-induced neuronal death
    • Sherwood TW, Lee KG, Gormley MG, and Askwith CC (2011) Heteromeric acidsensing ion channels (ASICs) composed of ASIC2b and ASIC1a display novel channel properties and contribute to acidosis-induced neuronal death. J Neurosci 31:9723–9734.
    • (2011) J Neurosci , vol.31 , pp. 9723-9734
    • Sherwood, T.W.1    Lee, K.G.2    Gormley, M.G.3    Askwith, C.C.4
  • 336
    • 0030820814 scopus 로고    scopus 로고
    • The activity of the epithelial sodium channel is regulated by clathrin-mediated endocytosis
    • Shimkets RA, Lifton RP, and Canessa CM (1997) The activity of the epithelial sodium channel is regulated by clathrin-mediated endocytosis. J Biol Chem 272: 25537–25541.
    • (1997) J Biol Chem , vol.272 , pp. 25537-25541
    • Shimkets, R.A.1    Lifton, R.P.2    Canessa, C.M.3
  • 338
    • 70149084337 scopus 로고    scopus 로고
    • Acid-sensing ion channels: A new target for pain and CNS diseases
    • Sluka KA, Winter OC, and Wemmie JA (2009) Acid-sensing ion channels: A new target for pain and CNS diseases. Curr Opin Drug Discov Devel 12:693–704.
    • (2009) Curr Opin Drug Discov Devel , vol.12 , pp. 693-704
    • Sluka, K.A.1    Winter, O.C.2    Wemmie, J.A.3
  • 339
    • 33847369550 scopus 로고    scopus 로고
    • Arachidonic acid potentiates acidsensing ion channels in rat sensory neurons by a direct action
    • Smith ES, Cadiou H, and McNaughton PA (2007) Arachidonic acid potentiates acidsensing ion channels in rat sensory neurons by a direct action. Neuroscience 145: 686–698.
    • (2007) Neuroscience , vol.145 , pp. 686-698
    • Smith, E.S.1    Cadiou, H.2    McNaughton, P.A.3
  • 341
    • 0033664533 scopus 로고    scopus 로고
    • Gating induces a conformational change in the outer vestibule of ENaC
    • Snyder PM, Bucher DB, and Olson DR (2000) Gating induces a conformational change in the outer vestibule of ENaC. J Gen Physiol 116:781–790.
    • (2000) J Gen Physiol , vol.116 , pp. 781-790
    • Snyder, P.M.1    Bucher, D.B.2    Olson, D.R.3
  • 342
    • 0028102539 scopus 로고
    • Membrane topology of the amiloride-sensitive epithelial sodium channel
    • Snyder PM, McDonald FJ, Stokes JB, and Welsh MJ (1994) Membrane topology of the amiloride-sensitive epithelial sodium channel. J Biol Chem 269:24379–24383.
    • (1994) J Biol Chem , vol.269 , pp. 24379-24383
    • Snyder, P.M.1    McDonald, F.J.2    Stokes, J.B.3    Welsh, M.J.4
  • 343
    • 0033215392 scopus 로고    scopus 로고
    • A pore segment in DEG/ENaC Na(+) channels
    • Snyder PM, Olson DR, and Bucher DB (1999) A pore segment in DEG/ENaC Na(+) channels. J Biol Chem 274:28484–28490.
    • (1999) J Biol Chem , vol.274 , pp. 28484-28490
    • Snyder, P.M.1    Olson, D.R.2    Bucher, D.B.3
  • 344
    • 8544270944 scopus 로고    scopus 로고
    • Zhou R, and Steines JC (2004) cAMP and serum and glucocorticoid-inducible kinase (SGK) regulate the epithelial Na(+) channel through convergent phosphorylation of Nedd4-2
    • Snyder PM, Olson DR, Kabra R, Zhou R, and Steines JC (2004) cAMP and serum and glucocorticoid-inducible kinase (SGK) regulate the epithelial Na(+) channel through convergent phosphorylation of Nedd4-2. J Biol Chem 279:45753–45758.
    • J Biol Chem , vol.279 , pp. 45753-45758
    • Snyder, P.M.1    Olson, D.R.2    Kabra, R.3
  • 345
    • 37549040597 scopus 로고    scopus 로고
    • Differential activities of glucocorticoid-induced leucine zipper protein isoforms
    • Soundararajan R, Wang J, Melters D, and Pearce D (2007) Differential activities of glucocorticoid-induced leucine zipper protein isoforms. J Biol Chem 282:36303–36313.
    • (2007) J Biol Chem , vol.282 , pp. 36303-36313
    • Soundararajan, R.1    Wang, J.2    Melters, D.3    Pearce, D.4
  • 346
    • 79959888193 scopus 로고    scopus 로고
    • The interaction between two extracellular linker regions controls sustained opening of acid-sensing ion channel 1
    • Springauf A, Bresenitz P, and Gründer S (2011) The interaction between two extracellular linker regions controls sustained opening of acid-sensing ion channel 1. J Biol Chem 286:24374–24384.
    • (2011) J Biol Chem , vol.286 , pp. 24374-24384
    • Springauf, A.1    Bresenitz, P.2    Gründer, S.3
  • 349
  • 350
    • 79960350216 scopus 로고    scopus 로고
    • Evolution of the epithelial sodium channel and the sodium pump as limiting factors of aldosterone action on sodium transport
    • Studer RA, Person E, Robinson-Rechavi M, and Rossier BC (2011) Evolution of the epithelial sodium channel and the sodium pump as limiting factors of aldosterone action on sodium transport. Physiol Genomics 43:844–854.
    • (2011) Physiol Genomics , vol.43 , pp. 844-854
    • Studer, R.A.1    Person, E.2    Robinson-Rechavi, M.3    Rossier, B.C.4
  • 351
    • 78751703302 scopus 로고    scopus 로고
    • Regulation of acid-sensing ion channel 1a function by tissue kallikrein may be through channel cleavage
    • Su J, Tang Y, Liu L, Zhou H, and Dong Q (2011) Regulation of acid-sensing ion channel 1a function by tissue kallikrein may be through channel cleavage. Neurosci Lett 490:46–51.
    • (2011) Neurosci Lett , vol.490 , pp. 46-51
    • Su, J.1    Tang, Y.2    Liu, L.3    Zhou, H.4    Dong, Q.5
  • 353
    • 84863238020 scopus 로고    scopus 로고
    • Angiotensin II stimulates epithelial sodium channels in the cortical collecting duct of the rat kidney
    • Sun P, Yue P, and Wang WH (2012) Angiotensin II stimulates epithelial sodium channels in the cortical collecting duct of the rat kidney. Am J Physiol Renal Physiol 302:F679–F687.
    • (2012) Am J Physiol Renal Physiol , vol.302 , pp. F679-F687
    • Sun, P.1    Yue, P.2    Wang, W.H.3
  • 354
    • 0035895248 scopus 로고    scopus 로고
    • Acid-sensing ion channel 3 matches the acid-gated current in cardiac ischemia-sensing neurons
    • Sutherland SP, Benson CJ, Adelman JP, and McCleskey EW (2001) Acid-sensing ion channel 3 matches the acid-gated current in cardiac ischemia-sensing neurons. Proc Natl Acad Sci USA 98:711–716.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 711-716
    • Sutherland, S.P.1    Benson, C.J.2    Adelman, J.P.3    McCleskey, E.W.4
  • 355
    • 36148964376 scopus 로고    scopus 로고
    • Cadmium trapping in an epithelial sodium channel pore mutant
    • Takeda AN, Gautschi I, van Bemmelen MX, and Schild L (2007) Cadmium trapping in an epithelial sodium channel pore mutant. J Biol Chem 282:31928–31936.
    • (2007) J Biol Chem , vol.282 , pp. 31928-31936
    • Takeda, A.N.1    Gautschi, I.2    Van Bemmelen, M.X.3    Schild, L.4
  • 357
    • 0036802854 scopus 로고    scopus 로고
    • Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors
    • Ugawa S, Ueda T, Ishida Y, Nishigaki M, Shibata Y, and Shimada S (2002) Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors. J Clin Invest 110:1185–1190.
    • (2002) J Clin Invest , vol.110 , pp. 1185-1190
    • Ugawa, S.1    Ueda, T.2    Ishida, Y.3    Nishigaki, M.4    Shibata, Y.5    Shimada, S.6
  • 358
    • 0030879756 scopus 로고    scopus 로고
    • An epithelial serine protease activates the amiloride-sensitive sodium channel
    • Vallet V, Chraibi A, Gaeggeler HP, Horisberger JD, and Rossier BC (1997) An epithelial serine protease activates the amiloride-sensitive sodium channel. Nature 389:607–610.
    • (1997) Nature , vol.389 , pp. 607-610
    • Vallet, V.1    Chraibi, A.2    Gaeggeler, H.P.3    Horisberger, J.D.4    Rossier, B.C.5
  • 359
    • 79551700814 scopus 로고    scopus 로고
    • Acid-sensing ion channel 1 is involved in both axonal injury and demyelination in multiple sclerosis and its animal model
    • Vergo S, Craner MJ, Etzensperger R, Attfield K, Friese MA, Newcombe J, Esiri M, and Fugger L (2011) Acid-sensing ion channel 1 is involved in both axonal injury and demyelination in multiple sclerosis and its animal model. Brain 134:571–584.
    • (2011) Brain , vol.134 , pp. 571-584
    • Vergo, S.1    Craner, M.J.2    Etzensperger, R.3    Attfield, K.4    Friese, M.A.5    Newcombe, J.6    Esiri, M.7    Fugger, L.8
  • 360
    • 0035887733 scopus 로고    scopus 로고
    • Nonsteroid antiinflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors
    • Voilley N, de Weille J, Mamet J, and Lazdunski M (2001) Nonsteroid antiinflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors. J Neurosci 21:8026–8033.
    • (2001) J Neurosci , vol.21 , pp. 8026-8033
    • Voilley, N.1    De Weille, J.2    Mamet, J.3    Lazdunski, M.4
  • 361
    • 0036023427 scopus 로고    scopus 로고
    • Synergistic activation of ENaC by three membrane-bound channel-activating serine proteases (mCAP1, mCAP2, and mCAP3) and serum- and glucocorticoid-regulated kinase (Sgk1) in Xenopus Oocytes
    • Vuagniaux G, Vallet V, Jaeger NF, Hummler E, and Rossier BC (2002) Synergistic activation of ENaC by three membrane-bound channel-activating serine proteases (mCAP1, mCAP2, and mCAP3) and serum- and glucocorticoid-regulated kinase (Sgk1) in Xenopus Oocytes. J Gen Physiol 120:191–201.
    • (2002) J Gen Physiol , vol.120 , pp. 191-201
    • Vuagniaux, G.1    Vallet, V.2    Jaeger, N.F.3    Hummler, E.4    Rossier, B.C.5
  • 363
    • 4143124351 scopus 로고    scopus 로고
    • Modulatory effects of acid-sensing ion channels on action potential generation in hippocampal neurons
    • Vukicevic M and Kellenberger S (2004) Modulatory effects of acid-sensing ion channels on action potential generation in hippocampal neurons. Am J Physiol Cell Physiol 287:C682–C690.
    • (2004) Am J Physiol Cell Physiol , vol.287 , pp. C682-C690
    • Vukicevic, M.1    Kellenberger, S.2
  • 364
    • 33644861783 scopus 로고    scopus 로고
    • Trypsin cleaves acid-sensing ion channel 1a in a domain that is critical for channel gating
    • Vukicevic M, Weder G, Boillat A, Boesch A, and Kellenberger S (2006) Trypsin cleaves acid-sensing ion channel 1a in a domain that is critical for channel gating. J Biol Chem 281:714–722.
    • (2006) J Biol Chem , vol.281 , pp. 714-722
    • Vukicevic, M.1    Weder, G.2    Boillat, A.3    Boesch, A.4    Kellenberger, S.5
  • 365
    • 0030826633 scopus 로고    scopus 로고
    • Molecular cloning of a non-inactivating proton-gated Na+ channel specific for sensory neurons
    • Waldmann R, Bassilana F, de Weille J, Champigny G, Heurteaux C, and Lazdunski M (1997a) Molecular cloning of a non-inactivating proton-gated Na+ channel specific for sensory neurons. J Biol Chem 272:20975–20978.
    • (1997) J Biol Chem , vol.272 , pp. 20975-20978
    • Waldmann, R.1    Bassilana, F.2    De Weille, J.3    Champigny, G.4    Heurteaux, C.5    Lazdunski, M.6
  • 367
    • 0028874955 scopus 로고
    • Molecular cloning and functional expression of a novel amiloride-sensitive Na+ channel
    • Waldmann R, Champigny G, Bassilana F, Voilley N, and Lazdunski M (1995) Molecular cloning and functional expression of a novel amiloride-sensitive Na+ channel. J Biol Chem 270:27411–27414.
    • (1995) J Biol Chem , vol.270 , pp. 27411-27414
    • Waldmann, R.1    Champigny, G.2    Bassilana, F.3    Voilley, N.4    Lazdunski, M.5
  • 368
    • 33749380313 scopus 로고    scopus 로고
    • Modulation of acid-sensing ion channel currents, acid-induced increase of intracellular Ca2+, and acidosis-mediated neuronal injury by intracellular pH
    • Wang WZ, Chu XP, Li MH, Seeds J, Simon RP, and Xiong ZG (2006) Modulation of acid-sensing ion channel currents, acid-induced increase of intracellular Ca2+, and acidosis-mediated neuronal injury by intracellular pH. J Biol Chem 281: 29369–29378.
    • (2006) J Biol Chem , vol.281 , pp. 29369-29378
    • Wang, W.Z.1    Chu, X.P.2    Li, M.H.3    Seeds, J.4    Simon, R.P.5    Xiong, Z.G.6
  • 369
    • 84874619981 scopus 로고    scopus 로고
    • Serotonin facilitates peripheral pain sensitivity in a manner that depends on the nonproton ligand sensing domain of ASIC3 channel
    • Wang X, Li WG, Yu Y, Xiao X, Cheng J, Zeng WZ, Peng Z, Xi Zhu M, and Xu TL (2013) Serotonin facilitates peripheral pain sensitivity in a manner that depends on the nonproton ligand sensing domain of ASIC3 channel. J Neurosci 33:4265–4279.
    • (2013) J Neurosci , vol.33 , pp. 4265-4279
    • Wang, X.1    Li, W.G.2    Yu, Y.3    Xiao, X.4    Cheng, J.5    Zeng, W.Z.6    Peng, Z.7    Xi Zhu, M.8    Xu, T.L.9
  • 370
    • 0033594911 scopus 로고    scopus 로고
    • Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis
    • Warner TD, Giuliano F, Vojnovic I, Bukasa A, Mitchell JA, and Vane JR (1999) Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis. Proc Natl Acad Sci USA 96:7563–7568.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 7563-7568
    • Warner, T.D.1    Giuliano, F.2    Vojnovic, I.3    Bukasa, A.4    Mitchell, J.A.5    Vane, J.R.6
  • 371
    • 0038384013 scopus 로고    scopus 로고
    • Acid-sensing ion channel 1 is localized in brain regions with high synaptic density and contributes to fear conditioning
    • Wemmie JA, Askwith CC, Lamani E, Cassell MD, Freeman JH Jr, and Welsh MJ (2003) Acid-sensing ion channel 1 is localized in brain regions with high synaptic density and contributes to fear conditioning. J Neurosci 23:5496–5502.
    • (2003) J Neurosci , vol.23 , pp. 5496-5502
    • Wemmie, J.A.1    Askwith, C.C.2    Lamani, E.3    Cassell, M.D.4    Freeman, J.H.5    Welsh, M.J.6
  • 374
    • 33748797928 scopus 로고    scopus 로고
    • Acid-sensing ion channels: Advances, questions and therapeutic opportunities
    • Wemmie JA, Price MP, and Welsh MJ (2006) Acid-sensing ion channels: advances, questions and therapeutic opportunities. Trends Neurosci 29:578–586.
    • (2006) Trends Neurosci , vol.29 , pp. 578-586
    • Wemmie, J.A.1    Price, M.P.2    Welsh, M.J.3
  • 375
  • 376
    • 77957258310 scopus 로고    scopus 로고
    • A single amino acid tunes Ca2+ inhibition of brain liver intestine Na+ channel (BLINaC)
    • Wiemuth D and Gründer S (2010) A single amino acid tunes Ca2+ inhibition of brain liver intestine Na+ channel (BLINaC). J Biol Chem 285:30404–30410.
    • (2010) J Biol Chem , vol.285 , pp. 30404-30410
    • Wiemuth, D.1    Gründer, S.2
  • 377
    • 80054777578 scopus 로고    scopus 로고
    • The pharmacological profile of brain liver intestine Na+ channel: Inhibition by diarylamidines and activation by fenamates
    • Wiemuth D and Gründer S (2011) The pharmacological profile of brain liver intestine Na+ channel: inhibition by diarylamidines and activation by fenamates. Mol Pharmacol 80:911–919.
    • (2011) Mol Pharmacol , vol.80 , pp. 911-919
    • Wiemuth, D.1    Gründer, S.2
  • 380
    • 6344281041 scopus 로고    scopus 로고
    • Characterization of acid-sensing ion channels in dorsal horn neurons of rat spinal cord
    • Wu LJ, Duan B, Mei YD, Gao J, Chen JG, Zhuo M, Xu L, Wu M, and Xu TL (2004) Characterization of acid-sensing ion channels in dorsal horn neurons of rat spinal cord. J Biol Chem 279:43716–43724.
    • (2004) J Biol Chem , vol.279 , pp. 43716-43724
    • Wu, L.J.1    Duan, B.2    Mei, Y.D.3    Gao, J.4    Chen, J.G.5    Zhuo, M.6    Xu, L.7    Wu, M.8    Xu, T.L.9
  • 383
    • 33748362837 scopus 로고    scopus 로고
    • Sustained currents through ASIC3 ion channels at the modest pH changes that occur during myocardial ischemia
    • Yagi J, Wenk HN, Naves LA, and McCleskey EW (2006) Sustained currents through ASIC3 ion channels at the modest pH changes that occur during myocardial ischemia. Circ Res 99:501–509.
    • (2006) Circ Res , vol.99 , pp. 501-509
    • Yagi, J.1    Wenk, H.N.2    Naves, L.A.3    McCleskey, E.W.4
  • 384
    • 84897568931 scopus 로고    scopus 로고
    • Ion channels and migraine
    • Yan J and Dussor G (2014) Ion channels and migraine. Headache 54:619–639.
    • (2014) Headache , vol.54 , pp. 619-639
    • Yan, J.1    Dussor, G.2
  • 385
    • 78650415308 scopus 로고    scopus 로고
    • Dural afferents express acid-sensing ion channels: A role for decreased meningeal pH in migraine headache
    • Yan J, Edelmayer RM, Wei X, De Felice M, Porreca F, and Dussor G (2011) Dural afferents express acid-sensing ion channels: a role for decreased meningeal pH in migraine headache. Pain 152:106–113.
    • (2011) Pain , vol.152 , pp. 106-113
    • Yan, J.1    Edelmayer, R.M.2    Wei, X.3    De Felice, M.4    Porreca, F.5    Dussor, G.6
  • 386
    • 68049145097 scopus 로고    scopus 로고
    • Inherent dynamics of the acid-sensing ion channel 1 correlates with the gating mechanism
    • Yang H, Yu Y, Li WG, Yu F, Cao H, Xu TL, and Jiang H (2009) Inherent dynamics of the acid-sensing ion channel 1 correlates with the gating mechanism. PLoS Biol 7:e1000151.
    • (2009) Plos Biol , vol.7
    • Yang, H.1    Yu, Y.2    Li, W.G.3    Yu, F.4    Cao, H.5    Xu, T.L.6    Jiang, H.7
  • 387
    • 84860352363 scopus 로고    scopus 로고
    • Highly conserved salt bridge stabilizes rigid signal patch at extracellular loop critical for surface expression of acid-sensing ion channels
    • Yang Y, Yu Y, Cheng J, Liu Y, Liu DS, Wang J, Zhu MX, Wang R, and Xu TL (2012) Highly conserved salt bridge stabilizes rigid signal patch at extracellular loop critical for surface expression of acid-sensing ion channels. J Biol Chem 287:14443–14455.
    • (2012) J Biol Chem , vol.287 , pp. 14443-14455
    • Yang, Y.1    Yu, Y.2    Cheng, J.3    Liu, Y.4    Liu, D.S.5    Wang, J.6    Zhu, M.X.7    Wang, R.8    Xu, T.L.9
  • 389
    • 79960127490 scopus 로고    scopus 로고
    • Atomic level characterization of the nonproton ligand-sensing domain of ASIC3 channels
    • Yu Y, Li WG, Chen Z, Cao H, Yang H, Jiang H, and Xu TL (2011) Atomic level characterization of the nonproton ligand-sensing domain of ASIC3 channels. J Biol Chem 286:24996–25006.
    • (2011) J Biol Chem , vol.286 , pp. 24996-25006
    • Yu, Y.1    Li, W.G.2    Chen, Z.3    Cao, H.4    Yang, H.5    Jiang, H.6    Xu, T.L.7
  • 390
    • 67649974460 scopus 로고    scopus 로고
    • ASIC2 subunits target acid-sensing ion channels to the synapse via an association with PSD-95
    • Zha XM, Costa V, Harding AM, Reznikov L, Benson CJ and Welsh MJ (2009) ASIC2 subunits target acid-sensing ion channels to the synapse via an association with PSD-95. J Neurosci 29:8438–8446.
    • (2009) J Neurosci , vol.29 , pp. 8438-8446
    • Zha, X.M.1    Costa, V.2    Harding, A.M.3    Reznikov, L.4    Benson, C.J.5    Welsh, M.J.6
  • 391
    • 33750840489 scopus 로고    scopus 로고
    • Acid-sensing ion channel 1a is a postsynaptic proton receptor that affects the density of dendritic spines
    • Zha XM, Wemmie JA, Green SH, and Welsh MJ (2006) Acid-sensing ion channel 1a is a postsynaptic proton receptor that affects the density of dendritic spines. Proc Natl Acad Sci USA 103:16556–16561.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 16556-16561
    • Zha, X.M.1    Wemmie, J.A.2    Green, S.H.3    Welsh, M.J.4
  • 392
    • 31744442245 scopus 로고    scopus 로고
    • Gating of acid-sensitive ion channel-1: Release of Ca2+ block vs. allosteric mechanism
    • Zhang P, Sigworth FJ, and Canessa CM (2006) Gating of acid-sensitive ion channel-1: release of Ca2+ block vs. allosteric mechanism. J Gen Physiol 127: 109–117.
    • (2006) J Gen Physiol , vol.127 , pp. 109-117
    • Zhang, P.1    Sigworth, F.J.2    Canessa, C.M.3


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