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Volumn 10, Issue 3, 2010, Pages 294-299

Osmolytes and ion transport modulators: New strategies for airway surface rehydration

Author keywords

[No Author keywords available]

Indexed keywords

AMILORIDE; AQUAPORIN 3; AQUAPORIN 4; AQUAPORIN 5; CAMOSTAT; DENUFOSOL; DEOXYRIBONUCLEASE; EPITHELIAL SODIUM CHANNEL; GS 9411; INO 4995; MANNITOL; OSMOTIC AGENT; P 552 02; PLACEBO; PURINERGIC P2Y2 RECEPTOR; QAU 145; SODIUM CHANNEL BLOCKING AGENT; SODIUM CHLORIDE; UNCLASSIFIED DRUG; OSMOTIC DIURETIC AGENT;

EID: 77954656825     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2010.04.003     Document Type: Review
Times cited : (25)

References (36)
  • 1
    • 33845992179 scopus 로고    scopus 로고
    • Evidence for airway surface dehydration as the initiating event in CF airway disease
    • Boucher R.C. Evidence for airway surface dehydration as the initiating event in CF airway disease. J Intern Med 2007, 261:5-16.
    • (2007) J Intern Med , vol.261 , pp. 5-16
    • Boucher, R.C.1
  • 3
    • 34447498842 scopus 로고    scopus 로고
    • Inhaled mannitol in cystic fibrosis
    • Wills P.J. Inhaled mannitol in cystic fibrosis. Expert Opin Investig Drugs 2007, 16:1121-1126.
    • (2007) Expert Opin Investig Drugs , vol.16 , pp. 1121-1126
    • Wills, P.J.1
  • 4
    • 0036371788 scopus 로고    scopus 로고
    • Osmotic stimuli increase clearance of mucus in patients with mucociliary dysfunction
    • Daviskas E., Robinson M., Anderson S.D., Bye P.T. Osmotic stimuli increase clearance of mucus in patients with mucociliary dysfunction. J Aerosol Med 2002, 15:331-341.
    • (2002) J Aerosol Med , vol.15 , pp. 331-341
    • Daviskas, E.1    Robinson, M.2    Anderson, S.D.3    Bye, P.T.4
  • 6
  • 7
    • 0029916071 scopus 로고    scopus 로고
    • Effect of hypertonic saline, amiloride, and cough on mucociliary clearance in patients with cystic fibrosis
    • Robinson M., Regnis J.A., Bailey D.L., King M., Bautovich G.J., Bye P.T. Effect of hypertonic saline, amiloride, and cough on mucociliary clearance in patients with cystic fibrosis. Am J Respir Crit Care Med 1996, 153:1503-1509.
    • (1996) Am J Respir Crit Care Med , vol.153 , pp. 1503-1509
    • Robinson, M.1    Regnis, J.A.2    Bailey, D.L.3    King, M.4    Bautovich, G.J.5    Bye, P.T.6
  • 9
    • 33748744717 scopus 로고    scopus 로고
    • Hypertonic saline therapy in cystic fibrosis: evidence against the proposed mechanism involving aquaporins
    • Levin M.H., Sullivan S., Nielson D., Yang B., Finkbeiner W.E., Verkman A.S. Hypertonic saline therapy in cystic fibrosis: evidence against the proposed mechanism involving aquaporins. J Biol Chem 2006, 281:25803-25812.
    • (2006) J Biol Chem , vol.281 , pp. 25803-25812
    • Levin, M.H.1    Sullivan, S.2    Nielson, D.3    Yang, B.4    Finkbeiner, W.E.5    Verkman, A.S.6
  • 11
    • 0035922668 scopus 로고    scopus 로고
    • Comparison of hypertonic saline and alternate-day or daily recombinant human deoxyribonuclease in children with cystic fibrosis: a randomised trial
    • Suri R., Metcalfe C., Lees B., Grieve R., Flather M., Normand C., Thompson S., Bush A., Wallis C. Comparison of hypertonic saline and alternate-day or daily recombinant human deoxyribonuclease in children with cystic fibrosis: a randomised trial. Lancet 2001, 358:1316-1321.
    • (2001) Lancet , vol.358 , pp. 1316-1321
    • Suri, R.1    Metcalfe, C.2    Lees, B.3    Grieve, R.4    Flather, M.5    Normand, C.6    Thompson, S.7    Bush, A.8    Wallis, C.9
  • 12
    • 30944452609 scopus 로고    scopus 로고
    • Restoring airway surface liquid in cystic fibrosis
    • Ratjen F. Restoring airway surface liquid in cystic fibrosis. N Engl J Med 2006, 354:291-293.
    • (2006) N Engl J Med , vol.354 , pp. 291-293
    • Ratjen, F.1
  • 13
    • 44649197130 scopus 로고    scopus 로고
    • Front-runners for pharmacotherapeutic correction of the airway ion transport defect in cystic fibrosis
    • Clunes M.T., Boucher R.C. Front-runners for pharmacotherapeutic correction of the airway ion transport defect in cystic fibrosis. Curr Opin Pharmacol 2008, 8:292-299.
    • (2008) Curr Opin Pharmacol , vol.8 , pp. 292-299
    • Clunes, M.T.1    Boucher, R.C.2
  • 15
    • 0036683406 scopus 로고    scopus 로고
    • Effects of recombinant human DNase and hypertonic saline on airway inflammation in children with cystic fibrosis
    • Suri R., Marshall L.J., Wallis C., Metcalfe C., Bush A., Shute J.K. Effects of recombinant human DNase and hypertonic saline on airway inflammation in children with cystic fibrosis. Am J Respir Crit Care Med 2002, 166:352-355.
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 352-355
    • Suri, R.1    Marshall, L.J.2    Wallis, C.3    Metcalfe, C.4    Bush, A.5    Shute, J.K.6
  • 16
    • 77954656248 scopus 로고    scopus 로고
    • Tolerability of Inhaled Hypertonic Saline in Infants With Cystic Fibrosis (ISIS Pilot) on World Wide Web URL:
    • Tolerability of Inhaled Hypertonic Saline in Infants With Cystic Fibrosis (ISIS Pilot) on World Wide Web URL: http://clinicaltrials.gov/ct2/show/study/NCT00546663.
  • 17
    • 77954656924 scopus 로고    scopus 로고
    • Infant Study of Inhaled Saline in Cystic Fibrosis (ISIS) on World Wide Web URL:
    • Infant Study of Inhaled Saline in Cystic Fibrosis (ISIS) on World Wide Web URL: http://clinicaltrials.gov/ct2/show/NCT00709280.
  • 19
    • 0032834277 scopus 로고    scopus 로고
    • The effect of inhaled mannitol on bronchial mucus clearance in cystic fibrosis patients: a pilot study
    • Robinson M., Daviskas E., Eberl S., Baker J., Chan H.K., Anderson S.D., Bye P.T. The effect of inhaled mannitol on bronchial mucus clearance in cystic fibrosis patients: a pilot study. Eur Respir J 1999, 14:678-685.
    • (1999) Eur Respir J , vol.14 , pp. 678-685
    • Robinson, M.1    Daviskas, E.2    Eberl, S.3    Baker, J.4    Chan, H.K.5    Anderson, S.D.6    Bye, P.T.7
  • 20
    • 73449118258 scopus 로고    scopus 로고
    • Comparison of inhaled mannitol, daily rhDNase and a combination of both in children with cystic fibrosis: a randomised trial
    • Minasian C., Wallis C., Metcalfe C., Bush A. Comparison of inhaled mannitol, daily rhDNase and a combination of both in children with cystic fibrosis: a randomised trial. Thorax 2010, 65:51-56.
    • (2010) Thorax , vol.65 , pp. 51-56
    • Minasian, C.1    Wallis, C.2    Metcalfe, C.3    Bush, A.4
  • 21
    • 77952558917 scopus 로고    scopus 로고
    • Randomized double blind, placebo-controlled phase III study of inhaled dry powder mannitol (Bronchitol) in CF
    • Bilton D., Robinson P., Cooper P., Charlton B. Randomized double blind, placebo-controlled phase III study of inhaled dry powder mannitol (Bronchitol) in CF. Pediatr Pulmonol 2009, S286.
    • (2009) Pediatr Pulmonol
    • Bilton, D.1    Robinson, P.2    Cooper, P.3    Charlton, B.4
  • 22
    • 57349176546 scopus 로고    scopus 로고
    • Bronchial provocation testing with dry powder mannitol in children with cystic fibrosis
    • Minasian C., Wallis C., Metcalfe C., Bush A. Bronchial provocation testing with dry powder mannitol in children with cystic fibrosis. Pediatr Pulmonol 2008, 43:1078-1084.
    • (2008) Pediatr Pulmonol , vol.43 , pp. 1078-1084
    • Minasian, C.1    Wallis, C.2    Metcalfe, C.3    Bush, A.4
  • 28
    • 34248354789 scopus 로고    scopus 로고
    • The epithelium as a target for therapy in cystic fibrosis
    • Thelin W.R., Boucher R.C. The epithelium as a target for therapy in cystic fibrosis. Curr Opin Pharmacol 2007, 7:290-295.
    • (2007) Curr Opin Pharmacol , vol.7 , pp. 290-295
    • Thelin, W.R.1    Boucher, R.C.2
  • 29
    • 20144363443 scopus 로고    scopus 로고
    • Safety and tolerability of denufosol tetrasodium inhalation solution, a novel P2Y2 receptor agonist: results of a phase 1/phase 2 multicenter study in mild to moderate cystic fibrosis
    • Deterding R., Retsch-Bogart G., Milgram L., Gibson R., Daines C., Zeitlin P.L., Milla C., Marshall B., Lavange L., Engels J., et al. Safety and tolerability of denufosol tetrasodium inhalation solution, a novel P2Y2 receptor agonist: results of a phase 1/phase 2 multicenter study in mild to moderate cystic fibrosis. Pediatr Pulmonol 2005, 39:339-348.
    • (2005) Pediatr Pulmonol , vol.39 , pp. 339-348
    • Deterding, R.1    Retsch-Bogart, G.2    Milgram, L.3    Gibson, R.4    Daines, C.5    Zeitlin, P.L.6    Milla, C.7    Marshall, B.8    Lavange, L.9    Engels, J.10
  • 30
    • 77954661291 scopus 로고    scopus 로고
    • Relationship between pulmonary exacerbations and lung function decline in a six month placebo-controlled trial of denufosol. In 32nd European Cystic Fibrosis Society Annual Conference. Brest, France
    • Accurso FJ, Durham TA, Schaberg AE: Relationship between pulmonary exacerbations and lung function decline in a six month placebo-controlled trial of denufosol. In 32nd European Cystic Fibrosis Society Annual Conference. Brest, France; 2009.
    • (2009)
    • Accurso, F.J.1    Durham, T.A.2    Schaberg, A.E.3
  • 31
    • 77954657133 scopus 로고    scopus 로고
    • Phase 3 study of denufosol tetrasodium for the treatment of cystic fibrosis. In American Thoracic Society 2009 International Conference. San Diego, California
    • Moss RB, Anbar RD, Wilmott RW, Barnes M, Schaberg AE, Durham TA, Accurso FJ: Phase 3 study of denufosol tetrasodium for the treatment of cystic fibrosis. In American Thoracic Society 2009 International Conference. San Diego, California; 2009.
    • (2009)
    • Moss, R.B.1    Anbar, R.D.2    Wilmott, R.W.3    Barnes, M.4    Schaberg, A.E.5    Durham, T.A.6    Accurso, F.J.7
  • 33
    • 41149164824 scopus 로고    scopus 로고
    • Pharmacological properties of N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-4-[4-(2,3-dihydroxypropoxy) phenyl]butyl-guanidine methanesulfonate (552-02), a novel epithelial sodium channel blocker with potential clinical efficacy for cystic fibrosis lung disease
    • Hirsh A.J., Zhang J., Zamurs A., Fleegle J., Thelin W.R., Caldwell R.A., Sabater J.R., Abraham W.M., Donowitz M., Cha B., et al. Pharmacological properties of N-(3,5-diamino-6-chloropyrazine-2-carbonyl)-N'-4-[4-(2,3-dihydroxypropoxy) phenyl]butyl-guanidine methanesulfonate (552-02), a novel epithelial sodium channel blocker with potential clinical efficacy for cystic fibrosis lung disease. J Pharmacol Exp Ther 2008, 325:77-88.
    • (2008) J Pharmacol Exp Ther , vol.325 , pp. 77-88
    • Hirsh, A.J.1    Zhang, J.2    Zamurs, A.3    Fleegle, J.4    Thelin, W.R.5    Caldwell, R.A.6    Sabater, J.R.7    Abraham, W.M.8    Donowitz, M.9    Cha, B.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.