A single point mutation in the pore region of the epithelial Na+ channel changes ion selectivity by modifying molecular sieving

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 7, 1999, Pages 4170-4175

  Kellenberger, Stephan ^a   Gautschi, Ivan ^a   Schild, Laurent ^a,b  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b University of Lausanne Departement de Pharmacologie et de Toxicologie   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CESIUM ION; LITHIUM ION; POTASSIUM ION; RUBIDIUM ION; SODIUM CHANNEL; SODIUM ION;

ANIMAL CELL; ARTICLE; CELL STRUCTURE; CHANNEL GATING; CONFORMATION; EPITHELIUM; GENE MUTATION; ION CURRENT; ION PERMEABILITY; ION TRANSPORT; MOLECULAR DYNAMICS; MOLECULAR SIZE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; RAT;

AMINO ACID SEQUENCE; ANIMALS; CATIONS, DIVALENT; CATIONS, MONOVALENT; CONSERVED SEQUENCE; EPITHELIAL SODIUM CHANNEL; FEMALE; MACROMOLECULAR SUBSTANCES; MEMBRANE POTENTIALS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OOCYTES; POINT MUTATION; PROTEIN CONFORMATION; RATS; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SERINE; SODIUM CHANNELS; XENOPUS LAEVIS;

ANIMALIA;

EID: 0033616609     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.7.4170     Document Type: Article

References (18)

1. Garty, H. & Palmer, L. G. (1997) Physiol. Rev. 77, 359-396.
2. Waldmann, R. & Lazdunski, M. (1998) Curr. Opin. Neurobiol. 8, 418-424.
3. Tavernarakis, N. & Driscoll, M. (1997) Annu. Rev. Physiol. 59, 659-689.
4. Firsov, D., Gautschi, I., Merillat, A. M., Rossier, B. C. & Schild, L. (1998) EMBO J. 17, 344-352.
5. Canessa, C. M., Schild, L., Buell, G., Thorens, B., Gautschi, I., Horisberger, J.-D. & Rossier, B. C. (1994) Nature (London) 367, 463-467.
6. Canessa, C. M., Merillat, A.-M. & Rossier, B. C. (1994) Am. J. Physiol. 267, C1682-C1690.
7. Schild, L., Schneeberger, E., Gautschi, I. & Firsov, D. (1997) J. Gen. Physiol. 109, 15-26.
8. Lingueglia, E., Champigny, G., Lazdunski, M. & Barbry, P. (1995) Nature (London) 378, 730-733.
9. Waldmann, R., Champigny, G. & Lazdunski, M. (1995) J. Biol. Chem. 270, 11735-11737.
10. Palmer, L. G. (1990) Renal Physiol. Biochem. 13, 51-58.
11. Dwyer, T. M., Adams, D. J. & Hille, B. (1980) J. Gen. Physiol. 75, 469-492.
12. Palmer, L. G. (1985) J. Membr. Biol. 87, 191-199.
13. Gomez-Hernandez, J. M., Stühmer, W. & Parekh, A. B. (1997) J. Physiol. (London) 502.3, 569-574.
14. Palmer, L. G. (1984) J. Membr. Biol. 80, 153-165.
15. Palmer, L. G. & Andersen, O. S. (1989) Biophys. J. 55, 779-787.
16. Doyle, D. A., Cabral, J. M., Pfuetzner, R. A., Kuo, A. L., Gulbis, J. M., Cohen, S. L., Chait, B. T. & MacKinnon, R. (1998) Science 280, 69-77.
17. Heinemann, S. H., Terlau, H., Stühmer, W., Imoto, K. & Numa, S. (1992) Nature (London) 356, 441-443.
18. Favre, I., Moczydlowski, E. & Schild, L. (1996) Biophys. J. 71, 3110-3125.