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Volumn 591, Issue 18, 2013, Pages 4377-4387

Does epithelial sodium channel hyperactivity contribute to cystic fibrosis lung disease?

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM); ANION CHANNEL; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; EPITHELIAL SODIUM CHANNEL;

EID: 84884284486     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2012.240861     Document Type: Review
Times cited : (77)

References (85)
  • 1
    • 84884282606 scopus 로고    scopus 로고
    • ENaC inhibitors and airway re-hydration in cystic fibrosis: state of the art
    • Althaus M (2013). ENaC inhibitors and airway re-hydration in cystic fibrosis: state of the art. Curr Mol Pharmacol 6, 3-12.
    • (2013) Curr Mol Pharmacol , vol.6 , pp. 3-12
    • Althaus, M.1
  • 2
    • 0025978119 scopus 로고
    • Effect of heart-lung transplantation on airway potential difference in patients with and without cystic fibrosis
    • Alton EW, Khagani A, Taylor RFH, Logan-Sinclair R, Yacoub M & Geddes DM (1991). Effect of heart-lung transplantation on airway potential difference in patients with and without cystic fibrosis. Eur Respir J 4, 5-9.
    • (1991) Eur Respir J , vol.4 , pp. 5-9
    • Alton, E.W.1    Khagani, A.2    Taylor, R.F.H.3    Logan-Sinclair, R.4    Yacoub, M.5    Geddes, D.M.6
  • 6
  • 8
    • 79960880754 scopus 로고    scopus 로고
    • Distribution of human PLUNC/BPI fold-containing (BPIF) proteins
    • Bingle L & Bingle CD (2011). Distribution of human PLUNC/BPI fold-containing (BPIF) proteins. Biochem Soc Trans 39, 1023-1027.
    • (2011) Biochem Soc Trans , vol.39 , pp. 1023-1027
    • Bingle, L.1    Bingle, C.D.2
  • 10
    • 0028309683 scopus 로고
    • Human airway ion transport (Part 1)
    • Boucher RC (1994). Human airway ion transport (Part 1). Am J Respir Crit Care Med 150, 271-281.
    • (1994) Am J Respir Crit Care Med , vol.150 , pp. 271-281
    • Boucher, R.C.1
  • 12
    • 0022973473 scopus 로고
    • + transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation
    • + transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation. J Clin Invest 78, 1245-1252.
    • (1986) J Clin Invest , vol.78 , pp. 1245-1252
    • Boucher, R.C.1    Stutts, M.J.2    Knowles, M.R.3    Cantley, L.4    Gatzy, J.T.5
  • 15
    • 84866527762 scopus 로고    scopus 로고
    • Activation of the epithelial sodium channel (ENaC) by the alkaline protease from Pseudomonas aeruginosa
    • Butterworth MB, Zhang L, Heidrich EM, Myerburg MM & Thibodeau PH (2012). Activation of the epithelial sodium channel (ENaC) by the alkaline protease from Pseudomonas aeruginosa. J Biol Chem 287, 32556-32565.
    • (2012) J Biol Chem , vol.287 , pp. 32556-32565
    • Butterworth, M.B.1    Zhang, L.2    Heidrich, E.M.3    Myerburg, M.M.4    Thibodeau, P.H.5
  • 17
    • 36148930617 scopus 로고    scopus 로고
    • Liquid movement across the surface epithelium of large airways
    • Chambers LA, Rollins BM & Tarran R (2007). Liquid movement across the surface epithelium of large airways. Respir Physiol Neurobiol 159, 256-270.
    • (2007) Respir Physiol Neurobiol , vol.159 , pp. 256-270
    • Chambers, L.A.1    Rollins, B.M.2    Tarran, R.3
  • 22
    • 0023150501 scopus 로고
    • Abnormal apical cell membrane in cystic fibrosis respiratory epithelium. An in vitro electrophysiologic analysis
    • Cotton CU, Stutts MJ, Knowles MR, Gatzy JT & Boucher RC (1987). Abnormal apical cell membrane in cystic fibrosis respiratory epithelium. An in vitro electrophysiologic analysis. J Clin Invest 79, 80-85.
    • (1987) J Clin Invest , vol.79 , pp. 80-85
    • Cotton, C.U.1    Stutts, M.J.2    Knowles, M.R.3    Gatzy, J.T.4    Boucher, R.C.5
  • 24
    • 0016434699 scopus 로고
    • Changes in non-electrolyte permeability of alveoli and the absorption of lung liquid at the start of breathing in the lamb
    • Egan EA, Olver RE & Strang LB (1975). Changes in non-electrolyte permeability of alveoli and the absorption of lung liquid at the start of breathing in the lamb. J Physiol 244, 161-179.
    • (1975) J Physiol , vol.244 , pp. 161-179
    • Egan, E.A.1    Olver, R.E.2    Strang, L.B.3
  • 28
    • 0028915902 scopus 로고
    • Ion transport across the jejunum in normal and cystic fibrosis mice
    • Grubb BR (1995). Ion transport across the jejunum in normal and cystic fibrosis mice. Am J Physiol Gastrointest Liver Physiol 268, G505-G513.
    • (1995) Am J Physiol Gastrointest Liver Physiol , vol.268
    • Grubb, B.R.1
  • 29
    • 0032962320 scopus 로고    scopus 로고
    • Pathophysiology of gene-targeted mouse models for cystic fibrosis
    • Grubb BR & Boucher RC (1999). Pathophysiology of gene-targeted mouse models for cystic fibrosis. Physiol Rev 79, S193-S214.
    • (1999) Physiol Rev , vol.79
    • Grubb, B.R.1    Boucher, R.C.2
  • 31
    • 0344743590 scopus 로고    scopus 로고
    • A mutation causing pseudohypoaldosteronism type 1 identifies a conserved glycine that is involved in the gating of the epithelial sodium channel
    • Grunder S, Firsov D, Chang SS, Jaeger NF, Gautschi I, Schild L, Lifton RP & Rossier BC (1997). A mutation causing pseudohypoaldosteronism type 1 identifies a conserved glycine that is involved in the gating of the epithelial sodium channel. EMBO J 16, 899-907.
    • (1997) EMBO J , vol.16 , pp. 899-907
    • Grunder, S.1    Firsov, D.2    Chang, S.S.3    Jaeger, N.F.4    Gautschi, I.5    Schild, L.6    Lifton, R.P.7    Rossier, B.C.8
  • 34
    • 33646364334 scopus 로고    scopus 로고
    • Delta-subunit confers novel biophysical features to alpha beta gamma-human epithelial sodium channel (ENaC) via a physical interaction
    • Ji HL, Su XF, Kedar S, Li J, Barbry P, Smith PR, Matalon S & Benos DJ (2006). Delta-subunit confers novel biophysical features to alpha beta gamma-human epithelial sodium channel (ENaC) via a physical interaction. J Biol Chem 281, 8233-8241.
    • (2006) J Biol Chem , vol.281 , pp. 8233-8241
    • Ji, H.L.1    Su, X.F.2    Kedar, S.3    Li, J.4    Barbry, P.5    Smith, P.R.6    Matalon, S.7    Benos, D.J.8
  • 36
    • 84866627429 scopus 로고    scopus 로고
    • CFTR regulates early pathogenesis of chronic obstructive lung disease in betaENaC-overexpressing mice
    • Johannesson B, Hirtz S, Schatterny J, Schultz C & Mall MA (2012). CFTR regulates early pathogenesis of chronic obstructive lung disease in betaENaC-overexpressing mice. PLoS ONE 7, e44059.
    • (2012) PLoS ONE , vol.7
    • Johannesson, B.1    Hirtz, S.2    Schatterny, J.3    Schultz, C.4    Mall, M.A.5
  • 37
    • 84859812575 scopus 로고    scopus 로고
    • (+) channel regulation by cytoplasmic and extracellular factors
    • (+) channel regulation by cytoplasmic and extracellular factors. Exp Cell Res 318, 1011-1019.
    • (2012) Exp Cell Res , vol.318 , pp. 1011-1019
    • Kashlan, O.B.1    Kleyman, T.R.2
  • 39
    • 84874102944 scopus 로고    scopus 로고
    • Molecular organization of the mucins and glycocalyx underlying mucus transport over mucosal surfaces of the airways
    • Kesimer M, Ehre C, Burns KA, Davis CW, Sheehan JK & Pickles RJ (2013). Molecular organization of the mucins and glycocalyx underlying mucus transport over mucosal surfaces of the airways. Mucosal Immunol 6, 379-392.
    • (2013) Mucosal Immunol , vol.6 , pp. 379-392
    • Kesimer, M.1    Ehre, C.2    Burns, K.A.3    Davis, C.W.4    Sheehan, J.K.5    Pickles, R.J.6
  • 42
    • 0019809960 scopus 로고
    • Increased bioelectric potential difference across respiratory epithelia in cystic fibrosis
    • Knowles M, Gatzy J & Boucher R (1981). Increased bioelectric potential difference across respiratory epithelia in cystic fibrosis. N Engl J Med 305, 1489-1495.
    • (1981) N Engl J Med , vol.305 , pp. 1489-1495
    • Knowles, M.1    Gatzy, J.2    Boucher, R.3
  • 43
    • 0020596438 scopus 로고
    • Relative ion permeability of normal and cystic fibrosis nasal epithelium
    • Knowles M, Gatzy J & Boucher R (1983a). Relative ion permeability of normal and cystic fibrosis nasal epithelium. J Clin Invest 71, 1410-1417.
    • (1983) J Clin Invest , vol.71 , pp. 1410-1417
    • Knowles, M.1    Gatzy, J.2    Boucher, R.3
  • 47
    • 0028015883 scopus 로고
    • Bronchoalveolar lavage findings in cystic fibrosis patients with stable, clinical mild lung disease suggest ongoing infection and inflammation
    • Konstan MW, Hilliard KA, Norvell TM & Berger M (1994). Bronchoalveolar lavage findings in cystic fibrosis patients with stable, clinical mild lung disease suggest ongoing infection and inflammation. Am J Respir Crit Care Med 150, 448-454.
    • (1994) Am J Respir Crit Care Med , vol.150 , pp. 448-454
    • Konstan, M.W.1    Hilliard, K.A.2    Norvell, T.M.3    Berger, M.4
  • 48
    • 0037283010 scopus 로고    scopus 로고
    • cAMP-dependent activation of CFTR inhibits the epithelial sodium channel (ENaC) without affecting its surface expression
    • Konstas AA, Koch JP & Korbmacher C (2003). cAMP-dependent activation of CFTR inhibits the epithelial sodium channel (ENaC) without affecting its surface expression. Pflugers Arch 445, 513-521.
    • (2003) Pflugers Arch , vol.445 , pp. 513-521
    • Konstas, A.A.1    Koch, J.P.2    Korbmacher, C.3
  • 49
    • 11044236102 scopus 로고    scopus 로고
    • Transepithelial electrical measurements with the Ussing chamber
    • Li H, Sheppard DN & Hug MJ (2004). Transepithelial electrical measurements with the Ussing chamber. J Cyst Fibros 3 Suppl 2, 123-126.
    • (2004) J Cyst Fibros , vol.3 , Issue.SUPPL 2 , pp. 123-126
    • Li, H.1    Sheppard, D.N.2    Hug, M.J.3
  • 51
    • 0032127980 scopus 로고    scopus 로고
    • + conductance is reduced by the cystic fibrosis transmembrane conductance regulator in normal but not in cystic fibrosis airways
    • + conductance is reduced by the cystic fibrosis transmembrane conductance regulator in normal but not in cystic fibrosis airways. J Clin Invest 102, 15-21.
    • (1998) J Clin Invest , vol.102 , pp. 15-21
    • Mall, M.1    Bleich, M.2    Greger, R.3    Schreiber, R.4    Kunzelmann, K.5
  • 53
    • 58449116969 scopus 로고    scopus 로고
    • + channel in the pathogenesis and as a therapeutic target for cystic fibrosis lung disease
    • + channel in the pathogenesis and as a therapeutic target for cystic fibrosis lung disease. Exp Physiol 94, 171-174.
    • (2009) Exp Physiol , vol.94 , pp. 171-174
    • Mall, M.A.1
  • 55
    • 0032433707 scopus 로고    scopus 로고
    • Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease
    • Matsui H, Grubb BR, Tarran R, Randell SH, Gatzy JT, Davis CW & Boucher RC (1998). Evidence for periciliary liquid layer depletion, not abnormal ion composition, in the pathogenesis of cystic fibrosis airways disease. Cell 95, 1005-1015.
    • (1998) Cell , vol.95 , pp. 1005-1015
    • Matsui, H.1    Grubb, B.R.2    Tarran, R.3    Randell, S.H.4    Gatzy, J.T.5    Davis, C.W.6    Boucher, R.C.7
  • 56
    • 78049266320 scopus 로고    scopus 로고
    • The multifunctional host defense peptide SPLUNC1 is critical for homeostasis of the mammalian upper airway
    • McGillivary G & Bakaletz LO (2010). The multifunctional host defense peptide SPLUNC1 is critical for homeostasis of the mammalian upper airway. PLoS ONE 5, e13224.
    • (2010) PLoS ONE , vol.5
    • McGillivary, G.1    Bakaletz, L.O.2
  • 58
    • 33748778207 scopus 로고    scopus 로고
    • Airway surface liquid volume regulates ENaC by altering the serine protease-protease inhibitor balance: a mechanism for sodium hyperabsorption in cystic fibrosis
    • Myerburg MM, Butterworth MB, McKenna EE, Peters KW, Frizzell RA, Kleyman TR & Pilewski JM (2006). Airway surface liquid volume regulates ENaC by altering the serine protease-protease inhibitor balance: a mechanism for sodium hyperabsorption in cystic fibrosis. J Biol Chem 281, 27942-27949.
    • (2006) J Biol Chem , vol.281 , pp. 27942-27949
    • Myerburg, M.M.1    Butterworth, M.B.2    McKenna, E.E.3    Peters, K.W.4    Frizzell, R.A.5    Kleyman, T.R.6    Pilewski, J.M.7
  • 66
    • 0029948974 scopus 로고    scopus 로고
    • Identification of a PY motif in the epithelial Na channel subunits as a target sequence for mutations causing channel activation found in Liddle syndrome
    • Schild L, Lu Y, Gautschi I, Schneeberger E, Lifton RP & Rossier BC (1996). Identification of a PY motif in the epithelial Na channel subunits as a target sequence for mutations causing channel activation found in Liddle syndrome. EMBO J 15, 2381-2387.
    • (1996) EMBO J , vol.15 , pp. 2381-2387
    • Schild, L.1    Lu, Y.2    Gautschi, I.3    Schneeberger, E.4    Lifton, R.P.5    Rossier, B.C.6
  • 73
    • 0023039339 scopus 로고
    • Oxygen consumption and ouabain binding sites in cystic fibrosis nasal epithelium
    • Stutts MJ, Knowles MR, Gatzy JT & Boucher RC (1986). Oxygen consumption and ouabain binding sites in cystic fibrosis nasal epithelium. Pediatr Res 20, 1316-1320.
    • (1986) Pediatr Res , vol.20 , pp. 1316-1320
    • Stutts, M.J.1    Knowles, M.R.2    Gatzy, J.T.3    Boucher, R.C.4
  • 74
    • 34247330452 scopus 로고    scopus 로고
    • Regulatory interactions of N1303K-CFTR and ENaC in Xenopus oocytes: evidence that chloride transport is not necessary for inhibition of ENaC
    • Suaud L, Yan W, Carattino MD, Robay A, Kleyman TR & Rubenstein RC (2007). Regulatory interactions of N1303K-CFTR and ENaC in Xenopus oocytes: evidence that chloride transport is not necessary for inhibition of ENaC. Am J Physiol Cell Physiol 292, C1553-C1561.
    • (2007) Am J Physiol Cell Physiol , vol.292
    • Suaud, L.1    Yan, W.2    Carattino, M.D.3    Robay, A.4    Kleyman, T.R.5    Rubenstein, R.C.6
  • 75
    • 80054746015 scopus 로고    scopus 로고
    • (+) transport in response to apical fluid volume expansion in human H441 airway epithelial cells
    • (+) transport in response to apical fluid volume expansion in human H441 airway epithelial cells. Pflugers Arch 462, 431-441.
    • (2011) Pflugers Arch , vol.462 , pp. 431-441
    • Tan, C.D.1    Selvanathar, I.A.2    Baines, D.L.3
  • 78
    • 0034885192 scopus 로고    scopus 로고
    • The relative roles of passive surface forces and active ion transport in the modulation of airway surface liquid volume and composition
    • Tarran R, Grubb BR, Gatzy JT, Davis CW & Boucher RC (2001a). The relative roles of passive surface forces and active ion transport in the modulation of airway surface liquid volume and composition. J Gen Physiol 118, 223-236.
    • (2001) J Gen Physiol , vol.118 , pp. 223-236
    • Tarran, R.1    Grubb, B.R.2    Gatzy, J.T.3    Davis, C.W.4    Boucher, R.C.5
  • 80
    • 33646138489 scopus 로고    scopus 로고
    • Soluble mediators, not cilia, determine airway surface liquid volume in normal and cystic fibrosis superficial airway epithelia
    • Tarran R, Trout L, Donaldson SH & Boucher RC (2006). Soluble mediators, not cilia, determine airway surface liquid volume in normal and cystic fibrosis superficial airway epithelia. J Gen Physiol 127, 591-604.
    • (2006) J Gen Physiol , vol.127 , pp. 591-604
    • Tarran, R.1    Trout, L.2    Donaldson, S.H.3    Boucher, R.C.4
  • 81
    • 84885679220 scopus 로고    scopus 로고
    • Proteases, cystic fibrosis and the epithelial sodium channel (ENaC)
    • Thibodeau PH & Butterworth MB (2013). Proteases, cystic fibrosis and the epithelial sodium channel (ENaC). Cell Tissue Res 351, 309-323.
    • (2013) Cell Tissue Res , vol.351 , pp. 309-323
    • Thibodeau, P.H.1    Butterworth, M.B.2
  • 82
    • 53349115703 scopus 로고
    • Active transport of sodium as the source of electric current in the short-circuited isolated frogskin
    • Ussing HH & Zerhan K (1951). Active transport of sodium as the source of electric current in the short-circuited isolated frogskin. Acta Physiol Scand 23, 110-127.
    • (1951) Acta Physiol Scand , vol.23 , pp. 110-127
    • Ussing, H.H.1    Zerhan, K.2
  • 83
    • 33646193597 scopus 로고    scopus 로고
    • Forskolin-induced cell shrinkage and apical translocation of functional enhanced green fluorescent protein-human alphaENaC in H441 lung epithelial cell monolayers
    • Woollhead AM & Baines DL (2006). Forskolin-induced cell shrinkage and apical translocation of functional enhanced green fluorescent protein-human alphaENaC in H441 lung epithelial cell monolayers. J Biol Chem 281, 5158-5168.
    • (2006) J Biol Chem , vol.281 , pp. 5158-5168
    • Woollhead, A.M.1    Baines, D.L.2


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