Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosis

Journal of Neuroscience

Volumn 31, Issue 6, 2011, Pages 2101-2112

  Duan, Bo ^a   Wang, Yi Zhi ^a   Yang, Tao ^b   Chu, Xiang Ping ^b,e   Yu, Ye ^a   Huang, Yu ^a   Cao, Hui ^a   Hansen, Jillian ^b   Simon, Roger P ^b,c   Zhu, Michael X ^d   Xiong, Zhi Gang ^b,c   Xu, Tian Le ^a  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^b LEGACY RESEARCH   (United States)

^c MOREHOUSE SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^e UNIVERSITY OF MISSOURI KANSAS CITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID SENSING ION CHANNEL; ACID SENSING ION CHANNEL 1A PROTEIN; CALCIUM ION; ION TRANSPORT AFFECTING AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PEPTIDE DERIVATIVE; PSALMOTOXIN 1; SPERMINE; UNCLASSIFIED DRUG;

ACIDOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING COMPETITION; BIOLOGICAL ACTIVITY; BRAIN INJURY; BRAIN ISCHEMIA; COMPETITIVE INHIBITION; CONTROLLED STUDY; CONVALESCENCE; CYTOPLASM; DESENSITIZATION; DISEASE EXACERBATION; EXTRACELLULAR ACIDOSIS; GENE DELETION; MALE; MOUSE; NERVE CELL CULTURE; NERVE CELL LESION; NERVE CELL MEMBRANE; NERVE CELL MEMBRANE STEADY POTENTIAL; NERVE STIMULATION; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NEUROPROTECTION; NONHUMAN; PH; PHARMACOLOGICAL BLOCKING; POLYAMINE SYNTHESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; RAT; SENSITIZATION; STEADY STATE; STROKE PATIENT;

ACIDOSIS; AMINO ACID TRANSPORT SYSTEM Y+; ANIMALS; ANOXIA; BIOPHYSICS; BRAIN INJURIES; CALCIUM; CELLS, CULTURED; CHO CELLS; CRICETINAE; CRICETULUS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; DRUG INTERACTIONS; ELECTRIC STIMULATION; EMBRYO, MAMMALIAN; EXCITATORY AMINO ACID ANTAGONISTS; EXTRACELLULAR FLUID; GABA ANTAGONISTS; GLUCOSE; HIPPOCAMPUS; HYDROGEN-ION CONCENTRATION; INFARCTION, MIDDLE CEREBRAL ARTERY; L-LACTATE DEHYDROGENASE; MEMBRANE POTENTIALS; MICE; MICE, KNOCKOUT; MUTATION; NERVE TISSUE PROTEINS; NEURONS; OLIGONUCLEOTIDES; PATCH-CLAMP TECHNIQUES; PICROTOXIN; PUTRESCINE; SODIUM CHANNELS; SPERMINE; TETRAZOLIUM SALTS; TIME FACTORS; TRANSFECTION; VALINE;

EID: 79951542315     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4351-10.2011     Document Type: Article

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