Structure of acid-sensing ion channel 1 at 1.9 Å resolution and low pH

Nature

Volumn 449, Issue 7160, 2007, Pages 316-323

  Jasti, Jayasankar ^a   Furukawa, Hiroyasu ^a,b   Gonzales, Eric B ^a   Gouaux, Eric ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID SENSING ION CHANNEL; ASPARAGINE; ASPARTIC ACID; CHLORIDE; DISULFIDE; SODIUM CHANNEL;

ACID; CHLORIDE; CRYSTAL STRUCTURE; ION; LEARNING; MEMORY; PH; POULTRY; SODIUM;

ACIDITY; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DELETION MUTANT; ELECTRIC POTENTIAL; ELECTROPHYSIOLOGY; PH; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN STRUCTURE; STRUCTURE ANALYSIS;

EID: 34548813656     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature06163     Document Type: Article

References (53)

1. Krishtal, O. The ASICs: Signaling molecules? Modulators? Trends Neurosci. 26, 477-483 (2003).
2. Lingueglia, E. Acid sensing ion channels in sensory perception. J. Biol. Chem. 282, 17325-17329 (2007).
3. Kellenberger, S. & Schild, L. Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure. Physiol. Rev. 82, 735-767 (2002).
4. Krishtal, O. A. & Pidoplichko, V. I. A receptor for protons in the nerve cell membrane. Neuroscience 5, 2325-2327 (1980).
5. Waldmann, R., Champigny, G., Bassilana, F., Heurteaux, C. & Lazdunski, M. A proton-gated cation channel involved in acid-sensing. Nature 386, 173-177 (1997).
6. O'Hagan, R. & Chalfie, M. Mechanosensation in Caenorhabditis elegans. Int. Rev. Neurobiol. 69, 169-203 (2006).
7. Lingueglia, E., Deval, E. & Lazdunski, M. FMRFamide-gated sodium channel and ASIC channels: a new class of ionotropic receptors for FMRF-amide and related peptides. Peptides 27, 1138-1152 (2006).
8. Chen, C. C., England, S., Akopian, A. N. & Wood, J. N. A sensory neuron-specific, proton-gated ion channel. Proc. Natl Acad. Sci. USA 95, 10240-10245 (1998).
9. + channel. J. Biol. Chem. 271, 7879-7882 (1996).
10. Lingueglia, E. et al. A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells. J. Biol. Chem. 272, 29778-29783 (1997).
11. + channel specific for sensory neurons. J. Biol. Chem. 272, 20975-20978 (1997).
12. Grunder, S., Geisler, H. S., Bassler, E. L. & Ruppersberg, J. P. A new member of acid-sensing ion channels from pituitary gland. Neuroreport 11, 1607-1611 (2000).
13. Alvarez de la Rosa, D., Zhang, P., Shao, D., White, F. & Canessa, C. M. Functional implications of the localization and activity of acid-sensing channels in rat peripheral nervous system. Proc. Natl Acad. Sci. USA 99, 2326-2331 (2002).
14. Alvarez de la Rosa, D. et al. Distribution, subcellular localization and ontogeny of ASIC1 in the mammalian central nervous system. J. Physiol. (Lond.) 546, 77-87 (2003).
15. Price, M. P. et al. The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice. Neuron 32, 1071-1083 (2001).
16. + channel with novel properties. J. Biol. Chem. 272, 28819-28822 (1997).
17. +-gated channels in mouse sensory neurons. Proc. Natl Acad. Sci. USA 99, 2338-2343 (2002).
18. Wemmie, J. A. et al. The acid-activated ion channel ASIC contributes to synaptic plasticity, learning and memory. Neuron 34, 463-477 (2002).
19. Sutherland, S. P., Benson, C. J., Adelman, J. & McCleskey, E. W. Acid-sensing ion channel 3 matches the acid-gated current in cardiac ischemia-sensing neurons. Proc. Natl Acad. Sci. USA 98, 711-716 (2001).
20. Xiong, Z. G. et al. Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels. Cell 118, 687-698 (2004).
21. Hesselager, M., Timmermann, D. B. & Ahring, P. K. pH dependency and desensitization kinetics of heterologously expressed combinations of acid-sensing ion channel subunits. J. Biol. Chem. 279, 11006-11015 (2004).
22. Korkushco, A. O., Krishtal, O. A. & Nowycky, M. C. Steady-state characteristics of the proton receptor in the somatic membrane of rat sensory neurons. Neurofiziologiya 15, 632-638 (1983).
23. 2+ block. Neuron 37, 75-84 (2003).
24. 2+ block vs allosteric mechanism. J. Gen. Physiol. 127, 109-117 (2006).
25. Baron, A., Waldmann, R. & Lazdunski, M. ASIC-like, proton-activated currents in rat hippocampal neurons. J. Physiol. (Lond.) 539, 485-494 (2002).
26. +-activated currents in hippocampal neurons. J. Biol. Chem. 279, 18296-18305 (2004).
27. Coscoy, S., Lingueglia, E., Lazdunski, M. & Barbry, P. The Phe-Met-Arg-Pheamide-activated sodium channel is a tetramer. J. Biol. Chem. 273, 8317-8322 (1998).
28. Snyder, P. M., Cheng, C., Prince, L. S., Rogers, J. C. & Welsh, M. J. Electrophysiological and biochemical evidence that DEG/ENaC cation channels are composed of nine subunits. J. Biol. Chem. 273, 681-684 (1998).
29. Coric, T., Zheng, D., Gerstein, M. & Canessa, C. M. Proton sensitivity of ASIC1 appeared with the rise of fishes by changes of residues in the region that follows TM1 in the ectodomain of the channel. J. Physiol. (Lond.) 568, 725-735 (2005).
30. Kawate, T. & Gouaux, E. Fluorescence-detection size-exclusion chromatography for precrystallization screening of integral membrane proteins. Structure 14, 673-681 (2006).
31. + channel subunit stoichiometry. Biophys. J. 88, 3966-3975 (2005).
32. Firsov, D., Gautschi, I., Merillat, A.-M., Rossier, B. C. & Schild, L. The heterotetrameric architecture of the epithelial sodium channel (ENaC). EMBO J. 17, 344-352 (1998).
33. Eskandari, S. et al. Number of subunits comprising the epithelial sodium channel. J. Biol. Chem. 274, 27281-27286 (1999).
34. Unwin, N. Refined structure of the nicotinic acetylcholine receptor. J. Mol. Biol. 346, 967-989 (2005).
35. Cushman, K. A., Marsh-Haffner, J., Adelman, J. & McCleskey, E. W. A conformational change in the extracellular domain that accompanies desensitization of acid-sensing ion channel (ASIC) 3. J. Gen. Physiol. 129, 345-350 (2007).
36. Coric, T., Zhang, P., Todorovic, N. & Canessa, C. M. The extracellular domain determines the kinetics of desensitization in acid-sensitive ion channel 1. J. Biol. Chem. 278, 45240-45247 (2003).
37. + are coactivators of acid-sensing ion channels. J. Biol. Chem. 276, 35361-35367 (2001).
38. Rosenmund, C., Stern-Bach, Y. & Stevens, C. F. The tetrameric structure of a glutamate receptor channel. Science 280, 1596-1599 (1998).
39. MacKinnon, R. Determination of the subunit stoichiometry of a voltage-activated potassium channel. Nature 350, 232-235 (1991).
40. Reynolds, J. A. & Karlin, A. Molecular weight in detergent solution of acetylcholine receptor from Torpedo californica. Biochemistry 17, 2035-2038 (1978).
41. 2+ blocking site of acid-sensing ion channel (ASIC) 1: Implications for channel gating. J. Gen. Physiol. 124, 383-394 (2004).
42. Kellenberger, S., Auberson, M., Gautschi, I., Schneeberger, E. & Schild, L. Permeability properties of ENaC selectivity filter mutants. J. Gen. Physiol. 118, 679-692 (2001).
43. + conduction and selectivity. Science 280, 69-77 (1998).
44. Pfister, Y. et al. A gating mutation in the internal pore of ASIC1a. J. Biol. Chem. 281, 11787-11791 (2006).
45. Goodman, M. B. et al. MEC-2 regulates C. elegans DEG/ENaC channels needed for mechanosensation. Nature 415, 1039-1042 (2002).
46. Sawyer, L. & James, M. N. Carboxyl-carboxylate interactions in proteins. Nature 295, 79-80 (1982).
47. Todorovic, N., Coric, T., Zhang, P.&Canessa, C. M. Effects of extracellular calcium on fASIC1 currents. Ann. NY Acad. Sci. 1048, 331-336 (2005).
48. Bellizzi, J. J. III, Widom, J., Kemp, C. W. & Clardy, J. Producing selenomethionine-labeled proteins with a baculovirus expression vector system. Structure 7, R263-R267 (1999).
49. Terwilliger, T. C. & Berendzen, J. Automated MAD and MIR structure solution. Acta Crystallogr. D 55, 849-861 (1999).
50. Cowtan, K. & Zhang, K. Y. Density modification for macromolecular phase improvement. Prog. Biophys. Mol. Biol. 72, 245-270 (1999).
51. Perrakis, A., Morris, R. & Lamzin, V. S. Automated protein model building combined with iterative structure refinement. Nature Struct. Biol. 6, 458-463 (1999).
52. Jones, T. A., Zou, J.-Y. & Cowan, S. W. Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A 47, 110-119 (1991).
53. Brunger, A. T. et al. Crystallography and NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr. D 54, 905-921 (1998).