Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2

Angewandte Chemie - International Edition

Volumn 53, Issue 4, 2014, Pages 1017-1020

  Schroeder, Christina I ^a   Rash, Lachlan D ^a   Vila Farrés, Xavier ^a   Rosengren, K Johan ^a   Mobli, Mehdi ^a   King, Glenn F ^a   Alewood, Paul F ^a   Craik, David J ^a   Durek, Thomas ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

ion channels; native chemical ligation; NMR spectroscopy; peptides; solid phase synthesis

Indexed keywords

ACID-SENSING ION CHANNELS; ELECTROPHYSIOLOGICAL ANALYSIS; ION CHANNEL; NATIVE CHEMICAL LIGATION; SOLID PHASE PEPTIDE SYNTHESIS; SOLID PHASE SYNTHESIS; STRUCTURE DETERMINATION; STRUCTURE-ACTIVITY RELATIONSHIPS;

ELECTROPHYSIOLOGY; IONS; METABOLITES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDES; SYNTHESIS (CHEMICAL); SYNTHETIC APERTURE RADAR; TOXIC MATERIALS;

BINDING SITES;

ACID SENSING ION CHANNEL; ASIC1 PROTEIN, RAT; ION CHANNEL; MAMBALGIN 1, DENDROASPIS POLYLEPIS; MAMBALGIN-1, DENDROASPIS POLYLEPIS; PEPTIDE; SNAKE VENOM;

ANIMAL; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; GENETICS; METABOLISM; NATIVE CHEMICAL LIGATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT; SOLID-PHASE SYNTHESIS; STRUCTURE ACTIVITY RELATION;

ION CHANNELS; NATIVE CHEMICAL LIGATION; NMR SPECTROSCOPY; PEPTIDES; SOLID-PHASE SYNTHESIS;

ACID SENSING ION CHANNELS; ANIMALS; BINDING SITES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELAPID VENOMS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PEPTIDES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84893302941     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201308898     Document Type: Article

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