A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain

Nature

Volumn 479, Issue 7373, 2011, Pages 410-414

  Bohlen, Christopher J ^a   Chesler, Alexander T ^a   Sharif Naeini, Reza ^b   Medzihradszky, Katalin F ^a   Zhou, Sharleen ^c   King, David ^c   Sánchez, Elda E ^d   Burlingame, Alma L ^a   Basbaum, Allan I ^b   Julius, David ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d TEXAS A AND M UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID SENSING ION CHANNEL; CAPSAICIN; MITTX TOXIN; PHOSPHOLIPASE A2; SNAKE VENOM; UNCLASSIFIED DRUG;

ENZYME ACTIVITY; ION; MOLECULAR ANALYSIS; NEUROLOGY; PH; PROTEIN; SENSORY SYSTEM; SNAKE; TOXIN; VENOM;

ANIMAL EXPERIMENT; ARTICLE; MICRURUS TENER TENER; MOUSE; NERVE FIBER; NOCICEPTION; NONHUMAN; PAIN; PH MEASUREMENT; PHARMACOPHORE; PRIORITY JOURNAL; SNAKE; SOMATOSENSORY SYSTEM; TOXIN ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; CAPSAICIN; CELLS, CULTURED; ELAPID VENOMS; ELAPIDAE; HINDLIMB; HUMANS; HYDROGEN-ION CONCENTRATION; ION CHANNEL GATING; MALE; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; NOCICEPTION; OOCYTES; PAIN; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTONS; RATS; SENSORY RECEPTOR CELLS; SODIUM CHANNELS; TRPV CATION CHANNELS; XENOPUS LAEVIS;

ANIMALIA; MICRURUS; MICRURUS FULVIUS TENER; MUS;

EID: 81555227923     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature10607     Document Type: Article

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