Asn415in the β11-β12 linker decreases proton-dependent desensitization of ASIC1

Journal of Biological Chemistry

Volumn 285, Issue 41, 2010, Pages 31285-31291

  Li, Tianbo ^a   Yang, Youshan ^a   Canessa, Cecilia M ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHANNEL RESPONSE; CONFORMATIONAL TRANSITIONS; DESENSITIZED STATE; EXTRACELLULAR DOMAINS; EXTRACELLULAR PH; ION CHANNEL; LOW CONCENTRATIONS; MACROSCOPIC CURRENTS; MAMMALIAN NERVOUS SYSTEM; PHYSIOLOGICAL PH; PROTON AFFINITY; PROTON CONCENTRATIONS; TIME COURSE;

MAMMALS; PH EFFECTS; PHYSIOLOGICAL MODELS; PHYSIOLOGY;

PROTONS;

ACID SENSING ION CHANNEL; ASPARAGINE; CYSTEINE; GLYCINE; PROTON; SERINE; ASIC CHANNEL; NERVE PROTEIN; SODIUM CHANNEL;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DESENSITIZATION; FEMALE; ION CURRENT; MEMBRANE CHANNEL; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STABILITY; PROTON TRANSPORT; STRUCTURE ACTIVITY RELATION; ANIMAL; CHEMISTRY; GENETICS; METABOLISM; PROTEIN TERTIARY STRUCTURE; RAT; XENOPUS LAEVIS;

MAMMALIA;

ANIMALS; ASPARAGINE; HYDROGEN-ION CONCENTRATION; NERVE TISSUE PROTEINS; PROTEIN STRUCTURE, TERTIARY; PROTONS; RATS; SODIUM CHANNELS; XENOPUS LAEVIS;

EID: 77957797513     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.160382     Document Type: Article

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