Regulation of the epithelial Na+ channel by Nedd4 and ubiquitination

Kidney International

Volumn 57, Issue 3, 2000, Pages 809-815

  Staub, Olivier ^a   Abriel, Hugues ^a   Plant, Pamela ^a   Isiiikawa, Toru ^a   Kanelis, Voula ^b   Saleki, Reza ^b   Horisberger, Jean Daniel ^b   Schild, Laurent ^b   Rotin, Daniela ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

C2 domain; ENaC channels; Liddle's syndrome; PY motif; Ubiquitin protein ligase; WW domain

Indexed keywords

PROTEIN SUBUNIT; SODIUM CHANNEL; UBIQUITIN;

CALCIUM CELL LEVEL; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELL SURFACE; CONFERENCE PAPER; ENDOCYTOSIS; HUMAN; LIDDLE SYNDROME; LYSOSOME; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; SODIUM TRANSPORT;

EID: 0001620648     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2000.00919.x     Document Type: Conference Paper

References (61)

1. GARIV H, PALMER LG: Epithelial sodium channels: Function, structure, and regulation. Pliysiol Rev 77:359-396, 1997
2. CANESSA CM, HORISBERGER J-D, ROSSIER BC: Epithelial sodium channel related to proteins involved in neurodegeneration. Nature 361:467-470, 1993
3. + channel is made of three homologous subunits. Nature 367:463-467, 1994
4. + channel. A new channel type with homoloaies to Caenorliabd'uis elegans degenerins. FEBS Lett 318:95-99, f993
5. + channel are differently regulated by aldosterone. J Biol Cliem 269:13736-13739, 1994
6. + channel. Am J Pliysiol 266:L728-L734, 1994
7. MCDONALD FJ, PRICE MP, SNYDER PM, WELSH MJ: Cloning and expression of the β- and γ-subunits of the human epithelial sodium channel. Am J Pliysiol 26S:C1157-C1163, 1995
8. VOILLEY N, LlNGUEGLIA E, ClIAMPIGNY G, MATTÉI M-G, WALDMANN R, LAZDUNSKI M, BARBRY P: The lung amiloride-sensitive Na+ channel: Biophysical properties, pharmacology, ontogenesis, and molecular cloning. Proc Natl Acad Sei USA 91:247-251, 1994
9. PUOTI A, MAY A, CANESSA CM, HORISBERGER J-D, SCHILD L, RosSIER BC: The highly selective low-conductance epithelial Na channel of Xenopits laevis A6 kidney cells. Am J Pliysiol 38:C18-C191, 1995
10. + channel subunit. AmJ Physiol 269:C641-C654, 1995
11. + channel subunits. Am J Pliysiol 272:C270-C277, 1997
12. KILLICK R, RICHARDSON G: Isolation of chicken alpha ENaC splice variants from a cochlear cDNA library. Biochim Biophys Acta Gene Struct Expression 1350:33-37, 1997
13. FIRSOV D, GAUTSCHI I, MéRILLAT A-M, ROSSIER BC, SCHILD L: The heterotetrameric architecture of the epithelial sodium channel (ENaC). EMBO J 17:344-352, 1998
14. 2+. J Gen Pliysiol 111:825-846, 1998
15. CANESSA CM, MéRILLAT A-M, ROSSIER BC: Membrane topology of the epithelial sodium channel in intact cells. Am J Pliysiol 267:C16S2-C1690, 1994
16. + channel. J Biol Cliem 269:12981-12986, 1994
17. SNYDER PM, MCDONALD FJ, STOKES JB, WELSH MJ: Membrane topology of the amiloride-sensitive epithelial sodium channel. J Biol Cliem 269:24379-24383, 1994
18. + channel deleted in Liddle's syndrome. EMBO J 15:2371-2380, 1996
19. + channel subunits as a target sequence for mutations causing channel activation found in Liddle syndrome. EMBO J 15:2381-2387, 1996
20. STUTTS MJ, CANESSA CM, OLSEN JC, HAMRICK M, COIIN JA, Ros-siER BC, BOUCHER RC: CFTR as a cAMP-dependent regulator of sodium channels. Science 269:847-850, 1995
21. HUMMLER E, BARKER P, GATZY J, BEERMANN F, VERDUMO C, SCHMIDT A, BOUCHER RC, ROSSIER BC: Early death due to defective neonatal lung liquid clearance in ctENaC-deficient mice. Nat Genet 12:325-328, 1996
22. CIIANG SS, GRüNDER S, HANUKOGLU A, RöSLER A, MATIIEW PM, HANUKOGLU I, SCHILD L, Lu Y, SHIMKETS RA, NELSON-WILLIAMS C, ROSSIER BC, LIFTON RP: Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1. Nnt Genet 12:248-253, 1996
23. STRAUTNIEKS SS, THOMPSON RJ, GARDINER RM, CHUNG E: A novel splice-site mutation in the gamma subunit of the epithelial sodium channel gene in three pseudohypoaldosteronism type 1 families. Nat Genet 13:248-250, 1996
24. LIDDLE GW, BLEDSOET, COPPAGE WS JR: A familial renal disorder simulating primary aldosteronism but with negligible aldosterone secretion. Trans Assoc Am Pliys 76:199-213, 1963
25. WARNOCK DO: Liddle syndrome: An autosomal dominant form of human hypertension. Kidney lut 53:18-24, 1998
26. SHIMKETS RA, WARNOCK DC, BOSITIS CM, NELSON-WILLIAMS C, HANSSON JH, SCIIAMBELAN M, GILL JR, ULICK S, MILORA RV, FINDLING JW, CANESSA CM, ROSSIER BC, LIFTON RP: Liddle's syndrome: Heritable human hypertension caused by mutations in the ßsubunit of the epithelial sodium channel. Cell 79:407-414, 1994
27. HANSSON JH, NELSON-WILLIAMS C, SUZUKI H, SCHILD L, SHIMKETS RA, Lu Y, CANESSA CM, IWASAKI T, ROSSIER BC, LIFTON RP: Hypertension caused by a truncated epithelial sodium channel gamma subunit: Genetic heterogeneity of Liddle syndrome. Nat Genet 11:76-82, 1995
28. HANSSON JH, SCHILD L, Lu Y, WILSON TA, GAUTSCHI I, SHIMKETS RA, NELSON-WILLIAMS C, ROSSIER BC, LIFTON RP: A de novo missense mutation of the ßsubunit of the epithelial sodium channel causes hypertension and Liddle syndrome, identifying a prolinerich segment critical for regulation of channel activity. Proc Natt Acad Sei USA 25:11495-11499, 1995
29. TAMURA H, SCHILD L, ENOMOTO N, MATSUI N, MARUMO F, ROSSIER BC, SASAKI S: Liddle disease caused by a missense mutation of beta subunit of the epithelial sodium channel gene. J Clin Invest 97:1780-1784, 1996
30. INOUE J, IWAOKA T, TOKUNAGA H, TAKAMUNE K, NAOMI S, ARAKI M, TAKAHAMA K, YAMAGUCHI K, TOMITA K: A family with Liddle's syndrome caused by a new missense mutation in the ßsubunit of the epithelial sodium channel. J Clin End Met 83:2210-2213, 1998
31. SCHILD L, CANESSA CM, SHIMKETS RA, WARNOCK DO, LIFTON RP, ROSSIER BC: A mutation in the epithelial sodium channel causing Liddle's disease increases channel activity in the Xenopns laevis oocyte expression system. Proc Natl Acad Sei USA 92:5699-5703, 1995
32. FIRSOV D, SCHILD L, GAUTSCHI I, MéRILLAT A-M, SCHNEEBERGER E, ROSSIER BC: Cell surface expression of the epithelial Na channel and a mutant causing Liddle syndrome: A quantitative approach. Proc Nail Acad Sei USA 93:15370-15375, 1996
33. KELLENBERGER S, GAUTSCHI I, ROSSIER BC, SCHILD L: Mutations causing Liddle syndrome reduce sodium-dependent downregulalion of the epithelial sodium channel in the Xenopns oocyte expression system. J din Invest 101:2741-2750, 1998
34. PALMER LG: Modulation of apical Na permeability of the toad urinary bladder by intracellular Na, Ca, and H. J Membr Biol 83:57-69, 1985
35. KUMAR S, TOMOOKA Y, NODA M: Identification of a set of genes with developmentally down-regulated expression in the mouse brain. Biochem Biophys Res Commun 185:1155-1161, 1992
36. STAUB O, YEGER H, PLANT P, KIM H, ERNST SA, ROTIN D: Immunolocalization of the ubiquitin-protein ligase Nedd4 in tissues expressing the epithelial Na channel (ENaC). Am J Physiol 272:C1871-C1SSO, 1997
37. BORK P, SUDOL M: The WW domain: A signalling site in dystrophin. Trends Biochem Sei 19:531-533, 1994
38. ANDRé B, SPRINGAEL J-Y: WWP, a new amino acid motif present in single or multiple copies in various proteins including dystrophin and the SH3-binding Yes-associated protein YAP65. Biochem Biophys Res Comimm 205:1201-1205, 1994
39. HOFMANN K, BuCHER P: The rsp5-domain is shared by proteins of diverse functions. FEBS Lett 358:153-157, 1995
40. STAUB O, ROTIN D: WW domains. Structure 4:495-499, 1996
41. CIIEN HI, SUDOL M: The WW domain of Yes-associated protein binds a novel proline-rich ligand that differs from the consensus established for SH3-binding modules. Proc Natl Acad Sei USA 92:7819-7823, 1995
42. JUNG D, YANG B, MEYER J, CHAMBERLAIN JS, CAMPBELL KP: Identification and characterization of the dystrophin anchoring site on b-dystroglycan. J Dial Cliem 270:27305-27310, 1995
43. CHAN DC, BEDFORD MT, LEDER P: Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains. EMBO J 15:1045-1054, 1996
44. BEDFORD MT, CHAN DC, LEDER P: FBP WW domains and the Abi SH3 domain bind to a specific class of proline-rich ligands. EMBO J 16:2376-2383, 1997
45. HERSIIKO A, CIECHANOVER A: The ubiquitin system. Anna Rev Biochem 67:425-479, 199S
46. HICKE L, RIEZMAN H: Ubiquitination of a yeast plasma membrane receptor signals its ligand-stimulated endocytosis. Cell 84:277-287, 1996
47. HICKE L: Ubiquitin-depcndent internalization and down-regulation of plasma membrane proteins. FASEB J 11:1215-1226, 1997
48. TERRELL J, Siiisn S, DUNN R, HICKE L: A function for monoubiquitination in the internalization of a G protein-coupled receptor. Molecular Cell 1:193-202, 1998
49. + channel (ENaC) by ubiquitination. EMBO J 16:6325-6336, 1997
50. MAY A, PUOTI A, GAEGGELER H-P, HORISBERGER J-D, ROSSIER BC: Early effect of aldosterone on the rate of synthesis of the epithelial sodium channel a subunit in A6 renal cells. J Ant Soc Ncphrol 8:1813-1822, 1997
51. VALENTIJN JA, FYFE GK, CANESSA CM: Biosynthesis and processing of epithelial sodium channels in Xenopus oocytcs. J Biol Cliem 273:30344-30351, 1998
52. GALAN JM, MOREAU V, ANDRé B, VOLLAND C, HAGUENAUERTSAPIS R: Ubiquitination mediated by the Npilp/RspSp ubiquitinprotein ligase is required for endocytosis of the yeast uracil permease. J Biol Client 271:10946-10952, 1996
53. SPRINGAEL J-Y, ANDRé B: Nitrogen-regulated ubiquitination of the Gapl permease of Saccharomyces cerevisiae. Mol Biol Cell 9:1253-1263, 1998
54. STROUSGJ, VAN KERKIIOFP, COVERS R, CIECHANOVER A, SCHWARTZ AL: The ubiquitin conjugation system is required for Iigand-induced endocytosis and degradation of the growth hormone receptor. EMBO J 15:3806-3812, 1996
55. + channel (ENaC) by Nedd4 in Liddle's syndrome. J Clin Invest 103:667-673, 1999
56. SHIMKETS RA, LIFTON RP, CANESSA CM: The activity of the epithelial sodium channel is regulated by clathrin-mediated endocytosis. J Biol Cliem 272:25537-25541, 1997
57. NALEFSKI EA, FALKE JJ: The C2 domain calcium-binding motif: Structural and functional diversity. Protein Sei 5:2375-2390, 1996
58. PONTING CP, PARKER PJ: Extending the C2 domain family: C2s in PKCs delta, epsilon, eta, theta, phospholipases, GAPs, and perform. Protein Sei 5:162-166, 1996
59. 2+-dependent plasma membrane localization. J Biol Cliem 272:32329-32336,1997
60. FIELDER K, LAFONT F, PARTON RG, SIMMONS K: Annexin Xlllb: A novel epithelial specific annexin is implicated in vesicular traffic to the apical membrane. J Cell Biol 128:1043-1053, 1995
61. +. Proc Natl Acad Sei USA 95:7169-7173, 1998