메뉴 건너뛰기




Volumn 7, Issue 4, 2012, Pages

Simultaneous disruption of mouse ASIC1a, ASIC2 and ASIC3 genes enhances cutaneous mechanosensitivity

Author keywords

[No Author keywords available]

Indexed keywords

ACID SENSING ION CANNEL 1A GENE; ACID SENSING ION CANNEL 2 GENE; ACID SENSING ION CANNEL 3 GENE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENOTYPE; MALE; MECHANICAL STIMULATION; MECHANORECEPTOR; MECHANOTRANSDUCTION; MOUSE; NOCICEPTIVE RECEPTOR; NONHUMAN; SENSORY NERVE CONDUCTION; SKIN NERVE; SPINAL GANGLION; WITHDRAWAL REFLEX; ANIMAL; ANIMAL BEHAVIOR; C57BL MOUSE; GENETICS; MECHANICAL STRESS; METABOLISM; MOUSE MUTANT; PHYSIOLOGY;

EID: 84859572137     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0035225     Document Type: Article
Times cited : (62)

References (57)
  • 1
    • 0032103129 scopus 로고    scopus 로고
    • H(+)-gated cation channels: neuronal acid sensors in the NaC/DEG family of ion channels
    • Waldmann R, Lazdunski M, (1998) H(+)-gated cation channels: neuronal acid sensors in the NaC/DEG family of ion channels. Curr Opin Neurobiol 8: 418-424.
    • (1998) Curr Opin Neurobiol , vol.8 , pp. 418-424
    • Waldmann, R.1    Lazdunski, M.2
  • 3
    • 80052419355 scopus 로고    scopus 로고
    • DEG/ENaC but Not TRP Channels Are the Major Mechanoelectrical Transduction Channels in a C. elegans Nociceptor
    • Geffeney SL, Cueva JG, Glauser DA, Doll JC, Lee TH, et al. (2011) DEG/ENaC but Not TRP Channels Are the Major Mechanoelectrical Transduction Channels in a C. elegans Nociceptor. Neuron 71: 845-857.
    • (2011) Neuron , vol.71 , pp. 845-857
    • Geffeney, S.L.1    Cueva, J.G.2    Glauser, D.A.3    Doll, J.C.4    Lee, T.H.5
  • 4
    • 0028127759 scopus 로고
    • Gene interactions affecting mechanosensory transduction in Caenorhabditis elegans
    • Huang M, Chalfie M, (1994) Gene interactions affecting mechanosensory transduction in Caenorhabditis elegans. Nature 367: 467-470.
    • (1994) Nature , vol.367 , pp. 467-470
    • Huang, M.1    Chalfie, M.2
  • 5
    • 16644397827 scopus 로고    scopus 로고
    • The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals
    • O'Hagan R, Chalfie M, Goodman MB, (2005) The MEC-4 DEG/ENaC channel of Caenorhabditis elegans touch receptor neurons transduces mechanical signals. Nat Neurosci 8: 43-50.
    • (2005) Nat Neurosci , vol.8 , pp. 43-50
    • O'Hagan, R.1    Chalfie, M.2    Goodman, M.B.3
  • 6
    • 0037133209 scopus 로고    scopus 로고
    • Functional implications of the localization and activity of acid-sensitive channels in rat peripheral nervous system
    • Alvarez de la Rosa D, Zhang P, Shao D, White F, Canessa CM, (2002) Functional implications of the localization and activity of acid-sensitive channels in rat peripheral nervous system. Proc Natl Acad Sci U S A 99: 2326-2331.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 2326-2331
    • Alvarez de la Rosa, D.1    Zhang, P.2    Shao, D.3    White, F.4    Canessa, C.M.5
  • 7
    • 0037133199 scopus 로고    scopus 로고
    • Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons
    • Benson CJ, Xie J, Wemmie JA, Price MP, Henss JM, et al. (2002) Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons. Proc Natl Acad Sci U S A 99: 2338-2343.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 2338-2343
    • Benson, C.J.1    Xie, J.2    Wemmie, J.A.3    Price, M.P.4    Henss, J.M.5
  • 8
    • 0035871647 scopus 로고    scopus 로고
    • Transport and localization of the DEG/ENaC ion channel BNaC1alpha to peripheral mechanosensory terminals of dorsal root ganglia neurons
    • Garcia-Anoveros J, Samad TA, Zuvela-Jelaska L, Woolf CJ, Corey DP, (2001) Transport and localization of the DEG/ENaC ion channel BNaC1alpha to peripheral mechanosensory terminals of dorsal root ganglia neurons. J Neurosci 21: 2678-2686.
    • (2001) J Neurosci , vol.21 , pp. 2678-2686
    • Garcia-Anoveros, J.1    Samad, T.A.2    Zuvela-Jelaska, L.3    Woolf, C.J.4    Corey, D.P.5
  • 9
    • 0034718899 scopus 로고    scopus 로고
    • The mammalian sodium channel BNC1 is required for normal touch sensation
    • Price MP, Lewin GR, McIlwrath SL, Cheng C, Xie J, et al. (2000) The mammalian sodium channel BNC1 is required for normal touch sensation. Nature 407: 1007-1011.
    • (2000) Nature , vol.407 , pp. 1007-1011
    • Price, M.P.1    Lewin, G.R.2    McIlwrath, S.L.3    Cheng, C.4    Xie, J.5
  • 10
    • 18244402692 scopus 로고    scopus 로고
    • The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice
    • Price MP, McIlwrath SL, Xie J, Cheng C, Qiao J, et al. (2001) The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice. Neuron 32: 1071-1083.
    • (2001) Neuron , vol.32 , pp. 1071-1083
    • Price, M.P.1    McIlwrath, S.L.2    Xie, J.3    Cheng, C.4    Qiao, J.5
  • 11
    • 9644263983 scopus 로고    scopus 로고
    • The ion channel ASIC1 contributes to visceral but not cutaneous mechanoreceptor function
    • Page AJ, Brierley SM, Martin CM, Martinez-Salgado C, Wemmie JA, et al. (2004) The ion channel ASIC1 contributes to visceral but not cutaneous mechanoreceptor function. Gastroenterology 127: 1739-1747.
    • (2004) Gastroenterology , vol.127 , pp. 1739-1747
    • Page, A.J.1    Brierley, S.M.2    Martin, C.M.3    Martinez-Salgado, C.4    Wemmie, J.A.5
  • 12
    • 4344605854 scopus 로고    scopus 로고
    • Knockout of the ASIC2 channel in mice does not impair cutaneous mechanosensation, visceral mechanonociception and hearing
    • Roza C, Puel JL, Kress M, Baron A, Diochot S, et al. (2004) Knockout of the ASIC2 channel in mice does not impair cutaneous mechanosensation, visceral mechanonociception and hearing. J Physiol 558: 659-669.
    • (2004) J Physiol , vol.558 , pp. 659-669
    • Roza, C.1    Puel, J.L.2    Kress, M.3    Baron, A.4    Diochot, S.5
  • 13
    • 0026089774 scopus 로고
    • The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration
    • Driscoll M, Chalfie M, (1991) The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration. Nature 349: 588-593.
    • (1991) Nature , vol.349 , pp. 588-593
    • Driscoll, M.1    Chalfie, M.2
  • 14
    • 67349250447 scopus 로고    scopus 로고
    • Mice lacking acid-sensing ion channels (ASIC) 1 or 2, but not ASIC3, show increased pain behaviour in the formalin test
    • Staniland AA, McMahon SB, (2009) Mice lacking acid-sensing ion channels (ASIC) 1 or 2, but not ASIC3, show increased pain behaviour in the formalin test. Eur J Pain 13: 554-563.
    • (2009) Eur J Pain , vol.13 , pp. 554-563
    • Staniland, A.A.1    McMahon, S.B.2
  • 15
    • 2442699006 scopus 로고    scopus 로고
    • Acid-sensing ion channels ASIC2 and ASIC3 do not contribute to mechanically activated currents in mammalian sensory neurones
    • Drew LJ, Rohrer DK, Price MP, Blaver KE, Cockayne DA, et al. (2004) Acid-sensing ion channels ASIC2 and ASIC3 do not contribute to mechanically activated currents in mammalian sensory neurones. J Physiol 556: 691-710.
    • (2004) J Physiol , vol.556 , pp. 691-710
    • Drew, L.J.1    Rohrer, D.K.2    Price, M.P.3    Blaver, K.E.4    Cockayne, D.A.5
  • 16
    • 0037169560 scopus 로고    scopus 로고
    • Biochemical basis of touch perception: mechanosensory function of degenerin/epithelial Na+ channels
    • Welsh MJ, Price MP, Xie J, (2002) Biochemical basis of touch perception: mechanosensory function of degenerin/epithelial Na+ channels. J Biol Chem 277: 2369-2372.
    • (2002) J Biol Chem , vol.277 , pp. 2369-2372
    • Welsh, M.J.1    Price, M.P.2    Xie, J.3
  • 17
    • 57349129522 scopus 로고    scopus 로고
    • Dorsal root ganglion neurons innervating skeletal muscle respond to physiological combinations of protons, ATP, and lactate mediated by ASIC, P2X, and TRPV1
    • Light AR, Hughen RW, Zhang J, Rainier J, Liu Z, et al. (2008) Dorsal root ganglion neurons innervating skeletal muscle respond to physiological combinations of protons, ATP, and lactate mediated by ASIC, P2X, and TRPV1. J Neurophysiol 100: 1184-1201.
    • (2008) J Neurophysiol , vol.100 , pp. 1184-1201
    • Light, A.R.1    Hughen, R.W.2    Zhang, J.3    Rainier, J.4    Liu, Z.5
  • 18
    • 18344371345 scopus 로고    scopus 로고
    • The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory
    • Wemmie JA, Chen J, Askwith CC, Hruska-Hageman AM, Price MP, et al. (2002) The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory. Neuron 34: 463-477.
    • (2002) Neuron , vol.34 , pp. 463-477
    • Wemmie, J.A.1    Chen, J.2    Askwith, C.C.3    Hruska-Hageman, A.M.4    Price, M.P.5
  • 19
    • 0020525719 scopus 로고
    • Ethical guidelines for investigations of experimental pain in conscious animals
    • Zimmermann M, (1983) Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16: 109-110.
    • (1983) Pain , vol.16 , pp. 109-110
    • Zimmermann, M.1
  • 20
    • 0030821372 scopus 로고    scopus 로고
    • Receptive properties of mouse sensory neurons innervating hairy skin
    • Koltzenburg M, Stucky CL, Lewin GR, (1997) Receptive properties of mouse sensory neurons innervating hairy skin. J Neurophysiol 78: 1841-1850.
    • (1997) J Neurophysiol , vol.78 , pp. 1841-1850
    • Koltzenburg, M.1    Stucky, C.L.2    Lewin, G.R.3
  • 21
    • 0030877657 scopus 로고    scopus 로고
    • Tensile and compressive responses of nociceptors in rat hairy skin
    • Khalsa PS, LaMotte RH, Grigg P, (1997) Tensile and compressive responses of nociceptors in rat hairy skin. J Neurophysiol 78: 492-505.
    • (1997) J Neurophysiol , vol.78 , pp. 492-505
    • Khalsa, P.S.1    LaMotte, R.H.2    Grigg, P.3
  • 22
    • 0027050717 scopus 로고
    • Somal membrane properties of physiologically identified sensory neurons in the rat: effects of nerve growth factor
    • Ritter AM, Mendell LM, (1992) Somal membrane properties of physiologically identified sensory neurons in the rat: effects of nerve growth factor. J Neurophysiol 68: 2033-2041.
    • (1992) J Neurophysiol , vol.68 , pp. 2033-2041
    • Ritter, A.M.1    Mendell, L.M.2
  • 23
    • 0032535249 scopus 로고    scopus 로고
    • Association of somatic action potential shape with sensory receptive properties in guinea-pig dorsal root ganglion neurones
    • Djouhri L, Bleazard L, Lawson SN, (1998) Association of somatic action potential shape with sensory receptive properties in guinea-pig dorsal root ganglion neurones. J Physiol 513 (Pt 3): 857-872.
    • (1998) J Physiol 513 Pt , vol.3 , pp. 857-872
    • Djouhri, L.1    Bleazard, L.2    Lawson, S.N.3
  • 24
    • 72149123909 scopus 로고    scopus 로고
    • The ion channel ASIC2 is required for baroreceptor and autonomic control of the circulation
    • Lu Y, Ma X, Sabharwal R, Snitsarev V, Morgan D, et al. (2009) The ion channel ASIC2 is required for baroreceptor and autonomic control of the circulation. Neuron 64: 885-897.
    • (2009) Neuron , vol.64 , pp. 885-897
    • Lu, Y.1    Ma, X.2    Sabharwal, R.3    Snitsarev, V.4    Morgan, D.5
  • 25
    • 0036521882 scopus 로고    scopus 로고
    • ASIC-like, proton-activated currents in rat hippocampal neurons
    • Baron A, Waldmann R, Lazdunski M, (2002) ASIC-like, proton-activated currents in rat hippocampal neurons. J Physiol 539: 485-494.
    • (2002) J Physiol , vol.539 , pp. 485-494
    • Baron, A.1    Waldmann, R.2    Lazdunski, M.3
  • 26
    • 0842347348 scopus 로고    scopus 로고
    • The discovery and characterization of a proton-gated sodium current in rat retinal ganglion cells
    • Lilley S, LeTissier P, Robbins J, (2004) The discovery and characterization of a proton-gated sodium current in rat retinal ganglion cells. J Neurosci 24: 1013-1022.
    • (2004) J Neurosci , vol.24 , pp. 1013-1022
    • Lilley, S.1    LeTissier, P.2    Robbins, J.3
  • 27
    • 4544230902 scopus 로고    scopus 로고
    • Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels
    • Xiong ZG, Zhu XM, Chu XP, Minami M, Hey J, et al. (2004) Neuroprotection in ischemia: blocking calcium-permeable acid-sensing ion channels. Cell 118: 687-698.
    • (2004) Cell , vol.118 , pp. 687-698
    • Xiong, Z.G.1    Zhu, X.M.2    Chu, X.P.3    Minami, M.4    Hey, J.5
  • 29
    • 0037452601 scopus 로고    scopus 로고
    • cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1
    • Leonard AS, Yermolaieva O, Hruska-Hageman A, Askwith CC, Price MP, et al. (2003) cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1. Proc Natl Acad Sci U S A 100: 2029-2034.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 2029-2034
    • Leonard, A.S.1    Yermolaieva, O.2    Hruska-Hageman, A.3    Askwith, C.C.4    Price, M.P.5
  • 30
    • 8744237238 scopus 로고    scopus 로고
    • PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current
    • Hruska-Hageman AM, Benson CJ, Leonard AS, Price MP, Welsh MJ, (2004) PSD-95 and Lin-7b interact with acid-sensing ion channel-3 and have opposite effects on H+- gated current. J Biol Chem 279: 46962-46968.
    • (2004) J Biol Chem , vol.279 , pp. 46962-46968
    • Hruska-Hageman, A.M.1    Benson, C.J.2    Leonard, A.S.3    Price, M.P.4    Welsh, M.J.5
  • 31
    • 67649974460 scopus 로고    scopus 로고
    • ASIC2 subunits target acid-sensing ion channels to the synapse via an association with PSD-95
    • Zha XM, Costa V, Harding AM, Reznikov L, Benson CJ, et al. (2009) ASIC2 subunits target acid-sensing ion channels to the synapse via an association with PSD-95. J Neurosci 29: 8438-8446.
    • (2009) J Neurosci , vol.29 , pp. 8438-8446
    • Zha, X.M.1    Costa, V.2    Harding, A.M.3    Reznikov, L.4    Benson, C.J.5
  • 32
    • 59149099842 scopus 로고    scopus 로고
    • The cytoskeletal protein alpha-actinin regulates acid-sensing ion channel 1a through a C-terminal interaction
    • Schnizler MK, Schnizler K, Zha XM, Hall DD, Wemmie JA, et al. (2009) The cytoskeletal protein alpha-actinin regulates acid-sensing ion channel 1a through a C-terminal interaction. J Biol Chem 284: 2697-2705.
    • (2009) J Biol Chem , vol.284 , pp. 2697-2705
    • Schnizler, M.K.1    Schnizler, K.2    Zha, X.M.3    Hall, D.D.4    Wemmie, J.A.5
  • 33
    • 0037053376 scopus 로고    scopus 로고
    • The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons
    • Anzai N, Deval E, Schaefer L, Friend V, Lazdunski M, et al. (2002) The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons. J Biol Chem 277: 16655-16661.
    • (2002) J Biol Chem , vol.277 , pp. 16655-16661
    • Anzai, N.1    Deval, E.2    Schaefer, L.3    Friend, V.4    Lazdunski, M.5
  • 34
    • 33644985209 scopus 로고    scopus 로고
    • Regulation of sensory neuron-specific acid-sensing ion channel 3 by the adaptor protein Na+/H+ exchanger regulatory factor-1
    • Deval E, Friend V, Thirant C, Salinas M, Jodar M, et al. (2006) Regulation of sensory neuron-specific acid-sensing ion channel 3 by the adaptor protein Na+/H+ exchanger regulatory factor-1. J Biol Chem 281: 1796-1807.
    • (2006) J Biol Chem , vol.281 , pp. 1796-1807
    • Deval, E.1    Friend, V.2    Thirant, C.3    Salinas, M.4    Jodar, M.5
  • 37
    • 78449300659 scopus 로고    scopus 로고
    • Sensing muscle ischemia: coincident detection of acid and ATP via interplay of two ion channels
    • Birdsong WT, Fierro L, Williams FG, Spelta V, Naves LA, et al. (2010) Sensing muscle ischemia: coincident detection of acid and ATP via interplay of two ion channels. Neuron 68: 739-749.
    • (2010) Neuron , vol.68 , pp. 739-749
    • Birdsong, W.T.1    Fierro, L.2    Williams, F.G.3    Spelta, V.4    Naves, L.A.5
  • 38
    • 33646369969 scopus 로고    scopus 로고
    • Vanilloid type 1 receptor and the acid-sensing ion channel mediate acid phosphate activation of muscle afferent nerves in rats
    • Gao Z, Henig O, Kehoe V, Sinoway LI, Li J, (2006) Vanilloid type 1 receptor and the acid-sensing ion channel mediate acid phosphate activation of muscle afferent nerves in rats. J Appl Physiol 100: 421-426.
    • (2006) J Appl Physiol , vol.100 , pp. 421-426
    • Gao, Z.1    Henig, O.2    Kehoe, V.3    Sinoway, L.I.4    Li, J.5
  • 39
    • 34447519136 scopus 로고    scopus 로고
    • Effect of muscle interstitial pH on P2X and TRPV1 receptor-mediated pressor response
    • Gao Z, Li JD, Sinoway LI, Li J, (2007) Effect of muscle interstitial pH on P2X and TRPV1 receptor-mediated pressor response. J Appl Physiol 102: 2288-2293.
    • (2007) J Appl Physiol , vol.102 , pp. 2288-2293
    • Gao, Z.1    Li, J.D.2    Sinoway, L.I.3    Li, J.4
  • 40
    • 27344452734 scopus 로고    scopus 로고
    • Transgenic expression of a dominant-negative ASIC3 subunit leads to increased sensitivity to mechanical and inflammatory stimuli
    • Mogil JS, Breese NM, Witty MF, Ritchie J, Rainville ML, et al. (2005) Transgenic expression of a dominant-negative ASIC3 subunit leads to increased sensitivity to mechanical and inflammatory stimuli. J Neurosci 25: 9893-9901.
    • (2005) J Neurosci , vol.25 , pp. 9893-9901
    • Mogil, J.S.1    Breese, N.M.2    Witty, M.F.3    Ritchie, J.4    Rainville, M.L.5
  • 41
    • 0037235086 scopus 로고    scopus 로고
    • Distribution, subcellular localization and ontogeny of ASIC1 in the mammalian central nervous system
    • Alvarez de la Rosa D, Krueger SR, Kolar A, Shao D, Fitzsimonds RM, et al. (2003) Distribution, subcellular localization and ontogeny of ASIC1 in the mammalian central nervous system. J Physiol 546: 77-87.
    • (2003) J Physiol , vol.546 , pp. 77-87
    • Alvarez de la Rosa, D.1    Krueger, S.R.2    Kolar, A.3    Shao, D.4    Fitzsimonds, R.M.5
  • 42
    • 0031029967 scopus 로고    scopus 로고
    • BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels
    • Garcia-Anoveros J, Derfler B, Neville-Golden J, Hyman BT, Corey DP, (1997) BNaC1 and BNaC2 constitute a new family of human neuronal sodium channels related to degenerins and epithelial sodium channels. Proc Natl Acad Sci U S A 94: 1459-1464.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 1459-1464
    • Garcia-Anoveros, J.1    Derfler, B.2    Neville-Golden, J.3    Hyman, B.T.4    Corey, D.P.5
  • 43
    • 58049196875 scopus 로고    scopus 로고
    • Neurosensory mechanotransduction
    • Chalfie M, (2009) Neurosensory mechanotransduction. Nat Rev Mol Cell Biol 10: 44-52.
    • (2009) Nat Rev Mol Cell Biol , vol.10 , pp. 44-52
    • Chalfie, M.1
  • 44
    • 77957332682 scopus 로고    scopus 로고
    • Coste B, Mathur J, Schmidt M, Earley TJ, Ranade S,et al. Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels
    • Coste B, Mathur J, Schmidt M, Earley TJ, Ranade S,et al. Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels. Science 330: 55-60.
    • Science , vol.330 , pp. 55-60
  • 45
    • 0027368882 scopus 로고
    • An animal model of neuropathic pain: a review
    • Bennett GJ, (1993) An animal model of neuropathic pain: a review. Muscle Nerve 16: 1040-1048.
    • (1993) Muscle Nerve , vol.16 , pp. 1040-1048
    • Bennett, G.J.1
  • 46
    • 0033030271 scopus 로고    scopus 로고
    • Heritability of nociception I: responses of 11 inbred mouse strains on 12 measures of nociception
    • Mogil JS, Wilson SG, Bon K, Lee SE, Chung K, et al. (1999) Heritability of nociception I: responses of 11 inbred mouse strains on 12 measures of nociception. Pain 80: 67-82.
    • (1999) Pain , vol.80 , pp. 67-82
    • Mogil, J.S.1    Wilson, S.G.2    Bon, K.3    Lee, S.E.4    Chung, K.5
  • 47
    • 0034853835 scopus 로고    scopus 로고
    • Roles of capsaicin-insensitive nociceptors in cutaneous pain and secondary hyperalgesia
    • Magerl W, Fuchs PN, Meyer RA, Treede RD, (2001) Roles of capsaicin-insensitive nociceptors in cutaneous pain and secondary hyperalgesia. Brain 124: 1754-1764.
    • (2001) Brain , vol.124 , pp. 1754-1764
    • Magerl, W.1    Fuchs, P.N.2    Meyer, R.A.3    Treede, R.D.4
  • 48
    • 0019376799 scopus 로고
    • Biochemical and anatomical observations on the degeneration of peptide-containing primary afferent neurons after neonatal capsaicin
    • Nagy JI, Hunt SP, Iversen LL, Emson PC, (1981) Biochemical and anatomical observations on the degeneration of peptide-containing primary afferent neurons after neonatal capsaicin. Neuroscience 6: 1923-1934.
    • (1981) Neuroscience , vol.6 , pp. 1923-1934
    • Nagy, J.I.1    Hunt, S.P.2    Iversen, L.L.3    Emson, P.C.4
  • 49
    • 0020600463 scopus 로고
    • Dose-dependent effects of capsaicin on primary sensory neurons in the neonatal rat
    • Nagy JI, Iversen LL, Goedert M, Chapman D, Hunt SP, (1983) Dose-dependent effects of capsaicin on primary sensory neurons in the neonatal rat. J Neurosci 3: 399-406.
    • (1983) J Neurosci , vol.3 , pp. 399-406
    • Nagy, J.I.1    Iversen, L.L.2    Goedert, M.3    Chapman, D.4    Hunt, S.P.5
  • 50
    • 0025316843 scopus 로고
    • A-fibers mediate mechanical hyperesthesia and allodynia and C-fibers mediate thermal hyperalgesia in a new model of causalgiform pain disorders in rats
    • Shir Y, Seltzer Z, (1990) A-fibers mediate mechanical hyperesthesia and allodynia and C-fibers mediate thermal hyperalgesia in a new model of causalgiform pain disorders in rats. Neurosci Lett 115: 62-67.
    • (1990) Neurosci Lett , vol.115 , pp. 62-67
    • Shir, Y.1    Seltzer, Z.2
  • 51
    • 0034031838 scopus 로고    scopus 로고
    • Encoding of location and intensity of noxious indentation into rat skin by spatial populations of cutaneous mechano-nociceptors
    • Khalsa PS, Zhang C, Qin YX, (2000) Encoding of location and intensity of noxious indentation into rat skin by spatial populations of cutaneous mechano-nociceptors. J Neurophysiol 83: 3049-3061.
    • (2000) J Neurophysiol , vol.83 , pp. 3049-3061
    • Khalsa, P.S.1    Zhang, C.2    Qin, Y.X.3
  • 52
    • 0036094570 scopus 로고    scopus 로고
    • Encoding of compressive stress during indentation by slowly adapting type I mechanoreceptors in rat hairy skin
    • Ge W, Khalsa PS, (2002) Encoding of compressive stress during indentation by slowly adapting type I mechanoreceptors in rat hairy skin. J Neurophysiol 87: 1686-1693.
    • (2002) J Neurophysiol , vol.87 , pp. 1686-1693
    • Ge, W.1    Khalsa, P.S.2
  • 53
    • 0034862157 scopus 로고    scopus 로고
    • Lactate enhances the acid-sensing Na+ channel on ischemia-sensing neurons
    • Immke DC, McCleskey EW, (2001) Lactate enhances the acid-sensing Na+ channel on ischemia-sensing neurons. Nat Neurosci 4: 869-870.
    • (2001) Nat Neurosci , vol.4 , pp. 869-870
    • Immke, D.C.1    McCleskey, E.W.2
  • 54
    • 27944440129 scopus 로고    scopus 로고
    • An acid-sensing ion channel that detects ischemic pain
    • Naves LA, McCleskey EW, (2005) An acid-sensing ion channel that detects ischemic pain. Braz J Med Biol Res 38: 1561-1569.
    • (2005) Braz J Med Biol Res , vol.38 , pp. 1561-1569
    • Naves, L.A.1    McCleskey, E.W.2
  • 55
    • 0026581550 scopus 로고
    • Protons selectively induce lasting excitation and sensitization to mechanical stimulation of nociceptors in rat skin, in vitro
    • Steen KH, Reeh PW, Anton F, Handwerker HO, (1992) Protons selectively induce lasting excitation and sensitization to mechanical stimulation of nociceptors in rat skin, in vitro. J Neurosci 12: 86-95.
    • (1992) J Neurosci , vol.12 , pp. 86-95
    • Steen, K.H.1    Reeh, P.W.2    Anton, F.3    Handwerker, H.O.4
  • 56
    • 77956183585 scopus 로고    scopus 로고
    • Calavia MG, Montano JA, Garcia-Suarez O, Feito J, Guervos MA,et al. Differential localization of Acid-sensing ion channels 1 and 2 in human cutaneus pacinian corpuscles
    • Calavia MG, Montano JA, Garcia-Suarez O, Feito J, Guervos MA,et al. Differential localization of Acid-sensing ion channels 1 and 2 in human cutaneus pacinian corpuscles. Cell Mol Neurobiol 30: 841-848.
    • Cell Mol Neurobiol , vol.30 , pp. 841-848
  • 57
    • 67649804916 scopus 로고    scopus 로고
    • Immunohistochemical detection of ENaCbeta in the terminal Schwann cells associated with the periodontal Ruffini endings of the rat incisor
    • Hitomi Y, Suzuki A, Kawano Y, Nozawa-Inoue K, Inoue M, et al. (2009) Immunohistochemical detection of ENaCbeta in the terminal Schwann cells associated with the periodontal Ruffini endings of the rat incisor. Biomed Res 30: 113-119.
    • (2009) Biomed Res , vol.30 , pp. 113-119
    • Hitomi, Y.1    Suzuki, A.2    Kawano, Y.3    Nozawa-Inoue, K.4    Inoue, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.