A natural point mutation changes both target selectivity and mechanism of action of sea anemone toxins

FASEB Journal

Volumn 26, Issue 12, 2012, Pages 5141-5151

  Peigneur, Steve ^a   Béress, László ^b,c   Möller, Carolina ^d   Marí, Frank ^d   Forssmann, Wolf Georg ^b,c   Tytgat, Jan ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c Pharis Biotec GmbH   (Germany)

^d FLORIDA ATLANTIC UNIVERSITY   (United States)

Author keywords

Ion channel inhibitor; Ion channel modulator; Voltage gated potassium channel; Voltage gated sodium channel

Indexed keywords

POTASSIUM CHANNEL KV1.1; POTASSIUM CHANNEL KV1.6; PROTEIN APETX1; PROTEIN APETX2; PROTEIN APETX3; SEA ANEMONE TOXIN; SODIUM CHANNEL NAV1.2; SODIUM CHANNEL NAV1.8; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTHOPLEURA ELEGANTISSIMA; ARTICLE; CHANNEL GATING; CHEMICAL ANALYSIS; CONTROLLED STUDY; ELECTROPHYSIOLOGY; FEMALE; IC 50; MOLECULAR CLONING; NONHUMAN; OOCYTE; POINT MUTATION; PRIORITY JOURNAL; SEA ANEMONE; STEADY STATE; XENOPUS LAEVIS;

ANIMALS; CNIDARIAN VENOMS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; FEMALE; HUMANS; INSECTS; ION CHANNEL GATING; OOCYTES; POINT MUTATION; POTASSIUM CHANNELS; SEA ANEMONES; SODIUM CHANNELS; TOXINS, BIOLOGICAL; XENOPUS LAEVIS;

ACTINIARIA; ANTHOPLEURA ELEGANTISSIMA; ARACHNIDA; HEXAPODA; MAMMALIA; XENOPUS LAEVIS;

EID: 84870325152     PISSN: None     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.12-218479     Document Type: Article

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